Visuospatial Memory Task Research Articles

Music cue during slow wave sleep improves visuospatial memory consolidation.

The active system consolidation theory assumes that sleep between encoding and retrieval promotes memory consolidation. In the present study, we cued new memories during slow-wave (SWS) or rapid eye movements (REM) sleep stages by presenting an instrumental music stimuli that had been previously presented during a learning session. In a within-subjects design, 18 participants slept for three nonconsecutive nights (cue during SWS, cue during REM, and no cue during control night) and were trained in a visuo-spatial memory task. The administration of cue during SWS produced better memory accuracy in comparison with REM and the control condition.

The anterior retrosplenial cortex is required for short-term object in place recognition memory retrieval: Role of ionotropic glutamate receptors in male and female Long-Evans rats.

The anterior retrosplenial cortex (aRSC) integrates multimodal sensory information into cohesive associative recognition memories. Little is known about how information is integrated during different learning phases (i.e., encoding and retrieval). Additionally, sex differences are observed in performance of some visuospatial memory tasks; however, inconsistent findings warrant more research. We conducted three experiments using the 1-h delay object-in-place (1-h OiP) test to assess recognition memory retrieval in male and female Long-Evans rats. (i) We found both sexes performed equally in three repeated 1-h OiP test sessions. (ii) We showed infusions of a mixture of muscimol/baclofen (GABAA/B receptor agonists) into the aRSC ~15-min prior to the test phase disrupted 1-h OiP in both sexes. (iii) We assessed the role of aRSC ionotropic glutamate receptors in 1-h OiP retrieval using another squad of cannulated rats and confirmed that infusions of either the competitive AMPA/Kainate receptor antagonist CNQX (3 mM) or competitive NMDA receptor antagonist AP-5 (30 mM) (volumes = 0.50 uL/side) significantly impaired 1-h OiP retrieval in both sexes compared to controls. Taken together, findings challenge reported sex differences and clearly establish a role for aRSC ionotropic glutamate receptors in short-term visuospatial recognition memory retrieval. Thus, modulating neural activity in the aRSC may alleviate some memory processing impairments in related disorders.

Cortical Correlates of Visuospatial Switching Processes Between Egocentric and Allocentric Frames of Reference: A fNIRS Study

Human beings represent spatial information according to egocentric (body-to-object) and allocentric (object-to-object) frames of reference. In everyday life, we constantly switch from one frame of reference to another in order to react effectively to the specific needs of the environment and task demands. However, to the best of our knowledge, no study to date has investigated the cortical activity of switching and non-switching processes between egocentric and allocentric spatial encodings. To this aim, a custom-designed visuo-spatial memory task was administered and the cortical activities underlying switching vs non-switching spatial processes were investigated. Changes in concentrations of oxygenated and deoxygenated haemoglobin were measured using functional near-infrared spectroscopy (fNIRS). Participants were asked to memorize triads of geometric objects and then make two consecutive judgments about the same triad. In the non-switching condition, both spatial judgments considered the same frame of reference: only egocentric or only allocentric. In the switching condition, if the first judgment was egocentric, the second one was allocentric (or vice versa). The results showed a generalized activation of the frontal regions during the switching compared to the non-switching condition. Additionally, increased cortical activity was found in the temporo-parietal junction during the switching condition compared to the non-switching condition. Overall, these results illustrate the cortical activity underlying the processing of switching between body position and environmental stimuli, showing an important role of the temporo-parietal junction and frontal regions in the preparation and switching between egocentric and allocentric reference frames.

The effect of estradiol add-back: a longitudinal MRI study in prostate cancer patients.

