Volumetric Modulated Arc Therapy Delivery Research Articles

Determination of Multileaf Collimator Positional Errors as a Function of Dose Rate, Speed, and Delivery Interruption for Volumetric-Modulated Arc Therapy Delivery.

Aim:To determine the multileaf collimator positional error (MLC-PE) during volumetric modulated arc therapy (VMAT) delivery by studying the time-dependent MLC velocity in mathematically derivable trajectories such as straight line and conic sections.Materials and Methods:VMAT delivery is planned in a way that MLCs are moving in a locus which can be defined by mathematical functions such as linear, parabolic, or circular velocity (PV or CV). The VMAT delivery was interrupted either once or multiple times during the delivery and projection images of the same were acquired in electronic portal imaging device. MLC-PE was then analyzed as a function of dose rate (DR), and MLC speed (SP) and number of interruptions in treatment delivery. In VMAT delivery with linear MLC motion, the delivery was interrupted either once (linear motion single interruption) or multiple (three) times (linear motion multiple interruptions). For PV and CV MLC velocity, the MLC motions are interrupted multiple times.Results:The maximum individual error obtained (DR of 35 MU/min, SP of 2.0 cm/s) was 1.96 ± 0.1 mm. Only 4.4% of MLCs showed ≥ ±1 mm positional error. When the treatment delivery is interrupted multiple times in VMAT delivery, the influence of interruption in MLC-PE overwhelmed the influence by DR and SP. For a sub-group analysis of independent and dependent variables, the mean MLC-PE was 0.18 ± 0.4 mm 0.19 ± 0.42 mm, respectively.Conclusion:Determination of MLC-PEs using a mathematical function without approximation indicates that MLC-PE is not a function of MLC speed. In less than 5% of the studied scenarios, the MLC-PE exceeds its tolerance value (±1 mm). The MLC-PE is significantly less in modern machines due to advancements in the delivery mechanism.

Correlation of the gamma passing rates with the differences in the dose-volumetric parameters between the original VMAT plans and actual deliveries of the VMAT plans

PurposeThe aim of this study was to investigate the correlations of the gamma passing rates (GPR) with the dose-volumetric parameter changes between the original volumetric modulated arc therapy (VMAT) plans and the actual deliveries of the VMAT plans (DV errors). We compared the correlations of the TrueBeam STx system to those of a C-series linac.MethodsA total of 20 patients with head and neck (H&N) cancer were retrospectively selected for this study. For each patient, two VMAT plans with the TrueBeam STx and Trilogy (C-series linac) systems were generated under similar modulation degrees. Both the global and local GPRs with various gamma criteria (3%/3 mm, 2%/2 mm, 2%/1 mm, 1%/2 mm, and 1%/1 mm) were acquired with the 2D dose distributions measured using the MapCHECK2 detector array. During VMAT deliveries, the linac log files of the multi-leaf collimator positions, gantry angles, and delivered monitor units were acquired. The DV errors were calculated with the 3D dose distributions reconstructed using the log files. Subsequently, Spearman’s rank correlation coefficients (rs) and the corresponding p values were calculated between the GPRs and the DV errors.ResultsFor the Trilogy system, the rs values with p < 0.05 showed weak correlations between the GPRs and the DV errors (rs<0.4) whereas for the TrueBeam STx system, moderate or strong correlations were observed (rs≥0.4). The DV errors in the V20Gy of the left parotid gland and those in the mean dose of the right parotid gland showed strong correlations (always with rs > 0.6) with the GPRs with gamma criteria except 3%/3 mm. As the GPRs increased, the DV errors decreased.ConclusionThe GPRs showed strong correlations with some of the DV errors for the VMAT plans for H&N cancer with the TrueBeam STx system.

