Flow induced vibration (FIV) and forced convection heat transfer from staggered cylinders are numerically investigated with Re = 150 and Pr = 0.7. Cylinders are arranged in a staggered manner with three different stagger angles (α) = 15°, 30°, and 45°. The upstream cylinder (UC) is kept fixed while the downstream cylinder (DC) is mounted. The cross section of the bluff body is altered by parameter (r*) = 0 (square cylinder), 0.5, 0.75, and 1 (circular cylinder). For every stagger angle and r*, the reduced velocity is varied from 2 to 10. The mass ratio (m*) of the DC is kept at 10 and damping constant set to zero for maximum vibrational amplitude. The incompressible Navier–Stokes equations are coupled with Newton's equation for the mass-damper system of the vibrating cylinder. Flow induced vibration was studied with the help of frequency characteristics, dynamics response of cylinders, and instantaneous phase plots of lift and amplitude. Generally, in the case of square cylinders a delayed response can be observed as compared to other configurations. For α=15°, the DC is fully submerged into the wake of static UC. P + S (P: pair; S: singlet)-type vortices can be observed for r* = 0. For other configurations of filleted cylinders, such as r* = 0.5, 0.75, and 1 at Ur=4, 2 parallel row formation is formed due to negative sign vortices while the other one was a combination of positive and negative vortices in pseudo-P formation. At higher Ur=6 and 8, coalesced and irregular wakes can be noticed. As the stagger angle is increased to higher than 30°, the wake of both cylinders becomes more pronounced. Due to the change in stagger angle, fs (vortex shedding frequency) of UC and DC forces decouples. 2P-type vortex shedding can be observed at Ur=4 for r* = 0.75 and 1. Pairs of vortices are coupled from each cylinder in a row where negative vortices coalesce while losing energy. For lower r* = 0 and 0.5, there is a tendency for three row formation. Further increase in angle pushed the DC completely out of the wake of the UC although vortices from both cylinders are still found to interact and exhibit three row formation and 2P-type vortex shedding. Heat transfer from the DC is highly dependent on the stagger angle. For r* = 1 and 0.5 at Ur=2, the change in Nuavg is 15% and 14.7%, respectively, when the angle changed from 15° to 45°. Heat transfer from any FIV system can be directly influenced by dynamic response, position, shape, and flow topology. The generated results are provide insight for understanding the vibrational modes and heat transfer from two bluff bodies involving fluid–structure interactions.