Visual Conditions Research Articles

Characterization of Mild Traumatic Brain Injury Cohort With Photophobia From the Defense and Veterans Eye Injury and Vision Registry.

Photophobia is a common visual symptom following mild traumatic brain injury (mTBI), which can adversely affect the military readiness and performance of service members (SMs). We employed the Defense and Veterans Eye Injury and Vision Registry (DVEIVR) to identify and describe a cohort of SMs diagnosed with photophobia post-mTBI. The objective of this study was to characterize comorbid conditions and symptoms in an mTBI cohort with photophobia, to assess their co-occurrence, to describe the persistence of photophobia, and to assess the effectiveness of utilization of currently available International Statistical Classification of Diseases and Related Health Problems (ICD) codes in reporting photophobia in this cohort. The DVEIVR database was searched to identify a cohort of SMs experiencing photophobia after mTBI. Photophobia and other potentially related conditions and symptoms, both coded and descriptive, which were abstracted directly from the medical records of SMs, were found within DVEIVR. The presence of the conditions and symptoms comorbid with photophobia was characterized on both patient and encounter levels. Analysis of co-occurrence of photophobia with these conditions or symptoms was performed on the encounter level using co-occur package in the statistical program R. Persistence of photophobia up to 1 year since the injury was assessed. The utilization of currently available ICD codes for photophobia was analyzed. A total of 639 SMs exhibiting photophobia after mTBI were identified in DVEIVR. Headaches, including migraines, were the most frequently experienced comorbidity affecting 92% of the SMs in the cohort. The second most frequent complaint was dizziness and/or vertigo (53%) followed by nausea (42%), blurry vision (31%), and irritation and discomfort in the eye (17%). In all, 20% of encounters with photophobia had a complaint of headaches, followed by 8.3% of photophobia encounters co-occurring with dizziness and vertigo, 5.7%-with nausea, 4.5%-with blurred vision, and 2.1%-with subjective sensations in the eye. All comorbidities co-occurred with photophobia at probabilities higher than by chance alone. The percentage of mTBI SMs experiencing photophobia declined to 20% at 30 days after the injury, 17% at 3 months, 12% at 6 months, and 7% at 12 months post-injury, respectively. The use of currently available ICD codes for photophobia was very low-only 27.1% of the cohort had at least 1 ICD code recorded in their medical records. The results of this study support the idea that there is a strong relationship between photophobia and headache after an mTBI. Additional research is warranted to better understand this relationship and its causes so that clinical management improves. The results of this study show a precipitous decline in the numbers of cases of photophobia after mTBI over the first 30 days and a longer-term persistence up to a year in a minority of cases, which is consistent with other research in this field. Various ICD codes, which are currently used to code for photophobia, along with other vision conditions, were not widely used to document photophobia symptoms. It is important to adopt a dedicated ICD code for photophobia to improve the surveillance, data collection, and analysis of this condition.

Is Visual Reliance Increased in Athletes After ACL Injury? A Scoping Review.

