Visual Food Research Articles

Systematic Review of fMRI Studies with Visual Food Stimuli in Anorexia Nervosa

Anorexia Nervosa (AN) is a disease with increasing prevalence and relatively high mortality that usually begins in adolescence. Patients with AN avoid food intake and may react specifically toward food images. We present a systematic review of fMRI studies with visual food stimulation in AN, based on a search through PubMed database under the recommendations of the PRISMA guidelines. After applying dates 2004.01.01-2021.01.01, we screened 319 papers and included 27 experimental designs, with only 7 studies focusing on adolescents. Adolescents with AN showed increased activity in the medial prefrontal cortex, the inferior frontal gyrus, the insula, the hippocampus, the fusiform gyrus, the parahippocampal gyrus and the cuneus when watching food images. Adult participants with AN revealed enhanced brain activity due to visual food stimuli in the fusiform gyrus, the inferior frontal gyrus, the lingual gyrus, the medial prefrontal cortex, the right dorsolateral prefrontal cortex, the right angular gyrus. There was deactivation detected in the parahippocampal gyrus, compared to healthy participants. We have found contrary reports according increased/decreased activation of the insula, the amygdala, the hippocampus, the hypothalamus, the anterior cingulate cortex, the thalamus, the orbitofrontal cortex in adults with AN. Although AN typically develops in adolescence, there is still very little fMRI research in this age group. Careful creation of a homogeneous group of study participants is an important factor determining the reliability and unequivocalness of the experiment. Only a detailed description of participants´ characteristics that may affect the results allows solid comparison of different studies´ findings.

Effects of the calorie content of visual food stimuli and simulated situations on event-related frontal alpha asymmetry and event-related potentials in the context of food choices

Approach and avoidance tendencies play an important role in everyday food choices when choosing between high-caloric, rather unhealthy, and low-caloric, rather healthy options. On a neuronal level, approach and avoidance motivation have been associated with asymmetrical activity of the frontal cortex, often quantified by alpha power averaged over several seconds of resting electroencephalogram (EEG). Going beyond the analysis of resting EEG, the present study aimed to investigate asymmetrical frontal activity in direct response to food stimuli in an event-related design and in combination with event-related potentials (ERPs). Therefore, a sample of 56 young and healthy participants completed a food choice task. They were asked to choose from a selection of high-caloric and low-caloric foods which they would want to eat on a normal day (baseline), when being on a diet, and in a reward situation. On the behavioural level, there was a clear preference for low-caloric foods. Well in line with that, time-frequency analyses of alpha asymmetry revealed relatively stronger temporary (950–1175 ms) left-hemispheric frontal activity, that is, a stronger approach tendency, in response to low-caloric as compared to high-caloric foods. Furthermore, larger P300 for low-caloric foods indicated an increased task relevance of low-caloric foods in the baseline and the reward situation. In contrast, the late positive potential (LPP), an index of subjective value, was larger for high-as compared to low-caloric foods, reflecting the intrinsic rewarding properties of high-caloric foods. ERPs, but not frontal alpha asymmetry, were influenced by the situational context.

Attentional bias towards high and low caloric food on repeated visual food stimuli: An ERP study.

Food variety influences appetitive behaviour, motivation to eat and energy intake. Research found that repeated exposure to varied food images increases the motivation towards food in adults and children. This study investigates the effects of repetition on the modulation of early and late components of event-related potentials (ERPs) when participants passively viewed the same food and non-food images repeatedly. The motivational attention to food and non-food images were assessed in frontal, centroparietal, parietooccipital and occipitotemporal areas of the brain. Participants showed increased late positive potential (late ERP component) to high caloric image in the occipitotemporal region compared to low caloric and non-food images. Similar effects could be seen in the early ERP component in the frontal region, but with reversed polarity. Data suggest that both the early and late ERP components show greater ERP amplitude when viewing high caloric images than low caloric and non-food images. Despite repeated exposure to same image, high caloric food continued to show sustained attention compared to low caloric and non-food image.

