Visual Analysis Software Research Articles

Relationship between the immunohistological examination and fluorescence visualization of oral squamous cell carcinoma.

Disorders of the oral mucosa are considered easy to diagnose since they can be visualized and examined directly. A change in the color of the oral mucosa reflects histopathological changes and is an important diagnostic parameter. However, the subjective perception of color varies. To determine the extent of resection for oral mucosa conditions, it is necessary to digitize the color and perform objective assessments. In recent years, fluorescence visualization devices and analysis software that measure tissue luminance G have been employed for the identification of oral mucosa diseases. Fluorescence visualization is presumably based on the decrease in epithelial flavin adenine dinucleotide content and luminance G values due to the destruction of collagen cross-links [fluorescence visualization loss (FVL)]. However, cases with differences between luminance values and histopathological presentation exist. Therefore, additional factors may affect fluorescence visualization. The present study used a portable, non-contact oral mucosa fluorescence visualization device for luminance measurements in seven patients with oral squamous cell carcinoma. Furthermore, Picro-Sirius Red and immunohistochemical staining were performed for CK13, CK17, Ki67, p53 and E-cadherin in the FVL(+) (lesion) and FVL(−) (resection stump) areas to elucidate the principle of fluorescence visualization. Fluorescence was significantly lower in the FVL(+) than in the FVL(−) areas, and the mean luminance G value was 56. The Picro-Sirius Red stain revealed collagen destruction in the FVL(+) areas but no collagen disruption in the FVL(−) areas. CK13 was negative in the FVL(+) and positive in the FVL(−) areas, whereas the opposite pattern was observed for CK17. In the FVL(+) area, p53 staining was positive. E-cadherin expression was enhanced in the FVL(−) areas and reduced in the FVL(+) areas. Furthermore, the luminance G value tended to be lower in cases with weaker E-cadherin staining. The aforementioned results suggest that decreased E-cadherin expression may be a factor that regulates fluorescence visualization.

Heart Rate Variability Assessment and Its Application for Autonomic Function Evaluation in Patients with Hyperhidrosis

Background: Pathophysiology mechanism of primary focal hyperhidrosis (PFHH) is controversial. Heart rate variability (HRV) could explain if there is a systemic component present. We aimed to investigate the functions of the autonomic nervous system in patients diagnosed with PFHH compared to controls using the analysis of HRV in the domains of time, frequency, and nonlinearity, as well as analysis of the recurrence plots (RPs). Methods: We selected 34 patients with PFHH (29.4 ± 10.2 years) and 34 controls (29.2 ± 9.6 years) for HRV analysis. Heart beats were recorded with Polar RS800CX monitor (20 min, at rest, in supine position), and RR intervals were analyzed with Kubios Premium HRV software. RPs were constructed with Visual Recurrence Analysis software. Statistical analysis included unpaired t test (p < 0.05). Results: Our results showed that HRV parameters in the 3 domains evaluated did not show any differences between the groups. The same was observed with RPs. Conclusions: The findings suggest that PFHH, from the pathophysiological point of view, may be caused by peripheral involvement of the sympathetic nervous system (glandular level or nerve terminals), as there was no difference between the groups studied. More specific studies should help elucidate this issue.

CiteSpace-based visualization analysis on mappings of alkali-activated cementitious materials in the field of engineering research

Alkali-activated cementitious materials (AACM) became the most promising alternative materials of Portland cement due to their merits including early strength, high environmental adaptability and low environmental impact. The scientific knowledge mapping was drawn with CiteSpace Visual Analysis Software and the method combining qualitative and quantitative analysis, the co-citation network based on the core collection of Web of Science is generated, and frontiers and hotspots of studies in AACM are explored to provide theoretical guidance for subsequent researches. The research results showed that the publications with respect to the field of AACM rocketed recently and had become an increasingly interdisciplinary research subject. Relevant researches were most conducted in China, Australia and USA, however, European countries have a high degree of research content centrality and are closely related to other countries. The most studied materials were the fly ash, slag and metakaolin based on the Visual Analysis, and researchers focused on the modification of AACM and studies in new solid wastes in recently, and the studies targeting at practical engineering applications. National or international agencies are to intensify cooperation and improve practical engineering applications of different AACM to improve scientific research significance. The follow-up researches are prospected in this paper. The relations between the research interest, subject, hotspot, author, journal and contributing institutions are highlighted, promoting comprehensive understandings on the field of AACM.