Individuals with anterior cruciate ligament (ACL) injury often exhibit visual cognitive deficits during tasks that require neuromuscular control. In this paper, we present evidence of increased visual reliance after ACL injury during a range of clinically applicable cognitive-motor tasks. This information is essential to strengthen the scientific rationale for therapeutic interventions that target maladaptive neuroplasticity and may translate to improved return-to-sport (RTS) outcomes following ACL injury. The objectives of this study are (1) to determine if visual reliance is present during common rehabilitation-based assessments after ACL deficiency (ACL-D) or ACL reconstruction (ACL-R), (2) to describe how visual reliance is assessed during such tasks, and (3) to provide information to help clinicians and patients understand the clinical relevance of cognitive load in the assessment and intervention of visual reliance. Scoping review. We searched MEDLINE, EMBASE, CINAHL, SCOPUS, and PEDro databases. Only primary studies published in English were included without time limitations. Qualitative analysis of the included studies was performed. We synthesized the results of 23 studies. A total of 7 studies (31%) included patients with ACL-D, 15 studies (65%) included patients with ACL-R, and 1 study (4%) included patients with ACL-D and ACL-R. Evaluation of tasks, task evaluation setting, visual conditions, outcome measures, and presence of increased visual reliance were identified. Most studies investigating patients with ACL-D, contrary to those with ACL-R, exhibited worse postural stability during eyes-closed conditions than uninjured controls. Complete visual obstruction (i.e., eyes closed or blindfolded) was the most frequently reported method to disrupt vision (52%). The addition of a visual-cognitive challenge resulted in significantly worse postural stability in patients with ACL-R compared with controls. Visual reliance was most commonly assessed during single leg stance with complete visual obstruction. The majority of studies on patients with ACL-D indicate that they exhibit poorer postural stability in eyes-closed conditions when compared with uninjured controls, which suggests increased visual reliance. There is less evidence of visual reliance in patients who have undergone ACL-R compared with those with ACL-D. Adding a visual-cognitive load was found to be more effective in inducing postural stability deficits in individuals who have undergone ACL-R. IV. The protocol was a priori registered on Open Science Framework ( https://osf.io/p4j95/ ).

Possible evidence for the Law of General Intelligence in honeybees (Apis mellifera)

Finke, Scheiner, Giurfa, and Avarguès-Weber (2023) published correlational data on the performance of honeybees (Apis mellifera) in three learning tasks (associative, reversal, and negative patterning, capturing the domains of operant conditioning, executive-functioning-like ability, and inhibition plus configural processing, respectively) evaluated under both visual and olfactory stimulus conditions. They speculate that general cognitive ability (GCA) may be weakly causing all-positive correlations between performance in these different learning modalities, but do not formally test this possibility. A factor-analytic model applied to Finke et al. (2023) data revealed the presence of two perfectly congruent GCA factors (one for each stimulus condition). Both exhibited all-positive loadings, with the visual factor accounting for 46.8% of the performance variance and the olfactory factor accounting for 52.3%. Diagnostic statistics confirmed that in both stimulus conditions, the correlation matrices were adequate for factor analysis. These findings support extant hypotheses that GCA influences covariation between cognitive measures in honeybees, and constitute the first formal potential demonstration of GCA in an invertebrate. It is argued that GCA might be ubiquitous with respect to metazoans possessing organized nervous systems, perhaps because it convergently evolved multiple times in independent phylogenies, this being a key prediction of Christopher Chabris' Law of General Intelligence. Indeed, GCA has now been identified in insect, avian, mammal, and fish taxa. Some “primordial” aspects of GCA may even by basal to metazoans, and experiments employing Caenorhabditis elegans are suggested that could potentially shed light on such aspects. The findings are also strikingly inconsistent with evolutionary and comparative psychological theories positing a “modules first” understanding of cognitive evolution, such as one recent proposal that smaller brains cannot accommodate structures that give rise to GCA. Other theoretical implications of these findings are discussed.

Comparative analysis of federated learning algorithms under extreme non-IID conditions for computer vision

Data heterogeneity presents enormous challenges for Federated Learning (FL) where data is characterized by non-independent and identically distributed (non-IID) patterns across participating clients. Although a prominent issue, there is a lack of comprehensive studies regarding the efficacy of FL algorithms under different configurations of hyperparameters and models. Three state-of-the-art algorithms were chosen to be the focus of this paper FedAvg, FedProx, and SCAFFOLD. Experiments of the paper study varying degrees of data imbalance and number of local training steps to see their effects on model training results. The algorithms and hyperparameters were evaluated using ResNet50, AlexNet, and DenseNet121 on the CIFAR-10 dataset. Experimental results reveal that FedAvg and SCAFFOLD generally outperform FedProx, except for the latter excelling in the scenario of extreme non-IID data distributions in combination with minimal local training. It was also observed that models with complex architectures like ResNet50 are more susceptible to data imbalances, while simpler models such as AlexNet prove to be more robust. This study provides valuable insights to how different configurations of hyperparameters affect FL in non-IID scenarios, contributing to future development of more efficient and robust FL algorithms.