Aberrant neural representation of food stimuli in women with acute anorexia nervosa predicts treatment outcome and is improved in weight restored individuals

Anorexia nervosa (AN) has been associated with altered reward processing. We recently reported greater neural response in secondary visual areas when processing visual food stimuli in acutely underweight AN patients (acAN). In order to examine whether the observed alterations are indicative of acute undernutrition or a potential trait marker of AN, we set out to assess neural responses in acAN and in individuals weight-recovered from AN (recAN). FMRI data were collected from a total of 126 female volunteers, 35 acAN, 33 recAN, and 58 age-matched healthy controls (HC) while they viewed streams of food, social and neutral stimuli. A standard general linear model (GLM) was used to interrogate neural responses to the different stimuli in recAN vs. age-matched HC. Moreover, within-subject multivoxel pattern analyses (MVPA) in the two matched samples (acAN/HC and recAN/HC) were used to estimate neural representation of food vs. neutral, and social vs. neutral stimuli. A multiple regression analysis was conducted to test associations between the accuracy of the neural representation and treatment outcome. The GLM revealed no group differences between recAN and HC. The MVPAs showed greater classification accuracy of food stimuli in the posterior fusiform gyrus in acAN but not recAN. Classification accuracy was associated with better treatment outcome. Our findings suggest that the neural representation of food stimuli is altered in secondary visual areas in acAN and normalizes with weight recovery. Possibly this altered representation reflects attentional engagement motivating food intake, which may promote the recovery process.

Influence of visual food cues on autonomic activity and craving

In this study, we tested the hypothesis that autonomic control of the stomach is related to craving and is modulated by visual food cues. Twenty-nine healthy human participants were shown pictures of either high- or low-appeal food, as well as non-food pictures, and were asked to rate how much they wanted to eat each item using a 7-point Likert scale. Simultaneously, the electrogastrogram, electrocardiogram, electrodermal activity, respiration rate, and pupil diameter were recorded. After the ingestion of a 500-kcal liquid meal, participants were asked to perform the task a second time. Despite changes in craving ratings, we did not find changes in the amplitude of the gastric rhythm, but we found increases in pupil diameter for the high appeal food pictures. Moreover, craving ratings were mostly related to increases in pupil and tonic electrodermal activity, compatible with an increase in arousal and a heightened motivational response to food.

Food on the Move: The Impact of Implied Motion in Pictures on Food Perceptions through Anticipated Pleasure of Consumption.

To tackle obesity, upgrading the image of healthy food is increasingly relevant. Rather than focusing on long-term benefits, an effective way to promote healthy food consumption through visual advertising is to increase its pleasure perception. We investigate whether implied motion, a popular trend in food pictures, affects food perceptions through anticipated consumption pleasure. Prior research shows that motion affects food perceptions, but these studies focused on limited food categories, using experiments with a single food stimulus, and mainly showing unhealthy food effects. Therefore, we aim to (1) replicate prior findings on the effects of food in motion on appeal, tastiness, healthiness, and freshness perceptions; (2) examine whether these effects differ for healthy and unhealthy food; and (3) investigate whether anticipated pleasure of consumption drives the effects of implied motion on food perceptions. Three between-subjects experiments (N = 626) reveal no evidence for the effectiveness of motion (vs. no motion) across a large variety of food products. We further show no differential effects for healthy versus unhealthy foods. Moreover, implied motion does not increase appeal or taste perceptions through anticipated pleasure. Considering the current replication crisis, these findings provide more nuanced insights into the effectiveness of motion in visual food advertising.

Changing the visualization of food to reduce food cue reactivity: An event-related potential study

Visual food cues automatically capture our attention. Moreover, food cue exposure is associated with an increased desire to eat (craving) and food consumption. We attempted to reduce the attentional bias to images depicting a specific food (M&Ms), craving, and consumption through mental imagery in a sample of 98 females (mean age = 23.82 years). The participants either listened to a guided imagery script that described the crushing of M&Ms to reduce the appetitive value of the chocolates, or they envisioned the sorting of M&Ms, or marbles (as control conditions). Afterward, participants were presented with images of M&Ms (not crushed) and marbles while their electroencephalogram, craving ratings, and M&M consumption were measured. The visualization of crushing M&Ms was associated with increased early (P200) and late positivity (P300, early LPP) to M&M pictures, which indicate automatic (P200/P300) and deliberate attention (LPP). M&M sorting increased craving but did not influence M&M consumption. Our findings show that imaginary M&M crushing cannot reduce attention to M&M images and even has the opposite of the intended effect.