We investigated the effect of estradiol add-back therapy (EAT) on brain activation related to cognitive function and affect in addition to putative changes in gray and white matter volume in testosterone depleted participants with prostate cancer. We conducted a randomized controlled, double-blinded trial in which 40 patients received 0.9 mg of transdermal estradiol per day for 6 months or matched placebo. Anatomical MRI and three functional MRI (fMRI) scans were obtained for the emotion recognition task, verbal memory task, and visuospatial memory task. Activation in corresponding cognitive and affective brain networks was demonstrated for all tasks. Longitudinally, there was no difference in brain activation, reaction time, or accuracy in response to the fMRI tasks between the EAT group and placebo group at 6 months. In addition, there was no detectable change in whole-brain gray or white matter volume or in hippocampal volume between the two groups after 6 months. This study supports earlier findings that EAT does not improve verbal memory or affect and has no immediate effect on hippocampal volume in testosterone depleted patients with prostate cancer.

Robotic assessment of sensorimotor and cognitive deficits in patients with temporal lobe epilepsy

ObjectiveIndividuals with temporal lobe epilepsy (TLE) frequently demonstrate impairments in executive function, working memory, and/or declarative memory. It is recommended that screening for cognitive impairment is undertaken in all people newly diagnosed with epilepsy. However, standard neuropsychological assessments are a limited resource and thus not available to all. Our study investigated the use of robotic technology (the Kinarm robot) for cognitive screening. Methods27 participants with TLE (17 left) underwent both a brief neuropsychological screening and a robotic (Kinarm) assessment. The degree of impairments and correlations between standardized scores from both approaches to assessments were analysed across different neurocognitive domains. Performance was compared between people with left and right TLE to look for laterality effects. Finally, the association between the duration of epilepsy and performance was assessed. ResultsAcross the 6 neurocognitive domains (attention, executive function, language, memory, motor and visuospatial) assessed by our neuropsychological screening, all showed scores that significantly correlated with Kinarm tasks assessing the same cognitive domains except language and memory that were not adequately assessed with Kinarm. Participants with right TLE performed worse on most tasks than those with left TLE, including both visuospatial (typically considered right hemisphere), and verbal memory and language tasks (typically considered left hemisphere). No correlations were found between the duration of epilepsy and either the neuropsychological screening or Kinarm assessment. SignificanceOur findings suggest that Kinarm may be a useful tool in screening for neurocognitive impairment in people with TLE. Further development may facilitate an easier and more rapid screening of cognition in people with epilepsy and distinguishing patterns of cognitive impairment.

Differential Outcomes Training of Visuospatial Memory: A Gamified Approach Using a Socially Assistive Robot

This study represents the first stage of evaluating whether cognitive training interventions may be facilitated by the presence of a socially assistive robot (SAR) and gamification. Our experimental setup involves using a SAR providing feedback to a gamified visuospatial working memory task, administered according to a differential outcomes training (DOT) protocol. The study’s main objective was to investigate whether performance and attitude towards the task would be affected by different robotic setups (none, simulated or physical) and in relation to different challenge levels. We measured performance accuracy on the gamified visuospatial memory task and self-reported affective ratings, which are relevant for assessing attitude towards the task and providing indicators to the potential for using a SAR for a longer-term cognitive intervention. Additionally, we conducted exploratory analyses of eye movement strategies for memory encoding during the task. The results demonstrated a significant differential outcomes effect (DOE) on memory performance accuracy, regardless of Robot type and Challenge level, providing evidence that a DOE can still be obtained when a SAR interacts with participants. Moreover, the results from the affective ratings revealed that participants accompanied by the physical robot reported lower levels of stress and increased levels of control. Our results demonstrate, for the first time, a DOE using a SAR in a gamified context. This result, coupled with positive subjective reporting of the human–robot interactive experience of participants, demonstrates the potential for using a SAR to: (i) promote positive attitudes for a DOT-based cognitive intervention, without (ii) negatively affecting task performance.

How the Spreading and Intensity of Interictal Epileptic Activity Are Associated with Visuo-Spatial Skills in Children with Self-Limited Focal Epilepsy with Centro-Temporal Spikes.

