Vital Values Research Articles

In-Site Phenotype of the Settlement Space along China’s Grand Canal Tianjin Section: GIS-sDNA-Based Model Analysis

The settlement space along China’s Grand Canal composes an important part of the Canal heritage, has a close bearing on the production and life of the residents there, nourishes rich culture and wisdom and boasts vital value of conservation and inheritance. Due to China’s rapid urbanization and industrialization, the settlements along the canal have been destroyed to some extent and their in-site characteristics urgently need excavation and conservation. Through field investigation, space syntax and GIS analysis, this paper performs quantitative analysis of the in-site characteristics of 18 typical rural settlements there. The findings show that: (1) The settlement space of industry dominant type for commerce and trade is comparatively dynamic and the capacity of topology and integration and the attractive force of the settlement center are stronger. (2) The dynamic scope of the citizens’ everyday traveling in the settlements has the closest correlation with the data of public-service facilities. (3) The settlements along the canal boast multiple, causal and blended in-site phenotype. The research findings provide new standards to categorize the settlements along China’s Grand Canal, paths and methods to explore the characteristics of the settlements and new cognitive perspectives to conserve and renew the settlements along China’s Grand Canal Tianjin Section.

STUDENTS’ PERCEPTIONS AND THEIR DERIVED SATISFACTION OF URBAN FORESTS IN THE MOST INDUSTRIALISED REGION OF POLAND

In the face of growing urbanised areas, the presence of forests and their appropriate shaping is a key challenge for contemporary urban planning. The importance of forests is largely identified with natural, economic and social functions in non-urban areas; however, forests are of vital value in urbanised areas. This article explores young Polish urbanites’ awareness of the role forests play, and submits diagnoses of the forests multidimensional benefits and their functions in Poland’s urban areas. Moreover, the research is based on the premise that the management of urban forests must ultimately lead to the satisfying of social needs. Based on empirical research, the perceptions of the value of urban forests as assessed by young people (students) in the Śląskie Voivodeship are presented, leading to the authors’ postulation that urban forests are underestimated resources. Furthermore, the study suggests that young Poles do not recognise the multi-beneficial aspects of urban forests; and the authors indicate feasible directions for local policy to achieve sustainable development. The final statements argue that in the face of serious threats to the functioning of Earth’s ecosystem, a campaign for the presence of forests and green spaces in cities is necessary.

Applications of internet of things for monitoring drivers-a comprehensive study

<span>Driving is a complex task that involves interacting adequately with the vehicle and the environmental changes simultaneously. Drivers' health is an essential factor in determining performance outcomes and enhancing road safety. It is a known reality that drivers with sudden health complications are most likely to be involved in road accidents and suffer several injuries. Besides that, drunk driving is another aspect of a significant public health issue, where drivers under the influence of alcohol show a clear vision loss and vehicle control. The internet of things (IoT) is a trendsetting advancement in which all sensor data can be collected in the cloud. In this paper, an active monitoring tool is developed to record the driver's heart rate if these readings reach vital values while on the move. Additionally, the tool monitors the driver's alcohol concentration, and if it rises beyond a certain threshold, an alarm is sent to the designated emergency contact. The tool has been tested and has been found to work satisfactorily.</span>

Evaluation of the content validity of the intrinsic-instrumental assessment tool for assessing the nature values of constructed wetlands

