Visual Memory Recall Research Articles

Visual free recall and recognition in art students and laypeople.

Artists and laypeople differ in their ability to create drawings. Previous research has shown that artists have improved memory performance during drawing; however, it is unclear whether they have better visual memory after the drawing is finished. In this paper, we focused on the question of differences in visual memory between art students and the general population in two studies. In Study 1, both groups studied a set of images and later drew them in a surprise visual recall test. In Study 2, the drawings from Study 1 were evaluated by a different set of raters based on their drawing quality and similarity to the original image to link drawing evaluations with memory performance for both groups.We found that both groups showed comparable visual recognition memory performance; however, the artist group showed increased recall memory performance. Moreover, they produced drawings that were both better quality and more similar to the original image. Individually, participants whose drawings were rated as better showed higher recognition accuracy. Results from Study 2 also have practical implications for the usage of drawing as a tool for measuring free recall - the majority of the drawings were recognizable, and raters showed a high level of consistency during their evaluation of the drawings. Taken together, we found that artists have better visual recall memory than laypeople.

Pork Liver Decomposition Product May Improve Frontal Lobe Function in Humans-Open Trial.

Porcine Liver Decomposition Product (PLDP) was obtained by treating pig liver homogenate with protease and filling it into capsules. We have already confirmed from three clinical trials that PLDP enhances visual memory and delays memory recall, and we believe that its activity is due to various phospholipids, including phosphatidylcholine (PC). In this study, we clinically evaluated PLDP for depressive symptoms caused by a decline in cognitive function. This clinical trial was conducted using the Revised Hasegawa Dementia Scale (HDS-R). The HDS-R (maximum score is 30 points) is a test similar to the Mini-Mental State Examination (MMSE), which is commonly used in Japan. Dementia is suspected if the score falls below 20 on the HDS-R. Additionally, in a previous clinical trial, there was no change in scores in the placebo group after three doses of the HDS-R. In order to clearly confirm the effectiveness of PLDP, this study was conducted under stricter conditions (HDS-R points of 15 to 23) than previous clinical trials (all participants had scores of 20 or higher). Therefore, from ethical considerations, a clinical trial was conducted using the scores before PLDP administration as a control. In this study, PLDP was administered orally at 4 capsules per day, and the HDS-R was confirmed 2 and 4 weeks after administration. A significant increase in HDS-R scores was observed at 2 and 4 weeks after PLDP administration. Additionally, regarding each item of the HDS-R, PLDP significantly increased 2 and 4 weeks after oral administration for the question items assessing delayed recall, and the question item assessing verbal fluency tasks was recognized. From the above results, we confirmed the reproducibility of the effect of PLDP in improving the delayed recall of verbal memories. Furthermore, increasing scores on verbal fluency tasks suggest that PLDP may enhance frontal lobe function and prevent or improve depressive symptoms. The effects observed in this study may differ from the mechanisms of action of existing antidepressants, and we believe that this may lead to the discovery of new antidepressants.

57 Clinical Utility of Neuropsychological Evaluation in the Differential Diagnosis Between Late-Onset Primary Progressive Aphasia Semantic Variant (PPA-SV) Versus Limbic Predominant Age-Related TDP-43 Encephalopathy (LATE): A Case Report

