Visible Effect Research Articles

Pengaruh Cangkang Pomacea canaliculata L Terhadap Sifat Fisika dan Kimia Air Sungai Cisadane

The Cisadane River is a very important ecosystem for the people of the city of Tangerang. Its utilization has the potential to produce waste that can damage aquatic life so that it becomes one of the sources of the problem of decreasing water quality both physically and chemically. One of the efforts made to overcome the problem of Cisadane river water is to use water purifiers derived from natural materials so that they do not endanger health and can bind heavy metals. The purpose of this study was to determine the effect of adding snail shells to the water quality of the Cisadane river in industrial areas, urban areas and slums in terms pH value, TDS value and Pb heavy metal. The experimental procedures in this study were snail shell preparation, Cisadane river water sampling, sample analysis before application, snail shell powder application, and sample analysis after application. The results of analys show that the clarity level of Cisadane river water ranges from 19 NTU to 59 NTU, the pH value ranges from 7.2 to 7.9, the TDS value ranges from 60 mg/l to 170 mg/l and the heavy metal content is 0.0047 mg /l. The conclusion of this research is that there is an increase in the level of clarity with the addition of snail shells by 45%, there is not visible effect of the snail shells addition’s on the pH value and content of Pb heavy metal. And there is an increase in the TDS value after adding snail shells.

Gender quotas and media representation of female members of parliament under authoritarianism: The case of Egypt

Drawing on studies of gendered mediation and women's political representation, this study explores the implications of using gender quotas to facilitate women's political representation on their portrayal in the media. Focused on the coverage of Egyptian female members of parliament in the daily newspaper al-Masry al-Yawm, the study employs feminist content analysis to examine more than two thousand news articles across three parliamentary terms (2012–2022). The article reveals a heightened visibility that challenges patriarchal stereotypes and legitimizes women as political actors. However, this coverage exists within an authoritarian setting, where the media's compliance with government narratives subtly upholds the regime's image. This, in turn, may limit the empowering effect of such visibility, especially among regime critics, highlighting the complex role the media plays in mirroring and molding power relations and in the negotiation of gender perceptions.

Psychological safety is associated with better work environment and lower levels of clinician burnout.

Burnout is attributed to negative work environments and threatens patient and clinician safety. Psychological safety is the perception that the work environment is safe for interpersonal risk-taking and may offer insight into the relationship between the work environment and burnout. In this cross-sectional analysis of survey data from 621 nurse practitioners in California, we found that one-third (34%) experienced high burnout. Four factors in the work environment were negatively associated with burnout and positively associated with psychological safety. Significant mediation effects of psychological safety were observed on the relationships between each work environment factor and both emotional exhaustion and depersonalization. The largest mediation effects were observed on the total effects of Nurse Practitioner-Physician Relations and Practice Visibility on Emotional Exhaustion (37% and 32%, respectively) and Independent Practice and Support and NP-Administration Relations on Depersonalization (32% and 29%, respectively). We found, overall, that psychological safety decreased the strength of the negative relationship between work environment and burnout. We argue that research, practice, and policy efforts to mitigate burnout and improve the work environment should consider psychological safety as a metric for system-level well-being.

The Role of Harm Visibility for Pictorial Health Warning Labels on Cigars.

Pictorial health warning labels (HWLs) can communicate the harms of tobacco product use, yet little research exists for cigars. We sought to identify the most effective types of images to pair with newly developed cigar HWLs. In September 2021, we conducted an online survey experiment with US adults who reported using little cigars, cigarillos, or large cigars in the past 30 days (n = 753). After developing nine statements about health effects of cigar use, we randomized participants to view one of three levels of harm visibility paired with each statement, either: (1) an image depicting internal harm not visible outside the body, (2) an image depicting external harm visible outside of the body, or (3) two images depicting both internal and external harm. After viewing each image, participants answered questions on perceived message effectiveness (PME), negative affect, and visual-verbal redundancy (VVR). We used linear mixed models to examine the effect of harm visibility on each outcome, controlling for warning statement. Warnings with both and external harm depictions performed significantly better than the internal harm depictions across all outcomes, including PME (B = 0.21 and B = 0.17), negative affect (B = 0.26 and B = 0.25), and VVR (B = 0.24 and B = 0.17), respectively (all p < .001). Compared to both, the external depiction of harm did not significantly change PME or negative affect but did significantly lower VVR (B = -0.07, p = .01). Future cigar pictorial HWLs may benefit from including images depicting both or external harm depictions. Future research should examine harm visibility's effect for other tobacco pictorial HWLs. The cigar health warning labels (HWLs) proposed by the US Food and Drug Administration are text-only. We conducted an online survey experiment among people who use cigars to examine the effectiveness of warnings with images depicting different levels of harm visibility. We found HWLs with images depicting both an internal and external depiction of cigar harm, or an external depiction of harm alone, performed better overall than images portraying internal depictions of harm. These findings provide important regulatory evidence regarding what type of images may increase warning effectiveness and offer a promising route for future cigar HWL development.

