Visible Signs Research Articles

Experimental and numerical investigation of low‐velocity impact behavior and failure mode of shear deficient RC beam strengthened with CFRP strips

AbstractIt is well‐known that shear failure is a collapse mechanism that is the riskiest, fastest, and catastrophic and occurs with no visible signs of damage or prior warning for RC beams. Therefore, to prevent brittle shear failure, the RC beams should include sufficient shear reinforcement, such as stirrups, and be designed to have sufficient shear capacity. However, the RC beams' shear capacity becomes inadequate for various reasons. One of these reasons may be the acting of the impulsive impact load, which is uncommon and disregarded in the design phase on the RC beams. An experimental program was conducted to examine the impact behavior and failure mode of shear‐deficient RC beams in the scope of the present study. Besides, it aims to investigate the effectiveness of the strengthening method using CFRP strips in improving the general behavior, failure mode, and performance of shear‐deficient RC beams exposed to impact load. The time histories of the accelerations, displacements, impact loads, and strains in the CFRP strips were measured. They were interpreted how they are affected by experimental variables examined in the experimental study. Furthermore, the finite element model of the specimens was generated in the LS‐DYNA software, and the experimental and numerical results were compared by performing finite element analysis in terms of failure modes and general behavior.

ANTI-AGING COSMETIC PROCEDURES: BENEFITS AND RISKS

The rising demand for aesthetic interventions reflects a broader cultural trend toward enhancing physical appearance and rejuvenation, fueled by technological advancements and increased accessibility of invasive and non-invasive cosmetic procedures. Skin aging, driven by a combination of genetic, hormonal, and environmental factors, results in visible changes such as wrinkles and reduced skin elasticity. The growing availability of cosmetic procedures, including botulinum toxin injections, dermal fillers, and surgical options like rhinoplasty and liposuction, underscores a shift in public attitudes toward cosmetic enhancement and concealing of visible signs of aging. Social media platforms play a crucial role in influencing treatment decisions, changing perceptions and practices of cosmetic procedures. However, uncontrolled expansion of these procedures is associated with risks, including psychological distress and physical complications. Technological innovations, such as ultrasound-guided injections and 3D facial modelling, are improving procedural accuracy, patient safety, and satisfaction. This review examines the driving factors behind the surge in cosmetic procedures, addresses some issues in the field, and evaluates how emerging advanced technologies are enhancing outcomes and safety.

Sequências textuais em uma tira on-line: critérios analíticos e construção de sentidos

In this paper, we foster a discussion of textual sequences according to the theoretical approach of textual discourse analysis (TDA) and promote a reflection on how these compositional units can subsidize the analysis of an online comic strip by Maurício de Sousa, posted on the Instagram profile @gibi_nostalgia. We intend to answer specifically the following questions: 1) How do the iconic images (described objects) textualize operations of the descriptive and contribute to the construction of a visual narrative? 2) Which textual-discursive functions does the descriptive assume in the construction of meaning(s)? To answer these questions, we remain on level 5 of the analysis, the compositional structure, and focus on the textual sequences and their functions in the textual organization of the selected comic strip. We establish an interface between the TDA (Adam, 2011; 2019) and studies of the descriptive (Marquesi, 2004; 2007; 2017; 2018), of the visual sign (GRUPO µ, 1993) as well as of comics (Acevedo, 1990; Cagnin, 2014; Ramos, 2007; 2009), according to the features and specifications of this genre. The analyses undertaken showed that, with due adaptations, notions of textual sequences are also valid for verbo-visual texts, specifically so for the analyzed comic strip, and they give relevant orientations for the construction of meaning(s).