Homeostasis and food craving in obesity: a functional MRI study

ObjectivesFood intake in obesity has been found to be reward-based and less contingent on homeostatic needs. Accordingly, previous studies investigating neural processing of food cues observed aberrant processing in reward- and control-related brain regions in obesity. To further investigate the relation between homeostasis and food intake, this study investigated the influence of glucose metabolism on the neuronal response during the regulation of food craving in participants with obesity.MethodsTwenty-five normal-weight and 25 women with obesity were examined on two occasions after receiving either water or glucose directly into the stomach using a nasogastric tube. Participants were blinded to the type of infusion and were required to refrain from eating for 16 h before each visit. An event-related fMRI paradigm was used to investigate the effect of intestinal glucose load on the neuronal response during the regulation of food craving.ResultsA 2 × 2 mixed-model ANOVA revealed that craving regulation was associated with increased activation in fronto-parietal regions in participants with obesity when compared to healthy controls. However, this effect was observed independently from homeostatic satiety. A regression analysis revealed that the reduction of food craving was related to increased activation in the lingual gyrus in individuals with obesity following the infusion of water.ConclusionsIn participants with obesity, the neuronal response during the regulation of food craving is associated with increased neural cognitive top-down control and increased visual food processing. Since this observation was independent from satiety status, our results indicate a reduced influence of homeostasis on neural processing during food craving in obesity. This study was registered on clinicaltrials.org: NCT03075371.

Hibiscus sabdariffa tea affects diet-induced thermogenesis and subjective satiety responses in healthy men but not in women: a randomized crossover trial.

The aim of this study was to investigate the effect of Hibiscus sabdariffa tea on energy expenditure, satiety response and food intake. This is an open-label, crossover, randomized clinical trial that comprised 21 subjects (11 women, 10 men). The individuals were evaluated at acute moments (fasting and after eating standardized breakfast accompanied by water or H. sabdariffa tea). Resting energy expenditure was measured by indirect calorimetry, subjective satiety responses were evaluated with a visual analogue scale and food intake was assessed by using food records. The volunteers who drank the H. sabdariffa tea had lower perception of hunger (p= 0.002) and greater feeling of satiety (p= 0.01) and fullness (p= 0.009) compared to control. Men who ingested the H. sabdariffa tea had an increase in nitrogen energy expenditure (water: 1501± 290.7kcal, H. sabdariffa tea: 1619± 288.9kcal; p= 0.029). In comparison to control, men presented less perception of hunger (p= 0.003) and desire to eat (p= 0.016), increased satiety (p= 0.021) and fullness (p= 0.01), and women oxidized more fat (p= 0.034) when they drank H. sabdariffa tea. There was no difference between treatments regarding the energy and macronutrient intake from the first meal and throughout the day (p> 0.05) for all participants. The H. sabdariffa tea only affected energy expenditure and satiety responses in men. Clinical trial registry: ReBEC Platform of the Brazilian Clinical Trials Registry (https://ensaiosclinicos.gov.br/) - RBR-5HZ86T. Novelty: H. sabdariffa tea promoted an increase in energy expenditure and caused less perception of hunger/desire to eat in men. H. sabdariffa tea intake increased postprandial fat oxidation in women.

Does intervention with GLP-1 receptor agonist semaglutide modulate perception of sweet taste in women with obesity: study protocol of a randomized, single-blinded, placebo-controlled clinical trial

BackgroundPreclinical studies demonstrated that glucagon-like peptide 1 (GLP-1) is locally synthesized in taste bud cells and that GLP-1 receptor exists on the gustatory nerves in close proximity to GLP-1-containing taste bud cells. This local paracrine GLP-1 signalling seems to be specifically involved in the perception of sweets. However, the role of GLP-1 in taste perception remains largely unaddressed in clinical studies. Whether any weight-reducing effects of GLP-1 receptor agonists are mediated through the modulation of taste perception is currently unknown.Methods and analysisThis is an investigator-initiated, randomized single-blind, placebo-controlled clinical trial. We will enrol 30 women with obesity and polycystic ovary syndrome (PCOS). Participants will be randomized in a 1:1 ratio to either semaglutide 1.0 mg or placebo for 16 weeks. The primary endpoints are alteration of transcriptomic profile of tongue tissue as changes in expression level from baseline to follow-up after 16 weeks of treatment, measured by RNA sequencing, and change in taste sensitivity as detected by chemical gustometry. Secondary endpoints include change in neural response to visual food cues and to sweet-tasting substances as assessed by functional MRI, change in body weight, change in fat mass and change in eating behaviour and food intake.DiscussionThis is the first study to investigate the role of semaglutide on taste perception, along with a neural response to visual food cues in reward processing regions. The study may identify the tongue and the taste perception as a novel target for GLP-1 receptor agonists.Ethics and disseminationsThe study has been approved by the Slovene National Medical Ethics Committee and will be conducted in accordance with the Declaration of Helsinki and Good Clinical Practice guidelines. Results will be submitted for publication in an international peer-reviewed scientific journal.Trial registrationClinicalTrials.govNCT04263415. Retrospectively registered on 10 February 2020