Constrained optimization towards marker-based tumor tracking in VMAT

This study proposes that incorporating marker-based visibility constraints into the optimization of volumetric modulated arc therapy (VMAT) will generate treatment plans which not only ensure a higher chance of successfully applying real-time tumor tracking techniques, but also simultaneously satisfy dosimetric objectives. This was applied clinically and investigated for multiple disease sites (10 prostate, 5 liver, and 5 lung) using a radiotherapy optimization software (MonArc), where these new constraints were added to conventional dosimetric constraints. For all the investigated sites, three fiducial markers were located inside or around the planning target volume (PTV), and VMAT plans were created for each patient. We modified MonArc to analyze the multi-leaf collimator (MLC) beam’s-eye-view at all control points in the gantry arc, while including marker-based visibility constraints of type ‘hard’ (i.e. requiring 100% visibility of all markers, HC) and ‘soft’ (i.e. penalizes visibility for one marker [SCI] or two markers [SCII] only) in the optimization process. Dose distributions resulting from the constrained plans (HC, SCI, and SCII) were compared to the non-constrained plan (NC—plans optimized without visibility constraints) using several quantitative dose metrics including the conformity index, homogeneity index, doses to PTV and to organs-at-risk (OAR). Generally, the NC plan produced the best PTV dose conformity and the least OAR doses for the entire patient datasets, followed by the SC and then HC plans, with all the optimization approaches typically achieving acceptable dose metrics. Across the three disease sites, visibility of all three markers in MLC apertures increased from 32% to 100% of available control points as visibility constraints strengthened. Although dose metrics showed some deterioration for constrained plans (−6% for SCI up to −15% for HC using the PTV average index), the required dosimetric objectives were still satisfied in at least 90% of patients. In conclusion, we demonstrated that marker and tumour visibility constraints can be incorporated with dosimetric objectives to produce treatment plans satisfying both objectives, which should ensure greater success when applying real-time tracking for VMAT delivery.

Monte Carlo simulation of 6-MV dynamic wave VMAT deliveries by Vero4DRT linear accelerator using EGSnrc moving sources.

The commissioning and benchmark of a Monte Carlo (MC) model of the 6‐MV Brainlab‐Mitsubishi Vero4DRT linear accelerator for the purpose of quality assurance of clinical dynamic wave arc (DWA) treatment plans is reported. Open‐source MC applications based on EGSnrc particle transport codes are used to simulate the medical linear accelerator head components. Complex radiotherapy irradiations can be simulated in a single MC run using a shared library format combined with BEAMnrc “source20.” Electron energy tuning is achieved by comparing measured vs simulated percentage depth doses (PDDs) for MLC‐defined field sizes in a water phantom. Electron spot size tuning is achieved by comparing measured and simulated inplane and crossplane beam profiles. DWA treatment plans generated from RayStation (RaySearch) treatment planning system (TPS) are simulated on voxelized (2.5 mm3) patient CT datasets. Planning target volume (PTV) and organs at risk (OAR) dose–volume histograms (DVHs) are compared to TPS‐calculated doses for clinically deliverable dynamic volumetric modulated arc therapy (VMAT) trajectories. MC simulations with an electron beam energy of 5.9 MeV and spot size FWHM of 1.9 mm had the closest agreement with measurement. DWA beam deliveries simulated on patient CT datasets results in DVH agreement with TPS‐calculated doses. PTV coverage agreed within 0.1% and OAR max doses (to 0.035 cc volume) agreed within 1 Gy. This MC model can be used as an independent dose calculation from the TPS and as a quality assurance tool for complex, dynamic radiotherapy treatment deliveries. Full patient CT treatment simulations are performed in a single Monte Carlo run in 23 min. Simulations are run in parallel using the Condor High‐Throughput Computing software1 on a cluster of eight servers. Each server has two physical processors (Intel Xeon CPU E5‐2650 0 @2.00 GHz), with 8 cores per CPU and two threads per core for 256 calculation nodes.

Gantry angle dependent beam control optimization of a traveling wave linear accelerator to improve VMAT delivery.

IntroductionIncreased modulation and dynamical delivery of external beam radiotherapy (EBRT), such as volumetric modulated arc therapy (VMAT) with dynamic gantry rotation, continuously variable dose rate (CVDR) and field shapes that change during the beam, place greater demands on the performance of linear accelerators (linac). In this study, the accuracy of the linac beam steering is improved by the application of a new method to determine the gantry‐dependent lookup table.MethodsAn improved method of lookup table creation based on service graphing information from the linac is investigated. This minimizes the impact of magnetic hysteresis due to the previous current in the steering magnets, which is dependent on the previous gantry angle. A software tool, programmed with MATLAB®, is used to calculate and export the new optimal lookup table (LUT).ResultsThis method is efficient requiring little clinical machine time or analysis time, and leads to an improved VMAT delivery with a reduction of about 60 percent in beam steering errors. If the surrounding magnetic field is changed, for example, ramping a nearby magnetic resonance imaging system (MRI), the beam steering LUT optimization can be quickly performed.ConclusionThis study shows an improved linac stability using improved lookup tables. Resulting in a lower number of interruptions, preventing down‐time, and a lower risk of intrafraction motion due to longer treatment times.

