Data science or specifically data analytics systems have become an emerging trend in information technology and have attracted many organizations, including higher education. Higher Education Systems (HES) involve very active entities (students, faculty members, researchers, employers) who generate and require large volumes of data that go beyond the structured data stored in the house. The collection, analysis, and visualization of such big data present a huge challenge for HES. Big data analysis could be the solution to this challenge. However, the rationale and decision process for the adoption of big data analytics can be difficult. Such a knowledge-driven process requires a multitude of technical and organizational aspects that must be accounted for to ensure informed decisions are made. Existing research and development indicates that the decision to adopt, although systematic research with a theoretical background is rare and none of the existing studies have considered diffusion of innovation (DOI) theory. This paper aims to support HES, by providing a systematic analysis of the determinants for the decision to adopt big data analytics. An integrated framework referred to as the Technology Organization Environment (TOE) framework is proposed. The proposed framework is validated using structural equation modeling. Eleven determinants are confirmed that influence the TOE-driven framework for data analytics in HES. The result is expected to contribute to on-going research that attempts to address the complex and multidimensional challenge that relates to data science and analytics implementation in HES.