This paper investigates brain-behaviour associations between interictal epileptic discharges and cognitive performance in a population of children with self-limited focal epilepsy with centro-temporal spikes (SeLECTS). Sixteen patients with SeLECTS underwent an extensive neuropsychological assessment, including verbal short-term and episodic memory, non-verbal short-term memory, attentional abilities and executive function. Two quantitative EEG indices were analysed, i.e., the Spike Wave Index (SWI) and the Spike Wave Frequency (SWF), and one qualitative EEG index, i.e., the EEG score, was used to evaluate the spreading of focal SW to other parts of the brain. We investigated associations between EEG indices and neuropsychological performance with non-parametric Spearman correlation analyses, including correction for multiple comparisons. The results showed a significant negative correlation between (i) the awake EEG score and the Block Tapping Test, a visuo-spatial short-term memory task, and (ii) the sleep SWI and the Tower of London, a visuo-spatial planning task (pcorr < 0.05). These findings suggest that, in addition to the usual quantitative EEG indices, the EEG analysis should include the qualitative EEG score evaluating the spreading of focal SW to other parts of the brain and that neuropsychological assessment should include visuo-spatial skills.

Are anxiety and depression associated with cognition and cardiovascular function in young male and female adults?

The results of recent studies suggested that emotional disorders (such as anxiety and depression), cognitive impairments and cardiovascular disorders are related on the subclinical level. These major health issues are often concomitant and have complex, sex-dependent relationships; it is therefore important to study these issues concomitantly in the general population, in order to gain a better understanding of early-stage subclinical relationships between these conditions. The objective of this exploratory study was to assess correlations between anxiety, depression, cognition, and endothelial function in young adults from the general population. Endothelial function (via the reactive hyperaemia index (RHI) was assessed with a plethysmographic device. Depression and anxiety were self-reported via the Beck Disorder Inventory II and the State-Trait Anxiety Inventory, respectively. The Cambridge Neuropsychological Test Automated Battery was used to measure performances in visuospatial memory, visuospatial working memory, and sustained attention. Performances in inhibition and flexibility were evaluated with the Color Word Interference Test. Forty-four young adults (21 males; mean ± standard deviation age: 25.8 ± 1.1; 23 females; mean age: 25.6 ± 1.4) were included in the study. Anxiety was correlated with a low RHI (r = -0.40, p = 0.015, 95% CI [-0.64, -0.08]). In females, the depression score was positively correlated with the number of errors in the visuospatial memory task (r = 0.42, p = 0.049; 95% CI [-0.002, 0.70]) and visuospatial working memory (r = 0.57, p = 0.005; 95% CI [0.10, 0.79]). In males, high anxiety and depression scores were negatively correlated with the number of errors in visuospatial working memory task (anxiety: r = -0.77, p = 0.001; 95% CI [-0.91, -0.43]; depression r = -0.61, p = 0.004, 95% CI [-0.82, -0.22], respectively). However, the relationship between cognitive performance and RHI was not significant. Our data suggest that anxiety and depression could be differentially related to cognitive and endothelial functions in a non-clinical population of young adults. More research is needed to confirm these results, understand the pathophysiological mechanisms in more details, and assess the importance of a sex-specific approach.

Forward and Backward Recalling Sequences in Spatial and Verbal Memory Tasks: What Do We Measure?

There are different views in the literature about the number and inter-relationships of cognitive domains (such as memory and executive function) and a lack of understanding of the cognitive processes underlying these domains. In previous publications, we demonstrated a methodology for formulating and testing cognitive constructs for visuo-spatial and verbal recall tasks, particularly for working memory task difficulty where entropy is found to play a major role. In the present paper, we applied those insights to a new set of such memory tasks, namely, backward recalling block tapping and digit sequences. Once again, we saw clear and strong entropy-based construct specification equations (CSEs) for task difficulty. In fact, the entropy contributions in the CSEs for the different tasks were of similar magnitudes (within the measurement uncertainties), which may indicate a shared factor in what is being measured with both forward and backward sequences, as well as visuo-spatial and verbal memory recalling tasks more generally. On the other hand, the analyses of dimensionality and the larger measurement uncertainties in the CSEs for the backward sequences suggest that caution is needed when attempting to unify a single unidimensional construct based on forward and backward sequences with visuo-spatial and verbal memory tasks.

