Vocal Cord Lesions Research Articles

The association of sulcus vocalis and benign vocal cord lesions: intraoperative findings.

To investigate the presence of sulcus vocalis in patients who underwent phonomicrosurgery due to benign vocal cord lesions. Between January 2013 and June 2018, the records of 133 patients who underwent operations for benign vocal fold pathology were retrospectively reviewed. Intraoperative findings of the patients were noted. Patients were divided into two groups: patients with only benign vocal fold lesions (BVFL) and patients with benign vocal fold lesions and accompanying sulcus vocalis (SV + BVFL). In total, 67 patients (50.4%; 38 females, 29 males) had BVFL and 66 (49.6%; 37 females, 29 males) had SV + BVFL. The patients in the SV + BVFL group were significantly younger than those in the BVFL group (p = 0.039). The sulcus was unilateral in 60.6% of the patients. The presence of sulcus vocalis was 49% and 47.6% in patients with a diagnosis of polyps (n = 51) and cysts (n = 42), respectively. A total of 12 of 13 patients with multiple benign vocal fold lesions had accompanying sulcus vocalis. Approximately half of the patients who underwent operations for benign vocal fold lesions had accompanying sulcus vocalis. More than half of the sulcus associated with benign lesions was unilateral.

A Wearable Skinlike Ultra-Sensitive Artificial Graphene Throat.

Most mute people cannot speak due to their vocal cord lesion. Herein, to assist mute people to "speak", we proposed a wearable skinlike ultrasensitive artificial graphene throat (WAGT) that integrated both sound/motion detection and sound emission in single device. In this work, the growth and patterning of graphene can be realized at the same time, and a thin poly(vinyl alcohol) film with laser-scribed graphene was obtained by a water-assisted transferring process. In virtue of the skinlike and low-resistant substrate, the WAGT has a high detection sensitivity (relative resistance changes up to 150% at 133 Ω) and an excellent sound-emitting ability (up to 75 dB at 0.38 W power and 2 mm distance). On the basis of the excellent mechanical-electrical performance of graphene structure, the sound detecting and emitting mechanisms of WAGT are realized and discussed. For sound detection, both the motion of larynx and vibration of vocal cord contribute to throat movements. For sound emission, a thermal acoustic model for WAGT was established to reveal the principle of sound emitting. More importantly, a homemade circuit board was fabricated to build a dual-mode system, combining the detection and emitting systems. Meanwhile, different human motions, such as strong and small throat movements, were also detected and transformed into different sounds like "OK" and "NO". Therefore, the implementation of these sound/motion detection acoustic systems enable graphene to achieve device-level applications to system-level applications, and those graphene acoustic systems are wearable for its miniaturization and light weight.

A Comparison of Surgical Outcomes of Carbon Dioxide Laser Versus Conventional Cold Instrument Excision of Benign Vocal Cord Lesions.

Benign vocal fold lesions affect the vibratory function of the vocal folds and cause dysphonia. Surgical excision has been the mainstay of management of benign vocal fold lesions for decades. This study compares the surgical outcomes of cold instruments versus carbon dioxide (CO2) laser excision of benign vocal fold lesions. A total of 49 cases diagnosed with benign vocal fold lesions were divided randomly to undergo excision either by conventional cold steel method or by CO2 laser. The postoperative assessment of the groups was done by videostroboscopy, acoustic analysis and voice handicap index. There was a significant improvement (P value < 0.05) when preoperative values of the parameters were compared with postoperative values in the individual groups. However, there was no significant difference when the two groups were compared with each other in terms of outcomes. Both the surgical techniques provide good outcomes in management of benign vocal fold lesions and each has its own advantages and disadvantages.

Retrospective analysis of patients who were operated with a benign vocal cord pathology

Aim: We aimed to evaluate the presentation and distribution of pathologic and clinical data of patients who were operated with benign vocal cord lesions in our clinic. Material and Method: The study was performed with retrospective evaluation of patient files diagnosed as benign vocal cord lesions between December 2013 and March 2017 at Kırıkkale University Medical Faculty Otorhinolaryngology Department. Results: Their average age was 47.8 a total of 108 patients were analyzed. Twenty four patients (22.3%) were female and 84 patients (77.7%) were male. According to pathological results of patients, 61 patients results were vocal cord polyp (56.4%), 20 patients results were leukoplakia (18.5%), 11 patients were Reinke’s edema (10.1%), 7 patients were laryngeal cyst (6.4%), 6 patients were vocal cord nodule (5.5%), 2 patients were laryngeal papillomatosis (1.8%), 1 patient was laryngocele (0.9%). Conclusion: Patients with benign vocal cord lesions are most frequently encountered with vocal cord polyp in pathology results. With the evaluation of pathological results of benign vocal cord lesions of each clinic, data on the distribution of the results of benign vocal cord lesions in our country can be created.