Objective:Primary progressive aphasia semantic variant (PPA-SV) is an atypical dementia subtype on the frontotemporal dementia (FTD) spectrum. PPA-SV is clinically defined by naming and semantic deficits, with progressive language decline that generalizes to other domains over time. Typically, it presents as an early-onset dementia with TDP-43 pathology, but 33-46% of PPA-SV cases display initial onset after age 65 with potentially different clinical features. Limbic Predominant Age-Related TDP-43 Encephalopathy (LATE), a more recently discovered neurodegenerative entity, is defined by an older age of onset, hippocampal sclerosis/atrophy, and TDP-43 pathology with a gradually progressive amnestic profile that expands to other cognitive deficits over time. The authors present a case report with overlapping features and suspected TDP-43 neuropathology ante-mortem for two reasons: first, to highlight the need for clinical criteria to formally diagnose LATE, and second, to address a gap in the literature on the possible clinical differences of late-onset PPA-SV.Participants and Methods:The authors present a case of a 78-year-old Indian bilingual man (English dominant) with 18 years of education, noncontributory medical history, and gradually progressive cognitive complaints reported over the past few years who was seen for outpatient neuropsychological evaluation. Prior workup was notable for negative amyloid PET scan, negative p-tau 217 blood test, and abnormal brain MRI revealing marked bilateral hippocampal atrophy with ex vacuo ventriculomegaly and minimal cerebrovascular disease. He scored 23/30 on prior MMSE, was diagnosed with amnestic MCI, prescribed Namenda and Exelon, and complained of minor memory and word-finding difficulties with reportedly intact IADLs and no signs of NPH.Results:Neuropsychological testing revealed a profound dysnomia (RBANS Naming raw score = 1/10), and he provided 0 words on two semantic fluency tasks but 15 words on letter fluency. Receptive vocabulary score was also impaired (PPVT-4, <1st %). Memory performance also demonstrated rapid forgetting of information (RBANS List Recall raw = 0/10, Story Recall raw = 0/12) with no benefit to recognition cues (RBANS List Recognition raw = 12/20), but slightly better visual memory recall, albeit still impaired (RBANS Figure Recall raw = 4/20). Grooved pegboard scores were significantly worse with right-hand than left-hand. Irregular word reading (NAART = 16th %ile) was significantly below expectations and thought to reflect more of a surface dyslexia rather than a cultural confounder given that he has lived in the US for over 50 years and his occupational and educational history was completed in English.Conclusions:Results support the clinical utility of neuropsychological evaluation in the differential diagnosis to support a predominant clinical syndrome of PPA-SV despite overlapping features with LATE and suspected TDP-43 pathology. This case report highlights the diagnostic issue with the lack of literature describing the typical clinical progression or suggested diagnostic criteria of LATE. These findings also indicate that late-onset PPA-SV may include greater memory deficits earlier in the course, but this may also be a clinical masquerade that is more reflective of the extent of language deficits. Further research on late-onset manifestations of PPA-SV and LATE consensus clinical guidelines is advised.

Cognition in older adults with healthy aging: analysis of the Mexican Health and Aging Study 2012-2015.

Maintaining older adults' health and well-being can be achieved through the optimization of physical and mental health, while preserving independence, social participation, and quality of life. Cognitive change has been described as a normal process of aging and it involves domains such as processing speed, attention, memory, language, visuospatial abilities, and executive functioning, among others. To describe cognitive changes in older adults with healthy aging. This is a study that involved data from 14,893 and 14,154 individuals aged >60 years or older from the 2012 and 2015 waves, respectively, who participated in the Mexican Health and Aging Study (MHAS). Participants with healthy aging were identified and described in the MHAS-2012 wave and followed to 2015. Eight cognitive domains evaluated in the Cross-Cultural Cognitive Evaluation (CCCE,) as well as sociodemographic and health characteristics, were described. Criteria for healthy aging involved the following: CCCE ≥ -1.5 standard deviations above the mean on reference norms, independence on basic and instrumental activities of daily living, self-reported "life close to ideal," and preserved functional and social performance. From a total of n = 9,160 older adults from the MHAS-2012 wave, n = 1,080 (11.8%) had healthy aging. In the healthy aging group, the median age was 67 years (IQR: 63-73), 58.1% were female and the median for education was 6 (IQR: 3-8) years. The mean CCCE score was 57 (SD: 16.9) points. In the MHAS-2012 cross-sectional analysis, except for orientation, visuospatial abilities, and verbal fluency, all cognitive domain scores were lower with passing age. When comparing cognitive domain scores in the 225 older adults identified with healthy aging between the 2012 and 2015 MHAS waves, there were almost no observable differences. In the cross-sectional analysis, Mexican adults with healthy aging had lower scores in the verbal learning memory, visual scanning, numeracy, visual memory, and verbal recall domains', as well as lower global cognitive scores in the higher age groups. There were no cognitive changes in the 3 year follow-up, except for a lower gradient of scores in the verbal recall memory domain. Longer prospective studies are needed to characterize greater cognitive changes.