VMAT Based TBI Prior to BMT in Malignant & Non-malignant Disorders – Single Institution Experience

The purpose of this paper is to report the feasibility of Total Body Irradiation (TBI) by multiple Iso-centric Volumetric Modulated Arc Therapy (VMAT) technique before Bone Marrow Transplant (BMT) in malignant & Non-malignant, hematological & non-hematological disorders. Total of 5 patients, 3 with ALL, 1each with Hurlor syndrome and Thalasemia Major were recruited for the TBI in our hospital from April 2018 to May 2019 before going for BMT. Immobilizations were done with thermoplastic masks and vaclocs for all patients in SBRT Multi-board. HFS&FFS two sets of CT scans done for 4 patients having more than 120 cm in heights with dosimetric reference marker in junction and only HFS scan done for a patient less than 120 cm in height. Dose prescribed to PTV excluding lung and kidneys was 12Gy in 6 fractions over 3 days (2 fractions per day) for ALL, single dose of 3 Gy for Hurler syndrome and 4 Gy in 2 fractions for Thalasemia Major. Treatment planning was done using VMAT technique in a treatment planning system. It consisted of average of 13 arcs for ALL and 8 arcs for other two patients with multiple isocenters and small static fields used to enhance the dose coverage. The best treatment plans were selected ensuring 90% PTV dose coverage and acceptable dose to OARs. Treatment executed with Linear accelerator equipped with OBI, CBCT used as Image Guided Radiation Therapy (IGRT) for each VMAT delivery. Quality assurance performed with mini-phantom and point dose measurements done with slab phantom and CC13 ion chamber followed by in vivo dosimetry performed with Optically Stimulated Luminescence Dosimeter nano chips. Contouring and planning time took 15-20 hours and quality assurance took 4-5 hours for each patient. PTV coverage of 90% achieved with PTV Dmean of 12.54 Gy for ALL patients and 3.02&4.32 respectively in other two cases. OAR average doses of lungs, kidneys and liver reduced to 9.8, 9.5 & 10.3 Gy respectively and lens restricted to 6 Gy for ALL patients and no OAR constraints for single and dual fraction low dose prescription patients. On couch treatment time on day one was 2.5 hours including setup and mounting of OSLD chips and irradiation for all cases. Further fractions time reduced to 1.5 hrs. 3 sets of CBCT performed for head first with average setup error of ±0.5 mm and two CBCT scans performed for feet first with average setup error of ±0.3 mm. OSLD dosimeter readings showed the results of within ±5% deviation. TBI by VMAT technique is feasible and provides satisfactory 3D dose distribution within PTV and reducing the dose to the critical OARs. VMAT provides a homogenous dose to the whole body, verified & confirmed by in vivo dosimetry. VMAT-TBI has advantage over extended SSD based conventional TBI methods in resource limited community as it can be used in regular radiotherapy department without requiring dedicated accessories.

Retrospective dose reconstruction of prostate stereotactic body radiotherapy using cone-beam CT and a log file during VMAT delivery with flattening-filter-free mode.

This study aimed to reconstruct the dose distribution of single fraction of stereotactic body radiotherapy for patients with prostate cancer using cone-beam computed tomography (CBCT) and a log file during volumetric-modulated arc therapy (VMAT) delivery with flattening-filter-free (FFF) mode. Twenty patients with clinically localized prostate cancer were treated with FFF-VMAT, and projection images for in-treatment CBCT (iCBCT) imaging were concomitantly acquired with a log file. A D95 dose of 36.25Gy in five fractions was prescribed to each planning target volume (PTV) on each treatment planning CT (pCT). Deformed pCT (dCT) was obtained from the iCBCT using a hybrid deformable image registration algorithm. Dose distributions on the dCT were calculated using Pinnacle3 v9.10 by converting the log file data to Pinnacle3 data format using an in-house software. Dose warping was performed by referring to deformation vector fields calculated from pCT and dCT. Reconstructed dose distribution was compared with that of the original plan. Dose differences between the original and reconstructed dose distributions were within 3% at the isocenter and observed in PTV and organ-at-risk (OAR) regions. Differences in OAR regions were relatively larger than those in the PTV, presumably because OARs were more deformed than the PTV. Therefore, our method can be used successfully to reconstruct the dose distributions of one fraction using iCBCT and a log file during FFF-VMAT delivery.