Air Injection and Transillumination in Phonosurgery: A Novel Technique

The goal of this study was to introduce two novel techniques in phonomicrosurgery, air injection (AIR), and transillumination (TI), to improve the diagnosis and surgical excision of pathological tissue in vocal folds during suspension laryngoscopy while preserving the healthy tissue as much as possible. Prospective clinical case series. Thirty-four patients with benign vocal cord lesions who underwent phonomicrosurgery between January 2016 and May 2017 were evaluated. Pre- and intraoperative recordings were evaluated by three experienced laryngologists. Stroboscopic video images taken during the preoperative diagnosis and interoperative video recordings made before and after AIR and TI were performed were reviewed and compared. During the preoperative evaluation, the surgeons declared their surgical plans and noted changes while observing the intraoperative evaluation during AIR and TI. Sixty-eight vocal folds were evaluated. The initial diagnosis was found to be consistent with the final diagnosis in only 10 patients (29.4%). The diagnoses of 29 vocal folds (42.6%) and the surgical plans changed after AIR and TI. In six cases, submucosal bands, additional morphological structures in the vicinity of the primary pathology, were observed; these could only be visualized with AIR and TI. AIR and TI revealed new pathologies in four vocal folds that were noted to be normal in the preoperative evaluation. AIR and TI are useful and promising techniques to identify undiagnosed lesions in vocal folds and to increase the success of minimally invasive phonosurgery.

Usefulness of narrow band imaging with magnifying endoscopy for the differential diagnosis of cancerous and noncancerous laryngeal lesions.

We evaluated the accuracy of endoscopic findings observed by narrow band imaging (NBI) combined with magnifying gastrointestinal endoscopy (GIE) for the differential diagnosis of cancerous and noncancerous laryngeal lesions. A total of 166 vocal cord lesions for which good images were obtained on NBI with magnifying GIE were evaluated with respect to the following 6 variables: macroscopic type, tumor location, color, white coat, keratinization, and abnormal microvessels. Multivariate analysis showed that white coat (odds ratio [OR], 2.95, P = 0.05), keratosis (OR, 3.14, P = 0.02) and abnormal microvessels (OR, 31.1, P < 0.0001) were significantly related to laryngeal cancer. In the diagnosis of laryngeal cancer, the sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of abnormal microvessels were 84.4%, 88.6%, 91%, 80.5%, and 86.1%, respectively. The abnormal microvessels on NBI combined with magnifying GIE are useful for the differential diagnosis of laryngeal lesions.

Excision of vocal cord lesions by electronic laryngoscope under general anesthesia with laryngeal mask, which is applicated in patients with glottis exposure difficulties

Excision of vocal cord lesions by electronic laryngoscope under general anesthesia with laryngeal mask, which is applicated in patients with glottis exposure difficulties

Treatment Outcomes of Angiolytic Laser-Assisted Glottoplasty in Patients With Sulcus Vocalis.

We have been performing glottoplasty using angiolytic laser, including pulsed dye laser (PDL) or potassium titanyl phosphate (KTP) laser, for the treatment of sulcus vocalis. In this study, we retrospectively reviewed the treatment results of sulcus vocalis patients who had undergone glottoplasty using angiolytic laser and evaluated the efficacy and safety of this surgical technique. From January 2008 to April 2016, 79 patients with sulcus vocalis who underwent angiolytic LASER-assisted glottoplasty were enrolled in the study. Of the 79 patients who participated in this study, 55 were male, and 24 were female. PDL was used for glottoplasty in 68 patients, and KTP was used in the remaining 11 patients. Seventy-seven patients underwent surgery for bilateral vocal cord lesions, and only 2 patients underwent surgery for unilateral vocal cord lesion. After glottoplasty using angiolytic laser, most patients showed continuous improvement of the GRBAS (grade, roughness, breathiness, asthenia, strain) score and Voice Handicap Index score until 6 months after the operation. In addition, we observed improvement of objective voice indices such as noise to harmonic ratio, jitter, shimmer, and maximal phonation time postoperatively. Based on these results, we confirmed the efficacy and safety of glottoplasty using angiolytic laser in sulcus vocalis patients. Further studies are needed to confirm appropriate laser settings such as frequency of treatments and total energy delivered to the lesion. Also, multi-institutional studies are needed to confirm the efficacy and safety of the operation.