How to fight acute sun damage? Current skin care strategies

Excessive exposure to sunlight can contribute for skin photo-damage, such as sunburn, dryness, wrinkles, hyperpigmentation, immunosuppressive events and skin sensitization reactions. The use of aftersun products is an effective strategy to reduce the visible signs and symptoms of acute photodamage in the skin. Aiming to unveil the active ingredients able to offset acute sun damage, this work focuses on the characterization of the aftersun products market. A total of 84 after-sun formulations from 41 international brands currently marketed in Portugal were analyzed concerning the composition described on the product label, identifying natural and synthetic/semi-synthetic ingredients with the ability to mitigate solar-induced effects. The majority of aftersun formulations contained ingredients derived from terrestrial and marine sources (> 80%). An in-depth examination of these compounds is also offered, revealing the top of the most used natural and synthetic/semi-synthetic ingredients present in aftersun products, as well as their mechanism of action. A critical appraisal of the scientific data was made aiming to highlight the scientific evidence of ingredients able to mitigate skin photodamage. Amino acids and peptides, and A. barbadensis extract were tested for their in vivo efficacy. Nevertheless, all the ingredients were analyzed with in vitro studies as preliminary screening before in vivo, ex vivo and/or clinical studies. In summary, this study provides an overview of the use of active ingredients in commercial aftersun products to understand better the benefits associated with their use in cosmetic formulations and identify opportunities for innovation.Graphical abstract

Appreciation, Analysis and Creation in the Teaching-learning of the Plastic Arts

Aim. The Didactics of the Plastic Education is necessarily nourished by the general didactics and the arts, as well as by their particular methodologies, in aspects related to the teaching-learning of the textual analysis, and specifically, the study of the visual code (iconic and visual signs, tropes or rhetorical figures, etc.), which dialogues with theory, semiotics, cultural anthropology, among other sciences. Methods. In academic research, methods such as the analysis of the results of pedagogical activity, ethnographic or experiential and inductive-deductive methods were used. Results. The Didactics of a Plastic Education requires an urgent review that includes, from its most general principles and laws, to the aspects related to the selection and sequencing of content, the role of the student's plastic education in achieving a social model, the distinctions between artistic education, aesthetic education and teaching of the plastic arts in all the integrality and complexity of their discourses, the teaching-learning process, its essence and contradictions, the categorical system of the teaching-learning process, among other fundamental aspects. The present study contributes to this rethinking of the theoretical and methodological postulates of the Didactics of Plastic Education, as it proposes as an objective: to argue the didactic principle of the unity between appreciation, analysis and textual creation in the teaching-learning process of the visual image analysis. Conclusion. This argument constitutes a theoretical contribution to the science, and clarifies, while unifying, criteria and procedures in the pedagogical practice of artists, teachers, instructors and masters of the plastic arts.

Natural history of cerebral visual impairment in children with cerebral palsy.

To longitudinally evaluate the natural history of cerebral visual impairment (CVI) in children with cerebral palsy (CP) and identify which early visual signs or symptoms are associated with cognitive visual disorders (CVDs) at school age. Fifty-one individuals with CP and CVI underwent an ophthalmological, oculomotor, and basic visual function evaluation at three time points: T0 (6-35 months old); T1 (3-5 years old); and T2 (≥6 years old). We also performed a cognitive visual evaluation at T2. Logistic regression fitted using a generalized estimation equation (binary) and cumulative link models (ordinal) were used to model the outcomes of interest. Ophthalmological deficits were stable over time, except for ocular fundus abnormalities (T1-T0, p = 0.01; T2-T1, p = 0.02; T2-T0, p < 0.01) and strabismus, whose frequency increased with age (T2-T0, p= 0.02 with T2-T0, p = 0.05). Conversely, fixation (T1-T0, T2-T0, p < 0.01), smooth pursuit (T2-T1, T2-T0, p < 0.01), saccades (T1-T0, T2-T1, T2-T0, p < 0.01), as well as visual acuity, contrast sensitivity, and visual field (T1-T0, T2-T0, p < 0.01) all improved over time. Early oculomotor dysfunction was associated with CVD at T2. Although a diagnosis of CVI was confirmed in all children at each time point, several visual signs and symptoms improved over time; in some cases, they reached complete recovery at T1 and T2. These results emphasize the 'permanent' but 'not unchanging' nature of the CVI associated with CP during development.

Can pin-site inflammation be detected with thermographic imaging? A cross-sectional study from the USA and Denmark of patients treated with external fixators.