Caffeic acid phenethyl ester derivative exerts remarkable anti-hepatocellular carcinoma effect, non-inferior to sorafenib, in vivo analysis

Caffeic acid phenethyl ester (CAPE) and its derivatives exhibit considerable effects against hepatocellular carcinoma (HCC), with unquestioned safety. Here we investigated CAPE derivative 1ʹ (CAPE 1ʹ) monotherapy to HCC, compared with sorafenib. HCC Bel-7402 cells were treated with CAPE 1ʹ, the IC50 was detected using CCK-8 analysis, and acute toxicity testing (5 g/kg) was performed to evaluate safety. In vivo, tumor growth after CAPE 1ʹ treatment was evaluated using an subcutaneous tumor xenograft model. Five groups were examined, with group 1 given vehicle solution, groups 2, 3, and 4 given CAPE 1ʹ (20, 50, and 100 mg/kg/day, respectively), and group 5 given sorafenib (30 mg/kg/day). Tumor volume growth and tumor volume-to-weight ratio were calculated and statistically analyzed. An estimated IC50 was 5.6 µM. Acute toxicity tests revealed no animal death or visible adverse effects with dosage up to 5 g/kg. Compared to negative controls, CAPE 1ʹ treatment led to significantly slower increases of tumor volume and tumor volume-to-weight. CAPE 1ʹ and sorafenib exerted similar inhibitory effects on HCC tumors. CAPE 1ʹ was non-inferior to sorafenib for HCC treatment, both in vitro and in vivo. It has great potential as a promising drug for HCC, based on effectiveness and safety profile.

Real-world experience with a treatment with a skincare regimen of products containing the Macrocystis pyrifera ferment for optimizing facial skin rejuvenation.

Specialized aesthetic skincare treatments are an important part of helping reduce facial signs of aging. This article highlights real-world experience with a Macrocystis pyrifera ferment-containing skincare regimen comprising a cleansing foam, a serum, and a moisturizer with anti-aging, anti-inflammatory, anti-erythema, and healing properties for facial skin condition improvement. The real-world case (RWC) series presented highlights and the expert panel's clinical experience with the M. pyrifera ferment-containing skincare regimen used for 12 weeks to improve facial skin conditions. The panelists convened a meeting to discuss and select RWCs from their practice using the M. pyrifera ferment-containing skincare regimen. The RWC series showed that erythema and inflamed, easily irritated skin bother patients, even when it is mild. Reducing inflammation, erythema, and visible signs of facial aging and improving skin health contributed to patient satisfaction. The M. pyrifera ferment-containing skincare regimen comprising a cleansing foam, a serum, and a moisturizer is effective in decreasing the visible effects of inflammation and signs of aging while promoting healing by enhancing barrier resilience and recovery.

Non-pharmacological methods and techniques used in the therapy of children diagnosed with adhd. Study of literature

Attention deficit and hyperactivity disorder (ADHD) is seen as a long-lasting and chal-lenging condition that affects various areas of life, such as academic and career success, relationships, and daily activities. Both the mind and the muscles jump from one task to another, failing to complete the activity, and thus difficulties arise in carrying out activities such as writing, tying shoelaces, riding a bicycle and more. Banal activities we would say, but essential for a normal lifestyle. Medical recovery has a signifiant contribution in relieving symptoms and treating many pathologies, in both physical and mental relaxation. Moreover, it has been shown countless times that physical activity reduces stress, mainly based on muscle relaxation and improving cognitive and motor function through the development of neural functions. More and more children are diagnosed with this disorder, but, not enough attention is paid to these cases, which is one of the reasons why we chose to address this topic. The paper aims to analyze studies carried out in recent years in different countries on motor impairments and other complications that can present children with ADHD, but also the way that balneophysiokinetotherapy has a positive effect in their therapy, being an essential form of therapy, alongside the psychological or medicinal one. The studies analyzed confirm the benefits of physical exercise for children diagnosed with ADHD, showing visible effects on both the motor skills of the children and their lev-els of agitation and attention deficit. Although movement therapy is widely used in this condition, there are no protocols standardizing the type, duration, and intensity of exer-cise programs used. Occupational therapy, massage, and yoga have been noted for their beneficial effects on patients diagnosed with ADHD. Keywords: ADHD, hyperactivity, therapy