Remote clinical cognitive assessment: Validation of mobile interactive cognitive self‐assessment scale

AbstractBackgroundThe diagnosis of Alzheimer’s disease relies on trained clinicians and specialized diagnostic tests. Under the circumstances of COVID‐19, the clinical interview is restricted, which caused an additional delay in diagnosis. Emerging demand for remote interactive cognitive assessment aroused for diagnosis and mass screening. We aimed to develop a mobile interactive cognitive self‐ assessment scale (ICSAS)MethodThe ICSAS was created by an expert group applying nominal group techniques and focus groups. Initial examination and iterative rounds were conducted in participants from the community and hospital to optimize the scale. The final version of ICSAS included 4 tasks, covering executive function, logic memory, visual memory, and logic memory recall. Validation was conducted in 387 cognitively impaired participants and 297 participants with normal cognition from the institution. 2034 participants were enrolled from the community.ResultNo significant difference was found in age and sex between cognitively impaired participants and normal controls. Years of education, the score of MMSE and MoCA were higher in normal controls. The Cronbach’s alpha was 0.79 which indicated relative good reliability. The KMO value was 0.76, and the optimal cutoff point was 228.90, leading to the sensitivity of 0.90 and specificity of 0.71. The positive likelihood ratio was 3.10, and the negative likelihood ratio was 0.14, which suggested ICSAS as an ideal scale. 284 participants from the community were predicted to be cognitively impaired, accounting for approximately 15% of participants from the community, which corresponds to the prevalence research.ConclusionOur research developed a remote interactive cognitive self‐assessment scale (ICSAS) which has relatively good reliability and sensitivity. The ICSAS may ease the struggle of remote clinical cognitive assessment brought by the COVID‐19 pandemic. Also, from the long‐term perspective, the application of ICSAS may enhance the feasibility of cognitive assessment, and it may be ideal for mass screening and cognitively impaired patients’ monitoring.

Negative emotion reduces visual working memory recall variability: A meta-analytical review.

Negative emotion is often hypothesized to trigger a more deliberate processing mode. This effect can manifest as increased precision of information maintained in working memory (WM) captured by reduced WM recall variability under an induced negative emotional state. However, some recent evidence shows that WM representations are immune to any emotional influences. Here, we meta-analyze existing evidence based on data from 13 experiments across 491 participants who performed a delay-estimation WM task under negative and neutral emotional states. We find that induced negative emotional state modestly reduces WM recall variability and increases recall failures relative to the neutral condition. These effects are moderated by participants' self-report negative experiences during emotion induction. Collectively, these data suggest that negative emotion influences how much and how well one can remember in WM. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Preoperative cognition predicts clinical stroke/TIA and mortality after surgical aortic valve replacement in older adults