Constructed wetlands possess tremendous nature values, namely instrumental and intrinsic values. Constructed wetlands also store and capture carbon which help to mitigate climate change in sustaining our earth system. Hence, sound management of constructed wetlands must consider its importance as essential assets that increase their resilience in mitigation and adaptation strategies towards adverse effects of climate change. To examine the vital value of constructed wetlands, this study attempts to evaluate the content validity of the developed Intrinsic-Instrument Assessment (IIA) tool for assessing the nature values of constructed wetlands in the context of climate change. A methodological study was conducted to evaluate the content validity of the IIA tool in two-phases. First, a comprehensive literature review was conducted at the development phase to identify the construct and dimension, generate items and instrument formation. In the second phase (evaluation), a committee of six experts performed the content validity evaluation, and the content validity index was implemented for content validity quantification. Finally, the researcher conducted a discussion between the team members to finalise the items of the IIA tool. The first version of the IIA tool identified three domains (instrumental, objective and intrinsic values) with 36 items. The item content validity index (I-CVI) ranges from 0.833 to 1. The overall content validity index using the average approach, the scale content validity index (S-CVI/Ave) is 0.97. Thus, the IIA tool was evaluated with highly relevant and excellent content validity. Researchers generated 17 additional items in the IIA version 2.0 after considering experts’ feedback. Still, after the second evaluation by researchers, the final version of the IIA tool consists of 42 items. This paper contributes to the body of knowledge by performing the systematic process of the essential steps to verify the developed instrument’s reliability and validity, especially in the field of socio-ecology. This study provides comprehensive information and example as guidance for evaluating content validity for a new instrument scale. Also, it helps to bring insight into constructed wetlands’ vital nature values as the nature solution in mitigating and adapting climate change to advocate the sustainable development of constructed wetlands ecosystems.

Characteristics, Outcomes, and Severity Risk Factors Associated With SARS-CoV-2 Infection Among Children in the US National COVID Cohort Collaborative

Understanding of SARS-CoV-2 infection in US children has been limited by the lack of large, multicenter studies with granular data. To examine the characteristics, changes over time, outcomes, and severity risk factors of children with SARS-CoV-2 within the National COVID Cohort Collaborative (N3C). A prospective cohort study of encounters with end dates before September 24, 2021, was conducted at 56 N3C facilities throughout the US. Participants included children younger than 19 years at initial SARS-CoV-2 testing. Case incidence and severity over time, demographic and comorbidity severity risk factors, vital sign and laboratory trajectories, clinical outcomes, and acute COVID-19 vs multisystem inflammatory syndrome in children (MIS-C), and Delta vs pre-Delta variant differences for children with SARS-CoV-2. A total of 1 068 410 children were tested for SARS-CoV-2 and 167 262 test results (15.6%) were positive (82 882 [49.6%] girls; median age, 11.9 [IQR, 6.0-16.1] years). Among the 10 245 children (6.1%) who were hospitalized, 1423 (13.9%) met the criteria for severe disease: mechanical ventilation (796 [7.8%]), vasopressor-inotropic support (868 [8.5%]), extracorporeal membrane oxygenation (42 [0.4%]), or death (131 [1.3%]). Male sex (odds ratio [OR], 1.37; 95% CI, 1.21-1.56), Black/African American race (OR, 1.25; 95% CI, 1.06-1.47), obesity (OR, 1.19; 95% CI, 1.01-1.41), and several pediatric complex chronic condition (PCCC) subcategories were associated with higher severity disease. Vital signs and many laboratory test values from the day of admission were predictive of peak disease severity. Variables associated with increased odds for MIS-C vs acute COVID-19 included male sex (OR, 1.59; 95% CI, 1.33-1.90), Black/African American race (OR, 1.44; 95% CI, 1.17-1.77), younger than 12 years (OR, 1.81; 95% CI, 1.51-2.18), obesity (OR, 1.76; 95% CI, 1.40-2.22), and not having a pediatric complex chronic condition (OR, 0.72; 95% CI, 0.65-0.80). The children with MIS-C had a more inflammatory laboratory profile and severe clinical phenotype, with higher rates of invasive ventilation (117 of 707 [16.5%] vs 514 of 8241 [6.2%]; P < .001) and need for vasoactive-inotropic support (191 of 707 [27.0%] vs 426 of 8241 [5.2%]; P < .001) compared with those who had acute COVID-19. Comparing children during the Delta vs pre-Delta eras, there was no significant change in hospitalization rate (1738 [6.0%] vs 8507 [6.2%]; P = .18) and lower odds for severe disease (179 [10.3%] vs 1242 [14.6%]) (decreased by a factor of 0.67; 95% CI, 0.57-0.79; P < .001). In this cohort study of US children with SARS-CoV-2, there were observed differences in demographic characteristics, preexisting comorbidities, and initial vital sign and laboratory values between severity subgroups. Taken together, these results suggest that early identification of children likely to progress to severe disease could be achieved using readily available data elements from the day of admission. Further work is needed to translate this knowledge into improved outcomes.