Flexible bronchoscopy-guided vocal cord biopsy under conscious sedation: An option to surgical biopsy in special situations.

Introduction:Vocal cord (VC) biopsies are usually performed with rigid laryngoscopy under general anesthesia (GA). In patients with comorbidities such as cardiovascular or pulmonary disease, the risk of GA is high, with morbidity and potential mortality. We describe VC biopsy (VCB) in such a high-risk cohort, done safely and successfully with flexible bronchoscopy-VCB (FB-VCB) and conscious sedation.Methods:FB-VCB was done in two groups of patients – the first at high risk for GA due to comorbidities and the second group where VC lesions were found incidentally in the course of FB done for other reasons. FB was done with local anesthesia and conscious sedation, and the VC lesion was identified. Flexible forceps were introduced through the working channel of the bronchoscope, and the lesions were carefully sampled.Results:FB-VCB was performed in 15 patients (14 males and 1 female) with a mean age of 60.7 ± 12.1 years. Of these 15 patients, 6 patients were poor candidates for GA due to comorbidities and 9 patients had incidental VC lesions found during bronchoscopy. A diagnosis was made in 14/15 (93.3%) patients. Complications included a mild ooze and hoarseness of voice for a few days, which did not require any intervention.Conclusion:We report one of the few series of patients with VC biopsies done with FB (FB-VCB) under conscious sedation, without significant complications. It is safe and useful in high-risk patients who are poor candidates for GA, with a good diagnostic yield.

Risk Factors and Diagnostic Methods in Vocal Cord Mucosal Lesions.

Objectives:This study was an examination of malignancy risk determined according to clinical characteristics and preoperative diagnosis in vocal cord lesions compared with the definitive pathology results.Methods:This was a retrospective study of the files of patients who were admitted to a clinic due to hoarseness and/or a laryngeal lesion and underwent a suspension laryngoscopy (SL) between 2014 and 2018. The patient files were examined and the parameters of age, gender, smoking status, alcohol use, and the site of the lesion were compared for the risk of malignancy. The details of the preoperative diagnoses, peroperative findings, and definite pathology results were evaluated for agreement.Results:In all, 296 cases were reviewed. Since some patients had undergone multiple SL procedures, only the final pathology results of these patients were included in the study and the final total was 260 patients. The study population consisted of 191 (73.5%) male and 69 (26.5%) female patients. Of the group, 169 (65%) were smokers and 13 (5%) consumed alcohol. The lesions were left-sided in 106 (40.8%), right-sided in 120 (46.2%), and bilateral in 34 (13.1%) cases. A total of 68 (26.2%) cases were malignant, 165 (63.5%) were benign, and 27 (10.4%) were determined to be premalignant. Analysis of patient age revealed that the risk of malignancy was significantly higher in patients in the fifth or sixth decade of life (p<0.001). Examination of gender and the risk of malignancy indicated that 64 (94.1%) of the malignant patients were male and 4 (5.9%) were female (p<0.001). It was also found that 64 of the malignant patients (94.1%) were smokers (p<0.001). Only 8 (11.8%) of the patients with malignant lesions used alcohol, and no significant relationship was found (p=0.018). The association of malignancy with the lesion site was similar (p=0.89). Logistic regression analysis determined that male gender increased the risk of malignancy 6.45% and smoking increased the risk 7.81%.Conclusion:Microscopic examination of the lesion and palpation are very important in the diagnosis of patients with hoarseness and laryngeal lesion. Smoking, advanced age, and male gender increased the risk of malignancy of vocal cord lesions.