ABSTRACT Stroke and death remain risks of surgical aortic valve replacement (SAVR). Preoperative cognitive screeners repeatedly show that reduced scores predict postoperative outcome, but less is known about comprehensive neuropsychological measures predicting risk. This study had two aims: 1) investigate whether preoperative cognitive measures predicted postoperative clinical stroke/transient ischemic attack (TIA) and mortality in older adults undergoing SAVR, and 2) identify the best predictors within a comprehensive cognitive protocol. A total of 165 participants aged 65 + with moderate-to-severe aortic stenosis completed a comprehensive cognitive test battery preoperatively. Postoperative stroke evaluations were conducted by trained stroke neurologists preoperatively and postoperatively, and mortality outcomes were obtained by report and records. Logistic regressions were conducted to evaluate preoperative cognitive predictors of clinical stroke/TIA within 1 week of surgery and mortality within 1 year of surgery. Multivariate models showed measures of delayed verbal memory recall (OR = 0.86; 95% CI 0.74–0.99) and visuospatial skills (OR = 0.95; 95% CI 0.90–1.01) predicted clinical stroke/TIA within 1 week of surgery, R 2 = .41, p < .001, ƒ2 = .69. Measures of naming ability (OR = 0.88; 95% CI 0.80–0.96), verbal memory recall (OR = 1.23; 95% CI 0.99–1.51), visual memory recall (OR = 0.90; 95% CI 0.80–1.00), medical comorbidities (OR = 1.71; 95% CI 1.22–2.65), and sex (OR = 2.39; 95% CI 0.90–7.04) were significant predictors of death within 1 year of surgery, R2 = .68, p < .001, ƒ2 = 2.12. Preoperative cognitive measures reflecting temporal and parietal lobe functions predicted postoperative clinical stroke/TIA within 1 week of SAVR and mortality within 1 year of SAVR. As such, cognitive measures may offer objective and timely indicators of preoperative health, specifically vulnerabilities in cerebral hypoperfusion, which may inform intervention and/or intensive postoperative monitoring and follow-up after SAVR.

Clinical evaluation and resting state fMRI analysis of virtual reality based training in Parkinson’s disease through a randomized controlled trial

There are few studies investigating the short-term effects of Virtual Reality based Exergaming (EG) on motor and cognition simultaneously and pursue the brain functional activity changes after these interventions in patients with Parkinson’s Disease (PD). The purpose of this study was to investigate the synergistic therapeutic effects of Virtual Reality based EG on motor and cognitive symptoms in PD and its possible effects on neuroplasticity. Eligible patients with the diagnosis of PD were randomly assigned to one of the two study groups: (1) an experimental EG group, (2) an active control Exercise Therapy (ET) group. All patients participated in a 4-week exercise program consisting of 12 treatment sessions. Every session lasted 60 min. Participants underwent a motor evaluation, extensive neuropsychological assessment battery and rs-fMRI before and after the interventions. Thirty patients fulfilled the inclusion criteria and were randomly assigned to the EG and ET groups. After the dropouts, 23 patients completed the assessments and interventions (11 in EG, 13 in ET). Within group analysis showed significant improvements in both groups. Between group comparisons considering the interaction of group × time effect, showed superiority of EG in terms of general cognition, delayed visual recall memory and Boston Naming Test. These results were consistent in the within-group and between-group analysis. Finally, rs-fMRI analysis showed increased activity in the precuneus region in the time × group interaction in the favor of EG group. EG can be an effective alternative in terms of motor and cognitive outcomes in patients with PD. Compared to ET, EG may affect brain functional connectivity and can have beneficial effects on patients’ cognitive functions and motor symptoms. Whenever possible, using EG and ET in combination, may have the better effects on patients daily living and patients can benefit from the advantages of both interventions.

Acute effects of cocoa flavanols on visual working memory: maintenance and updating.

Consumption of cocoa flavanols may have acute physiological effects on the brain due to their ability to activate nitric oxide synthesis. Nitric oxide mediates vasodilation, which increases cerebral blood flow, and can also act as a neurotransmitter. This study aimed to examine whether cocoa flavanols have an acute influence on visual working memory (WM). Two separate randomised, double-blind, placebo-controlled, counterbalanced crossover experiments were conducted on normal healthy young adult volunteers (NExp1 = 48 and NExp2 = 32, gender-balanced). In these experiments, 415mg of cocoa flavanols were administered to test their acute effects on visual working memory. In the first experiment, memory recall precision was measured in a task that required only passive maintenance of grating orientations in WM. In the second experiment, recall was measured after active updating (mental rotation) of WM contents. Habitual daily flavanols intake, body mass index, and gender were also considered in the analysis. The results suggested that neither passive maintenance in visual WM nor active updating of WM were acutely enhanced by consumption of cocoa flavanols. Exploratory analyses with covariates (body mass index and daily flavanols intake), and the between-subjects factor of gender also showed no evidence for effects of cocoa flavanols, neither in terms of reaction time, nor accuracy. Overall, cocoa flavanols did not improve visual working memory recall performance during maintenance, nor did it improve recall accuracy after memory updating.

