Objective To investigate clinical features of vulvar lichen simplex chronicus (VLSC) . Methods Clinical data were collected from 137 VLSC patients who visited a Vulvar Clinic in the Department of Dermatology, Beijing Hospital from 2017 to 2018, and analyzed retrospectively. Non-normally distributed measurement data (age and disease duration) were described as median (P25, P75) , and analyzed by using rank sum test, and enumeration data were compared by using chi-square test. Results Among the 137 patients with VLSC, the age at onset was 32.0 (25.5, 40.0) years, and the disease duration was 36.0 (15.0, 72.0) months. Thirty-two (23.4%) patients had a history of atopic diseases, and the age at onset of VLSC was significantly lower in these patients with a history of atopic diseases (29.5[25.0, 35.8] years) than in those without a history of atopic diseases (33.0[27.0, 41.0] years, Z = 2.03, P = 0.042) . The most frequently involved site was the labia majora (130/137, 94.9%) , and the labia minora was rarely involved (13/137, 9.5%) . Bilateral lesions were observed in 103 (75.2%) patients, and hypopigmentation occurred in 8 (5.8%) patients. All the patients experienced itching to different extents, including moderate itching in 44 (32.1%) cases and severe itching in 80 (58.4%) . The ratio of patients with severe itching to those with disease duration > 2 years (68.1%) was significantly higher than that of patients with severe itching to those with disease duration < 2 years (47.7%, χ2 = 5.830, P = 0.016) . Patients reported that local wetness and sweating (55 cases, 40.1%) , spicy diet (41 cases, 29.9%) and mental stress (36 cases, 26.3%) could aggravate itching. Conclusions VLSC commonly occurs in patients aged 20 - 39 years, and atopic predisposition may be an important factor for VLSC. VLSC mostly involves bilateral labia majora, and the longer the disease duration, the more severe the itching. Key words: Neurodermatitis; Vulvar diseases; Pruritus; Femininity; Hypopigmentation; Local wetness