Motor learning alters vision, but vision does not alter motor learning.

During visuomotor learning, improvements in motor performance accompany changes in how people use vision. However, the dependencies between altered visual reliance and improvements in motor skill is unclear. The present studies used an online sequence learning task to quantify how changing the availability of visual information affected motor skill learning (study 1) and how changing motor skill affected visual reliance (study 2). Participants used their keyboard to respond to targets falling vertically down a game screen. In study 1 (n = 49), the availability of visual information was altered by manipulating where the targets were visible on the screen. Three experimental groups practiced the task during full or limited vision conditions (when the targets were only visible in specific areas). We hypothesized that limiting visual information would reduce motor learning (i.e., the rate of improvement during training trial blocks). Instead, although participants performed worse during limited vision trials (P < 0.001), there was no difference in learning rate (P = 0.87). In study 2 (n = 119), all participants practiced the task with full vision and their visual reliance (i.e., their performance change between full and limited vision conditions) was quantified before and after training. We hypothesized that with motor learning, visual reliance on future targets would increase, whereas visual reliance on the current targets would decrease. The results of study 2 partially support our hypotheses with visual reliance decreasing for all visual areas (P < 0.001). Together, the results suggest changing motor skill alters how people use vision, but changing visual availability does not affect motor learning.NEW & NOTEWORTHY Previous research has established how people use visual information changes with motor learning. However, the dependencies of these two processes on each other are unclear. We find that limiting the availability of visual information degrades motor performance but not motor learning. We also find that motor learning reduces the impact of limiting the availability of visual information on motor performance. Together, these results suggest that how people use visual information depends on their motor skill.

Visual Impairment, Eye Conditions, and Diagnoses of Neurodegeneration and Dementia

Vision and eye conditions are associated with increased risk for Alzheimer disease and related dementias (ADRDs), but the nature of the association and the underlying biological pathways remain unclear. If causal, vision would be an important modifiable risk factor with viable population-level interventions. To evaluate potentially causal associations between visual acuity, eye conditions (specifically cataracts and myopia), neuroimaging outcomes, and ADRDs. A cohort and 2-sample bidirectional mendelian randomization (MR) study was conducted using UK Biobank participants and summary statistics from previously published genome-wide association studies on cataract, myopia, and AD. The participants included in the analysis were aged 55 to 70 years without dementia at baseline (calendar years 2006 to 2010), underwent genotyping, and reported on eye conditions; a subset completed visual acuity examinations (n = 69 852-71 429) or brain imaging (n = 36 591-36 855). Data were analyzed from August 15, 2022, through November 28, 2023. Self-reported cataracts, visual acuity, and myopia measured by refraction error. ADRD, AD, and vascular dementia were identified from electronic medical records. Total and regional brain volumes were determined using magnetic resonance imaging. The sample included 304 953 participants (mean [SD] age, 62.1 (4.1) years; 163 825 women [53.72%]); 14 295 (4.69%) had cataracts and 2754 (3.86%) had worse than 20/40 vision. Cataracts (hazard ratio [HR], 1.18; 95% CI, 1.07-1.29) and myopia (HR, 1.35; 95% CI, 1.06-1.70) were associated with a higher hazard of ADRD. In MR analyses to estimate potential causal effects, cataracts were associated with increased risk of vascular dementia (inverse variance-weighted odds ratio [OR], 1.92; 95% CI, 1.26-2.92) but were not associated with increased dementia (OR, 1.21; 95% CI, 0.98-1.50). There were no associations between myopia and dementia. In MR for potential reverse causality, AD was not associated with cataracts (inverse variance-weighted OR, 0.99; 95% CI, 0.96-1.01). Genetic risk for cataracts was associated with smaller total brain (β = -597.43 mm3; 95% CI, -1077.87 to -117.00 mm3) and gray matter (β = -375.17 mm3; 95% CI, -680.10 to -70.24 mm3) volumes, but not other brain regions. In this cohort and MR study of UK Biobank participants, cataracts were associated with increased risk of dementia, especially vascular dementia, and reduced total brain volumes. These findings lend further support to the hypothesis that cataract extraction may reduce the risk for dementia.