Challenges in the development of accurate normative neuropsychological test data for older adults: Findings from the HELIAD Study

AbstractBackgroundNormative data collected from older adult cohorts may be tainted by the inadvertent inclusion of undiagnosed individuals at the very early stage of a dementia process or Mild Cognitive Impairment (MCI). To avoid this pitfall, we developed normative data from an older adult group who remained cognitively intact at follow‐up examination. The present work addresses the challenge and the absence of appropriate normative data for a range of neuropsychological tests in older adults in Greece.Method1031 community dwelling participants (age≥65) underwent neurological and neuropsychological assessment on two occasions with a mean interval of 2.8 years (range:1.2‐5.2; SD:0.8) for the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD). A value of 0 or 0.5 for the Clinical Dementia Rating (CDR) and a threshold value of ≥ 26 on the Mini Mental State Examination (MMSE) were used as clinical diagnostic criteria to determine the cognitive status of the participants. Based on these criteria, 750 individuals were cognitively intact in both evaluations and their data were used for norms development. Participants received a comprehensive neuropsychological assessment encompassing five cognitive domains: memory, language, attention/speed, executive and visual‐spatial functioning. Multiple linear regression models were performed, with age at baseline (years), education (years) and sex as the demographic predictors for regression‐based normative formulae, and raw test scores as the dependent variables. The effects of age, education and sex were investigated for each test and subtest separately. Discrete norms were also derived, stratified by four age strata (64‐69, 70‐74, 75‐79, 80‐89) and by three education strata (0, 1‐9, 10+).ResultRegression analyses revealed that education was associated with all test scores, whereas age was an important predictor of all but a few visuoperceptual, executive functioning and memory variables. Women outperformed men on verbal memory, attention/information processing speed and subtests of executive functioning. Men, however, outperformed women on visual memory recall and visuospatial perception.ConclusionThe current study provides sound normative data for widely‐used neuropsychological tests among older adults, untainted by potential early and undiagnosed cognitive impairment. We report both discrete and regression‐based norms for use in clinical settings to identify cognitive decline in older adults.

Visual memory recall‐induced focal seizures: A case report

AbstractAn 82‐year‐old woman presented with a complaint of sudden difficulty in chanting the Heart Sutra because visual hallucinations of Tetris‐like color blocks disturbed the image of the Sutra in her mind. Neuropsychological examination revealed transient impairment of visual memory recall with hallucinations. Physical examination showed no abnormalities except mild hypertension. She was alert, oriented with normal motor, sensory, and cerebellar function. She was diagnosed with mid‐temporal lobe seizures based on electroencephalography and single‐photon emission computed tomography (SPECT) findings. Subtraction ictal SPECT co‐registered to MRI (SISCOM) examination was useful in detecting the seizure focus. Symptoms resolved completely after the administration of antiepileptic drugs. This case report provides new insights into the mechanism of visual memory recall.

Visual memory recall for personally familiar objects in medial parietal cortex

Visual memory recall for personally familiar objects in medial parietal cortex

Risk-benefit modeling to guide health research in collaboration with Great Lakes fish consuming Native American communities