Spatiotemporal Parameters of Gait Among Adolescent Athletes with Concussion When Performing a Visuospatial Cognitive Task.

Adolescent athletes aged 10 to 19 years are at the highest risk of experiencing sport-related concussions (SRCs). Despite the known deficits and battery of assessments following concussion, postural stability during dual-task gait remains understudied in this population. The purpose of this study was to evaluate the dual-task cost (DTC) in adolescents with an acute or chronic SRC compared to reference values from healthy athlete peers for spatiotemporal parameters of gait during walking with and without a concurrent visuospatial memory task presented on a hand-held tablet. Researchers hypothesized that adolescents during the acute phase of concussion would be likely to experience a greater DTC compared to healthy peers in at least one spatiotemporal parameter of gait when walking within the dual-task paradigm. Cross-sectional, observational cohort design. Adolescents with concussion were recruited to participate. Subjects were divided into acute and chronic categories based on significant differences in the neuropsychological function after a period of 28 days. They walked at a self-selected speed along the 5.186-meter GAITRite® Walkway System with and without a concurrent visuospatial cognitive task presented on a hand-held tablet. Outcomes included normalized velocity (m/s), step length (m), and double limb (DLS) and single limb support (SLS) (defined as the percent of a gait cycle [%GC]). The data were then compared to the previously published reference values established using the same methods in the healthy athlete participants for all spatiotemporal parameters of gait. Data was collected on 29 adolescent athletes with SRC. Among males (15.53+/-1.12 years) with SRC, 20% of acute and 10% of chronic cases experienced a greater DTC compared to healthy athlete reference values. A similarly increased DTC was experienced by 83% of acute and 29% of chronic SRC cases for females (15.58+/-1.16 years). Adolescent athletes with concussion may continue demonstrating deficits in gait capabilities even in the chronic phase, and compensatory gait strategies were not the same between males and females. Dual-task cost assessment using the GAITRite® may be a valuable adjunct to comprehensive analysis of gait following SRC. 2.

Cognition and maths in children with Attention-Deficit/Hyperactivity disorder with and without co-occurring movement difficulties

BackgroundMovement difficulties are common in ADHD, however, the implications of their co-occurrences on cognitive and maths performance is unknown. AimsThis study set out to examine whether cognitive and maths performance of children with high ADHD symptoms differs depending on the co-occurrence of movement difficulties given evidence that weaker visuospatial processing, known to be important for maths performance, differentiates ADHD and DCD. We also aimed to examine whether relationships between cognition and maths in ADHD differs depending on co-occurring movement difficulties. MethodsParticipants were 43 drug naïve children between 6 and 12 years old (M = 101.53 months SD = 19.58). The ADHD-only group (n = 18) included children with high ADHD scores, and those in the ADHD+DCD group (n = 25) concurrently had high movement difficulty scores. All completed executive function and memory, including 2 visuo-spatial memory tasks from the CANTAB battery and Mathematics Problem Solving, Numeracy, and Maths Fluency tasks from the WIAT-III and specific factual, conceptual, and procedural maths component tasks. ResultsChildren in the ADHD+DCD group scored significantly lower on visuospatial working memory (WM) capacity, than those in the ADHD-only group. Both groups were comparable on all other cognitive assessments of executive functions, memory, and processing speed. The groups did not differ in their maths attainment scores, nor on more specific maths skills. Comparison of the correlations between cognitive processes and maths revealed that the association between visuospatial WM updating and procedural skill efficiency was stronger for the ADHD-only group. Moreover, associations between visuospatial WM and maths problem solving attainment were stronger in the ADHD+DCD group. ConclusionsDespite similarities in maths performance, children with ADHD+DCD could be distinguished by lower visuospatial WM. Differential associations with some of the maths domain implicate recruitment of different cognitive processes for some aspects of maths. This distinction can be particularly useful for conceptualising cognitive characteristics of different clinical groups and understanding cognitive pathways of maths difficulties. Implications for interventions are discussed.