Visual and auditory attention in individuals with DYRK1A and SCN2A disruptive variants.

This preliminary study sought to assess biomarkers of attention using electroencephalography (EEG) and eye tracking in two ultra-rare monogenic populations associated with autism spectrum disorder (ASD). Relative to idiopathic ASD (n = 12) and neurotypical comparison (n = 49) groups, divergent attention profiles were observed for the monogenic groups, such that individuals with DYRK1A (n = 9) exhibited diminished auditory attention condition differences during an oddball EEG paradigm whereas individuals with SCN2A (n = 5) exhibited diminished visual attention condition differences noted by eye gaze tracking when viewing social interactions. Findings provide initial support for alignment of auditory and visual attention markers in idiopathic ASD and neurotypical development but not monogenic groups. These results support ongoing efforts to develop translational ASD biomarkers within the attention domain.

Visualizing numbers: Investigating the effect of presentation format on emotional responses and performance in lottery tasks.

Numeracy is the ability to understand, manipulate, and make sense of numerical information. It is crucial for everyday decision making that involves dealing with numbers. In this study, we tested whether we can help people make better choices in monetary lotteries by communicating numerical values (i.e., payoffs and probabilities) using visual aids. We also checked whether presenting this information in a visual form reduces affect negativity. Participants (N = 210) made choices in 10 monetary lotteries accompanied with visual aids (experimental condition) or without visual aids (control condition). After the lottery task, participants completed questionnaires measuring experienced emotions and numerical skills. Despite finding no hypothesized effect of visual aids on performance in a lottery task, the exploratory analysis revealed the interaction effect. In a visual aid condition, participants who were relatively less educated scored significantly higher in a lottery task in comparison to those in the control condition. Additionally, participants in the visual aid condition reported significantly lower intensity of negative emotions after the lottery task than those in the control condition. We discuss possible causes and mechanisms that can explain the results we obtained. We argue that visual aids are a promising tool for future learning, and their friendly format can positively influence people's reactions to decisions involving numerical information. However, we also point out the necessity for further research and exploration of the role of different designs of visual aids and individual differences. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Balance Control Impairments in Usher Syndrome.

To explore postural disability in Usher Syndrome (USH) patients using temporal posturographic analysis to better elucidate sensory compensation strategies of deafblind patients for posture control and correlate the Activities-specific Balance Confidence (ABC) scale with posturographic variables. Thirty-four genetically confirmed USH patients (11 USH1, 21 USH2, 2 USH 4) from the Otolaryngology Outpatient Clinic and 35 controls were prospectively studied using both classical and wavelet temporal analysis of center of pressure (CoP) under different visual conditions on static and dynamic platforms. The functional impact of balance was assessed with the ABC scale. Classical data in the spatial domain, Sensorial Organization Test, and frequency analysis of the CoP were analyzed. On unstable surfaces, USH1 had greater CoP surface area with eyes open (38.51 ± 68.67) and closed (28.14 ± 31.64) versus controls (3.31 ± 4.60), p < 0.001 and (7.37 ± 7.91), p < 0.001, respectively. On an unstable platform, USH consistently showed increased postural sway, with elevated angular velocity versus controls with eyes open (USH1 [44.94 ± 62.54]; USH2 [55.64 ± 38.61]; controls [13.4 ± 8.57]) (p = 0.003; p < 0.001) and closed (USH1 [60.36 ± 49.85], USH2 [57.62 ± 42.36]; controls [27.31 ± 19.79]) (p = 0.002; p = 0.042). USH visual impairment appears to be the primary factor influencing postural deficits, with a statistically significant difference observed in the visual Sensorial Organization Test ratio for USH1 (80.73 ± 40.07, p = 0.04) and a highly significant difference for USH2 (75.48 ± 31.67, p < 0.001) versus controls (100). In contrast, vestibular (p = 0.08) and somatosensory (p = 0.537) factors did not reach statistical significance. USH exhibited lower visual dependence than controls (30.31 ± 30.08) (USH1 [6 ± 11.46], p = 0.004; USH2 [8 ± 14.15], p = 0.005). The postural instability index, that corresponds to the ratio of spectral power index and canceling time, differentiated USH from controls on unstable surface with eyes open USH1 (3.33 ± 1.85) p < 0.001; USH2 (3.87 ± 1.05) p < 0.002; controls (1.91 ± 0.85) and closed USH1 (3.91 ± 1.65) p = 0.005; USH2 (3.92 ± 1.05) p = 0.045; controls (2.74 ± 1.27), but not USH1 from USH2. The canceling time in the anteroposterior direction in lower zone distinguished USH subtypes on stable surface with optokinetic USH1 (0.88 ± 1.03), USH2 (0.29 ± 0.23), p = 0.026 and on unstable surface with eyes open USH1 (0.56 ± 1.26), USH2 (0.072 ± 0.09), p = 0.036. ABC scale could distinguish between USH patients and controls, but not between USH subtypes and it correlated with CoP surface area on unstable surface with eyes open only in USH1(ρ = 0.714, p = 0.047). USH patients, particularly USH1, exhibited poorer balance control than controls on unstable platform with eyes open and appeared to rely more on proprioceptive information while suppressing visual input. USH2 seems to use different multisensory balance strategies that do not align as well with the ABC scale. The advanced analysis provided insights into sensory compensation strategies in USH subtypes.