The relationship between lymphedema, posture, respiratory functions, exercise capacity, and the quality of life after breast cancer treatment

IntroductionTo evaluate the relationship between lymphedema, posture, respiratory functions, exercise capacity, and the quality of life after breast cancer treatment.MethodsThis cross-sectional study consisted of 38 women who had unilateral breast cancer treatment. Pulmonary function with a spirometer, functional exercise capacity via 6-minute walking test, postural alignment changes, and quality of life were evaluated. Circumferential measurements were used to determine the severity of lymphedema.ResultsThe median age of female participants was 53 years (range, 40–64). The mean body mass index was 26.66 ± 2.96 kg/m&lt;sup&gt;2&lt;/sup&gt;, of which 76% had lymphedema. The expected changes in posture were moderate. The mean of the 6-minute walking distance decreased, which corresponded to 58.55% of normative values. MIP and MEP values were significantly lower than expected values. An intermediate negative correlation was observed between postural changes and body mass index (&lt;i&gt;r&lt;/i&gt; = –0.348; &lt;i&gt;p&lt;/i&gt; = 0.05). Moreover, there was a positive correlation between forced expiration volume and forced vital capacity values and walking distance (&lt;i&gt;p&lt;/i&gt; &lt; 0.05).ConclusionAfter breast cancer treatment, 76% of female patients had lymphedema, the functional exercise capacity, MIP and MEP were below the expected values in all of them, and as functional capacity decreases, respiratory parameters affected negatively.

Abstract TMP13: Risk Stratification Models For Stroke In Patients Hospitalized With Covid-19 Infection: An American Heart Association Covid-19 CVD Registry Study

Introduction: Coronavirus Disease 2019 (COVID-19) is associated with an increased risk of stroke and worse stroke outcomes. A clinical score that can identify high-risk patients could enable closer monitoring and targeted preventative strategies. Methods: We used data from the AHA’s COVID-19 CVD Registry to create a clinical score to predict the risk of stroke among patients hospitalized with COVID-19. We included patients aged &gt;18 years who were hospitalized with COVID-19 at 122 centers from March 2020-March 2021. To build our score, we used demographics, preexisting comorbidities, home medications, and vital sign and lab values at admission. The outcome was a cerebrovascular event, defined as any ischemic or hemorrhagic stroke, TIA, or cerebral vein thrombosis. We used two separate analytical approaches to build the score. First, we used Cox regression with cross validation techniques to identify factors associated with the outcome in both univariable (p&lt;0.10) and multivariable analyses (p&lt;0.05), then assigned points for each variable based on corresponding coefficients. Second, we used regularized Cox regression, XGBoost, and Random Forest machine learning techniques to create an estimator using all available covariates. We used Harrel’s C-statistic to measure discriminatory performance. Results: Among 21,420 patients hospitalized with COVID-19 (mean age 61 years, 54% men), 312 (1.5%) had a cerebrovascular event. Using traditional Cox regression, we created and internally validated a risk stratification score (CANDLE) (Fig) with a C-statistic of 0.66 (95% CI, 0.60-0.72). The machine learning estimator had similar discriminatory performance, with a C-statistic of 0.69 (95% CI, 0.65-0.72). For ischemic stroke or TIA, CANDLE’s C-statistic was 0.67 (95% 0.59-0.76). Conclusion: We developed an easy-to-use clinical score, with similar performance to a machine learning estimator, to help stratify stroke risk among patients hospitalized with COVID-19.