Dosimetric effect of MLC speed obtained with machine log files of VMAT delivery

This paper aims to investigate the stability of volumetric modulated arc therapy (VMAT) delivery during treatment using the multi-leaf collimator (MLC) speed recorded in the log files. The mechanical error, such as the position error and speed of the MLC recorded in the log file, affects the dose accuracy of the VMAT delivery. We evaluated the stability of VAMT delivery by determining the relationship between the gamma pass rate (GPR) and MLC speed. The 15 VMAT plans were used to investigate the stability of the beam delivery. The Mobius software calculated the dose distribution by the log files from the planning CT image set. The GPR was evaluated by comparing the reconstructed dose with the planned dose. To validate the gamma analysis calculated from the log file, we compared the results with the GPR measured by the ArcCHECK phantom. A comparison of the GPRs between ArcCHECK and Mobius was performed based on different criteria: 3%/3 mm and 2%/2 mm. Based on the results, we represent that (1) the 2%/2 mm criterion of the Mobius system is comparable to perform the quality assurance (QA) with ArcCHECK using the criterion of 3%/3 mm, and (2) the interfractional variation of the VMAT delivery depends on the distribution of the MLC speed. In this study, we determined that the variation of the GPRs during the whole treatment is less than 2% and the average leaves speed is less than 10 mm/s. These results reveal that the log files are one of the indicators to monitor the variation of VMAT delivery.

Feasibility study for marker-based VMAT plan optimization toward tumor tracking.

This work investigates the incorporation of fiducial marker‐based visibility parameters into the optimization of volumetric modulated arc therapy (VMAT) plans. We propose that via this incorporation, one may produce treatment plans that aid real‐time tumor tracking approaches employing exit imaging of the therapeutic beam (e.g., via EPID), in addition to satisfying purely dosimetric requirements. We investigated the feasibility of this approach for a thorax and prostate site using optimization software (MonArc). For a thorax phantom and a lung patient, three fiducial markers were inserted around the tumor and VMAT plans were created with two partial arcs and prescription dose of 48 Gy (4 fractions). For a prostate patient with three markers in the prostate organ, a VMAT plan was created with two partial arcs and prescription dose 72.8 Gy (28 fractions). We modified MonArc to include marker‐based visibility constraints (“hard”and “soft”). A hard constraint (HC) imposes full visibility for all markers, while a soft constraint (SC) penalizes visibility for specific markers in the beams‐eye‐view. Dose distributions from constrained plans (HC and SC) were compared to the reference nonconstrained (NC) plan using metrics including conformity index (CI), homogeneity index (HI), gradient measure (GM), and dose to 95% of planning target volume (PTV) and organs at risk (OARs). The NC plan produced the best target conformity and the least doses to the OARs for the entire dataset, followed by the SC and HC plans. Using SC plans provided acceptable dosimetric tolerances for both the target and OARs. However, OAR doses may be increased or decreased based on the constrained marker location and number of trackable markers. In conclusion, we demonstrate that visibility constraints can be incorporated into the optimization together with dosimetric objectives to produce treatment plans satisfying both objectives. This approach should ensure greater clinical success when applying real‐time tracking algorithms, using VMAT delivery.

Prostate SBRT With Intrafraction Motion Management Using a Novel Linear Accelerator–Based MV-kV Imaging Method

PurposeThis study reports clinical experience using a linear accelerator-based MV-kV imaging system for intrafraction motion management during prostate stereotactic body radiation therapy (SBRT). Methods and MaterialsFrom June 2016 to August 2018, 193 prostate SBRT patients were treated using MV-kV motion management (median dose 40 Gy in 5 fractions). Patients had 3 fiducials implanted then simulated and treated with a full bladder and empty rectum. Pretreatment orthogonal kVs and cone beam computed tomography were used to position patients and evaluate internal anatomy. Motion was tracked during volumetric modulated arc therapy delivery using simultaneously acquired kV and MV images from standard on-board systems. Treatment was interrupted to reposition patients when motion >1.5-2 mm was detected. Motion traces were analyzed and compared with Calypso traces from a previously treated similar patient cohort. To evaluate “natural motion” (ie, if we had not interrupted treatment and repositioned), intrafraction couch corrections were removed from all traces. Clinical effectiveness of the MV-kV system was explored by evaluating toxicity (Common Terminology Criteria for Adverse Events v3.0) and biochemical recurrence rates (nadir + 2 ng/mL). ResultsMedian number of interruptions for patient repositioning was 1 per fraction (range, 0-9). Median overall treatment time was 8.2 minutes (range, 4.2-44.8 minutes). Predominant motion was inferior and posterior, and probability of motion increased with time. Natural motion >3 mm and >5 mm in any direction was observed in 32.3% and 10.2% of fractions, respectively. Calypso monitoring (n = 50) demonstrated similar motion results. In the 151 MV-kV patients with ≥3-month follow-up (median, 9.5 months; range, 3-26.5 months), grade ≥2 acute genitourinary/gastrointestinal and late genitourinary/gastrointestinal toxicity was observed in 9.9%/2.0% and 11.9%/2.7%, respectively. Biochemical control was 99.3% with a single failure in a high-risk patient. ConclusionsThe MV-kV system is an effective method to manage intrafraction prostate motion during SBRT, offering the opportunity to correct for prostate clinical target volume displacements that would have otherwise extended beyond typical planning target volume margins.