Investigating the influence of eye-catching effect on mental workload in highway tunnel entrances: a comprehensive analysis of eye blink behavior

Objective The objective of this study was to investigate the relationship between eye-catching effects and mental workload at highway tunnel entrances. Specifically, the study aimed to analyze drivers’ eye blink behavior to gain a comprehensive understanding of how visual attraction at tunnel entrances affects cognitive workload. Methods 50 participants were recruited for the naturalistic driving experiment. Four different visually attractive driving scenarios (baseline, landscape-style architecture, tip slogan, and billboard) were selected. Eye-tracking technology was utilized to record and analyze the eye blink behavior of participating drivers. Various metrics, including blink frequency, blink duration, inter-blink interval, and pupil diameter after a blink, were measured and compared across different scenarios. Results The results of the study demonstrated significant differences in drivers’ eye blink behavior across the different experimental scenarios, indicating the influence of visual attraction conditions on mental workload. The presence of eye-catching stimuli (landscape-style architecture, tip slogan, and billboard scenarios) at tunnel entrances resulted in decreased blink frequency, shorter blink duration, longer inter-blink intervals, and larger pupil diameter after a blink compared to when no specific eye-catching stimuli were present (baseline condition). These findings suggest that visual attractions capture drivers’ attention, leading to increased cognitive workload and attentional demands. Conclusions The findings of this study contribute to the existing literature on driver attention and mental workload, particularly in relation to eye-catching effect in tunnel environments. The presence of eye-catching stimuli at tunnel entrances can distract drivers and increase their mental workload, potentially compromising driving performance and safety. It is crucial for transportation authorities and designers to carefully consider the design and placement of visual attractions in tunnel entrances to minimize distraction and cognitive workload. By doing so, driving safety and performance can be enhanced in tunnel entrances.

Light-YOLO: A Study of a Lightweight YOLOv8n-Based Method for Underwater Fishing Net Detection

Detecting small dark targets underwater, such as fishing nets, is critical to the operation of underwater robots. Existing techniques often require more computational resources and operate under harsh underwater imaging conditions when handling such tasks. This study aims to develop a model with low computational resource consumption and high efficiency to improve the detection accuracy of fishing nets for safe and efficient underwater operations. The Light-YOLO model proposed in this paper introduces an attention mechanism based on sparse connectivity and deformable convolution optimized for complex underwater lighting and visual conditions. This novel attention mechanism enhances the detection performance by focusing on the key visual features of fishing nets, while the introduced CoTAttention and SEAM modules further improve the model’s recognition accuracy of fishing nets through deeper feature interactions. The results demonstrate that the proposed Light-YOLO model achieves a precision of 89.3%, a recall of 80.7%, and an mAP@0.5 of 86.7%. Compared to other models, our model has the highest precision for its computational size and is the lightest while maintaining similar accuracy, providing an effective solution for fishing net detection and identification.