Construction of computer model for enterprise green innovation by PSO-BPNN algorithm and its impact on economic performance.

The present work aims to analyze the elements that affect corporate green technology innovation and investigate a method suitable for predicting and evaluating corporate performance. First, the elements of green technology innovation and their relationships are analyzed and explained. Then, the Complex Adaptive System (CAS) theory is introduced. On this basis, a computer model for the driving mechanism system of corporate green technology innovation is constructed on the Recursive Porus Agent Simulation (Repast) platform. Finally, the Backpropagation Neural Network (BPNN) model is optimized by Particle Swarm Optimization (PSO), constituting the PSO-BPNN algorithm to evaluate corporate performance. The results of network training and simulation demonstrate that compared with traditional BPNN, PSO-BPNN achieve a faster convergence speed and fewer errors. Besides, the actual output value has a tiny difference from the expected value, showing the application potential of this algorithm in corporate performance prediction. Moreover, the driving factors of green technology innovation greatly affect the profitability and performance of enterprises. Given insufficient corporate profit margin, continuous technological innovation activities can ensure the normal operation of enterprises. A smaller corporate tax rate can shorten the time for the system to reach equilibrium. When the corporate tax rate is above 0.2, the system takes longer to reach equilibrium. In addition, the public opinion coefficient directly affects the time needed for the system to attain equilibrium. When the public opinion coefficient is within 50,00 ~ 6,000 interval, the time that the system takes to reach equilibrium changes significantly. Furthermore, corporate internal and external driving factors have a direct effect on corporate green technology innovation and performance. The research findings indicate that the PSO-BPNN algorithm is of vital practical value to corporate performance evaluation.

An individualized algorithm to predict mortality in COVID-19 pneumonia: a machine learning based study.

IntroductionIdentifying SARS-CoV-2 patients at higher risk of mortality is crucial in the management of a pandemic. Artificial intelligence techniques allow one to analyze large amounts of data to find hidden patterns. We aimed to develop and validate a mortality score at admission for COVID-19 based on high-level machine learning.Material and methodsWe conducted a retrospective cohort study on hospitalized adult COVID-19 patients between March and December 2020. The primary outcome was in-hospital mortality. A machine learning approach based on vital parameters, laboratory values and demographic features was applied to develop different models. Then, a feature importance analysis was performed to reduce the number of variables included in the model, to develop a risk score with good overall performance, that was finally evaluated in terms of discrimination and calibration capabilities. All results underwent cross-validation.Results1,135 consecutive patients (median age 70 years, 64% male) were enrolled, 48 patients were excluded, and the cohort was randomly divided into training (760) and test (327) groups. During hospitalization, 251 (22%) patients died. After feature selection, the best performing classifier was random forest (AUC 0.88 ±0.03). Based on the relative importance of each variable, a pragmatic score was developed, showing good performances (AUC 0.85 ±0.025), and three levels were defined that correlated well with in-hospital mortality.ConclusionsMachine learning techniques were applied in order to develop an accurate in-hospital mortality risk score for COVID-19 based on ten variables. The application of the proposed score has utility in clinical settings to guide the management and prognostication of COVID-19 patients.

Erratum: Roadkills in Northern Peninsular Malaysia

An erratum on: Hui TCY, Slade EM and Chong JL (2021) Roadkills in Northern Peninsular Malaysia. Front. Environ. Sci. 9:637462. doi: 10.3389/fenvs.2021.637462Due to a production error, some vital values in Tables 1, 2 and 3 were not marked in bold to signify “the most parsimonious models”. The corrected Tables 1, 2, and 3 appear below.Figures 1, 2, and 3 in the article as published had low resolution and have been corrected and appear below. The publisher apologizes for this mistake. The original version of this article has been updated.

