To the Editor: Gambling et al. [1] compared postcesarean outcomes of epidural morphine 3 mg plus epidural butorphanol 3 mg versus epidural morphine 3 mg alone. Patients receiving butorphanol had less analgesia, an equivalent need for treatment of pruritus, and equivalent satisfaction compared with controls. In an earlier study [2], we had compared postcesarean outcomes of epidural morphine 4 mg plus epidural butorphanol 3 mg versus epidural morphine 4 mg alone. Patients receiving butorphanol in our study had significantly greater analgesia, a significantly lower incidence of treatment for pruritus, and significantly greater overall satisfaction compared with controls. We carefully reviewed both studies to determine why our results differed Table 1.Table 1: Epidural Morphine and Epidural Butorphanol: Comparison of Similar Studies with Contrasting ResultsWith 10-cm visual analog scales (VASs), numerical pain score values imply the following: 1) VAS > 3.0 represents inadequate analgesia; 2) VAS = 1-3 represents good analgesia; and 3) VAS < 1 represents extraordinary analgesia ("pain prevention") [3]. Over the expected range of adequate-to-superb VAS analgesia scores (0-3 cm), a difference of 0.5 cm is clinically important. Specifically, postoperative pain scores < 1 cm generally require continuous epidural administration of local anesthetics [3,4]. VAS sensitivity depends on administering an anchored scale in a standardized manner, evaluating patients on multiple occasions, and obtaining a uniform distribution of scores [5]. With respect to cumulative pain assessment, our study group was unique in achieving "pain prevention" (mean VAS = 0.7 cm) with an extremely narrow distribution of low scores (SD = 1.0 cm) that was both statistically and clinically significant. Statistical analysis of VAS scores involved pairwise comparisons of each study group with the control group using one-way analysis of variance. Furthermore, chi squared analysis of 265 evaluations among the two groups demonstrated that butorphanol significantly reduced the incidence of inadequate analgesia to a level (4%) threefold less than control (11%). Our post hoc power analysis demonstrated that 265 evaluations among two groups produced a statistically significant difference (P < 0.05) in mean VAS pain scores of less than 0.5 cm. In contrast, the study design of Gambling et al. [1] presumed that 102 evaluations among two groups produced a power of 0.8 to detect a difference (P < 0.005) in mean VAS scores of 2.0 cm. Nearly a third of their pain score evaluations claimed inadequate analgesia (VAS pain score > 3). The duration of analgesia after epidural morphine administration does not reliably extend to 24 h [2,6], so one third of their patient assessments occurred at a time (24 h) when epidural opioid analgesia was dissipating. Overall, the lack of statistically significant differences in the study by Gambling et al. [1] appears to be due to inadequate numbers of patient evaluations (no VAS satisfaction scores were presented), unusually high VAS pain scores [2,6], and statistical methods that were biased toward unreasonable limits of detection. Bernard Wittels, MD, PhD Alicia Toledano, ScD Department of Anesthesia and Critical Care, The University of Chicago, Chicago, IL 60637