It is well documented that fish consumption imparts both health risks and benefits. Furthermore, fish harvest and consumption are an essential part of Great Lakes Native American cultures. Quantitative models that compare risk and benefits to potential consumption scenarios can help guide future health research as well as consumption advice for potentially sensitive populations. This article presents fish consumption scenarios based on self-reported meal plans constructed by tribal members in eastern upper peninsula and northern lower Michigan Anishinaabe. Two risk–benefit models were applied to these scenarios to estimate the potential neurodevelopmental and cardiovascular risks (either increased or reduced risk) from dioxin-like polychlorinated biphenyls (DL-PCBs), methylmercury (MeHg), and omega-3 polyunsaturated fatty acids (n3-PUFA). All scenarios except maximum exposure estimates (i.e. 25th–75th percentile MeHg, DL-PCB, and n3-PUFA intakes) predicted reduced cardiovascular risk and improved neurodevelopmental outcomes. The greatest predicted benefits (adjusted for risks) occurred at the 75th percentile intake of MeHg, DL-PCB, and n3-PUFA scenarios: 5.0 visual recall memory (VRM) and 4.41 Intelligence Quotient (IQ) benefits, and 28% reduced risk of cardio-vascular disease. Scenarios based on maximum self-reported intake, however, predicted health detriments. These results suggest that most fish consumption scenarios as constructed in collaboration with Native American communities could impart health benefits despite the presence of contaminants. However, high-end consumption estimates warrant caution as well as the need for well-crafted advice. Potential benefits further underscore the value of reducing contamination burdens in Great Lakes fisheries. Future priorities of ongoing contamination monitoring and health research are discussed.

Consistent Failure to Produce a Cognitive Load Effect in Visual Working Memory Using a Standard Dual-Task Procedure.

Working memory performance is impaired when an attention-demanding task is executed during memory retention. The cognitive load effect is the consistent finding that the size of the memory impairment is determined by the relative amount of time that the secondary processing task occupies attention during memory retention. Cognitive load has been proposed to be a Priority-A benchmark any model of working memory should be able to explain (Oberauer et al., 2018), in part because the effect appears to generalize across different experimental procedures and materials. Using a standard dual-task procedure, we detail four experiments using a visual working memory recall task, two requiring memory for low-level features and two requiring memory for canonical angles (up, down, left, right, etc.). In all four experiments, we failed to find a cognitive load effect, calling into question the generality of the cognitive load effect and whether it is driving forgetting in multitasking contexts.

Neuropsychological Impairments in Young Patients With Subclinical Hypothyroidism: A Case Control Study.

Background:There is a lack of clarity about the cognitive dysfunction in young patients with subclinical hypothyroidism (SCH). This study was done to explore the neuropsychological impairments in young patients with SCH and compare them with euthyroid controls.Methods:Patients between 18 and 45 years of age and diagnosed with SCH were recruited. Controls were euthyroid age, gender, and education matched. All the cases and controls underwent a detailed neuropsychological assessment with a battery of tests validated for use in the age groups of 18 to 65 years.Results:Thirty-nine patients with a mean age of 30.3 ± 7.7 years (female:male ratio 12:1) and 23 controls (female:male ratio 21:2) with a mean age of 33.4 ± 7.1 years (P = .24) were included in the study. The mean TSH value was 6.36 ± 1.3 mIU/L and 2.49 ± 1.03 mIU/L in cases and controls, respectively (P < .001). The visual memory delayed recall was impaired, in 48.71% (n = 19) and 21.7% (n = 5) cases and controls, respectively (P = .03). The category fluency test showed impairment in a greater number of cases (35.9%, n = 14) as compared to controls (13%, n = 3; P = .04).Conclusion:This study shows that younger patients with SCH have delayed visual memory recall and category fluency deficits, which are suggestive of dysfunction of the prefrontal cortex and temporal lobe in young SCH patients. These impairments may justify the treatment of young SCH patients with replacement therapy.

A-34 Sex and Sport Differences in Baseline Neurocognitive Performance in Division-I Collegiate Athletes using the NIH Toolbox® Cognition Battery