Quality assurance of VMAT on flattened and flattening filter-free accelerators using a high spatial resolution detector.

PurposeThis study investigated the use of high spatial resolution solid‐state detectors (DUO and Octa) combined with an inclinometer for machine‐based quality assurance (QA) of Volumetric Modulated Arc Therapy (VMAT) with flattened and flattening filter‐free beams.MethodThe proposed system was inserted in the accessory tray of the gantry head of a Varian 21iX Clinac and a Truebeam linear accelerator. Mutual dependence of the dose rate (DR) and gantry speed (GS) was assessed using the standard Varian customer acceptance plan (CAP). The multi‐leaf collimator (MLC) leaf speed was evaluated under static gantry conditions in directions parallel and orthogonal to gravity as well as under dynamic gantry conditions. Measurements were compared to machine log files.ResultsDR and GS as a function of gantry angle were reconstructed using the DUO/inclinometer and in agreement to within 1% with the machine log files in the sectors of constant DR and GS. The MLC leaf speeds agreed with the nominal speeds and those extracted from the machine log files to within 0.03 cm s−1. The effect of gravity on the leaf motion was only observed when the leaves traveled faster than the nominal maximum velocity stated by the vendor. Under dynamic gantry conditions, MLC leaf speeds ranging between 0.33 and 1.42 cm s−1 were evaluated. Comparing the average MLC leaf speeds with the machine log files found differences between 0.9% and 5.7%, with the largest discrepancy occurring under conditions of fastest leaf velocity, lowest DR and lowest detector signal.ConclusionsThe investigation on the use of solid‐state detectors in combination with an inclinometer has demonstrated the capability to provide efficient and independent verification of DR, GS, and MLC leaf speed during dynamic VMAT delivery. Good agreement with machine log files suggests the detector/inclinometer system is a useful tool for machine‐specific VMAT QA.

Optimal VMAT Delivery for Elekta MLC Beam Modulator: A Study of Collimator Rotation for Head and Neck Planning

BackgroundWell-optimized treatment planning parameters are vital for optimum beam delivery in advanced radiotherapy techniques. The Elekta “Beam-Modulator” (BM) is a high-resolution multileaf collimation system where each individual leaf is 4 mm wide at the isocentre, without backup diaphragms and jaws. Its maximum aperture is 21 × 16 cm2, which results in a limited clinical use for the target geometry of maximum 20 cm in length. The collimator rotation provides an opportunity to treat slightly extended treatment length with optimal target coverage. The study aims to observe the collimator rotation influence on volumetric modulated arc therapy (VMAT) plan quality for different head and neck target geometries using limited field collimator of BM. MethodsTen patients with head and neck cancer were planned by means of simultaneous integrated boost to deliver VMAT for five patients with three dose levels (70/60/56) and five patients with two dose levels (60/54). The single arc, dual arc, and combined two independent single arcs of 356° each were well optimized for four collimator angles (C) 15°,30°, 45°, and 90°. The plans were prepared for BM with SmartArc module of Pinnacle³ treatment planning system. Statistical significance (P ≤ .05) among collimator angles for planning target volume dose-volume indices was calculated with Student's t-test. Organ-at-risk doses were compared and monitor units were also evaluated as a parameter for dose-delivery efficiency and out-of-field dose index. ResultsThe dual arc and combined two independent single arcs achieved planning objectives for C15°, C30°, and C45°. Single arc for all collimator angles and C90° for all VMAT schemes failed to achieve planning objectives. The spread of low dose bath 20, 35, and 40 Gy and deterioration of doses were higher towards periphery at C90° and statistically significant. ConclusionThe small and medium collimator angles for dual-arc VMAT scheme(s) are suitable, whereas single arc and C90° are not suitable in VMAT implementation for Elekta Beam-Modulator collimation system.