Patients with external fixators are at risk of pin-site infection. A tool for objective monitoring of pin sites for evolving signs of infection is warranted. We aimed to investigate the temperature (MaxTp) difference between clean and visually inflamed pin sites using thermography and to establish the optimal cut-off value of MaxTp using thermography as a screening tool for inflammation detection. This was a cross-sectional study performed in the USA and Denmark of patients with circular external fixators. Pin sites were visually judged by a surgeon or a nurse as clean or as showing signs of inflammation. The MaxTp was obtained at the pin site by thermographic imaging using an infrared camera (FLIR T540). We included 1,970 pin sites from 83 patients. The mean MaxTp for clean pin sites (n = 1,739) was 33.1°C (95% confidence interval [CI] 32.8-33.4) and the mean MaxTp for visual inflamed pin sites (n = 231) was 34.0°C (CI 33.6-34.3). The mean difference, when adjusted for repeated observations of patients and pin sites, was statistically significant with a difference of 0.9°C (CI 0.7-1.1) (P < 0.001). The area under the receiver operating characteristic curve for MaxTp as a screening tool to detect visual signs of inflammation was 0.71 (CI 0.65-0.76). The empirically optimal cut-off value was 34.1°C with a sensitivity of 65%, a specificity of 72%, a positive predictive value of 23%, and a negative predictive value of 94%. We found a statistically significant difference in mean temperature between pin sites with and without visual signs of inflammation. Thermography could be a promising tool for future point of care technology for monitoring inflammation around pin sites.

Environmental contamination of arsenic: pathway analysis through water-soil-feed-livestock in Nadia District (India) and potential human health risk.

This study investigated arsenic (As) concentrations in diverse environmental components and their potential impact on the health risks faced by residents of the arsenic (As)-contaminated Nadia district in West Bengal, India. A random selection of 182 cattle and 255 goats from 40 livestock farmers in the district revealed that both animals and humans were naturally exposed to elevated arsenic levels through contaminated drinking water, foods, grasses, concentrate feeds, various fodder tree leaves, and other food/feed resources. The mean As concentration in roughages (483.18µg/kg DM) was significantly higher (p < 0.001) than in tree leaves (391.53µg/kg DM), and concentrate feed/ingredients (186.66µg/kg DM). Pond water exhibited higher arsenic levels (106.11µg/L) compared to shallow tube well water (47.96µg/L) and deep tube well water/tap water (10.64µg/L and 10.04µg/L, respectively). The mean arsenic concentration in soils DM of fodder fields, crop fields, and grassland was 10.25, 10.58, and 10.20mg/kg, respectively. It was observed that protein-rich feeds had lower levels of arsenic accumulation (p < 0.048), while fiber-rich feeds containing more cellulose, hemicellulose, and lignin had higher arsenic levels (p < 0.017). Goats consumed 73.46% more arsenic per kg body weight compared to dairy cows. Although chronic and sub-chronic arsenic exposure in the district did not typically manifest symptoms or visible signs in ruminant animals, concentrations in the hair and feces of both cattle and goats exceeded normal values. Cattle feces had significantly higher arsenic (410.43µg/kg DM) levels (p < 0.001) than goat feces (227.00µg/kg DM), and arsenic concentration in cattle hair (1917.74µg/kg DM) was also significantly greater (p < 0.001) than goat hair (1435.74µg/kg DM). Arsenic levels in milk samples from both species were below 10µg/kg. Liver (356.02µg/kg DM) and kidney (317.22µg/kg DM) contained significantly higher (p < 0.001) levels of arsenic compared to muscle (204.23µg/kg DM), and bone (161.98µg/kg DM) in local meat-type adult male goats. The skin accumulated the highest amount of arsenic (576.24µg/kg DM) among the non-edible parts of the goat carcass. The cumulative cancer risk value for adults was 4.96 × 10-3, exceeding the threshold value (1 × 10-6). This suggests a significant risk of cancer development for the population in arsenic-affected areas. Non-cancer risks (hazard indexes) were estimated at 11.01 for adults. Our observations revealed that the highest bioaccumulation of arsenic occurred in the hair of cows, and goats in the examined localities. The biotransformation factor (BTF) for hair was much higher compared to other excreted samples from both species. The calculated BTF followed the order: hair > feces > milk for cows and goats. Livestock farmers in Nadia district are advised to carefully select feed resources, prioritizing those high in crude protein and low in neutral detergent fiber, and they should provide drinking water from deep aquifers to ensure the safety of milk and meat for human consumption.