Research on the Library Users’ Information Retrieval Behaviour: From a Bibliometric Perspective

This paper presents an international literature review on the hot topic of library users’ information retrieval behaviour in recent years. Through the usage of bibliometric content analysis and social network analysis methods, the paper finishes the work of data cleaning and integration, referring to the quantitative analysis of results produced by CiteSpace, a literature citation visualization analysis software, to summarize the main branches and focuses of this area. The researchers find that academia primarily focuses on the field of mechanisms and model research of users’ information retrieval behaviour, users’ information demands research, information literacy cultivation, and information retrieval system design and optimization, among other significant findings. Through the panoramic analysis and interpretation of research on international library users’ information retrieval behaviour provided by this article, conducted from a bibliometrics perspective, the researchers establish a clear overview and an effective reference of the research hotspots in this area.

A Scientometric Review of Resource Recycling Industry.

With rapid economic development and urbanization, a large number of primary resources are consumed and accumulate in society as recyclable resource, which causes great pressure on the environment. The development of the resource recycling industry (RRI) can reduce environmental impacts and achieve sustainable development and green growth. Scholars are paying more attention to the resource recycling industry (RRI), and the related literature continues to increase. There are over 7041 publications covering RRI in the Web of Science database from 1996 to 2018. This paper analyzes the time distribution characteristics of the literature and the status of the scientific research cooperation network using the visualization analysis software CiteSpace. The number of documents increased from 94 in 1996 to a peak of 963 in 2018. There is no relatively stable core author group. The number of papers published by “Chinese Acad Sci” ranks first among all research institutions. Document co-citation analysis and burst detection are adopted to assess the status and emerging trends in the RRI research domain. A publication by M.C. Monte on waste management is the most cited paper. Additionally, “green and sustainable and technology” and “science and technology—other topics” are the latest emerging subject categories in RRI research. Furthermore, “e-waste”, “reverse logistics” and “lean manufacturing” are emerging research trends for RRI, and “carbon emissions”, “policy”, “demolition waste”, “supply chain management” and “compressive strength” have become hot topics. These findings may provide inspiration for scholars to search for new research directions and ideas.

Visualization Analysis for Tunnel Researches Based on CiteSpace

In order to find out the history, present situation and hot trend of tunnel research, this article is based on the literature data of tunnel study from 1997 to 2017 in CNKI database, using CiteSpace visual econometric analysis software to co-occurrence analysis and keyword co-word analysis and processing by citation data of authors and research institutions. The results showed that there is close cooperation among the authors of the main research groups, haveing a good cooperative relationship chain among the research institutions, and the keywords of hot research are diversion tunnel, deep buried tunnel, numerical simulation, water conveyance tunnel, lining, rock burst, rock mechanics, surrounding rock, river diversion tunnel, TBM and so on.

Harnessing Knowledge for Improving Access to Fruits and Vegetables at Farmers Markets: Interactive Data Visualization to Inform Food Security Programs and Policy.

High consumption of fruits and vegetables leads to decreased risk of various chronic diseases, including obesity and cardiovascular disease. Community-level barriers to access fruits and vegetables include the high cost, limited availability, and transportation. Farmers markets are a priority strategy for improving community access to fresh fruits and vegetables. The U.S. Department of Agriculture (USDA) National Farmers Market Directory is a voluntary self-reported data source on farmers markets. The objective of this investigation of the USDA farmers markets data directory was to determine how farmers markets in the United States are grouped according to (1) availability of fruits and vegetables and (2) the payment accepted. We designed and implemented interactive data visualizations in visual analytics software to understand access to fruits and vegetables at farmers markets from 8,497 entries in the USDA Farmers Market Directory. Among the 665 new or updated entries in year 2018, a subset of 641 (96%) farmers markets with availability of fresh fruits and vegetables had 16 subgroups. Additionally, a subgroup of 102 (16%) farmer markets accepted all four federal nutrition assistance benefits (SFMNP, SNAP, WIC CVVs, and WIC FMNP). The interactive data visualizations including geographic maps connected to social media resources can be useful in advocacy efforts and can inform policy improvements designed to improve physical, social, and economic access to fruits and vegetables at farmers markets.

