1093 Some consensus exists in that physiological domains, symptoms, functional status, and health perceptions contribute to quality of life in a wide range of populations. Specific to heart failure, Green et al. (JACC 35:1245–55, 2000.) determined a significant correlation (r2 = 0.48, p < 0.001) between quality of life and a six-minute physical function walk test. PURPOSE: The intent of this investigation was to examine the relationship between functional capacity, cardiac function, and quality of life in male and female NYHA class II and III heart failure patients. METHODS: A total of 20 male (n = 11) and female (n = 9) subjects (age = 57 ± 2.5 yrs; height = 171.6 ± 2.0 cm; weight = 84.3 ± 3.0 kg) underwent a peak oxygen consumption (VO2peak) test on a treadmill to assess functional capacity (VO2peak = 16.6 ± 1.2 ml/kg/min; anaerobic threshold = 913.6 ± 51.9 ml). In the same visit, each subject completed the Kansas City Cardiomyopathy Questionnaire to assess the individual's quality of life. A twodimensional echocardiogram was performed on each subject to obtain an ejection fraction (EF) measurement (EF = 28.4 ± 1.8%). RESULTS: A regression analysis revealed a non-significant correlation between VO2peak and ejection fraction (r 2 = 0.07, p = 0.14). Additionally, there was a non-significant correlation between the quality of life and VO2peak (r2 = 0.11, p = 0.08), and between quality of life and ejection fraction (r2 = 0.02, p = 0.27). Anaerobic threshold demonstrated a non-significant correlation with both the quality of life (r2 = 0.16, p = 0.10) and the ejection fraction (r2 = 0.05, p = 0.39). Furthermore, there were no significant correlations detected between gender and either the VO2peak, ejection fraction, anaerobic threshold, or quality of life. CONCLUSION: This study exhibits that the VO2peak, anaerobic threshold, and EF% are all unrelated to quality of life in NYHA class II and III heart failure subjects. Our findings are in disagreement with those of Green et al. who utilized a 6-minute walk test. Perhaps this difference is specific to the direct assessment that we obtained for physiological metabolic capacity (VO2peak and anaerobic threshold) compared to the field testing that was performed by Green et al.