Neuroethology is concerned with the analysis of the neural substrates and mechanisms that underlie behaviour. In 1951, Tinbergen implied the following goals of Ethophysiology, today known as Neuroethology: (1) recognition and localization of behaviourally meaningful stimuli, e.g. key stimuli; (2) sensorimotor interfacing and feedback interactions; (3) modulations according to internal states and acquired information; (4) motor pattern generation; and (5) ontogenetic and phylogenetic aspects. Using the toad's ( Bufo bufo) visually-guided prey-catching behaviour as an example, experimental strategies and concepts of vertebrate Neuroethology can be demonstrated: (i) visual space is mapped in the brain in a multiple manner; (ii) specification of neurons results from inhibitory and/or excitatory interactions among and within space-mapped neuronal networks; (iii) specialized neurons, e.g. those with stimulus recognition and localization properties, show information processing that takes place in functional units of cell assemblies (so-called ‘neuronal machines’ or ‘brain chips’); (iv) activation of motor pattern generators for different behavioural actions may require coincidence of inputs from different combinations of specialized neurons that serve as command elements and together form a command system; (v) a command system can be regarded as a sensorimotor interface fulfilling tasks with respect to (a) visual pattern recognition and localization, (b) command functions, by initiating the activation of the motor pattern generation system, (c) motor pattern generation through participation in the temporal sequence of the positive feedback from the motor system, and (d) integration of modulatory inputs according to internal states; (vi) the motor pattern generation circuitry consists of a neuronal network capable of producing a consistent distribution of excitation and inhibition and whose output has privileged access to the required motoneuronal pools; (vii) the basic principles of prey selection and motor pattern generation of prey capture emerge in the post-metamorphic juvenile toad with the transition to land and without previous prey experience. During early ontogeny the acuity of sensory discrimination and the performance of motor patterns are subject to maturation paralleled by neural differentiations in the bbrain. performance of motor patterns are subject to maturation paralleled by neural differentiations in the brain. those are programmed and, in amphibians, presumably less dependent on the interaction with the environment than in mammals. This of course does not exclude the possibility of modulating, modifying, specifying and/or extending the visual pattern recognition system of toads due to internal states and individual experience.