AbstractBackgroundModifiable lifestyle factors account for ∼40% of the population attributable risk of dementia. This provides a strong rationale to develop remotely administered, personally tailored, home‐based interventions to reduce these risk factors. CAN‐THUMBS UP (CTU) is a fully remote program that has enrolled a cohort of individuals at risk of dementia, developed an interactive online educational intervention to address personalized risk factors and their modification, and supports an open platform trial to test and compare the efficacy of multidomain interventions. CTU is reaching a broader geography with potential for inclusion of more representative research populations and with an easier and less demanding participant experience.MethodCTU’s two research intervention programs include: a) The Brain Health Support Program (BHSP) with individuals at increased risk of dementia participating in the Brain Health PRO, a 12‐month online educational program which focuses on lifestyle and dementia risk factors; b) Synchronizing, Exercises and Remedies to Gain Cognition (SYNERGIC), a clinical trial intervention platform whose RCTs are investigating personalized multidomain interventions including those administered fully remotely. In SYNERGIC‐2, the BHPro educational intervention is used as an active control to a more personalized and tailored interventional approach. CTU programs are informed by initial pilot studies, have extensive community input, and incorporate innovative features including an interactive E‐consent platform, remote cognitive testing, wearable technology for sleep and activity monitoring, and home saliva collection for genomics.ResultTarget enrollment of 350 participants in BHSP has been rapidly achieved within 8 months utilizing geotargeted mailing and a coordinated national media campaign. Participants are recruited from all regions of Canada. Pilot studies demonstrated the feasibility of conducting a 100% remote study with high rates of participant satisfaction and completion rates across various virtual outcomes. Results of each of these components of the remote program will be detailed in this FRS.ConclusionCTU demonstrates the feasibility and high rate of participant acceptance in fully remote, comprehensive, online programs that include an educational intervention as well as fully remote, multi‐domain lifestyle intervention trials. The adoption of the various technologies has exceeded expectations and supports further clinical trial development with this approach.