A crop disease severity index derived from transfer learning and feature fusion using enhanced OPTICS algorithm

The adoption of automated methods for the identification and assessment of tomato-related disorders is highly sought-after in the agriculture sector. Using this technology is crucial for reducing wasteful spending, increasing the efficiency of treatments, and ultimately growing more resilient crops by reducing losses in agricultural output and maximising the effectiveness of these processes. An automated method has been suggested for accurately identifying and classifying diseases using a single photograph. The described method for disease detection in tomato plants makes use of a computer vision-based technique. Image processing, ML, and deep learning are just a few of the methods that this strategy uses. The goal of this approach is to prevent tomato crops from being damaged by various illnesses by reducing the need of conventional procedures. Bacterial spot, early blight, late blight, leaf mould, spider mites, target spot, spotted spider mite, mosaic virus, and yellow leaf curl are all examples of these illnesses. The following ten diseases frequently strike tomato crops in India. By utilising picture segmentation in combination with the Enhanced OPTICS algorithm (EOPTICSA), the affected area of the tomato plant may be precisely detected and defined after image pre-processing procedures have been used. It may be necessary to look for certain visual signs in order to diagnose the previously mentioned illnesses. The primary goal of this study was to evaluate the efficacy of the EOPTICSA method for detecting diseases in plant leaves. To eliminate the geometric features associated with colour, texture, and leaf arrangement in the provided plant pictures, image segmentation and edge detection methods are employed. Using these methods allows us to achieve our goal. Various efficacy measures are used to assess and provide a technique recommendation. This research shows that when performance metrics are used to implement these strategies, the suggested strategy outperforms the current methods in terms of accuracy, precision, and F1-score. The process of detecting sickness involves several consecutive steps. Capturing images, segmenting them, detecting edges, and determining the infection’s severity are all steps in this process. To accomplish the goal of recognising and categorising different types of diseases that might impact tomato plants, the method of transfer learning is employed. As soon as the problem is identified, it is recommended to take proactive measures to help individuals and organisations involved in agriculture address the effects of these disorders using appropriate measures.

A Machine Learning Approach to Concussion Risk Estimation Among Players Exhibiting Visible Signs in Professional Hockey.

The identification of concussion risk factors, such as visible signs and mechanisms of injury, improves concussion identification. Exploring individual risk factors, such as concussion history, may help to improve existing concussion risk models and algorithms. The primary aim of the current study was to use machine learning techniques to develop a comprehensive, prospectively coded concussion risk model in professional hockey among players exhibiting visible signs. The secondary aim was to examine whether including concussion history improves model performance. Data from the National Hockey League (NHL) spotter program, including coded visible signs and mechanisms of injury associated with possible concussive events, were extracted from the 2018-2019 to the 2021-2022 seasons. Each unique spotter event was matched with data extracted from the medical record to determine whether the event was associated with a subsequent physician diagnosed concussion. We compared the ability of three machine learning-based approaches to identify the likelihood of physician diagnosed concussion: conditional inference tree, conditional inference random forest, and logistic regression. A total of 1563 unique events with visible signs were identified by spotters (183 leading to a concussion diagnosis). A randomly selected training sample had 1250 events (146 concussions) and the remaining set-aside test sample had 313 events (37 concussions). The obtained models performed at a high level with large effects in the training [area under the receiver operating characteristic curve (AUC) = 0.79] and set-aside test data (AUC = 0.82). Concussion history was retained in the tree and logistic regression models, with each additional prior concussion associated with a 1.32 times increased odds of concussion diagnosis. We present simple tree and logistic algorithms for concussion screening and as diagnostic aids. Our results show that player concussion history can explain additional risk above and beyond that explained by visible signs and mechanisms of injury alone.

Floating photovoltaic systems: photovoltaic cable submersion testing and potential impacts.

Floating photovoltaics (FPV) is an emerging technology that is gaining attention worldwide. However, little information is still available on its possible impacts in the aquatic ecosystems, as well as on the durability of its components. Therefore, this work intends to provide a contribution to this field, analysing possible obstacles that can compromise the performance of this technology, adding to an increase of its reliability and assessing possible impacts.The problem under study is related to the potential submersion of photovoltaic cables, that can lead to a degradation of its electrical insulation capabilities and, consequently, higher energy production losses and water contamination. In the present study, the submersion of photovoltaic cables (with two different insulation materials) in freshwater and artificial seawater was tested, in order to replicate real life conditions, when FPV systems are located in reservoirs or in the marine environment. Electrical insulation tests were carried out weekly to assess possible cable degradation, the physical-chemical characteristics of the water were also periodically monitored, complemented by analysis to detect traces of copper and microplastics in the water. The results showed that the submersion of photovoltaic cables with rubber sheath in saltwater can lead to a cable accelerated degradation, with reduction of its electrical insulation and, consequently, copper release into the aquatic environment. The test results pointed a probable relationship between submersion of cables with rubber outer shell and water freezing temperatures and the occurrence of accelerated degradation of the cable insulation layer. Reduced insulation resistance values were measured in this cable type after the occurrence of such temperatures, both in salt and freshwater, the cable presented visible exterior degradation signs. For this case copper residues were detected in the water.