Selective 5-hydroxytryptamine receptor 7 antagonism influences neural activation during visuospatial memory task

Selective 5-hydroxytryptamine receptor 7 antagonism influences neural activation during visuospatial memory task

物語理解時の共感的反応における視空間作動記憶の役割

The present study examines whether the activation of visuospatial perceptual processing affects empathic responses during narrative comprehension. Specifically, using a dual-task method, we investigated the effects of load on a visuospatial memory task and capacity of visuospatial working memory on empathic response rating scores for reading. Consequently, the results revealed that the effects of load on the visuospatial memory task reduced empathic response scores for reading in the higher visuospatial working memory capacity. The results suggest that the activation of visuospatial perceptual processing influence empathic responses during narrative comprehension. Moreover, elaboration through activation of visuospatial perceptual processing plays an important role in empathic responses, particularly for readers having a large capacity of visuospatial working memory.

Switching between body and environment: The selective effect of spatial misalignment

The ability to switch between egocentric (subject-to-object) and allocentric (object-to-object) frames of reference is a pivotal requirement in many everyday life spatial activities. Behavioural and neurofunctional evidence has demonstrated that the structure of an environment can influence our ability to represent spatial information. Given the complexity of our spatial environment, this raises the question of how enduring (aligned/misaligned) environmental axes can influence a demanding but necessary process in everyday spatial tasks, such as switching from one frame of reference to another. To the best of our knowledge, no study so far has investigated this issue. In the present study, an egocentric-allocentric visuo-spatial memory task was administered using Immersive Virtual Reality technology, while the orientation of the environmental axes was either parallel (aligned condition) or rotated by 45° (misaligned condition) with respect to the egocentric perspective. Participants were required to memorize triads of objects and then to provide switching (from egocentric-to-allocentric or allocentric-to-egocentric) and non-switching (only-egocentric or only-allocentric) spatial judgments of relative distances in the two virtual environments. Results showed that overall spatial judgments were worse in the misaligned than aligned condition, and in the allocentric-based than egocentric-based judgments. Interestingly, a specific difficulty due to the switching from an allocentric to an egocentric condition in the misaligned environment emerged. Moreover, the allocentric based (Allo-Ego, Allo-Allo) spatial judgments were more penalized in the misaligned than aligned condition. These results suggest that the presence of an environmental frame misaligned with the egocentric learning perspective has a negative impact on allocentric representations, especially in the switching condition when the first anchor point is allocentric. Therefore, the processes of switching between unstable local spatial array and stable body position are significantly influenced by the representation of an enduring allocentric environmental frame.

A pilot study to investigate postural sway and saccadic eye movements comprehensively for MCI classification

AbstractBackgroundWhile single assessment of postural sway or saccadic eye movements is potentially useful for dementia screening at clinical settings [1, 2], multimodal assessment of the two movements could improve the screening accuracy [3‐5]. We have developed a novel comprehensive assessment system of posture and saccades, with integrated additional cognitive tasks of visuospatial memory and spatial orientation. We hypothesised that the new system would improve the classification of mild cognitive impairment (MCI).Method23 older adults joined the experiment and were split into two group based on the score of Montreal Cognitive Assessment (MoCA) [6]: 20 healthy older adults (HA) (70.35±4.93 years, 11 men / 9 women) and 3 older adults with MCI (74.7±4.04 years, 1 man / 2 women). The assessment system consists of stabilometer (GP‐5000, ANIMA Corporation, Japan) and a head‐mounted display virtual reality (VR) technology (VIVE Pro Eye, HTC Corporation, Taiwan). We measured postural sway and pro‐ or anti‐saccadic eye movements simultaneously in each of three different VR environments: #1) no additional cognitive task, #2) with visuospatial memory task, and #3) with spatial orientation task. We compared the parameters of saccades and postural sway between HA and MCI groups.ResultHA group achieved the MoCA score of 27.2±1.64, while MCI group scored 20.3±2.08 (P=0.006). Our analysis did not find significant differences between the two groups in all parameters. However, we observed moderate effect on standard deviation of centre of pressure in medio‐lateral direction in two test conditions: 1) the condition with pro‐saccade and visuospatial memory tasks (P=0.14; effect size = 0.32) and 2) the condition with anti‐saccade and spatial orientation tasks (P=0.09; effect size = 0.36).ConclusionModerate effect was observed on postural sway behaviours in the two test conditions. Since these conditions theoretically activate wider areas of the brain, our comprehensive assessment approach could be useful for dementia screening. Future research requires more sample size of MCI population for further analysis.