RETRACTED ARTICLE: Efficacy of dexmedetomidine as an adjunct to ropivacaine in bilateral dual-transversus abdominis plane blocks in patients with ovarian cancer who underwent cytoreductive surgery

ObjectiveWe sought to evaluate the postoperative control of pain and recovery in patients with ovarian cancer who underwent cytoreductive surgery by adding dexmedetomidine to ropivacaine in bilateral dual-transversus abdominis plane (Bd-TAP) blocks.MethodsWe enrolled 90 patients with an American Society of Anesthesiologists physical status I to III undergoing open abdominal cytoreductive surgery in this study. Patients were randomized and assigned into three groups (TAP-R, TAP-DR, or CON) of 30 participants each. All of the patients received standardized general anesthesia, and postoperative Bd-TAP blocks were performed. The TAP-R, TAP-DR, and CON groups received Bd-TAP blocks with 0.3% ropivacaine, 0.3% ropivacaine and 0.5 μg/kg of dexmedetomidine, and 0.9% normal saline, respectively. All of the patients received patient-controlled analgesia (PCA) (formula, 100 μg of sufentanil and 16 mg of ondansetron diluted with normal saline to 100 mL). Flurbiprofen axetil was used as a rescue drug if the visual analog scale (VAS) score was more than four points. The first request time for PCA bolus; the VAS scores at 0, 6, 12, 24, and 48 h after operation; and the cumulative sufentanil consumption within 24 and 48 h, respectively, were compared. Pulmonary function was evaluated preoperatively and at 24 h after the operation. The use of the rescue drug was recorded. Postoperative functional recovery, including time to stand, time to walk, time to return of bowel function, time to readiness for discharge, and postoperative complications, were recorded.ResultsMedian values of the first request time for PCA of the TAP-R group was significantly prolonged compared to that of the CON group (median [interquartile range], 7.3 [6.5–8.0] hours vs. 3.0 [2.3–3.5] hours) (P < .001), while the TAP-DR group has the longest request time among the three groups (median [interquartile range], 13.5 [12.4–14.5] hours) (P < .001). The VAS scores at rest and upon coughing of the TAP-R group in the first 12 h were significantly lower than those of the CON group (P < 0.05), but showed no significant difference compared to those of the TAP-DR group. The VAS scores at rest and upon coughing were lower in the TAP-DR group at each time point compared to those of the CON group (P < .05). The cumulative sufentanil consumption in the TAP-DR group was significantly lower at 48 h (P = .04) after surgery than in the CON group, while there was no significant difference compared to that in the TAP-R group (P > .05). Less rescue analgesic was required by patients in the TAP-DR group than in the CON group (P < .05). Postoperative mean measured forced expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity values in the TAP-DR group were significantly higher than those of the CON group (P = .009), while there was no significant difference compared to those of the TAP-R group (P = .10). There was no significantly difference in postoperative functional recovery between TAP-DR and CON group (P > 0.05).ConclusionTAP blocks can provide effective pain relief up to 12 h postoperatively without a significant improvement in postoperative pulmonary function. The addition of dexmedetomidine to ropivacaine for Bd-TAP block prolonged the first bolus time of PCA when compared to that in the TAP-R group and decreased sufentanil consumption and the need of rescue analgesia relative to in the CON group at 48 h postoperative. The procedure provided better postoperative analgesia and improved postoperative pulmonary function relative to the CON group. Our results indicate that dexmedetomidine as an adjuvant of Bd-TAP can provide effective pain relief up to 48 h.