Diagnostic mistakes in assessing MRI semiotics of primary extra-axial brain tumors tumors.

Primary extra-axial brain tumors (PExT) are represented by benign and malignant tumors of the meninges and cranial nerves. Their preoperative differential diagnosis based on an analysis of the semiotics of magnetic resonance imaging. The critically important points that make it possible to classify tumors of this group are the following characteristics: tumors structure, contrast enhancements, invasion and relationship tumors with the meninges or cranial nerves. Differential diagnostic typical PExT is not difficult, because most of they heave typical MRI visual signs. With atypical MRI manifestations, reliable differentiation of tumors can be difficult. The greatest difficulty in this case is the differentiation of benign and malignant meningiomas, the distinction between solitary fibrous tumors and meningiomas, and the tumors when they localized in the cerebellopontine angles. The case series presented containing the most typical situations leading to errors in the differential diagnosis of PexT, all tumors had untypical signs. All presented tumors were histological verified. Analysis of the given clinical examples shows that consideration of the entire set of semiotic signs can reduce the number of diagnostic errors.

Os signos visuais de marca das instituições culturais de Belém às vésperas da COP30: uma análise semiótica Peirceana

This study investigates the identifying visual signs (logos) of public cultural institutions in Belém do Pará. After reviewing the literature on tangible brand manifestations, the logos of 12 institutions were analyzed following the methodological principles based on Peircean semiotics, specifically following the semiotics of Charles W. Morris (1901-1979). Analysis found syntactic, semantic, and pragmatic problems in the visual signs. To address them, this study recommends that the logos be redesigned as part of a comprehensive rebranding of the public cultural institutions in Belém do Pará, seizing the opportunity opened up by the proximity of COP30.

Clinical, neuropathological, and molecular characteristics of rapidly progressive dementia with Lewy bodies: a distinct clinicopathological entity?

BackgroundThe term rapidly progressive dementia (RPD) with Lewy bodies (rpDLB) is used for DLB patients who develop a rapidly progressive neurological syndrome and have reduced survival. Here, we characterise the clinical, neuropathological, and molecular characteristics of a large rpDLB neuropathological series.MethodsWe included all RPD patients with a disease duration < 4 years submitted to our prion disease referral centre between 2003 and 2022 who showed Lewy body pathology (LBP) in limbic or neocortical stages as primary neuropathological diagnosis, had no systemic condition justifying the rapid deterioration and were previously neurologically unimpaired. Clinical features were retrieved and compared with Creutzfeldt-Jakob disease (CJD) and rapidly progressive Alzheimer’s disease (rpAD) cohorts. Neuropathological and genetic (whole exome sequencing, APOE genotyping, and C9orf72 repeat expansion analysis) characteristics of rpDLB patients were systematically investigated. We scored semi-quantitatively the LBP load and performed a α-synuclein (αSyn) RT-QuIC seeding amplification assay (SAA) on cerebrospinal fluid (CSF) and tenfold serially diluted brain homogenates from different brain areas in rpDLB patients and typical long-lasting Lewy body disease (LBD) with dementia patients as control group.ResultsRpDLB patients were older (p = 0.047) and presented more cognitive fluctuations (p = 0.005), visual hallucinations (p = 0.020), neuropsychiatric symptoms (p = 0.006) and seizures (p = 0.032), and fewer cerebellar (p < 0.001) and visual (p = 0.004) signs than CJD ones. Delirium onset was more common than in both CJD (p < 0.001) and rpAD (p = 0.008). Atypical LBD signs (pyramidal, myoclonus, akinetic mutism) were common. All tested patients were positive by CSF αSyn SAA. Concomitant pathologies were common, with only four cases showing relatively “pure” LBP. LBP load and αSyn seeding activity measured through αSyn RT-QuIC SAA were not significantly different between rpDLB patients and typical LBD. We found a likely pathogenic variant in GBA in one patient.ConclusionsOur results indicate that: 1) rpDLB exhibits a distinct clinical signature (2) CSF αSyn SAA is a reliable diagnostic test; 3) rpDLB is a heterogeneous neuropathological entity that can be underlain by both widespread pure LBP, or multiple copathologies 4) rpDLB is likely not sustained by distinct αSyn conformational strains; 5) genetic defects may, at least occasionally, contribute to the poor prognosis in these patients.