Visualization Analysis for Aqueduct Researches Based on CiteSpace

In order to learn the aqueduct researches situation in China, we analyze the published literature about aqueduct from 1988 to 2017 in the CNKI database, and process on the CiteSpace visual analysis software. The scientific knowledge maps are obtained to tease out the changes of the literature about aqueduct researches, the cooperation relationship between authors and the institutions, and the keywords about hot spots. They visually reflect the complex relationships among the knowledge groups of aqueduct researches, such as network, structure and crossover, and clarify the current research situation and development trend of aqueduct researches. This study indicates that there are relatively few research literature about aqueduct; The number of authors researching on aqueduct is large, but the number of prolific ones is relatively small. Meanwhile, the collaboration between authors is relatively dispersive, since it does not form close relation. The distribution of research institutions is centralized which is not beneficial to mutual cooperation between research institutions and research institutions. The analysis of keywords shows that the researches about aqueduct are mainly in the aspects of internal stress, external stress, structure and construction technology.

CiteSpace-based Document Information Visualization of Literature Published by Journal of Forensic Medicine from 1985 to 2018.

Objective To analyze a knowledge web of the literature published by Journal of Forensic Medicine from its founding in 1985 to 2018, describe the evolving process of forensic science research and explore the research hotspots and frontiers at present. Methods The literature that was published by Journal of Forensic Medicine from 1985 to 2018 was collected and analyzed in terms of elements, such as emerging research hotspots, high frequency keywords, authors, dispatching units, location of institution and funding, by CiteSpace5.3 information visualization analysis software. Results All disciplines of forensic medicine were continually developing and maturing, and the publication volume of the literature on forensic pathology had the highest weight; in research hotspots, the two categories, research and identification each had their own emphasis; as the main source of contributions to the journal, research institutes accounted for 38.99% of the total number of publications; Shanghai ranked first among all regions with 1 046 articles published. The number of funded articles was generally on the rise, with the number of funded articles published largest in 2015. Conclusion As an authoritative academic journal in the field of forensic science in China, Journal of Forensic Medicine carries the development of forensic science and witnesses the institutional reform of universities and colleges, and offers a wide range of communication and cooperation in terms of technicality and application. Many scholars and scientific research institutions have gained progress continually in various research directions in the form of teamwork; and emerging research hotspots will continue to play a huge role in future practical applications.

Advancing the theory and practice of system evaluation: a case study in geovisual analytics of social media

ABSTRACT This paper advances the state-of-the-art in methodology design for empirical evaluation of (geo)visual analytics software. Specifically, we describe the process of design, development and application of a prototypical user study tailored to the evaluation of complex geovisual analytics tools that focus on social media analysis. We fist perform a synthesis of existing theory and best practices for software evaluation of comparable systems. We then demonstrate how the product of said synthesis – a methodological ‘check list’ – can be used to inform a proof-of-concept user study of an actual geovisual analytics software system. The resulting user study design accommodates for the use of real geographic social media datasets, the complexity of the intended analytical process, and for the learning challenges faced by the participants working with a fully-functional and mature geovisual analytics application, and is likely representative of a wide range of evaluation scenarios in (geo)visual analytics. A complete summary of all the study instruments is included to encourage their scrutiny, reuse and modification by others. Finally, we have discovered that participants’ curiosity and desire for autonomy played a noticeable role in the evaluation process – something not previously reported.