Abstract Objective Understanding sex and sport-related differences in baseline neurocognitive scores may aid in interpreting post-injury performance. Sex and sport-related differences in neurocognitive performance for collegiate athletes have not been examined on the NIH Toolbox® Cognition Battery (NIHTB-CB). Therefore, this study sought to determine if baseline scores on the NIHTB-CB differ between sex or sport in collegiate athletes. It was hypothesized that sex, but not sport-related differences would exist in CB baseline performance. Method 107 Division-I athletes (47 females, 60 males) that participated in soccer (n = 45), football (n = 30), or cheerleading (n = 32) volunteered to participate. Participants completed tablet-based NIHTB-CB assessments including the Flanker Inhibitory Control &amp; Attention (FICA), Dimensional Change Card Sort (DCCS), Picture Sequence Memory (PSM), and Pattern Comparison Processing Speed (PCPS) tests. These assessments measured visual attention, cognitive flexibility, memory recall, and processing speed, respectively. Fully corrected t-scores were used for analyses. Parametric and non-parametric tests compared scores based on sex and sport. Results Females demonstrated greater performance on the PCPS (Females: 64.72 ± 9.84, Males: 61.08 ± 8.85; p = 0.006). Males exhibited better performance on the FICA (Females: 45.72 ± 10.12, Males: 51.03 ± 10.70; p = 0.009). After controlling for sex, a significant difference across sports was identified in the FICA (p = 0.007) with cheerleading (43.81 ± 9.28) exhibiting poorer performance than football (54.33 ± 10.44; p = 0.002) and soccer (48.42 ± 10.28; p = 0.047). No sex or sport differences were identified for the DCCS or PSM. Conclusions Baseline differences in neurocognitive performance exist on the NIHTB-CB based on sex and sport suggesting these variables be taken into consideration when interpreting post-concussion scores in collegiate athletes.

Nocturnal Hypoxemia Is Associated with Altered Parahippocampal Functional Brain Connectivity in Older Adults at Risk for Dementia.

Obstructive sleep apnea is associated with an increased risk of developing mild cognitive impairment and dementia. Intermittent nocturnal hypoxemia in obstructive sleep apnea is associated with brain changes in key regions that underpin memory. To determine whether older adults with severe nocturnal hypoxemia would exhibit reduced functional connectivity within these regions, with associated deficits in memory. Seventy-two participants 51 years and over underwent polysomnography with continuous blood oxygen saturation recorded via oximetry. The oxygen desaturation index (ODI, 3% dips in oxygen levels per hour) was the primary outcome measure. ODI was split into tertiles, with analyses comparing the lowest and highest tertiles (N = 48). Thirty-five of the 48 participants from these two tertiles had mild cognitive impairment. Participants also underwent resting-state fMRI and comprehensive neuropsychological, medical, and psychiatric assessment. The highest ODI tertile group demonstrated significantly reduced connectivity between the left and right parahippocampal cortex, relative to the lowest ODI tertile group (t(42) = -3.26, p = 0.041, beta = -1.99).The highest ODI tertile group also had poorer working memory performance. In the highest ODI tertile group only, higher left-right parahippocampal functional connectivity was associated with poorer visual memory recall (between-groups z = -2.93, p = 0.0034). Older adults with severe nocturnal hypoxemia demonstrate impaired functional connectivity in medial temporal structures, key regions involved in sleep memory processing and implicated in dementia pathophysiology. Oxygen desaturation and functional connectivity in these individuals each relate to cognitive performance. Research is now required to further elucidate these findings.

Improving neuropsychological seizure lateralization in Spanish-speaking people with epilepsy in the US: The need to account for education and demographic differences

ObjectiveThe objective of the study was to investigate the predictive seizure lateralization ability of the Neuropsychological Screening Battery for Hispanics (NeSBHIS) in an optimally, demographically matched cohort of primarily immigrant Spanish-speaking people with epilepsy (PWE) living in the US. Linguistically and culturally appropriate neuropsychological measures for Spanish-speaking people are increasingly needed in the US, especially as this diverse, international population grows. The NeSBHIS was developed to meet this need. Previous studies were inconclusive regarding its utility in epilepsy lateralization with PWE. Sample size and demographic variables, particularly educational levels, which anchor neuropsychological normative data and guide clinical use, limited the conclusions of earlier studies. MethodsA retrospective study, the NeSBHIS battery's ability to predict seizure lateralization in a large cohort of Spanish-speaking PWE (n = 108) was conducted using normative data based on refined, smaller education ranges suggested by the author of the NeSBHIS, Pontón. ResultsRegression analysis revealed that four NeSBHIS subtests representing different cognitive domains produced the best model for predicting lateralization: 1) language, 2) attention/mental control, 3) visual memory recall, and 4) verbal memory recall. Prediction accuracy overall was 62% (67.3% for left hemisphere (LH) and 55.8% for right hemisphere (RH)). ConclusionThis study demonstrated the clinical utility of the NeSBHIS in seizure lateralization in a large cohort of Spanish-speaking PWE by analyzing standardized scores based on refined, education-based normative samples. These results also highlight that demographic variables, in particular, education, which varies greatly across Spanish-speaking nations in terms of compulsory educational opportunity and quality, must be accounted for more carefully in clinical and research practice.

