Voltage-clamped Squid Giant Axons Research Articles

Diphenylhydantoin Inhibition of Sodium Conductance in Squid Giant Axon

Diphenylhydantoin, in concentration of 5-50 muM, decreases the early, transient (sodium) currents of voltage-clamped squid giant axons. These effects are dose-dependent and largely reversible. It appears that diphenylhydantoin reduces the number of open, early, transient (sodium) channels.