Mashru Redux: From the Calico Museum in Ahmedabad to a Loom in the Great Plains

A zigzag line of resist dye characterizes a fabric called Mashru. It was produced in several different geographic locations; however, this paper discusses examples from India and my efforts to reconstruct patterns that have not been actively produced in this century. The Calico Museum in Ahmedabad is the first place I saw this style of warp resist fabric. The literature says that it was produced for Muslim clients who were not allowed to wear silk next to their skin. The word “Mashru” means “permitted” in Arabic and its Sanskrit variation “Misru” means “mixed.” A mashru fabric historically has a silk warp and cotton weft hence the decorative side in satin weave is silk and the cotton weft is worn next to the skin. Patan is historically one of two cities in Gujarat known for producing mashru. I have visited the surviving producers in Patan who use a shaft weave structure and synthetic fibers to make their current production. The Salvi family has a loom on the second floor of their museum in which they are trying to recreate silk mashru, to modes success when I saw the work in 2015. This paper documents my process of recording examples of mashru fabric house in the on-line collections of the Victoria and Albert Museum. With visual analysis and weave structure software, which I used to make graphic representations of the fabric, I developed a system for binding the resist on the warp and have obtained results that suggest a possible method that was used historically for creating this visually stunning pattern. I have taught students how to prepare warp for ikat resist in the Indian style, using these proposed resist methods to build a small set of samples testing this procedure which will be illustrated in my paper. https://www.utsavpedia.com/textiles/mashru-fabric/

Research Progress and Trends of Domestic Smart Learning Environment

In order to explore the main progress and current status of domestic research on smart learning environment, this paper takes 260 core and CSSCI journal papers included in the CNKI database as the research objects, and uses CiteSpace visual analysis software and uses bibliometrics and knowledge graph analysis as the main research methods, summarizes and analyzes the time distribution of the literature, the distribution of institutions and authors, co-occurrence and clustering of keywords, and research hotspots, etc.

CONCEPTUAL BIG DATA CASE STUDY TO IDENTIFYING RISKS OF NEW NUCLEAR TECHNOLOGIES

New technologies associated with nuclear power plants are being introduced regularly. However, many of the risks and uncertainties associated with these new nuclear technologies have yet to be identified. In this study, the risks related to newly-developed nuclear technologies were determined through an extensive review of the extant literature. A qualitative visual content analysis was selected as the research method employed to identify words repeatedly occurring in 147 journal articles. Through this conceptual “big data” approach, frequently mentioned words were identified using a co-occurrence map. The analysis results were then grouped into four categories: fuel resources, operational system designs, nuclear reactor cooling systems, and steam generators. Words used repeatedly to reference these four key categories were determined to also represent potential causes of risk factors. Many texts could be analyzed in a short period of time through the use of visual content analysis software. Frequently emphasized correlating words were then identified. This big data approach can also be applied to additional nuclear power practices to identify other uncertainties. Last, the limitations of a visual content analysis employed as a risk identification approach were revealed through this study.

Mapping the Knowledge Domain: Research on Service-Oriented Government in China

Establishing a service-oriented government (SOG) that can satisfy the needs of the people is not only a critical research topic in the field of public administration, but also a strategic agenda officially proposed since the Nineteenth National Congress of the Communist Party of China (CPC). As SOG research increases, it is important to thoroughly review the topics and trajectory of research on SOG in China. This paper uses CiteSpace, a visual analysis software, to provide an up-to-date overview and systematic summary of the research topics, trajectory, and gaps in SOG research in China. SOG research in China is classified into four categories: SOG concepts, development paths, government reforms, and performance evaluations. This paper illustrates the underlying problems, such as unsystematic theoretical development, research perspectives, and deficiency of the integrated research on the development mechanism, prominent focuses, and practical applicability. We concluded by identifying new trends in SOG research in China regarding government–society relations and big data.