Evaluation of the correlation between perfusion index and prognosis in patients with chronic obstructive pulmonary disease

Objectives: This study aims to investigate whether perfusion index (PI) values, which are measured non-invasively, affect emergency management, especially in hospitalization and discharge decision in patients with Chronic Obstructive Pulmonary Disease (COPD). Methods: Patients who were admitted to the emergency department of Okmeydanı Training and Research Hospital with a COPD exacerbation in 3-months period and who volunteered to participate were included in the study. Vital parameters and PI values of the patients at the time of admission, at the first, second and third hour of the admittance and at the time of hospitalization (in the case of hospitalization) were recorded. The patients were treated for COPD exacerbation according to the Global Initiative for Chronic Obstructive Lung Disease 2011 guide and the decision of discharge, hospitalization in the emergency department, andhospitalization in the intensive care unit was taken based on the relevant guideline. Results: A total of 57 patients were included in the study. Of the patients, 45 (78.9%) were male. The mean age of the patients was 65.65 ± 9.90 years. There was no statistically significant difference in arrival vital parameters and PI in terms of the gender (p &amp;gt; 0.05). The change between PI values at the time of admission and the first hour in the patients admitted to intensive care unit was found to be significantly lower compared to patients who were hospitalized in the emergency department or discharged (p = 0.035; p = 0.033). The difference between the PI values at the time of admission and at the third hour of the follow up of the discharged patients was found to be significantly higher compared to the hospitalized patients (p = 0.035). There was no statistically significant difference between the arrival PI measurements in terms of the presence of comorbid diseases (p &amp;gt; 0.05). Conclusions: Considering the hourly changes, the PI values of patients admitted to the emergency department with COPD exacerbation may be helpful in predicting the decision of discharge, hospitalization in the emergency department or intensive care unit.

Humanized childbirth: the values of health professionals in daily obstetric care

To understand health professionals' values in the process of thinking and feeling about obstetric care, based on their experienced needs in the care process. Phenomenological study based on the Schelerian framework, with 48 health professionals from four maternity hospitals within the Metropolitan Region II of the state of Rio de Janeiro. Data collection was done through a phenomenological interview; and the analysis, with the Ricoeurian methodological framework. The vital value was signified in care centered on physiological processes, for an individualized and safe monitoring. The ethical value was signified in the attitudes that provide women with autonomy in their way of giving birth, and recognize dialogue as a process of sympathy, affection, and bonding. The resignification of obstetric practice, articulated with public policies in the field of delivery and birth, supported by a vital ethical value, positively contributes to the humanization of care for women.

O VALOR VITAL DO ALEITAMENTO MATERNO PARA MULHERES CUSTODIADAS

ABSTRACT Objective: to understand the perceptions about the values of breastfeeding for nursing mothers under custody of the penitentiary system. Method: a qualitative and phenomenological research study based on the Schelerian values, with seven phenomenological interviews conducted with nursing mothers deprived of their freedom in a women's prison unit from Rio de Janeiro, Brazil. The interviews took place between November 2020 and May 2021. Content analysis for treatment of the results was performed after transcribing the testimonies. Results: two categories were identified for the vital value: The value of bonding as a breastfeeding expansion process; and The nursing mother as a safety and protection value for the infant. Through the perception of the nursing mothers deprived of their freedom, the vital value identified acts as protection for breastfeeding within the prison setting, strengthening the woman's and child's health. Conclusion: by unveiling the vital value, it is observed that it is related to the mother's and infant's everyday life in prison. However, the prison institution does not meet the real vital needs of imprisoned nursing mothers, with the consequent need to redirect the breastfeeding practice in the prison setting, transforming it into a legitimate environment that values the meaning of breastfeeding.

Immature Erythroid Precursors and/or Erythrocyte Dysplasia in Peripheral Blood.