Age-related changes in fast spindle clustering during non-rapid eye movement sleep and their relevance for memory consolidation.

Sleep plays a crucial role in memory consolidation. Recent data in rodents and young adults revealed that fast spindle band power fluctuates at a 0.02-Hz infraslow scale during non-rapid eye movement (NREM) sleep. These fluctuations result from a periodic temporal clustering of spindles and may modulate sleep maintenance and memory consolidation. With age, sleep undergoes substantial changes but age-related changes in spindle clustering have never been investigated. Polysomnography data were collected in 147 older (mean age ± SD: 69.3 ± 4.1 years) and 32 young-middle aged (34.5 ± 10.9 years) adults. Sleep-dependent memory consolidation was assessed in a subsample of 57 older adults using a visuospatial memory task. We analyzed power fluctuations in fast spindle frequency band, detected fast spindles, and quantified their clustering during the night separating encoding and retrieval. Fast spindle band power fluctuated at a 0.02-Hz infraslow scale in young-middle aged and older adults. However, the proportion of clustered fast spindles decreased non-linearly with age (p < .001). This effect was not mediated by NREM sleep fragmentation. The clustering level of fast spindles modulated their characteristics (p < .001). Finally, the mean size of spindle clusters was positively associated with memory consolidation (p = .036) and negatively with NREM sleep micro-arousal density (p = .033). These results suggest that clusters of fast spindles may constitute stable sleep periods promoting off-line processes such as memory consolidation. We emphasize the relevance of considering spindle dynamics, obviously impaired during aging, to understand the impact of age-related sleep changes on memory. Clinical Trial Information: Name: Study in Cognitively Intact Seniors Aiming to Assess the Effects of Meditation Training (Age-Well). URL: https://clinicaltrials.gov/ct2/show/NCT02977819?term=Age-Well&draw=2&rank=1. See STROBE_statement_AGEWELL.doc in supplementary material. Registration: EudraCT: 2016-002441-36; IDRCB: 2016-A01767-44; ClinicalTrials.gov Identifier: NCT02977819.

Effects of Display Layout on Spatial Memory for Immersive Environments

In immersive environments, positioning data visualisations around the user in a wraparound layout has been advocated as advantageous over flat arrangements more typical of traditional screens. However, other than limiting the distance users must walk, there is no clear design rationale behind this common practice, and little research on the impact of wraparound layouts on visualisation tasks. The ability to remember the spatial location of elements of visualisations within the display space is crucial to support visual analytical tasks, especially those that require users to shift their focus or perform comparisons. This ability is influenced by the user's spatial memory but how spatial memory is affected by different display layouts remains unclear. In this paper, we perform two user studies to evaluate the effects of three layouts with varying degrees of curvature around the user (flat-wall, semicircular-wraparound, and circular-wraparound) on a visuo-spatial memory task in a virtual environment. The results show that participants are able to recall spatial patterns with greater accuracy and report more positive subjective ratings using flat than circular-wraparound layouts. While we didn't find any significant performance differences between the flat and semicircular-wraparound layouts, participants overwhelmingly preferred the semicircular-wraparound layout suggesting it is a good compromise between the two extremes of display curvature.