P093 Next generation sequencing – evolution to a workflow model for exclusive primary HLA typing of hematopoietic stem cell and solid organ transplantation

Aim Our lab has established the NXType™ kit on the Ion-Chef and Ion-S5 workflow for high resolution HLA typing. This work was aimed to evaluate the analytical performance of the method for accuracy, precision, sensitivity, specificity, reportable range, repeatability, and reproducibility. We also determined optimal run size and workflow within the lab to strike a balance between suitable number of reads per locus and number of samples to avoid low coverage and dropouts. Using NGS as primary typing method for hematopoietic stem cell (HSC) and the solid organ (SO) programs was assessed. Methods Class I and HLA Class II were amplified with NXType™ or ALLType™ primer sets. Automated template preparation and chip loading were performed in the Ion Chef™ system and run on Ion S5™. Data was analyzed with TypeStream™ v1.1.0.11 and TypeStream™ Visual NGS Analysis Software. Results We found that the optimal run size was a minimum of 24 samples, a 3-fold increase of previous capacity. To maximize the use of chip space the number of samples/run was increased with confirmatory solid organ typings. We determined that running 24 samples with SSOP or NGS required similar manpower and instrument time. Although lab work was less with SSOP, analysis time and effort was greater than with NGS. After two years of experience with NGS HLA typing (∼1500 samples), we considered using NGS as the primary typing method for the HSC and the solid organ programs. Our historical data showed only 2 cases where NGS gave non-concordant results with SSOP or SSP. However, these samples were flagged by the software and both had associations that were red-flagged during analysis. The repeat rate for SSOP was 2.8% while for NGS was 0.3%. All NGS repeats were technical failures and not ambiguity resolution. We evaluated the ALLtype kit, which includes DQA1 necessary for solid organ initial typing, and a liquid handler for automation of library preparation. In addition, we implemented the TypeStream Visual (TSV) analysis software that includes serological equivalents. Conclusions We confirmed that NGS is a robust methodology for HLA typing. It provides results first time is run, reducing reflex testing. Combining automation with ALLType™ kit and TSV software, the analysis will be used as the primary method and SSOP as a reflex method for HSC and SO.

A Cross-Sectional and Longitudinal Study of Retinal Sensitivity in RPE65-Associated Leber Congenital Amaurosis.

PurposeRPE65-associated Leber congenital amaurosis (RPE65-LCA) is an early-onset severe retinal dystrophy associated with progressive visual field loss. Phase I/II and III gene therapy trials have identified improved retinal sensitivity but little is known about the natural history of retinal sensitivity in RPE65-LCA.MethodsA total of 19 subjects (aged 9 to 23 years) undertook monocular full-field static perimetry of which 13 subjects were monitored longitudinally. Retinal sensitivity was measured as mean sensitivity (MS) and volumetrically quantified (in decibel-steradian) using visual field modeling and analysis software for the total (VTOT), central 30° (V30) and central 15° (V15) visual field. Correlation was evaluated between retinal sensitivity and age, best-corrected visual acuity (BCVA), contrast sensitivity, vision-related quality of life, and genotype. Test-retest reliability was also investigated.ResultsV30 was identified to have a strong, weak, and moderate correlation with age, BCVA and contrast sensitivity respectively. Furthermore, V30 was identified as having a weak linear relationship with the mobility and independence domains of the vision-related quality of life questionnaire. Longitudinal analysis demonstrated a slow loss of retinal sensitivity in this cohort. Subjects with at least one RPE65 nonsense variant appeared to show greater progressive loss of retinal sensitivity in the second decade of life than those without.ConclusionsVolumetric assessment of central 30° visual field sensitivity, V30, is a useful independent measure of retinal function and, in our data, represented the best metric to monitor deterioration of retinal sensitivity in RPE65-LCA. Furthermore, functional correlation with genotype may enable more informed prognostic counseling. (ClinicalTrials.gov number, NCT02714816.)

Characterization of Visual Function, Interocular Variability and Progression Using Static Perimetry-Derived Metrics in RPGR-Associated Retinopathy.