RCRFNet: Enhancing Object Detection with Self-Supervised Radar-Camera Fusion and Open-Set Recognition.

Robust object detection in complex environments, poor visual conditions, and open scenarios presents significant technical challenges in autonomous driving. These challenges necessitate the development of advanced fusion methods for millimeter-wave (mmWave) radar point cloud data and visual images. To address these issues, this paper proposes a radar-camera robust fusion network (RCRFNet), which leverages self-supervised learning and open-set recognition to effectively utilise the complementary information from both sensors. Specifically, the network uses matched radar-camera data through a frustum association approach to generate self-supervised signals, enhancing network training. The integration of global and local depth consistencies between radar point clouds and visual images, along with image features, helps construct object class confidence levels for detecting unknown targets. Additionally, these techniques are combined with a multi-layer feature extraction backbone and a multimodal feature detection head to achieve robust object detection. Experiments on the nuScenes public dataset demonstrate that RCRFNet outperforms state-of-the-art (SOTA) methods, particularly in conditions of low visual visibility and when detecting unknown class objects.

Romberg's test revisited: Changes in classical and advanced sway metrics in patients with pure sensory neuropathy

ObjectivesThe Romberg test, undoubtedly a classical and well-established method in physical neurological assessment of patients with sensory ataxia, has long been suspected to be prone to several limitations. Here, we quantified upright stance before and after visual deprivation in a selected cohort of patients with pure sensory neuropathy. MethodsStatic balance was assessed in sensory neuropathy patients during quiet stance on a force platform under different visual and proprioceptive feedback conditions. Sural nerve neurography was employed to evaluate the severity of peripheral neuropathy. Conventional and advanced postural sway metrics were investigated to draw a quantitative analogy to the clinical Romberg test. ResultsPosturographic analyses showed that patients displayed Romberg and vestibular Romberg quotient values around 2, indicating an approximately twofold increase in body sway in the absence of vision. However, the diagnostic discrimination ability between patients and controls was only modest. Even less impactful were the diagnostic contributions of frequency domain and non-linear sway analyses. This was primarily attributed to the heightened body sway exhibited by patients with sensory neuropathy under 'eyes open' conditions, diminishing the contrast with the 'eyes closed' condition as assessed in the classical Romberg test. ConclusionWe conclude that the Romberg test, even in its quantitative form with the aid of an apparatus, had an unsatisfactory classification value in terms of distinguishing patients from healthy controls. Instead, it should be interpreted within the comprehensive context of the broader neurological examination and the electrodiagnosis of peripheral nerve function.

Single-file movement of pedestrians at different visibility levels

Previous studies indicate that the movement of pedestrians under poor visibility conditions is significantly different from that under good visibility conditions. To investigate the influence of visibility factor on the longitudinal movement of pedestrian, series of single-file experiments were performed under the quantitative control of visibility level. Based on the extracted trajectories, typical evacuation behavior and movement characteristics of pedestrians under different visibility conditions are explored. It is found that the lateral swing amplitude of pedestrians during movement is within 20 cm under low densities while it is close to 30 cm at high densities. The free velocity under the light transmission of 100 %, 2.2 %, 0.5 % and 0.1 % is 0.856 m/s, 0.823 m/s, 0.741 m/s and 0.712 m/s respectively. Individuals cannot accurately perceive the surrounding situations with the worsening of visual condition, therefore the movement speed decreases under the poor visibilities. Besides, two regimes including the constrained regime and free regime are identified in the headway-velocity relation at different visibility levels. The maximum specific flow under the light transmission of 100 %, 2.2 %, 0.5 % and 0.1 % is 0.70 s−1, 0.67 s−1, 0.62 s−1 and 0.55 s−1 respectively. The study is helpful to reveal the pedestrian dynamics of single-file movement under the limited visibility conditions.