Reassessing relationships between appetite and adiposity in people at risk of obesity: A twin study using fMRI

BackgroundNeuroimaging studies suggest that appetitive drive is enhanced in obesity. ObjectiveTo test if appetitive drive varies in direct proportion to the level of body adiposity after accounting for genetic factors that contribute to both brain response and obesity risk. Subjects/MethodsParticipants were adult monozygotic (n = 54) and dizygotic (n = 30) twins with at least one member of the pair with obesity. Body composition was assessed by dual-energy X-ray absorptiometry. Hormonal and appetite measures were obtained in response to a standardized meal that provided 20% of estimated daily caloric needs and to an ad libitum buffet meal. Pre- and post-meal functional magnetic resonance imaging (fMRI) assessed brain response to visual food cues in a set of a priori appetite-regulating regions. Exploratory voxelwise analyses outside a priori regions were performed with correction for multiple comparisons. ResultsIn a group of 84 adults, the majority with obesity (75%), body fat mass was not associated with hormonal responses to a meal (glucose, insulin, glucagon-like peptide-1 and ghrelin, all P>0.40), subjective feelings of hunger (β=−0.01 mm [95% CI −0.35, 0.34] P = 0.97) and fullness (β=0.15 mm [−0.15, 0.44] P = 0.33), or buffet meal intake in relation to estimated daily caloric needs (β=0.28% [−0.05, 0.60] P = 0.10). Body fat mass was also not associated with brain response to high-calorie food cues in appetite-regulating regions (Pre-meal β=−0.12 [−0.32, 0.09] P = 0.26; Post-meal β=0.18 [−0.02, 0.37] P = 0.09; Change by a meal β=0.29 [−0.02, 0.61] P = 0.07). Conversely, lower fat mass was associated with being weight reduced (β=−0.05% [−0.07, −0.03] P<0.001) and greater pre-meal activation to high-calorie food cues in the dorsolateral prefrontal cortex (Z = 3.63 P = 0.017). ConclusionsIn a large study of adult twins, the majority with overweight or obesity, the level of adiposity was not associated with excess appetitive drive as assessed by behavioral, hormonal, or fMRI measures.

Effects of Acute Dance and Aerobic Exercise on Drug Craving and Food Reward in Women with Methamphetamine Dependence.

Drug dependence causes an overestimation of drug-related stimuli and an underestimation of non-drug-related stimuli, such as food. The purpose of this study was to investigate the effects of acute moderate-intensity dance and aerobic exercise on drug craving, appetite, prefrontal neural activation to food cues, and food reward in women with methamphetamine MA dependence. Thirty-nine women who met the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition MA dependence criteria participated in the experiment and were randomly assigned to either a dance (n = 20) or exercise (n = 19) group. A moderate-intensity (65%-75% maximum heart rate) 35-min dance or treadmill intervention counterbalanced with a reading control session was conducted. After the intervention or control, subjective drug craving was measured before and after exposure to drug-related cues. Visual analog scales were used to measure subjective feelings of appetite. Participants then completed a visual food cue paradigm while using functional near-infrared spectroscopy to monitor prefrontal blood oxygen changes. Finally, the Leeds Food Preference Questionnaire was used to measure reward responses to different categories of food. The results showed that the dance and exercise interventions reduced subjective craving for drugs after being exposed to drug cues (P = 0.019). Implicit wanting (P < 0.001) and relative preferences (P = 0.001) for high-calorie savory foods were all increased after interventions relative to control. Compared with the control session, the left dorsolateral prefrontal cortex (P = 0.020) was activated when viewing high-calorie foods after moderate-intensity aerobic exercise. The current results support the use of moderate-intensity exercise as a therapeutic intervention to restore the balance between drug and nondrug rewards by decreasing cue-induced MA craving and increasing food reward.