PurposeTo characterize bilateral visual function, interocular variability and progression by using static perimetry–derived volumetric and pointwise metrics in subjects with retinitis pigmentosa associated with mutations in the retinitis pigmentosa GTPase regulator (RPGR) gene.MethodsThis was a prospective longitudinal observational study of 47 genetically confirmed subjects. Visual function was assessed with ETDRS and Pelli-Robson charts; and Octopus 900 static perimetry using a customized, radially oriented 185-point grid. Three-dimensional hill-of-vision topographic models were produced and interrogated with the Visual Field Modeling and Analysis software to obtain three volumetric metrics: VTotal, V30, and V5. These were analyzed together with Octopus mean sensitivity values. Interocular differences were assessed with the Bland-Altman method. Metric-specific exponential decline rates were calculated.ResultsBaseline symmetry was demonstrated by relative interocular difference values of 1% for VTotal and 8% with V30. Degree of symmetry varied between subjects and was quantified with the subject percentage interocular difference (SPID). SPID was 16% for VTotal and 17% for V30. Interocular symmetry in progression was greatest when quantified by VTotal and V30, with 73% and 64% of subjects possessing interocular rate differences smaller in magnitude than respective annual progression rates. Functional decline was evident with increasing age. An overall annual exponential decline of 6% was evident with both VTotal and V30.ConclusionsIn general, good interocular symmetry exists; however, there was both variation between subjects and with the use of various metrics. Our findings will guide patient selection and design of RPGR treatment trials, and provide clinicians with specific prognostic information to offer patients affected by this condition.

Ion Transport in Microphase Separating Polymer Thin Films

Microphase separating block copolymers (BCPs) are attractive candidates as electrolytes and ion exchange membranes due to their ability to simultaneously optimize for two or more orthogonal material properties. For an example, BCP electrolytes have been synthesized with one mechanically stable domain and one ion conducting domain to overcome the inverse relationship of the two properties. These films can exhibit both high structural stability and high ionic conductivity at the bulk scale.1,2 However, the formation of nanoscale architectures results in the creation of domain interfaces, grain boundaries, and tortuous ion conduction pathways. In such a film, ions can experience transport pathways that are non-parallel to the applied electric field. To date, this structure transport relationship has been investigated in thick films with bicontinuous structures as well as thick films with nanoscale domains aligned across macroscopic scales.3–5 However, assumptions are made about structure when correlating to the transport. This is due to the difficulties of characterizing all possible nanoscale pathways across macroscales (e.g. 20 nm domains across a 1 cm2 x 1mm membrane).6 In this work, the structure - ion transport relationship was investigated by characterizing all possible ion transport pathways from one electrode to the other by assembling thin film morphologies on top of interdigitated electrodes. The poly(styrene)-block-poly(2vinyl pyridine) (PSbP2VP) model BCP thin film (ca. 40nm) was assembled into a variety of morphologies on top of interdigitated electrodes. Trench topographies were formed on top of the IDEs to confine the BCPs. Neutrality conditions of the trench walls and the substrate were controlled by grafting monohydroxy terminated brushes at different stages of device fabrication. The confined BCP was microphase separated using solvent vapor annealing. Following orientation, the P2VP domain was converted into n-methyl 2-pyrilidinium iodide converting the domain into an anion conductor.7 Due to the perpendicular orientation of the PS and P2VP domains to the substrate and free surface, simple top down metrology could be used to characterize all possible ion conduction pathways from one electrode to the other. Visual analysis software was used to quantify the pathways that were connected from one electrode to the other. Molecular dynamics simulations of the lamellae cross section were used to understand water and ion distributions near the PS/P2VP interface. The ion transport behavior was studied under different humidity, temperature, and degrees of functionalization conditions. With path information alone, the conductivity values of different morphologies could be predicted within experimental error. When the ion conduction pathways were aligned parallel to the applied electric field, the resulting conductivity approached 74% of the theoretical maximum conductivity predicted using the Sax Ottino model.8 The remaining 26% difference in the conductivity could be rectified by the reduced water content at the interface of the hydrophilic P2VP/NMP+ I- domain and the hydrophobic PS domain. With the knowledge of the structure and the dimensions of the interface, the ion conductivity of the parallel oriented film could be predicted within experimental error. Surprisingly, the conductivity of the isotropic fingerprint lamellae morphology could also be predicted within error by assuming: 1) that the resistance of the total conduction path is linearly related to the tortuosity of the conduction path and 2) that only the domains that are connected from one electrode to the other contribute to conductivity. As demonstrated, the control of morphology and the ability to quantify structure and ion transport is envisioned as an attractive analytical platform to understand the role of heterogenous interfaces of microphase separating systems on ion transport behavior. References Inceoglu, S. et al. ACS Macro Lett. 3, 510–514 (2014).Schulze, M. W., McIntosh, L. D., Hillmyer, M. A. & Lodge, T. P. Nano Lett. 14, 122–126 (2014).Majewski, P. W., Gopinadhan, M., Jang, W.-S. S., Lutkenhaus, J. L. & Osuji, C. O. J. Am. Chem. Soc. 40, 17516–17522 (2010).Chopade, S. A. et al. ACS Appl. Mater. Interfaces 9, 14561–14565 (2017).Chintapalli, M., Higa, K., Chen, X. C., Srinivasan, V. & Balsara, N. P. Polym. Phys. 55, 266–274 (2017).Kambe, Y., Arges, C. G., Patel, S. N., Stoykovich, M. P. & Nealey, P. F. ECS Interface (2017).Arges, C. G., Kambe, Y., Suh, H. S., Ocola, L. E. & Nealey, P. F. Chem. Mater. 28, 1377–1389 (2015).Sax, J. & Ottino, J. M. Polym. Eng. Sci. 23, 165–176 (1983).

