Currently, aquaculture is a reliable source of increasing the volume of fish food products and serves as a guarantor of food security. The sterlet Acipenser ruthenus L. is one of the main objects of freshwater aquaculture. Feeding with artificial feed, high planting densities and other negative factors of industrial fish farming inevitably lead to increased stress loads. This affects the physiological state of fish. Disturbances in the functioning of the immune system leads to outbreaks of infectious diseases and epizootic disadvantage of pond fish farms. In modern aquaculture, various antibiotics, probiotics and plant preparations are used to treat and prevent bacterial diseases. In this paper, the effect of different feed additives on the survival rate of sterlet fry to infectious agents was investigated. For this purpose, 150 individuals each were seeded into separate pools with high content of myxobacteria and aeromonads in the water microflora. Studies were conducted in 5 separate pools: control group with feed and 4 experimental pools with different feed additives. The duration of the experiment was 75 days. During the experiment, the number of surviving fries was recorded, and at the end, survival rate was calculated as a percentage of the total number of fish initially planted in each pool. Differences in the effect of different feed additives on the survival rate of fry were found. The highest escapement was recorded in the control group and the least in the group with Antibac-100. In the other experimental groups, the percentage of surviving fry was higher than in the control.