Visual food cue processing in children with Prader-Willi Syndrome

Hyperphagia and the associated interest in food is a characteristic feature of Prader-Willi syndrome (PWS) that emerges during childhood and remains a life-long concern. This study examined neural responses reflecting food cue salience in children with PWS and typical controls, age 3–12 years. Visual event-related potentials were recorded while participants in satiated state passively viewed photographs of high- and low-calorie foods, animals, and neutral objects. Contrary to the prediction, children with PWS did not demonstrate greater than typical neural responses to food, suggesting that it is not an exceptionally motivationally salient stimulus in PWS. Caregiver reports of greater hyperphagia were associated with neural responses to low-calorie foods suggesting accelerated and more fine-grained visual stimulus categorization in terms of edibility and caloric content. Overall, the findings align more closely with the altered satiety rather than increased food reward models of hyperphagia in PWS.

Investigation of eye tracking, electrodermal activity and facial expressions as biometric signatures of food reward and intake in normal weight adults

Pervasive exposure to a vast and varied food repertoire has contributed to the obesity epidemic. Within this issue, there is a need for a better understanding of the psychophysiological responses to food cues that precede food choice and food intake to establish how these responses contribute to the link between food availability and increasing obesity levels. Biometric measures such as eye tracking, electrodermal activity and facial expressions may separately or collectively provide deeper insight into psychophysiological processes underlying food reward and food intake. We examined how biometric responses differed in foods varying in fat and taste and explored how these biometric signatures to food cues were related to food preference behaviours, food choice, and food intake. We developed and tested a biometric food preference task designed to concurrently assess biometric responses (eye tracking, electrodermal activity and facial expressions) and food reward to visual food stimuli from different food categories in 100 normal weight adults. Food intake and selection was examined using a simultaneous choice ad libitum buffet. The results from this cross-sectional study showed significant differences in visual attention towards foods varying in fat content and taste prior to making rapid food choice decisions. Furthermore, the study found positive associations between maintained attention during a forced choice paradigm and subsequent food reward and food intake measures. Attention, arousal and facial expression during passive viewing were not associated with food reward or intake measures, except for an association between negative valence and explicit liking such that less liked foods elicited stronger negative facial expressions. The findings indicate that implicit, biometric responses to food cues predict both food reward and actual food intake.

The processing of visual food cues during bitter aftertaste perception in females with high vs. low disgust propensity: an fMRI study.

An extremely bitter taste can signal food spoilage, and therefore typically elicits disgust. The present cross-modal functional magnetic resonance imaging experiment investigated whether the personality trait ‘disgust propensity’ (DP; temporally stable tendency to experience disgust across different situations) has an influence on the processing of visual food cues during bitter aftertaste perception. Thirty females with high DP and 30 females with low DP viewed images depicting sweet food (e.g., cakes, ice cream) and vegetables, once in combination with an extremely bitter aftertaste (concentrated wormwood tea), and once with a neutral taste (water). Females highly prone to disgust (compared to low disgust-prone females) showed increased activity in the anterior cingulate cortex (ACC) and increased mPFC-insula connectivity when presented with the mismatch of a bitter aftertaste and visual cues of sweet food. The ACC is involved in conflict monitoring and is strongly interconnected with insular areas. This connection plays a critical role in awareness of changes in homeostatic states. Our findings indicate that the personality trait DP is associated with cross-modal integration processes of disgust-relevant information. Females high in DP were more alert to food-related sensory mismatch (pleasant visual features, aversive taste) than females low in DP.

Acute diet soda consumption alters brain responses to food cues in humans: A randomized, controlled, cross-over pilot study.

Diet soda consumption has frequently been linked to obesity and its comorbidities in epidemiological studies. Whether this link is causal and a potential mechanism remains to be determined. This randomized, cross-over, controlled pilot study sought to determine whether there may be changes in reward-related brain activations to visual food cues after acute consumption of diet soda versus regular soda or carbonated water using functional magnetic resonance imaging. Diet soda as compared to carbonated water consumption increased activation of reward-related caudate to highly versus less desirable food cues. Diet soda as compared to regular soda increased reward-related insula and decreased activation of cognitive control-related dorsolateral prefrontal cortex to food cues versus non-food cues. No changes in ratings of hunger an hour after beverage consumption were observed. These results may suggest a potential mechanism for diet soda to increase food palatability through activation of the reward system and suppression of inhibitory control that remains to be confirmed by future studies.