Comparison of Microdissection Microlaryngeal Surgery with Carbon Dioxide Laser in Management of Benign and Premalignant Lesions of Larynx

Introduction&#x0D; Dysphonia is caused by voice misuse and various environmental factors. It is manifested as varied pathological lesions of the vocal cords. Surgical excision of these lesions is mainly by conventional cold steel or laser assisted microsurgical techniques. Both modalities have seen extensive advancements and refinement in technologies in the recent past. In this study we have compared the microdissection microlaryngeal treatment and microspot superpulsed beam carbon dioxide (CO2) laser assisted surgical techniques for the management of benign and precancerous lesions of the vocal cords.&#x0D; Material and Methods&#x0D; A total of 36 cases of benign lesions of vocal cord, were divided randomly to undergo surgery either by microdissection or CO2laser assisted techniques. The groups were assessed through vocal cord morphological observation and subjective voice assessment parameters GRBAS score and VHI10 index.&#x0D; Results&#x0D; Peroperative bleeding was observed to be significantly reduced in the laser excision group. However, operating time was significantly increased in this group. Patients recovered remarkably well following both the techniques as denoted by voice parameters. No difference was observed in duration of hospital stay. &#x0D; Conclusion&#x0D; Both surgical techniques give satisfactory results in their management of benign and precancerous lesions of the vocal cords. Both techniques have their advantages and disadvantages. After a learning curve, laser surgery with its precision and cleaner surgical fields will be more effective in the management of such cases.

Endoscopic keel placementto treat and prevent-bilateral vocal cord adhension

Objective: To investigate the effectiveness of endoscopic keel placement for the prevention and treatment of bilateral vocal cord adhesion. Method: There are 47 cases with bilateral vocal cord lesions and 38 cases with laryngeal adhesion in this study. Bilateral vocal cord lesions were removed and laryngeal adhesion was cut and divided. Afterwards, a silicone keel was placed in each case using a Lichtenberger endo-extralaryngeal needle carrier. The keel was removed 4 weeks post-surgery and the vocal cords were observed using a laryngoscopy monthly. Result: During the 1-year follow-up, 39 (83.0%) cases with bilateral vocal cord lesions and 28(73.7%) cases with laryngeal adhesion did not develop laryngeal webs. A pseudomembrane covering the vocal cords was observed at the time of keel removal in 16 cases of all. Unfortunately, 15 cases (93.75%) developed laryngeal webs among them. However, in the cases without a pseudomembrane, only 3 (4.35%) cases formed glottic webs post-surgery(P<0.01). Conclusion: Endoscopic keel placement is an effective method for the prevention and treatment of bilateral vocal cord adhesion. The pseudomembrane detected at the time of keel removal is probably a risk factor for the development of glottic webs.

Geriatric Dysphonia: Etiological Analysis in a Rural Hospital in India.

To establish the prevalence of etiological factors for dysphonia in elderly individuals in rural India. Hundred adults aged ≥ 65years, who presented with dysphonia for ≥ 4weeks and underwent detailed clinical evaluation including videolaryngoscopic assessment and other appropriate investigations/evaluation, were included in a retrospective cohort clinical study. Patients were classified into eight groups for further descriptive statistical analysis based on standard diagnostic criteria/guidelines i.e. benign vocal cord lesions, inflammatory disorders of the larynx, laryngeal and hypopharyngeal neoplasms, isolated vocal cord palsy/paresis, presbylaryngis, central neurological disorders affecting laryngeal function, impaired pulmonary function and non specific dysphonia. Mean age was 70.73 ± 4.29years. 58% were aged between 65 and 69years. Overall, the common causes for dysphonia were laryngopharyngeal reflux disease (23%), carcinoma larynx (12%) and presbylaryngis (8%). Inflammatory disorders of the larynx, benign vocal cord lesions and laryngeal/hypopharyngeal malignancies were the commonest causes for dysphonia in individuals aged between 65 and 74years. Presbylaryngis and systemic causes were the commonest among individuals aged 75-89years. 63 males and 37 females met the inclusion criteria. The most common cause for dysphonia among females was laryngopharyngeal reflux disease (17%), followed by vocal palsy (5%) and spasmodic dysphonia (4%). Carcinoma larynx (12%) was the most common cause for dysphonia among males, followed by laryngopharyngeal reflux (6%) and presbylaryngis (6%). Geriatric dysphonia is an often overlooked symptom of greater underlying disease as evidenced in this study. With its impact on the quality of life in this age group and life expectancy in the rural population, dysphonia requires early detection, prompt evaluation and appropriate management.

