Abstract: Autonomous drone navigation with computer vision is an innovative technology that allows drones to move through intricate surroundings without needing human control. This system uses live visual information to identify objects, steer clear of obstacles, and determine routes, improving operational safety and precision. The project's main objective is to create a visionbased navigation system that combines object detection and obstacle avoidance algorithms through deep learning methods like YOLO (You Only Look Once), alongside real-time sensor fusion. The drone uses computer vision algorithms to process aerial images and automatically changes its flight path to prevent crashes. A personalized dataset of aerial images is generated and utilized for improving object detection skills in various environments. In order to guarantee practicality in real- world situations, the system undergoes validation through simulations and field tests on different terrains, focusing on its resilience in changing environments. Improvements in navigation accuracy and obstacle detection are accomplished by implementing adaptive pathplanning and integrating multiple sensors, guaranteeing the drone's efficient operation in real-life situations. The goal of this method is to enhance the drone's ability to make decisions, minimize human mistakes, and expand its range of potential uses in areas like surveillance, agriculture, and disaster response