Attosecond photoionization delays in molecules: The role of nuclear motion

Molecular photoionization delays are often analyzed by assuming that nuclei remain fixed during the ionization process since they move much more slowly than electrons. However, recent high-energy resolution and multicoincidence experiments have shown that nuclear motion can have a significant and visible effect on the measured ionization delays on the attosecond time scale. To analyze this behavior, we have chosen the simplest of all molecules, H2+, and performed nearly exact calculations of streaking and RABBIT (reconstruction of attosecond beatings by interferences in two-photon transitions) spectra by solving the time-dependent Schrödinger equation in full dimensionality, and retrieved the corresponding photoionization delays. We show that, when two-center effects are at play, nuclear motion is responsible for a substantial increase of the photoionization delays, in particular of the so-called continuum-continuum delays. The magnitude of such an increase is comparable to the absolute values of the measured delays. Published by the American Physical Society 2024

Experimental and analytical investigations into flexural behavior of composite beams with UHPC T-section and HRS H-section

This study investigated the flexural behavior of composite beams with ultra-high performance concrete (UHPC) T-section and hot rolled steel (HRS) H-section. First, a four-point bending test on six specimens was conducted. The effects of stud spacing and tensile reinforcement ratio on flexural performance were investigated in terms of crack patterns, failure modes, ultimate load, load-strain response, relative interfacial slip, and ductility. The experimental results indicated that the stud spacing and the presence of tensile reinforcement had a visible effect on the crack patterns of UHPC web. The distribution of group cracks was observed at UHPC web of specimens with unreinforced UHPC bulb. During the failure stage, the whole HRS H-section in the constant moment region yielded. In particular, the partial cross section of HRS entered the strain hardening stage. In addition, an analytical approach verified by six tested specimens was developed to study the moment-curvature response of HRS-UHPC composite beams (HUCBs). The comparison results indicated the good accuracy of the analytical approach. Then, the proposed sectional analysis model was utilized to investigate the effects of the strength of HRS and UHPC, the total depth of cross section, and the depth of HRS H-section on yielding moment, including ultimate moment and ductility. The analytical results revealed that the strength of HRS and the total depth of cross section had a significant impact on the moment-curvature response of HUCBs. The sectional analysis also illustrated that the yielding point was mainly determined by the yielding of HRS H-beam. Compared with UC120, the ultimate moment and ductility coefficient of the composite beam using UC200 increased by 20.6 % and 87.7 %, respectively. However, the tensile strength of UHPC had a slight influence on the yielding and ultimate moment as well as ductility.

Exploring the Relationships among HRM Investment, Strategy Implementation, and Firm Performance with Multiple Correspondence Analysis

This study visually explores the relationships among human resource management (HRM) investment, strategy implementation, and firm performance for small- and medium-sized enterprises (SMEs) in Korea. This exploratory research focuses on the significance of strategy implementation, an often overlooked factor in the relationship between HRM and firm performance, as well as HRM investment, which can enable the development of organizational capabilities. We conducted a multiple correspondence analysis to understand the interrelationship between HRM investment, competitive strategy implementation, and firm performance. We differentiated the results by group type according to the level of HRM investment, competitive strategy implementation, and firm performance. We found that firms with high HRM investment achieve the highest performance by implementing an ambidextrous strategy that simultaneously pursues cost leadership and differentiation. Ultimately, this study’s results suggest that for firms to create a competitive advantage through the strategic capitalization of human resources, long-term and continuous investment in HRM is necessary, even if short-term visible effects are not observed while the HRM system is being built, to eventually establish the organization’s capacity to support strategy execution. This study’s potential contribution is to extend the resource-based view by establishing the role of strategy implementation in linking HRM systems as organizational capabilities to performance.