Forward to the past: Revisiting the role of immediate recognition in the assessment of episodic memory

ABSTRACTIntroduction: During the clinical assessment of episodic memory, encoding ability is typically inferred from immediate recall performance. This dependency on effortful retrieval may not be optimal for estimating encoding, particularly in the presence of executive dysfunction. We examined whether a test of immediate recognition memory could meaningfully supplement recall in estimating encoding and provide unique information about memory retention.Method: Fifty older adult outpatients were administered a neuropsychological test battery including original and revised versions of the Hopkins Verbal Learning Test; the former (HVLT) assesses recognition memory immediately after learning trials, while the latter (HVLT-R) assesses only delayed recognition. Hierarchical regressions evaluated the incremental value of immediate recognition in predicting both delayed verbal and visual recognition. ANCOVA was performed on subgroups defined by the number of impaired performances on executive functioning tests (EF-intact, EF-1, EF-2) to examine the influence of executive impairment on measures of immediate recall and recognition. Recall- and recognition-based estimates of verbal memory retention were also compared across groups to determine whether they yield distinct patterns of memory consolidation.Results: Immediate verbal recognition accounted for significant variance in both delayed verbal and visual recognition beyond immediate recall, age, and education. Although subgroups were demographically similar, EF-1 and EF-2 performed significantly worse than EF-intact across verbal and visual memory recall. Contrastingly, there were no group differences in immediate recognition. Subgroups attained similar scores on a conventional, recall-based memory retention measure, but EF-2 showed relatively greater forgetting on a recognition-based retention measure.Conclusions: Immediate verbal recognition is an independent determinant of delayed memory performance but is not captured in current test paradigms. Study results provide proof-of-concept that recognition testing at learning can provide a more comprehensive index of encoding ability than recall alone, may facilitate disentangling memory functions from executive deficits, and could have important downstream implications for estimating memory consolidation.

Emotion as an emergent phenomenon of the neurocomputational energy regulation mechanism of a cognitive agent in a decision-making task

Biological agents need to complete perception-action cycles to perform various cognitive and biological tasks such as maximizing their wellbeing and their chances of genetic continuation. However, the processes performed in these cycles come at a cost. Such costs force the agent to evaluate a tradeoff between the optimality of the decision making and the time and computational effort required to make it. Several cognitive mechanisms that play critical roles in managing this tradeoff have been identified. These mechanisms include adaptation, learning, memory, attention, and planning. One of the often overlooked outcomes of these cognitive mechanisms, in spite of the critical effect that they may have on the perception-action cycle of organisms, is “emotion.” In this study, we hold that emotion can be considered as an emergent phenomenon of a plausible neurocomputational energy regulation mechanism, which generates an internal reward signal to minimize the neural energy consumption of a sequence of actions (decisions), where each action triggers a visual memory recall process. To realize an optimal action selection over a sequence of actions in a visual recalling task, we adopted a model-free reinforcement learning framework, in which the reward signal—that is, the cost—was based on the iteration steps of the convergence state of an associative memory network. The proposed mechanism has been implemented in simulation and on a robotic platform: the iCub humanoid robot. The results show that the computational energy regulation mechanism enables the agent to modulate its behavior to minimize the required neurocomputational energy in performing the visual recalling task.