Gaze behavior in open-angle glaucoma patients during visuo-cognitive-motor tasks: a cross-sectional study

This study investigated gaze behavior during visuo-cognitive-motor tasks with a change of movement direction in glaucoma patients and healthy controls. Nineteen glaucoma patients (10 females, 9 males) and 30 healthy sighted controls (17 females, 13 males) participated in this cross-sectional study. Participants performed two visuo-cognitive-motor tasks with a change of movement direction: (i) the “Speed-Court-Test” that involved stepping on different sensors in response to a visual sign displayed on either a large or small screen (165″ and 55″, respectively); (ii) the “Trail-Walking-Test” that required walking to 15 cones labeled with numbers (1–8) or letters (A-G) in an alternately ascending order. During these tasks, the time needed for completing each task was determined and the gaze behavior (e.g., saccade duration, fixation duration) was recorded via eye tracking. Data were analyzed with repeated measures analyses of covariance (ANCOVA; GROUP × SCREEN) and one-way ANCOVA. No differences between groups were found for the time needed to complete the tasks. However, during the “Trail-Walking-Test”, the fixation duration was longer for glaucoma patients than for controls (p = 0.016, ηp2\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$${\\upeta }_{\ ext{p}}^{2}$$\\end{document} = 0.131). Furthermore, during the “Speed-Court-Test”, there was a screen size effect. Irrespective of group, saccade amplitudes were lower (p < 0.001, ηp2\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$${\\upeta }_{\ ext{p}}^{2}$$\\end{document} = 0.242) and fixation durations were higher (p = 0.021, ηp2\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$${\\upeta }_{\ ext{p}}^{2}$$\\end{document} = 0.125) for the small screen. Fixation durations were longer in glaucoma patients during the cognitively demanding “Trail-Walking-Test”, which might indicate a strategy to compensate for their visual impairment.

Surgical Treatment of Primary Mast Cell Tumor in Mucosal Surface of Lower Lip in a Dog: A Case Report

Introduction: Mast cell tumors (MCTs) have been described as a form of cancer affecting a specific type of blood cell that typically plays a role in the body's reaction to allergens and inflammatory processes. The MCTs have been classified as skin tumors in dogs which can also affect other areas of the body, such as the spleen, liver, gastrointestinal tract, and bone marrow. The present study investigated the clinical and histological signs, biological behavior, and treatment of primary oral mast cell tumors. Case report: A 3-year-old neutered female, weighing 18 kg and classified as a medium mixed breed, was referred to a veterinary clinic in Mashhad (Iran) due to the presence of a pink, lobulated mucosal mass located on the internal surface of her lower lip. Although the vital signs were normal, clinical examination, radiology, and an incisional biopsy were performed from the lesion site under general anesthesia for histology study. Histopathological features were similar to those of mastocytoma in this case. On presentation, no concurrent mass was found on other sides of the body. Mandibular lymph nodes were not enlarged; however, the incisor teeth of the mandible were loosed. Accordingly, the primary oral MCTs were diagnosed. The surgery was done and After a follow-up period of 150 days post-excisional surgery for a Mast cell tumor, the patient remained alive and exhibited no visible signs of tumor recurrence or surgical complications. Conclusion: The current case report defined a primary Mast cell tumor with slow tumor growth and without metastasis in the mucosal surface of the lower lip in a dog treated by complete excisional surgery only, unlike some previous studies of primary oral MCTs in dogs with aggressive biological behaviors.

Ectoin attenuates cortisone-induced skin issues by suppression GR signaling and the UVB-induced overexpression of 11β-HSD1.