The State of Surgical Research in Sub-Saharan Africa: An Urgent Call for Surgical Research Trainers.

Surgery in low- and middle-income countries (LMICs) is poorly developed because of years of neglect. Sustained research on global surgery led to its recognition as an indivisible and indispensable part of primary healthcare in 2015. However, this has had little visible effect on surgical ecosystems within LMICs, especially in sub-Saharan Africa (SSA). SSA surgical research systems strengthening, which includes skills transfer, with local priority setting driving the research agenda, is needed to propel global surgery into the future. The authors performed a literature review of the state of surgical research within SSA and also report the initial efforts of two research training nonprofits to empower young African surgeons with research skills. Surgical research in SSA is disadvantaged even before it is birthed, facing monumental challenges at every stage of development, from research agenda determination to funding, study execution, and publication. Compared with a global output of 17.49 publications per 100,000 population, SSA produces 0.9 (P < 0.0001). The Surgeons in Humanitarian Alliance for Reconstructive, Research, and Education and Enabling Africa Clinical Health Research programs are involved in the longitudinal research mentorship of surgical residents within SSA; the improved quality of research and successful publications by participants suggest nascent steps in growing young surgical scientists. In the absence of an existing surgical research infrastructure within LMICs, global surgery research trainers should link up and collaborate to help develop a surgical research community that will provide the local data required to help transform the SSA surgical ecosystem.

Cold prevention of alopecia during chemotherapy: Real clinical practice.

e24132 Background: Alopecia is one of the most common visible adverse effects of anticancer drug therapy. The incidence of grade 2 alopecia can be as high as 90% in patients getting anthracyclines or taxanes. Decreased scalp temperature causes vasoconstriction which limits the flow of chemotherapeutic agents into the scalp and reduces the metabolism of hair follicle cells at the time of maximum concentration of cytotoxic agents in plasma. This leads to a decrease in the antimitotic and antimetabolic effects of chemotherapy. ORBIS II scalp cooling device has been successfully implemented in comprehensive oncology centers. However, the results of large-scale studies are still lacking which delays application of this technology in clinical practice. The aim of our study was to evaluate the efficacy and safety of alopecia cold prophylaxis using ORBIS device in a regional referral center in Russia. Methods: Between 22 June 2022 and 13 December 2023 101 patients (100 women and 1 man) were treated using ORBIS II in the Department of Chemotherapy N1, City Clinical Cancer Hospital N1, Moscow. Various combinations of chemotherapeutic agents depending on cancer type were administered. Breast cancer was the most common type (63), followed by ovarian (15), uterine (9), lung (6) and cervical cancer (3). Other primaries were represented by 1 patient each: pancreatic, rectal, gastric, fallopian tube and colon cancer. Totally 431 scalp cooling procedures were performed including 261 (61%) in breast cancer and 78 (18%) in ovarian cancer patients. Outcomes were evaluated using the CTCAE/CTCAE V5.0 toxicity criteria. We evaluated the development of 1 grade alopecia (hair loss of less than 50% and not requiring a wig) as a positive result. On the contrary, a negative result was registered in patients with grade 2 alopecia, namely hair loss of 50% or more and/or requiring a wig. Results: Grade 1 alopecia was experienced by 61% of patients and the other 39% had grade 2 alopecia. Notably, the highest incidence of grade 2 alopecia was observed in patients who received doxorubicin 60 mg/cm2 + cyclophosphamide 600 mg/cm2 once every 21 days (9.9%). Taxane-based regimens had a 21% incidence of grade 2 alopecia, while platinum-containing regimens had a 11% incidence. No serious adverse events occurred during the application of cold prophylaxis. The procedure was well-tolerated by all patients. Conclusions: The use of a cold helmet is an effective method of preventing chemotherapy-induced alopecia. Our analysis yielded a success rate of 61%, which is comparable to the worldwide data range of 50% to 80%.