Cross-cultural emotional response to food stimuli: Influence of consumption context

Emotional responses elicited by certain types of food can be influenced by past experiences, frequency of consumption, culture, and other personal preferences. The present research aimed i) to investigate the impact of culture (Brazilian and Spaniard) on consumers' emotional responses and acceptability of different food stimuli, and ii) to explore the influence of evoked contexts. Brazilian (n = 437) and Spanish (n = 397) participants were exposed to three visual food stimuli (image of chocolate, potato chips, and yogurt) in an online survey and reported their emotional responses. Sociodemographic data, liking, and frequency of consumption were also collected. The evoked context in our study were designed and proposed, for each product and culture, based on four dimensions (consumption time, location, social setting, and hungry state). The evoked emotional lexicon was different for each food stimulus and was clearly influenced by the cultural factor. However, there are more similarities between cultures when evaluating the same product category. The evoked contexts were appropriated and influenced the citing frequency of some emotion terms, including positive ones. The most cited emotion terms tended to positively impact product liking ratings, acting as drivers of liking. Consumption level was positively related to liking regardless of cultural interactions for both chocolate and potato chips stimuli. In conclusion, the cultural background demonstrated to be an important impact factor to be considered for understanding the effects of product, consumption occasions, and degree of liking, on emotional responses to foods. These findings offer new possibilities to be explored in marketing messages for interventions or stimuli that guide food choices.

Exercise Shifts Hypothetical Food Choices toward Greater Amounts and More Immediate Consumption.

Although exercise modulates appetite regulation and food intake, it remains poorly understood how exercise impacts decision-making about food. The purpose of the present study was to assess the impact of an acute exercise bout on hypothetical choices related to the amount and timing of food intake. Forty-one healthy participants (22.0 ± 2.6 years; 23.7 ± 2.5 kg/m2, 56% female) completed 45 min of aerobic exercise and a resting control condition in randomized order. Food amount preferences and intertemporal food preferences (preference for immediate vs. delayed consumption) were assessed using electronic questionnaires with visual food cues. Compared to rest, exercise resulted in a greater increase in the food amount selected, both immediately post-exercise (+25.8 ± 11.0 vs. +7.8 ± 11.0 kcal/item, p = 0.02) and 30 min post-exercise (+47.3 ± 12.4 vs. +21.3 ± 12.4 kcal/item, p = 0.005). Exercise further resulted in a greater increase in the preference for immediate consumption immediately post-exercise (+0.23 ± 0.10 vs. +0.06 ± 0.10; p = 0.03) and 30 min post-exercise (+0.30 ± 0.12 vs. +0.08 ± 0.12; p = 0.01). Our findings demonstrate that a single bout of aerobic exercise shifts hypothetical food choices toward greater amounts and more immediate consumption, highlighting the importance of the timing of food choices made in the exercise context.

Fasting oxyntomodulin, glicentin, and gastric inhibitory polypeptide levels are associated with activation of reward- and attention-related brain centres in response to visual food cues in adults with obesity: A cross-sectional functional MRI study.

Postprandial increases in gastrointestinal hormones are associated with reduced energy intake, partially through direct effects on the brain. However, it remains unknown whether the fasting levels of gastrointestinal hormones are associated with altered brain activity in response to visual food stimuli. We therefore performed a whole-brain regression cross-sectional analysis to assess the association between fasting brain activations according to functional magnetic resonance imaging, performed during viewing of highly desirable versus less desirable food images, with fasting levels of five gastrointestinal hormones (glucagon-like peptide [GLP]-1, GLP-2, oxyntomodulin, glicentin and gastric inhibitory polypeptide [GIP]) in 36 subjects with obesity. We observed that fasting blood levels of GIP were inversely associated with the activation of attention-related areas (visual cortices of the occipital lobe, parietal lobe) and of oxyntomodulin and glicentin with reward-related areas (insula, putamen, caudate for both, and additionally orbitofrontal cortex for glicentin) and the hypothalamus when viewing highly desirable as compared to less desirable food images. Future studies are needed to confirm whether fasting levels of oxyntomodulin, glicentin and GIP are associated with the activation of brain areas involved in appetite regulation and with energy intake in people with obesity.

Visual Purple Food Pigment: Harvest and Physiology

Visual Purple Food Pigment: Harvest and Physiology