Clinical treatment of benign vocal cord lesions with occult vocal cord sulcus

Objective:To discuss the correlation of benign vocal cord lesions with occult vocal cord sulcus and the treatment of benign vocal cord lesions with occult vocal cord sulcus, through the analysis of surgical data, preoperative voice evaluation data and postoperative follow-up data of patients.Method:The data from 377 patients of benign vocal cord lesions with concealed vocal cord sulcus admitted to Beijing Tongren Hospital from 2005 to 2016 were reviewed. The follow-up time was more than half a year after surgery.Result:About 2.9% of the benign lesions of the vocal cords were associated with occult vocal cords sulcus,of which 61.27% were bilateral vocal cords sulcus,22.55% was right vocal cords sulcus,and 16.18% was left vocal cord sulcus.Of the patients with bilateral vocal fold sulcus,64.5% had benign vocal cord lesions and 35.5% had unilateral vocal cord benign lesions.Of the patients with unilateral vocal fold,73.97% were associated with ipsilateral vocal cord benign lesions, and 26.03% were associated with contralateral vocal cord lesions.In the 531 sides of the vocal cords sulcus,183 sides of vocal fold sulcus typeⅠwere not treated. The 332 sides of vocal fold sulcus type Ⅱ were treated with removed lesions of the vocal cords and microdissection of vocal cord adhesion.The 16 sides of vocal fold sulcus type Ⅲ were treated with removed lesions of the vocal cords,local tamponaded of autogenous abdominal fascia and microsutured to close the wound. There were 9 cases with 11 sides of vocal fold sulcus combined with the mucous bridge.The satisfactory rate of sound improvement was 80.37% in half a year after the operation.Postoperative fundamental frequency,jitter,shimmer and maximum phonation time were significantly improved compared with preoperative.Conclusion:The occurrence of benign vocal cord lesions may be related to occult vocal fold sulcus.Simultaneous treatment of benign vocal cord lesions with occult vocal cord sulcus can achieve satisfactory voice improvement.Therefore, we should pay attention to the treatment of vocal fold sulcus in the diagnosis and treatment of benign vocal cord diseases.

Primary Laryngeal Aspergillosis in an Immunocompetent Host

Introduction&#x0D; Aspergillosis of Larynx is very rare and may present with symptoms suspicious of malignancy. Prevention of dissemination warrants early diagnosis. It is found mainly in Immunocompromised patients and is usually necrotizing, invasive with disseminated systemic infection, associated with poor prognosis. In Immunocompetent patients it is extremely rare and may present as colonization associated with excellent prognosis.&#x0D; Case Report&#x0D; A 43 year old male patient presented with hoarseness of voice for about 3 months with whitish irregular lesion that involved the anterior 1/3 of both the vocal cords. A cheesy material was found covering indurated lesion of both the vocal cords, intraoperatively. Stripping of mucosa over vocal cords was done and cheesy material collected and sent for HPE which revealed Aspergillus hyphae overlying Mild dysplastic changes. Following diagnosis the patient was followed up with oral dosages of Itraconazole.&#x0D; Discussion&#x0D; The primary Aspergillosis of larynx is extremely rare. Involvement is always secondary to immunocompromised states like AIDS, malignancy, Diabetes, etc. This was a rare case in Immunocompetent patient.&#x0D; Management constitute removal of the vocal cord lesions during biopsy. Amphotericin B is first-line agent for this infection, however aerosolised and liposomal amphotericin B offer effective dosing with less toxicity. Newer antifungal Itraconazole may produce more reliable results.

Management of Difficult Laryngeal Exposure During Suspension Microlaryngoscopy.

Difficult laryngeal exposure during suspension microlaryngoscopic surgeries is a common situation encountered by the phonosurgeons nowadays. It leads to unnecessary trauma, incomplete surgery and even abortion of the procedure. Although various methods have been described to counter the situation, they might not be adequate in some cases with very anteriorly placed larynx. This study is intended to determine the utility of angled rigid endoscope along with malleable endoscopic instruments to improve surgical access in cases with inadequate glottic exposure during suspension microlaryngoscopy. In this cross sectional study conducted at Lokmanya Tilak Municipal Medical College and General Hospital in Mumbai, 50 patients of voice disorders who underwent Suspension Microlaryngoscopy from July 2014 to December 2017 were included. Out of these patients, 5 patients (10%) presented with difficult laryngeal exposure that were operated using readily available angled rigid endoscope along with malleable endoscopic instruments, without requirement of any specially designed instruments. There was improvement in laryngeal exposure in all the cases following utilisation of angled endoscopes. The surgeries were carried out under video monitor guidance with complete excision of the vocal cord lesions. Our study concluded that the cases in which the laryngeal exposure cannot be improved even by various external procedures, can be enhanced by application of angled rigid endoscopes and the vocal cord lesions can be excised completely by using malleable endoscopic instruments.

