<h3>Research Objectives</h3> To describe the physical therapy intervention of a patient with multiple fractures and associated Hodgkin's lymphoma. <h3>Design</h3> Single case report with daily sessions for 15 consecutive days. <h3>Setting</h3> The setting is a Level II Trauma Center hospital. <h3>Participants</h3> A 22 year old female in head on collision and resultant Hodgkin's lymphoma diagnosis was chosen by a student physical therapist during a full time clinical experience with patient consent. <h3>Interventions</h3> i. Transfer training- slide board progressing to stand pivot ii. Assistive device training- front wheeled walker and wheelchair mobility iii. Seated stair management training iv. Gait training in parallel bars v. Therapeutic activity like supine, seated, and standing exercises for strengthening vi. Parallel bar gait training vii. Patient Instruction like energy conservation techniques, assistive device training, caregiver training, use of incentive spirometry. <h3>Main Outcome Measures</h3> Fatigue Severity Scale Visual Analog Fatigue Scale Manual Muscle Testing Verbal Pain Rating Scale Functional Movement Report. <h3>Results</h3> Reduced fatigue and pain reports with improved strength and functional movements. <h3>Conclusions</h3> Physical therapy interventions may benefit a patient with multiple fractures and new Hodgkin's lymphoma diagnosis with emphasis on fatigue management. <h3>Author(s) Disclosures</h3> No disclosures by the authors.