ITV versus mid-ventilation for treatment planning in lung SBRT: a comparison of target coverage and PTV adequacy by using in-treatment 4D cone beam CT

BackgroundThe internal target volume (ITV) approach and the mid-ventilation (MidV) concept are the two main respiratory motion-management strategies under free breathing. The purpose of this work was to compare the actual in-treatment target coverage during volumetric modulated arctherapy (VMAT) delivered through both ITV-based and MidV-based planning target volume (PTV) and to provide knowledge in choosing the optimal PTV for stereotactic body radiotherapy (SBRT) for lung lesions.Methods and materialsThirty-two lung cancer patients treated by a VMAT technique were included in the study. For each fraction, the mean time-weighted position of the target was localized by using a 4-dimensional cone-beam CT (4D-CBCT)-based image guidance procedure. The respiratory-correlated location of the gross tumor volume (GTV) during treatment delivery was determined for each fraction by using in-treatment 4D-CBCT images acquired concurrently with VMAT delivery (4D-CBCTin-treat). The GTV was delineated from each of the ten respiratory phase-sorted 4D-CBCTin-treat datasets for each fraction. We defined target coverage as the average percentage of the GTV included within the PTV during the patient’s breathing cycle averaged over the treatment course. Target coverage and PTVs were reported for a MidV-based PTV (PTVMidV) using dose-probabilistic margins and three ITV-based PTVs using isotropic margins of 5 mm (PTVITV + 5mm), 4 mm (PTVITV + 4mm) and 3 mm (PTVITV + 3mm). The in-treatment baseline displacements and target motion amplitudes were reported to evaluate the impact of both parameters on target coverage.ResultsOverall, 100 4D-CBCTin-treat images were analyzed. The mean target coverage was 98.6, 99.6, 98.9 and 97.2% for PTVMidV, PTVITV + 5mm, PTVITV + 4mm and PTVITV + 3mm, respectively. All the PTV margins led to a target coverage per treatment higher than 95% in at least 90% of the evaluated cases. Compared to PTVITV + 5mm, PTVMidV, PTVITV + 4mm and PTVITV + 3mm had mean PTV reductions of 16, 19 and 33%, respectively.ConclusionWhen implementing VMAT with 4D-CBCT-based image guidance, an ITV-based approach with a tighter margin than the commonly used 5 mm margin remains an alternative to the MidV-based approach for reducing healthy tissue exposure in lung SBRT. Compared to PTVMidV, PTVITV + 3mm significantly reduced the PTV while still maintaining an adequate in-treatment target coverage.

Hypofractionated volumetric modulated arc therapy (VMAT) for fragile patients with oesophageal cancer.

To evaluate the feasibility, safety, and dosimetric results of volumetric modulated arc therapy (VMAT) to deliver hypofractionated radiotherapy (RT) in oesophageal cancer patients, unfit for a multimodality curative strategy. From 2010 to 2017, 22 patients were treated with hypofractionated VMAT for palliative/symptomatic setting. The prescription dose was 40Gy in 16 fractions (EQD2 41.7Gy considering an α/β ratio of 10Gy, and 44Gy considering an α/β ratio of 3Gy). Eight patients (36%) were symptomatic for grade 3 baseline dysphagia. RT was generally well tolerated, and no patient interrupted the daily treatment. Acute toxicity was generally mild; no G3 acute toxicities were reported. At the end of treatment, 5 patients (22.7%) experienced a stable dysphagia and 14 (63.6%) an improvement of baseline dysphagia, while 3 patients (13.7%) reported a worsening of oesophagitis. At a mean follow-up of 8.7months, 15 patients (79%) had a complete clinical recovery (G0-1) of the symptomatic moderate/severe dysphagia. At 3months after the end of RT, seven patients (31.8%) achieved a partial or complete response. Two coplanar arcs were employed for VMAT delivery. Dosimetric results were consistent in terms of both target coverage and normal tissue sparing. Finally, 1-year progression-free and overall survival was 20% and 27.3%, respectively. Hypofractionated VMAT was feasible, safe, and effective to deliver symptomatic radiation in locally advanced oesophageal cancer patients, non-suitable for a standard curative treatment.

