Nonlinear vibrations of a fluid-conveying functionally graded (FG) cylindrical shell with piezoelectric actuator layer and subjected to external excitation and piezoelectric parametric excitation are analyzed theoretically. Considering the electric-thermo-fluid-structure interaction effect, a nonlinear dynamic model of fluid-conveying FG cylindrical shell with piezoelectric actuator layer is developed based on Hamilton’s principle and von-Karman geometrical nonlinearity. The inviscid, incompressible, isentropic and irrotational fluid is coupled into governing equations using the linearized potential theory. The nonlinear coupled differential governing equations of system are obtained by using Galerkin’s method with two modes. The developed coupled model is validated by comparing with the prior data and good agreements are observed. Multiple scales method is used to obtain nonlinear dynamic behaviors of the coupled system in case of 1:2 internal resonance, primary parametric resonance and 1/2 subharmonic resonance. The effects of three coupling cases between two modes on the dynamic behaviors of system are explored. Considering strongly coupled effect between two modes, the effect of external excitation, damping coefficient, piezoelectric harmonic voltage, fluid flow velocity, temperature and volume fraction exponent of FG cylindrical shell on the frequency-response curves are investigated. The influence of detuning parameters on force-amplitude response and voltage-amplitude response of system are also discussed.