Effectiveness of a Complex Antioxidant Product Applied by Sonophoresis and Micro-Needle Mesotherapy

Antioxidants (including Vitamin C, ferulic acid, and phloretin) are among the compounds used in skincare products. The purpose of this study was to evaluate the effect of a combination containing L-ascorbic acid, ferulic acid, and phloretin. The delivery of active substances was facilitated by micro-needle mesotherapy and sonophoresis. The study was completed by 22 volunteers. The study resulted in a significant reduction of erythema and an improvement in skin hydration. According to participants, the therapy yielded visible anti-aging effects. The combination of up to three antioxidant-active ingredients and the use of transdermal application methods proved to be both safe and effective.

Probing noncovalent binding, spectroscopic characteristics and antiproliferative behavior of inclusion complex between quinoline and para-sulfonatothiacalix[4]arene

The inclusion complex between bowl-shaped para-sulfonatothiacalix[4]arene (TSCX4) macrocycle and quinoline has been studied with a unison of UV–visible, infra-red, flourescence emission and 1H nuclear magnetic resonance (NMR) and 2D nuclear overhauser effect spectroscopy (NOESY), high resolution mass spectrometry (HRMS) experiments. Both 1H NMR titration and HRMS experiments point to 1:1 stoichiometry for the water soluble Q⊂TSCX4 complex. The electronic structure of the inclusion complex obtained from density functional theory (DFT) showed a partial encapsulation of quinoline guest, which is held within the host cavity by C–H---π, π---π and hydrogen bonding interactions. The fluorescence emission spectra upon complexation display marginal blue shift of the 411 nm band in TSCX4. Moreover, the binding constant (7.1 × 103 M−1) determined from fluoresence emission experiments underline the effective host–guest binding in the complex, which was corroborated through frequency up-shift (‘blue shift’) of characteristic Ar-OH (3433 cm−1) and SO3- vibrations (1141 cm−1 and 1037 cm−1) in the measured infrared spectra of TSCX4. The antiproliferative activitities of the Q⊂TSCX4 complex against HeLA, MDA-MB-231and N2a cells are presented. The Q⊂TSCX4 complex has been shown to be efficient against N2a (neuroblastoma) cell line.

Implementation of Adopt-A-Struggling Reader Program: A Basis for Localized Framework

In response to the growing number of struggling readers with the Division of Ilocos Sur, the Adopt-a-Struggling Reader Program under the 3Bs initiatives is being implemented. While there are studies that explored the status of the 3Bs Initiatives, none of them endeavored an exploration of the status of the Adopt-a-Struggling Reader Program within the Division. Hence, this study was conceptualized to describe the status of the Adopt-a-Struggling Reader Program and its perceived effects on both struggling readers and teachers, and the potential factors affecting its implementation as bases in developing a localized framework. The study employed the Quantitative Descriptive Design, using a validated researcher-made survey questionnaire. It considered total enumeration covering the 122 teachers of the District, however only 51% of the targeted respondents responded to the call. The study reveals that the program is highly implemented within the District. The perceived impact of the program on both teachers and struggling learners is very effective. Among the profiles of teachers, generation classification and educational attainment were found to be essential factors in successfully implementing the program. The findings mean that Quirino District is highly committed to the implementation of the program due to its visible effects on both teachers and struggling readers. Its successful implementation is driven by the time-tested experiences of teachers and their positive outlook on professional growth and development. These salient findings informed the development of the “Sulong ASRP Framework”. Quirino District may sustain its excellent culture of implementing the program by infusing it with the developed localized framework to continuously benefit from the program.

A GIS-based approach to determining optimal location for decentralized inner city smart filters: Toward net zero cities

Climate change has already begun to take visible effect globally in recent years. Given the climate change paradox and urbanization trends, cities’ success would not only depend on smartness and sustainability, but also resilience to all forthcoming economic, environmental, or behavioral changes. Numerous technologies have surfaced and proved effective in CO2 removal from the local environment. However, the optimal placement of these smart filters is a complex task and require logical and strategic decision-making. Determining the optimal location is one of the key factors for establishing a network of smart air filters. This study used a GIS-based suitability analysis for identifying optimal locations for smart filters based on pollution hotspots (population and spatial proximity to industry, commercial centers, roads, high-traffic areas, and intersections). The spatial analysis involves the determination and preparation of input layers, ranking layers, assigning weights to each criterion, and generation of a suitability map. The sites with a higher suitability score (7 or above) are optimum sites for air filters. The sites are spatially distributed over different regions. The findings revealed that GIS-based suitability analysis can be an effective technique for placing smart filters within an urban environment. These findings can help decision-makers to prioritize the location considering environmental constraints. The proposed solution aims to pave the way for fostering resilient, smart, and sustainable cities through a community sensing platform targeting hotspots within spatial variations.