Improvement in Image Quality of CBCT during Treatment by Cycle Generative Adversarial Network

Volumetric modulated arc therapy (VMAT) can acquire projection images during rotational irradiation, and cone-beam computed tomography (CBCT) images during VMAT delivery can be reconstructed. The poor quality of CBCT images prevents accurate recognition of organ position during the treatment. The purpose of this study was to improve the image quality of CBCT during the treatment by cycle generative adversarial network (CycleGAN). Twenty patients with clinically localized prostate cancer were treated with VMAT, and projection images for intra-treatment CBCT (iCBCT) were acquired. Synthesis of PCT (SynPCT) with improved image quality by CycleGAN requires only unpaired and unaligned iCBCT and planning CT (PCT) images for training. We performed visual and quantitative evaluation to compare iCBCT, SynPCT and PCT deformable image registration (DIR) to confirm the clinical usefulness. We demonstrated suitable CycleGAN networks and hyperparameters for SynPCT. The image quality of SynPCT improved visually and quantitatively while preserving anatomical structures of the original iCBCT. The undesirable deformation of PCT was reduced when SynPCT was used as its reference instead of iCBCT. We have performed image synthesis with preservation of organ position by CycleGAN for iCBCT and confirmed the clinical usefulness.

Prediction of VMAT delivery accuracy with textural features calculated from fluence maps

BackgroundComprehensively textural feature performance test from volumetric modulated arc therapy (VMAT) fluences to predict plan delivery accuracy.MethodsA total of 240 VMAT plans for various treatment sites were analyzed, with Trilogy and TrueBeam STx systems. Fluence maps superposed fluences at each control point per plan. The textural features were the angular second moment (ASM), inverse difference moment (IDM), contrast, variance, correlation, and entropy, calculated from fluence maps using three displacement distances. Correlation analysis of textural feature performance as predictors of VMAT delivery accuracy used global gamma passing rates with MapCHECK2 and ArcCHECK dosimeters, and mechanical delivery errors calculated from machine log files.ResultsSpearman’s rank correlation coefficients (r) of the ASM (d = 10) to the gamma passing rates with 1%/2 mm using the MapCHECK2 were 0.358 and 0.519, respectively (p < 0.001). For the ArcCHECK, they were 0.273 (p = 0.001) and 0.259 (p = 0.009), respectively. The r-values of the ASM (d = 10) to the Trilogy and TrueBeam STx MLC errors were − 0.843 and − 0.859, respectively (p < 0.001), and those to the MU delivery errors were − 0.482 and − 0.589, respectively (p < 0.001). The ASM (d = 10) showed better performance in predicting VMAT delivery accuracy.ConclusionsThe ASM (d = 10) calculated from VMAT plan fluence maps were strongly correlated with global gamma passing rates and MLC delivery errors, and can predict VMAT delivery accuracy.

Technical Note: Improving VMAT delivery efficiency by optimizing the dynamic collimator trajectory.

To provide a method for optimizing the multileaf collimator angle trajectory in volumetric modulated arc therapy (VMAT) in order to make VMAT delivery and planning more efficient. Static fluence maps are optimized at a 10-degree spacing around the patient. Sliding window delivery time of each of these fields is computed for a large set of possible collimator orientations. An optimal trajectory, which selects a collimator angle for each field and assures that the collimator angles do not differ excessively between adjacent fields, is computed by solving a network flow model of a shortest path problem. For four clinical cases (two brains, an anal, and a spine), we demonstrate time reductions from 6% to 32% (average: 24%) for the optimal static angle vs the worst static angle. Further reductions from 3% to 17% (average 9%) are achievable when dynamic collimator trajectories are allowed. Dynamic collimator trajectories, which can be computed with an efficient linear programming formulation, can improve the efficiency of VMAT delivery.

Evaluation of auto-planning in IMRT and VMAT for head and neck cancer.