Effects of different virtual reality technology driven dual-tasking paradigms on posture and saccadic eye movements in healthy older adults

Postural sway and eye movements are potential biomarkers for dementia screening. Assessing the two movements comprehensively could improve the understanding of complicated syndrome for more accurate screening. The purpose of this research is to evaluate the effects of comprehensive assessment in healthy older adults (OA), using a novel concurrent comprehensive assessment system consisting of stabilometer and virtual reality headset. 20 healthy OA (70.4 ± 4.9 years) were recruited. Using a cross-sectional study design, this study investigated the effects of various dual-tasking paradigms with integrated tasks of visuospatial memory (VM), spatial orientation (SO), and visual challenge on posture and saccades. Dual-task paradigms with VM and SO affected the saccadic eye movements significantly. Two highly intensive tests of anti-saccade with VM task and pro-saccade with SO task also influenced postural sway significantly. Strong associations were seen between postural sway and eye movements for the conditions where the two movements theoretically shared common neural pathways in the brain, and vice versa. This study suggests that assessing posture and saccades with the integrated tasks comprehensively and simultaneously could be useful to explain different functions of the brain. The results warrant a cross-sectional study in OA with and without dementia to explore differences between these groups.

A novel deep learning approach for diagnosing Alzheimer's disease based on eye-tracking data.

Eye-tracking technology has become a powerful tool for biomedical-related applications due to its simplicity of operation and low requirements on patient language skills. This study aims to use the machine-learning models and deep-learning networks to identify key features of eye movements in Alzheimer's Disease (AD) under specific visual tasks, thereby facilitating computer-aided diagnosis of AD. Firstly, a three-dimensional (3D) visuospatial memory task is designed to provide participants with visual stimuli while their eye-movement data are recorded and used to build an eye-tracking dataset. Then, we propose a novel deep-learning-based model for identifying patients with Alzheimer's Disease (PwAD) and healthy controls (HCs) based on the collected eye-movement data. The proposed model utilizes a nested autoencoder network to extract the eye-movement features from the generated fixation heatmaps and a weight adaptive network layer for the feature fusion, which can preserve as much useful information as possible for the final binary classification. To fully verify the performance of the proposed model, we also design two types of models based on traditional machine-learning and typical deep-learning for comparison. Furthermore, we have also done ablation experiments to verify the effectiveness of each module of the proposed network. Finally, these models are evaluated by four-fold cross-validation on the built eye-tracking dataset. The proposed model shows 85% average accuracy in AD recognition, outperforming machine-learning methods and other typical deep-learning networks.

1438P Effects of tamoxifen on cognitive functions in premenopausal patients with breast cancer: A cross-sectional study

Cognitive side-effects of selective estrogen receptor modulators is a topic of great interest, but the phenomenon has remained less understood. Estrogen receptors are found with significant density in brain regions associated with cognition (e.g., prefrontal cortex, hippocampus), and the benefits of estrogen on cognition are well known. Whether tamoxifen acts as an antiestrogen or estrogen agonist is tissue-specific. It has mainly been studied in peripheral tissues, not in the brain, so less is known about the effect of tamoxifen on cognitive domains.We aimed to investigate the effects of tamoxifen on domain-specific cognitive functions in a cross-sectional study. We assigned 45 premenopausal women who were operated on with hormone receptor-positive early breast cancer and treated with tamoxifen and GnRh-antagonist. Neuropsychological assessment contained measurement of complex working memory (Counting Span Test), executive functions (Berg’s Card Sorting Test, Go-No Go Task, Verbal Fluency Tasks), visuo-spatial memory (Corsi block-tapping test), verbal learning and memory (Rey Auditory Verbal Learning Test; RAVLT) and implicit learning (Alternating Serial Reaction Time Task ASRT). We measured also anxiety (STAI), depression (Beck) and perceived/subjective cognitive function (FACT-Cog). Data were compared to an age- and educational- level matched healthy control group (45 premenopausal women). Mann-Whitney U-test and repeated measures ANOVA were used for statistical analysis. Here, we show that the premenopausal treated group had a higher performance than the healthy controls on the shifting component of the executive function task (Berg’s Card Sorting Test). There were no difference between groups' performance on complex working memory, visuo-spatial memory, verbal learning and memory task, and both of groups showed evidence of implicit learning. Groups did not differ from each other in anxiety, depression and perceived/subjective cognitive function. Our findings suggest that tamoxifen affects specifically cognitive functions such as set-shifting related to dorsolateral prefrontal cortex and anterior cingulate cortex.