Efficacy of Intralesional Steroid Injection in Small Benign Vocal Fold Lesions

The present study was conducted to study the efficacy of intralesional steroid (ILS) injection in small benign vocal fold lesions and compare the outcomes with microlaryngeal surgery in terms of improvement in symptoms and reduction in lesion size. The current randomized control trial was conducted in the Department of Otolaryngology at the Postgraduate Institute of Medical Education and Research in Chandigarh between 2014 and 2015. The clinical diagnosis was based on appearance of the lesion during endoscopy and the mucosal vibration pattern. Subjects with lesions of size less than or equal to 5 mm were included. A total of 29 subjects were included in the study and 15 (nine men and six women) of them were randomized to receive ILS injection. Fourteen (13 men and one woman) were randomized to the second group to receive initial microlaryngeal surgery. We noted significant reduction in the size of the lesion among subjects undergoing ILS injection at 12 weeks (1.11 + 1.45 mm) as compared to baseline (2.63 + 1.28 mm) with no recurrence. ILSs are effective in reducing size of lesion and also improve acoustic parameters, perceptual analysis, and grade of dysphonia in patients presenting with small benign vocal cord lesions.

Pathological Voice Source Analysis System Using a Flow Waveform-Matched Biomechanical Model.

Voice production occurs through vocal cord and vibration coupled to glottal airflow. Vocal cord lesions affect the vocal system and lead to voice disorders. In this paper, a pathological voice source analysis system is designed. This study integrates nonlinear dynamics with an optimized asymmetric two-mass model to explore nonlinear characteristics of vocal cord vibration, and changes in acoustic parameters, such as fundamental frequency, caused by distinct subglottal pressure and varying degrees of vocal cord paralysis are analyzed. Various samples of sustained vowel /a/ of normal and pathological voices were extracted from MEEI (Massachusetts Eye and Ear Infirmary) database. A fitting procedure combining genetic particle swarm optimization and a quasi-Newton method was developed to optimize the biomechanical model parameters and match the targeted voice source. Experimental results validate the applicability of the proposed model to reproduce vocal cord vibration with high accuracy, and show that paralyzed vocal cord increases the model coupling stiffness.

Comparative study between microdebrider, radiofrequency and classic microlaryngosurgical in the treatment of benign vocal cord lesions

BackgroundBenign vocal fold lesions are a common cause for hoarseness of voice.AimThe aim of this work was to investigate the efficacy and safety of microdebrider and radiofrequency in excision of benign vocal fold lesions compared with the classic microlaryngosurgical (MLS).Patients and MethodsThis study included 30 patients, 22 male and eight female, diagnosed to have benign vocal fold lesions, who were divided into three groups: They were assessed preoperatively and 2 weeks postoperatively using the GRB scale for auditory perceptual assessment and computerized speech lab.ResultsMarked improvement of vocal functions with no statistically significant differences between the three groups was observed.ConclusionRadiofrequency and microdebrider could be used in the treatment of benign vocal fold lesions with nearly the same results of MLS.

Association Between Voice Handicap Index and Praat Voice Analysis in Patientswith Benign Vocal Cord Lesion Before and After Microscopic Laryngeal Surgery.

Benign vocal cord lesion is a benign mass formed in vocal cord in form of vocul nodule, vocal cord polyp, vocal cord cyst and vocal cord granuloma. Voice handicap index (VHI) is one of subjective voice analyses. This study aimed to analyse correlation between VHI score and praat voice analysis in benign vocal cord lesion before and after microscopic laryngeal surgery. This study was carried out from November 2009 to December 2010 at Outpatient Unit of Otorhinolaryngology, Head and Neck Surgery and Integrated Oncology Center of Dr. Soetomo General Hospital, Surabaya, Indonesia. Pearson's correlation test found a negative correlation between total VHI score with base frequency and harmonic-to-noise ratio (HNR) (r = - 0.186, p = 0.689; r = - 0.650, p = 0.114). On the other hand, there was a positive correlation between total VHI score with jitter and shimmer (r = 0.812, p = 0.027; r = 0.638, p = 0.123). It could be inferred that base frequency, shimmer and HNR after surgery had no significant correlation (p > 0.05), while VHI total score significantly correlated with jitter after surgery (p < 0.05). We found no correlation between VHI score and Praat voice analysis in patients with benign vocal cord lesion before and after surgery, except correlation between VHI functional subscale with HNR and VHI total score with jitter.