Researching the Autonomous Province of Vojvodina as a region of Serbia and an European Union (EU) border region, we have long been concerned with the raison d’être of cross-border programmes, their impact, sustainability and long-term results. Against that background, the current study is focused on the results of the 2014-2020 cycle. The region of Vojvodina has neighbouring external borders with three EU Member States. While the partner countries have already applied for almost 100% of the available amounts, the implementation of projects and thus the payment of grants is only 50% effected so far. Our intention has been to examine the Vojvodina region in terms of cross-border programmes based on already completed projects and running along the lines of different Priorities. The Programme Areas of the four (Hungarian-Serbian, Croatian-Serbian, Romanian-Serbian and Serbia-Bosnia and Hercegovina) Cross-border cooperation programmes do overlap significantly. Primarily, we have been researching the territorial distribution of each, by reference to the locations of project owners and of project activities; as well as the related networking character of the projects implemented in Vojvodina in the Interreg-IPA (Instrument for Pre-accession Assistance) 2014-2020 programming period. It is then in this context that we examine the focal and connection points of the cross-border connections, in this way potentially indicating deficiencies in regard to sustainable project implementation. Without claiming to be exhaustive, we have also sought to reference impeding circumstances relating to a barrier effect that is obviously of particular importance given the fact that external borders of the EU are involved.