Accelerated pace of modern work and lifestyles subject individuals to various external and psychological stressors, which, in turn, can trigger additional stress through visible signs of fatigue, hair loss, and obesity. As the primary stress hormone affecting skin health, cortisol connects to the glucocorticoid receptor (GR) to aggravate skin issues induced by stress. This activation depends on the expression of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) in skin cells, which locally converts cortisone-produced by the central and peripheral hypothalamic-pituitary-adrenal axis-into its active form. Our study delves deeper into stress's adverse effects on the skin, including the disruption of keratinocyte structural proteins, the loss of basement membrane proteins, and the degradation of collagen. Remarkably, we discovered that Ectoin, an amino acid derivative obtained from halophilic bacteria, is capable of mitigating the inhibitory impacts of cortisone on the expression of cutaneous functional proteins, including involucrin, loricrin, laminin-5, and claudin-1. Moreover, Ectoin reduces the suppressive effect of stress on collagen and hyaluronic acid synthesis by impeding GR signal transduction. Additionally, Ectoin counterbalances the UVB-induced overexpression of 11β-HSD1, thereby diminishing the concentration of endogenous glucocorticoids. Our findings illuminate the significant potential of Ectoin as a preventative agent against stress-induced skin maladies.

Unmanned aerial vehicle landing localization technology based on visual dual-channel uniqueness coding

Unmanned aerial vehicle (UAV) mainly uses GPS (Global Positioning System) for positioning, but it is difficult to locate in areas where GPS signal is missing or being disturbed. Therefore, the relative positioning technology based on visual method is also widely used in UAV landing, but due to the influence of cross wind and the motion of the landing plane, the traditional visual landing sign and positioning method is prone to lose the positioning target at the end stage of the landing. Therefore, this article proposes a landing sign based on double-layer unique coding, which can realize continuous positioning in the horizontal direction and accurate positioning of large-scale changes in the vertical direction. Firstly, real-time image acquisition and image processing are carried out through the airborne camera. Based on the flight altitude and encoding extraction effect of the UAV, the red or blue channel component is extracted, and then the image is preprocessed, edge detection, line detection, coding grid extraction, etc. As long as any 5 × 5 small squares of the whole pattern can be extracted, the perspective-n-point algorithm is used to obtain the relative pose estimation between the UAV and the landing sign. Experiments show that the landing sign and recognition algorithm effectively improve the UAV landing reliability.

Linguistic landscape of Pyla, a bi-communal village in Cyprus: multilingualism, ethnolinguistic vitality and internationalisation

ABSTRACT This study investigated the linguistic landscape (LL) of Pyla, a bi-communal village in Cyprus. The data collection and analysis were based on the geosemiotics theoretical framework. The researcher created a corpus of visible linguistic signs photographed during the fieldwork with a focus on bottom-up and top-down signs in Pyla. The analysis of the data showed that the overall pattern of Pyla's LL was monolingual, with English playing a prominent role. However, bilingual, and multilingual signs were also present, with English, Greek and Turkish being the dominant language constellation. The LL in Pyla is indicative of its ethnolinguistic vitality as a bi-communal village inhabited by both Greek Cypriot and Turkish Cypriot populations; the LL also reveals the agency of the sign creators and owners regarding the choice of languages and the content of the signs, as well as such processes as internationalisation, commodification and linguistic instrumentalism. The importance of this study stems from its goal to deepen the understanding of linguistic landscape (LL) and multilingualism in Cyprus. It specifically analyses both private and public signage in the mixed village of Pyla, while considering the island's geopolitical division and the role of English as a mediating language in the process of peacebuilding.

Acetylation of Aspen and Alder Wood - Preliminary Tests

An experimental study of the physical and mechanical properties of untreated and acetylated wood was conducted. The effect of acetylation on wood density was investigated. It was established that the density of the samples generally decreases after acetylation. As the level of acetylation increases, the fiber saturation point decreases in both conifers and hardwoods. Acetylation of wood helps to reduce the sorption properties of wood. The amount of swelling was analyzed. For untreated wood (aspen and alder), the volume swelling index is at the level of 7.5 %. Acetylation contributes to the stability of the geometric dimensions of structures, as the volume swelling index for aspen decreased by 4 times, for alder – by 2 times. An increase in the amount of swelling along the fibers is observed in all samples. Regarding the nature of the destruction of the samples during compression, the aspen (both untreated and acetylated) only crumples without visible signs of destruction. In some samples of alder, partial exfoliation is visible. It was found that acetylation has an ambiguous effect on the mechanical properties of wood of both species.