Postural stability at activation and deactivation of the cochlear implant in adolescents with late lateral implantations: a quasi-experiment

BackgroundCochlear implantation (CI) surgery has become a prevalent method of hearing rehabilitation, since it has been acknowledged that it impacts effectively on the vestibular system. However, there is still no consensus among clinicians on the most appropriate age and area (lateral/bilateral) of CI surgery in terms of postural control. The present study aimed to assess the postural control in late lateral CI adolescents with different visual (eyes opened(EO)/eyes closed(EC)) and auditory (CI activated/deactivated) conditions and to build a theoretical model of postural control based on sensual compensatory mechanisms that are predominant in late CI individuals. It was hypothesized that kinesthetic sensation and exteroceptors of the superficial sensation are critical for neuromuscular control after late CI.MethodsA quasi-experimental study protocol was used in this study to assess the postural stability performance in the studied adolescents with different visual and auditory perceptions. 27 adolescent students with hearing loss participated in the study. A force plate (Accu Gait AMTI) with computer software (NetForce) was used in the study to assess the postural stability with four different conditions(EO)/EC), CI activated/deactivated).ResultsvCOP was found to have a significant growing tendency within the conditions of CI activated/deactivated.No statistically significant relationships were noted between the range of the displacement of feet pressure (Area) and both the visual and auditory conditions. Hearing loss etiology was statistically significantly related to the values of vCOP, within the conditions of EO, CI activated/deactivated (p < 0.01), what did not occure with the condition of EC (p > 0.05). Neuromuscular control with the condition of EC x CI deactivated was found to be based on the kinesthetic-tactual compensatory model.ConclusionsKinesthetic sensation and exteroceptors of the superficial sensation seem to be the predominant source of information to maintain postural control in late CI adolescents, regardless of the visual and auditory conditions. The etiology of hearing loss (congenital/acquired) can be a predictor of the values of the vCOP. In order to improve neuromuscular control in this population, it is recommended that the patients perform physical activity tasks, especially to develop core muscles, based on direct stimulation and rotational stability.

A Piezoelectric Nanogenerator-Driven Dual-Mode Platform for Visualization and Impedance Sensing.

Traditional visual biosensing platforms rely on color to display detection results, which can be influenced by individual visual abilities, equipment, parameters, and lighting conditions during photo capture. This limitation significantly impedes the advancement of next-generation portable electrochemical biosensors. Therefore, we propose a visual biosensing device that utilizes distance as an indicator, enabling the facile determination of the length of discoloration, which is inversely proportional to the concentration of the target analyte. The separation of the Signal Generation (SG) and Signal Output (SO) regions effectively mitigates potential interference from the sample color. Additionally, the SG region can be disassembled to facilitate electrochemical impedance spectroscopy (EIS) detection in laboratory settings, enabling dual-mode detection. Meanwhile, the utilization of piezoelectric nanogenerators (PENG) empowers the entire point-of-care testing (POCT) sensing device, effectively addressing the issue of a limited battery life. The biosensing device exhibited a satisfactory linear range (EIS mode, 5 pg/L to 5 mg/L; visual mode, 0.5 ng/L to 5 mg/L) and a low limit of detection (EIS mode, 2.3 pg/L; visual mode, 0.14 ng/L) with S/N = 3 for ochratoxin A (OTA) under optimized conditions. The self-powered and cost-effective dual-mode biosensing platform developed for OTA detection offers clear and easily interpretable results, demonstrating a high accuracy in laboratory settings.

The induced defocus by Defocus Incorporated Soft Contact lenses is dependent on visual distance and ambient illuminance.