Added Value of NeuroGam Software Analysis in Single Photon Emission Computed Tomography Localization Diagnosis of Epilepsy in Interictal Stage.

BackgroundThis study aimed to investigate the added value of NeuroGam software analysis in the localization diagnosis of epileptogenic zone during interictal phase of seizures.Material/MethodsThe clinical data of 67 patients, clinically diagnosed as epilepsy, were analyzed retrospectively. Visual analysis and NeuroGam software analysis were used for independent analysis. The 2 methods were used to compare the efficacy indicator of the diagnosis of epileptogenic zone, and the receiver operating characteristic (ROC) curve evaluated the diagnostic efficacy.ResultsThrough the final clinical diagnostic comprehensive localization, among 67 epilepsy patients, the epileptogenic zone in 51 cases could be located distinctly, and those in 16 cases could not be located. Compared to the visual analysis, the NeuroGam software analysis was more sensitive in the location of epileptogenic zone (χ2=4.876, P=0.027). The area under the ROC curve (AUC) and 95% confidence interval (CI) of the NeuroGam software and visual analyses was 0.760 and 0.689, (0.613, 0.908) and (0.547, 0.832), respectively. However, the consistency of the 2 methods was poor (Kappa=0.367, P=0.001). Compared to visual analysis, the NeuroGam software analysis exerted more advantages in the localization diagnosis of the epileptogenic zone (P<0.001).ConclusionsIn the location diagnosis of brain perfusion, single photon emission computed tomography (SPECT) epileptogenic zone was used in interictal phase of seizures, and NeuroGam software analysis exerted a distinct added value for visual analysis.

Research focuses and advances in professionalism studies in the field of nursing based on Web of Science

Objective To analyze the focuses and advances of professionalism studies in the field of nursing, and to provide reference for China′s nursing research. Methods Papers published from 1997 to 2016 on professionalism in nursing were retrieved from Web of Science TM core collection citation database using the strategy of Mesh= (professionalism AND Nurs*). The knowledge atlas of the relevant literature of nursing professionalism were displayed by citespace visual analysis software. Results From 1997 to 2016, papers on professionalism in nursing amounted to 265, with the USA having the largest amount of publication of 32.94%, followed by the UK (8.67%) and Australia (8.30%), China was at No.7 on the list, accounting for only 3.77%. It was found that there was a wide range of research on professionalism studies in the field of nursing in foreign countries, including nursing education, nursing student, nursing profession, professional development, etc. Conclusions Nursing professionalism research mainly concentrated in nursing education in foreign, the present research on nursing professional spirit is still in its preliminary exploration phase in China. It should optimize the structure of nursing education and promote the development of nursing students professional. Key words: Nursing care; Professionalism; Research focus; Citespace; Web of Science