PurposeThe purposes of this work are to (a) investigate whether the use of auto‐planning and multiple iterations improves quality of head and neck (HN) radiotherapy plans; (b) determine whether delivery methods such as step‐and‐shoot (SS) and volumetric modulated arc therapy (VMAT) impact plan quality; (c) report on the observations of plan quality predictions of a commercial feasibility tool.Materials and methodsTwenty HN cases were retrospectively selected from our clinical database for this study. The first ten plans were used to test setting up planning goals and other optimization parameters in the auto‐planning module. Subsequently, the other ten plans were replanned with auto‐planning using step‐and‐shoot (AP‐SS) and VMAT (AP‐VMAT) delivery methods. Dosimetric endpoints were compared between the clinical plans and the corresponding AP‐SS and AP‐VMAT plans. Finally, predicted dosimetric endpoints from a commercial program were assessed.ResultsAll AP‐SS and AP‐VMAT plans met the clinical dose constraints. With auto‐planning, the dose coverage of the low dose planning target volume (PTV) was improved while the dose coverage of the high dose PTV was maintained. Compared to the clinical plans, the doses to critical organs, such as the brainstem, parotid, larynx, esophagus, and oral cavity were significantly reduced in the AP‐VMAT (P < 0.05); the AP‐SS plans had similar homogeneity indices (HI) and conformality indices (CI) and the AP‐VMAT plans had comparable HI and improved CI. Good agreement in dosimetric endpoints between predictions and AP‐VMAT plans were observed in five of seven critical organs.ConclusionWith improved planning quality and efficiency, auto‐planning module is an effective tool to enable planners to generate HN IMRT plans that are meeting institution specific planning protocols. DVH prediction is feasible in improving workflow and plan quality.

Impact of delivery characteristics on dose delivery accuracy of volumetric modulated arc therapy for different treatment sites.

This study aimed to investigate the impact of delivery characteristics on the dose delivery accuracy of volumetric modulated arc therapy (VMAT) for different treatment sites. The pretreatment quality assurance (QA) results of 344 VMAT patients diagnosed with gynecological (GYN), head and neck (H&N), rectal or prostate cancer were randomly chosen in this study. Ten metrics reflecting VMAT delivery characteristics were extracted from the QA plans. Compared with GYN and rectal plans, H&N and prostate plans had higher aperture complexity and monitor units (MU), and smaller aperture area. Prostate plans had the smallest aperture area and lowest leaf speed compared with other plans (P < 0.001). No differences in gantry speed were found among the four sites. The gamma passing rates (GPRs) of GYN, rectal and H&N plans were inversely associated with union aperture area (UAA) and leaf speed (Pearson’s r: −0.39 to −0.68). GPRs of prostate plans were inversely correlated with aperture complexity, MU and small aperture score (SAS) (absolute Pearson’s r: 0.34 to 0.49). Significant differences in GPR between high SAS and low SAS subgroups were found only when leaf speed was <0.42 cm s–1 (P < 0.001). No association of GPR with gantry speed was found in four sites. Leaf speed was more strongly associated with UAA. Aperture complexity and MU were more strongly associated with SAS. VMAT plans from different sites have distinct delivery characteristics. Affecting dose delivery accuracy, leaf speed is the key factor for GYN, rectal and H&N plans, while aperture complexity, MU and small apertures have a higher influence on prostate plans.

Modulation indices and plan delivery accuracy of volumetric modulated arc therapy.

PurposeWe evaluated the performance of various modulation indices (MI) for volumetric modulated arc therapy (VMAT) to predict plan delivery accuracy.MethodsThe specific indices evaluated were MI quantifying the mechanical uncertainty (MI t), MI quantifying the mechanical and dose calculation uncertainties (MI c), MI for station parameter optimized radiation therapy (MISPORT), modulation complexity score for VMAT (MCS v), leaf travel modulation complexity score (LTMCS), plan averaged beam area (PA), plan averaged beam irregularity (PI), plan averaged beam modulation (PM), and plan normalized monitor unit (PMU) to predict VMAT delivery accuracy. By utilizing 240 VMAT plans generated with the Trilogy and TrueBeam STx, Spearman's rank correlation coefficients (r) were calculated between the MIs and measures of conventional methods.ResultsFor the Trilogy system, MI c showed the highest r values with gamma passing rates (GPRs) (r = −0.624 with P < 0.001 for MapCHECK2 and r = −0.655 with P < 0.001 for ArcCHECK). For TrueBeam STx, MI c also showed the highest r values with GPRs (r = −0.625 with P < 0.001 for the MapCHECK2 and r = −0.561 with P < 0.001 for the ArcCHECK). The MI t and MI c showed the highest r values to the MLC position errors for the Trilogy and TrueBeam STx systems (r = 0.770 with P < 0.001 and r = 0.712 with P < 0.001, respectively). The PA showed the highest percent of r values (P < 0.05) to differences in the dose‐volume parameters between original VMAT plans and actual deliveries for the Trilogy systems (30.9%). Both the MI t and MI c showed the highest percent of r values (P < 0.05) to differences in the dose‐volume parameters between original VMAT plans and actual deliveries for the TrueBeam STx systems (31.8%).ConclusionTo comprehensively review the results, the MI c showed the best performance to predict the VMAT delivery accuracy.