With the progress of technology in automated hematology analyzers, in the vast majority of cases, nucleated red corpuscles (NRC) can be automatically identified by most types of automated hematology analyzers, thus correcting the leukocyte count and avoiding pseudoleukocytosis by the analyzers themselves. The objective of the study was to explore pseudoleukocytosis due to immature erythroid precursors and/or erythrocyte dysplasia in the peripheral blood resulting from different rare situations. Four rare cases showing pseudoleukocytosis due to immature erythroid precursors and/or erythrocyte dysplasia in the peripheral blood were analyzed and the effects on complete blood count (CBC) performed on a Sysmex XN-2000 analyzer and microscopic morphological features of the peripheral blood were investigated. These cases were selected for their vital value in describing all pseudoleukocytosis due to immature erythroid pre-cursors and/or erythrocyte dysplasia in the peripheral blood. The causes of immature erythroid precursors and/or erythrocyte dysplasia in the peripheral blood were analyzed. In all these cases, proportions of NRC and leukocyte counts were affected to varying degrees by the presence of numerous immature erythroid precursors and/or obvious erythrocyte dysplasia in the peripheral blood. All cases associated with an alarm concerning NRC presentation, and abnormal scattergrams of WDF and WNR, thus leading to pseudoleukocytosis. Laboratory artifacts led by NRC may be an indicator towards the occurrence of numerous immature erythroid precursors and/or obvious erythrocyte dysplasia in the peripheral blood, and active extramedullary hematopoiesis, breakdown of the bone marrow barrier, and the stress response of acute bleeding and severe multiple infection.

Environmental education and the formation of ecological consciousness in the structure of professional training: theoretical aspect

The article reveals the theoretical aspects of environmental education and environmental awareness in the structure of professional training. It is noted that the state of the environment and the ecological crisis actualize the need for the development of environmental awareness and culture through the prism of environmental education for modern Ukrainian society. The article also analyzes several interpretations of the concept of "ecological consciousness". As a result of this, It is concluded that the individual ecological consciousness is understood as the highest level of individual’s reflection of the environment and reality, which ensures the harmonious coexistence and interaction of man and nature. The signs, structure, and main properties of the individual ecological consciousness are specified. It is indicated that its development takes place throughout a person's life, but in older youth, this process becomes especially intensive in connection with the acquisition of professional education, which sets personal worldview guidelines and principles of attitude to the environment. Environmental education plays an important role in the formation of a person's ecological consciousness. It is a complex process, that is designed to form a person's responsibility for the preservation and renewal of nature, to realize its vital value in practice. As a result of environmental education, environmental knowledge is transformed into environmental beliefs, the development of environmental skills, and environmental behavior. Education for sustainable development should contribute to the further spread of the teaching of the subject "Social ecology" in higher education institutions that train specialists in socionomic professions. In conclusion, It is determined that by forming an ecological worldview, we form an ecologically conscious and responsible personality of the future specialist, thereby providing a path to the sustainable development of our country.

АКМЕОЛОГІЧНИЙ РОЗВИТОК МАЙБУТНЬОГО ПЕДАГОГА: ОСНОВНІ УМОВИ ДЛЯ ПРОФЕСІЙНОГО САМОВДОСКОНАЛЕННЯ ТА САМОРОЗВИТКУ

A teacher is a socially active individual, capable of purposeful and conscious self-improvement, free life self-determination and creative self-realization in the profession. The choice of optimal means of influence on personality formation directs the future teacher to achieve the highest degree of development, namely acmeological self-improvement and self-development. The basis of professionalism is self-development, self-education, self-organization, self-control of a mature person, self-realization of his creative potential in the process of creative activity on the way to the top, which is what we understand as «acme». The article reveals the essence of the acmeological approach in the training of future teachers. The concept of «acmeological development» of the future teacher is defined and analyzed. In the context of our research, we will pay attention to those aspects of acmeological development that lead to self-improvement and self-development of the future teacher's personality. Such characteristics of acmeological development as: acmeological potential, acmeological competence, acmeological culture are described. We believe that essential factors in the acmeological development of a teacher are skills that allow overcoming professional difficulties, compensating for the effects of psychological obstacles and limitations. The work presents the structure of acmeological culture, highlights its functional and structural components, in particular: cognitive, mental, valuable and creative. Separate constituent elements of the individual and professional self-development of the future teacher are presented. It was concluded that the high level of development of acmeological culture and the formation of acmeological competence make it possible to understand the process of self-development as a vital value and to learn, actualize, creatively reveal oneself by creating conditions for self-improvement in the course of professional training of the future teacher and further life activities.