CRISPR/Cas editing of a &lt;i&gt;CPC gene in Arabidopsis thaliana&lt;/i&gt;

BACKGROUND: Identification of target genes responsible for visible phenotypic effect may contribute to the development of transgene-free bioengineering strategies and application of crop varieties with edited genome. CAPRICE (CPC) is a single-repeat R3 MYB transcription factor, involved in anthocyanin biosynthesis and trichome formation. It is assumed that CPC controls the expression of Dihydroflavonol-4-reductase (DFR), a key gene of anthocyanin biosynthesis. AIM: The aim of the study was to determine whether knockout of the CPC gene using CRISPR/Cas9 results in visible anthocyanin accumulation. MATERIALS AND METHODS: Three guide RNAs were designed to excise a MYB domain from the CPC gene of Arabidopsis thaliana. Anthocyanin content and expression of CPC and DFR genes were studied in edited plants. RESULTS: The expected 662 bp deletion was detected in 2,7% of glufosinate-resistant plants, however none of the mutations were homozygous. Four edited lines were studied in four generations. An upregulation of the DFR gene was observed in edited lines, however CPC gene expression, anthocyanin content and trichome development were not significantly different from those in control plants. Moreover, in A. thaliana pigmentation did not directly depend on DFR or CPC gene expression. CONCLUSIONS: Our results suggest that CPC gene is involved in regulation of DFR gene expression and anthocyanin biosynthesis pathway, however in case of mutations plants might utilize other transcription factors to maintain homeostasis. Therefore, CPC gene is not a suitable target for CRISPR/Cas studies in Arabidopsis.

Quantifying the Visibility and Human Health Effects of Aerosol Optical Depth Chemical Species in Some Cities of West Africa

Quantifying the Visibility and Human Health Effects of Aerosol Optical Depth Chemical Species in Some Cities of West Africa

Morphological abnormalities in Tribolium castaneum Herbst (Coleoptera: Tenebrionidae) treated with eight toxic compounds

Toxicity testing is essential for preventing chemical pollution of the environment. T. castaneum can be used as an alternative model for preliminary toxicity screening, eight chemical compounds having known toxicity were evaluated. For example, mercury (II) chloride is considered toxic at concentrations higher than 0.1 mg/L in drinking water, phenol exposure to concentrations greater than 5 mg/L in drinking water can be dangerous, in the case of toluene exposure to concentrations greater than 200 ppm (parts per million) in the air can be harmful to health, hydrazine can be dangerous at concentrations higher than 1 mg/L in drinking water, and caffeine can cause adverse effects such as nervousness, insomnia, tachycardia, and tremors from exposure to doses higher than 500 - 600 mg in adults. In this case, adult insects were fed a diet of oatmeal supplemented with each separately toxic. The number of offspring insects, size, weight, and observation of abnormalities was evaluated. The eight chemicals assessed compounds only five had a visible effect on insect development, BPA and mercury (II) chloride induced abnormalities in the larval and pupal stages, while the phenol, toluene, and metronidazole, in the pupal stage only. Major anomalies were observed necrosis in larvae appendices, in pupae, papillae for sex differentiation are sclerotic or absent, and abnormality in the formation of head, limbs, wings, and appendages. Mercury (II) chloride was the most toxic due to the affected growth, development and reproduction of the insect.

A novel high-throughput screening method for identifying compounds that inhibit plasmid conjugation

Plasmid conjugation is an important contributing factor to the spread of antibiotic resistance among bacteria, posing a significant global health threat. Our method introduces an innovative high-throughput screening approach to identify compounds that inhibit or reduce conjugation, addressing the need for new strategies against the spread of antimicrobial resistance.Using Escherichia coli strains as donor and recipient, we screened 3500 compounds from a library provided by ABAC Therapeutics. Each 96 –well plate was loaded with 88 different compounds and bacterial cultures. Every plate also included negative and positive controls of conjugation. After an hour, cultures from wells were spotted on agar plates and assessed visually. Compounds that showed a visible effect on conjugation were retested. Six compounds targeting conjugation were found, showing promise for further analysis.