Defocus Incorporated Soft Contact (DISC) lenses, a commonly used type of multifocal lens in clinical practice, may slow down myopia progression by inducing myopic retinal defocus. The purpose of this study was to explore whether the induced defocus across the retina could be affected by visual environments encountered in the real world, such as differences in viewing distance and ambient illuminance. In this cross-over trial, 30 myopic adults wore both DISC lenses and single vision contact (SVC) lenses in random order. An open-view Hartmann-Shack scanning wavefront sensor was used to measure defocus at different retinal locations along the horizontal meridian under four experimental conditions: far target (3 m) and near targets (0.33 m) under scotopic (<1 lux) or photopic (~300 lux) conditions. The results showed that DISC lenses induced more myopic retinal defocus than SVC lenses in all conditions (all p < 0.05), except for the scotopic near target. In addition, for DISC lenses, the defocus was greater in the photopic than the scotopic conditions for both the far and near targets (both p < 0.05). In conclusion, the retinal defocus induced by these multifocal lenses was dependent on both visual distance and ambient illuminance, indicating that the visual conditions might affect the anti-myopia efficacy of these devices.

Effects of Chronic Pain on Static and Dynamic Postural Control in Chronic Ankle Instability.

To identify the effects of chronic pain levels on static and dynamic postural (DP) control in individuals with chronic ankle instability (CAI). Cross-sectional study. Controlled laboratory. Sixty participants were divided into the following 3 groups: 20 high pain individuals with CAI (high pain), 20 low pain individuals with CAI (low pain), and 20 healthy controls (control). Groups (CAI with high pain, CAI with low pain, and control) and visual conditions (eyes open and closed) for single-leg stance. Participants performed single-leg stance with eyes open and closed, the star excursion balance test, and single-leg hop to stabilization. The high pain group experienced worse self-reported outcomes, including Foot and Ankle Ability Measure activities of daily living and sports, than the low pain and control groups. Regardless of visual condition, both the high and low pain groups exhibited decreased static postural control in mediolateral (ML) compared with the control group. Specifically, the high pain group showed decreased static postural control in ML under closed eyes compared with the low pain and the control groups. The high pain group showed less reach distance than the control group and increased DP control in vertical and overall DP stability index compared with the low and control groups. Chronic pain can significantly affect both static and DP control in individuals with CAI. Therefore, clinicians should consider chronic pain as one of the factors affecting postural control in individuals with CAI.

Cerebral Ischemic Coma Model Induced by Modified Four-Vessel Occlusion.

Coma caused by cerebral ischemia is the most serious complication of cerebral ischemia. Four-vessel occlusion can establish a cerebral ischemic coma model for disease research and drug development. However, the commonly used four-vessel occlusion method mainly involves inserting an electrocoagulation pen into the bilateral pterygoid foramen of the first cervical vertebra behind the neck to electrocoagulate the vertebral arteries. This process carries the risk of incomplete electrocoagulation, bleeding, and damage to the brainstem and spinal cord. Twenty-four hours after surgery, re-anesthetized rats undergo carotid artery ligation in front of the neck. Two surgeries expose the rats to a higher risk of infection and increase the experimental period. In this study, during a single surgical procedure, an anterior cervical incision was used to locate the key site where the vertebral artery penetrates the first cervical vertebra. The bilateral vertebral arteries were electrocauterized under visual conditions, while the bilateral common carotid arteries were separated to place loose knots. When the rats showed consciousness of the inversion reaction, the bilateral common carotid arteries were quickly ligated to induce ischemic coma. This method can avoid the risk of infection caused by two surgical operations and is easy to perform with a high success rate, providing a useful reference for relevant practitioners.

The Aging Eye

Sight is arguably the most precious of our senses. With the aging world population, it is vitally important to learn about the four major conditions that affect people as they age, namely, Macular Degeneration or Age-Related Macular Degeneration (AMD); Cataracts; Diabetic Retinopathy; and Glaucoma. This column will offer information on web-based sites that not only provide accurate and reliable information on these conditions to patients and their care-givers, but also identify help available to protect vision, treat vision conditions, and ways and encouragement that allow individuals to continue to live fulfilling lives.