Is vasoactive-inotropic score associated with early lactate clearance a predictive outcome of children with septic shock?

The main goal of septic shock therapy is to keep hemodynamic parameters in the normal range for adequate tissue perfusion. Persistent lactic acidemia has increased mortality. We evaluate the association between vasoactive-inotropic score (VIS) and lactate clearance (LC) to predict mortality of septic shock in children. This is a retrospective study of consecutive septic shock in children admitted to the pediatric intensive care unit. Vital signs, laboratory values, and VIS were obtained at admission and the 6th hour of hospitalization. LC was calculated at the 6th hour. The associations between LC and VIS were evaluated using univariate and multivariate analysis. Receiver operating characteristic analysis was used to describe the cutoff values of LC and VIS. Eighty-two children, age 82.3 ± 59.8 months, were included, with an overall lactate clearance of 29 ± 26%, and a mortality rate of 25.6%. The optimal cutoff value of LC was 20%. Children with LC ≥ 20% compared with LC < 20% had a lower VIS [(21.41 ± 8.36) vs. (27.48 ± 10.11) (p: 0.009)]. In multivariate comparison, PELOD score and VIS were significantly associated with 6-hour lactate clearance < 20% but VIS at 6 hours had a significant inverse relationship with LC < 20%. The cutoff for VIS was ≥ 16.2 for prognosticating the 6-hour LC and the high VIS group had a significantly lower LC and higher mortality ratio than the low VIS group. High VIS was associated with lower lactate clearance and has been described as a predictor of greater mortality among septic shock in children.

Circulating fibrocyte level in children with cystic fibrosis.

This study aimed to evaluate circulating fibrocyte levels in cystic fibrosis (CF) patients during stable and exacerbation periods of the condition. The study group consisted of 39 patients diagnosed with CF and 20 healthy controls. Individuals included in the study were divided into three groups: CF, CF exacerbated, and a healthy control group. Their circulating fibrocyte levels were compared. Findings from a pulmonary function test and high-resolution computed tomography of the lung were evaluated and compared. The circulating fibrocyte count was found to be significantly higher in patients with CF compared with the exacerbated and control groups. No correlation was found between the forced expiratory volume in 1 s and forced vital capacity values in the pulmonary function test and the circulating fibrocyte count. The circulating fibrocyte count in patients (in the CF group) with positive findings in the high-resolution computed tomography was statistically significantly lower. The circulating fibrocyte level in the peripheral blood of the patients with CF was increased.

Linguistic expression in the modern information space of Ukraine

The article analyzes the functioning of language units in today’s information space in the conditions of a large-scale war against Ukrainian statehood. Extraneous factors become decisive in the selection of orthographic, lexical, syntactic, and stylistic means for semantic, evaluative, and figurative juxtaposition of war and peace, foreign and own, enemy and vital national values. Negatively evaluated rational and expressive units form a dictionary of low expression of nominations of the enemy, and positively evaluated — a dictionary of high expression for the verbal expression of phenomena of national resistance in the struggle to preserve one’s own identity. The core of both evaluation paradigms is socio-political vocabulary, which in the context acquires new semantic and stylistic connotations. In the language of mass communication, the processes of creating a new socio-political terminology based on expressive vocabulary take place, and terminology becomes the basic element for the acquisition of an expressive connotation by a word. The basis of creating a journalistic dictionary of linguistic and psychological resistance to war is the stylistic potential of language: epithets, metaphors, comparisons with transparent figurative semantics. The most expressive means in journalistic texts are metaphors, which form a transparent psychological image of the nation in the context of non-verbal factors. Today’s activated language resources enable one of the most important functions of mass communication — the formation of the national-linguistic consciousness of society. Keywords: rational vocabulary, expressive vocabulary, socio-political vocabulary, positively valued units, negatively valued units, semantics, stylistic connotation