Visceral Yolk Sac Placenta Research Articles

Protein absorption and transport by the guinea pig visceral yolk sac placenta.

AbstractThe cytological basis for protein transport across the guinea pig visceral yolk sac at 36–44 days of gestation was studied by means of electron microscopy following injection of horseradish peroxidase and ferritin. These results were compared with those obtained after administration of colloidal thorium dioxide. Distribution of the tracer molecules was studied at 2, 10, 20, 40, and 160 minutes after injection into the uterine lumen. All three tracer molecules were rapidly absorbed by endoderm cells. Although most of the protein appeared to be retained in droplets in endoderm cells, some protein was transmitted. Peroxidase was found to be rapidly transmitted across the yolk sac, ferritin somewhat more slowly, and colloidal thorium was not transmitted at all. Protein which had exited from the endoderm cells followed any of three pathways: (1) it crossed the visceral basement membrane and entered the vitelline capillaries; (2) it crossed the mesodermal compartment, crossed the mesothelial cells and entered the exocoelomic cavity; or (3) some of the protein was sequestered by macrophages in the splanchnic mesoderm. The pathways observed are consistent with those suggested by previous authors for the passage of maternal antibodies and serum proteins to the guinea pig fetus.

Plasma protein metabolism and transfer to the fetus during pregnancy in the rat.

ARTICLESPlasma protein metabolism and transfer to the fetus during pregnancy in the ratCL Masters, LP Bignold, and EH MorganCL Masters, LP Bignold, and EH MorganPublished Online:01 Apr 1969https://doi.org/10.1152/ajplegacy.1969.216.4.876MoreSectionsPDF (2 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByPhysicochemical and Structural Properties Regulating Placental Drug TransferPreclinical Safety Considerations for the Development of Antibody-Based Therapeutics24 April 2012Physicochemical and Structural Properties Regulating Placental Drug TransferPhysicochemical and Structural Properties Regulating Placental Drug TransferChanges in Cathepsin D Activity of Maternal Tissues During Lactation and Weaning in RatsArchives of Medical Research, Vol. 30, No. 1Plasma protein (albumin) catabolism by the tumor itself—implications for tumor metabolism and the genesis of cachexiaCritical Reviews in Oncology/Hematology, Vol. 26, No. 2Experimental manipulation of the rodent visceral yolk sacTeratology, Vol. 41, No. 4Effect of nicotine on transferrin binding and iron uptake by cultured rat placentaJournal of Cellular Physiology, Vol. 134, No. 3Localization of immunoglobulins in the mouse uterus, embryo, and placenta during the second half of pregnancyJournal of Reproductive Immunology, Vol. 8, No. 2-3The mechanism of iron uptake by the rat placentaJournal of Cellular Physiology, Vol. 124, No. 3Uptake of transferrin and iron by cultured rat placental cellsJournal of Cellular Physiology, Vol. 122, No. 3Transferrin binding by microvillar vesicles isolated from rat placentaPlacenta, Vol. 5, No. 2The effect of monoclonal antibodies to the human transferrin receptor on transferrin and iron uptake by rat and rabbit reticulocytes.Journal of Biological Chemistry, Vol. 259, No. 3Placental permeability during early gestation in the hamster. Electron microscopic observations using horseradish peroxidase as a macromolecular tracerThe Anatomical Record, Vol. 197, No. 2Protein synthesis in rat maternal and fetal tissues with starvationAmerican Journal of Obstetrics and Gynecology, Vol. 136, No. 7Evolution of Blood Serum Globulins as Determined by Pregnancy in the Domestic Donkey ( Equus Asinus L.)British Veterinary Journal, Vol. 133, No. 6Ultrastructural observations on the maturation of the placental labyrinth of the golden hamster (days 10 to 16 of gestation)American Journal of Anatomy, Vol. 143, No. 3An ultrastructural comparison of the uptake and transport of horseradish peroxidase by the rat visceral yolk-sac placenta during mid- and late gestationAmerican Journal of Anatomy, Vol. 140, No. 2Catabolism and urinary excretion of albumin and transferrin before and after intravenous injection of albumin in the rat: With observations on the urinary excretion of IgG globulinBiochemical Medicine, Vol. 8, No. 2Transport of horseradish peroxidase in the murine placentaThe Journal of Pathology, Vol. 103, No. 3CONTROL OF ALBUMIN DEGRADATION IN VIVO AND IN THE PERFUSED LIVER More from this issue > Volume 216Issue 4April 1969Pages 876-883 Copyright & PermissionsCopyright © 1969 by American Physiological Societyhttps://doi.org/10.1152/ajplegacy.1969.216.4.876PubMed4180404History Published online 1 April 1969 Published in print 1 April 1969 Metrics