The study was conducted to evaluate the effects of organic fertilisers on the growth, yield, and quality of the Khassib RZ F1 cucumber variety in Vinh Phuc. The one-factor experiment was arranged in a completely randomised block design with 3 replications, including 4 treatments (fertilise for 1 hectare) including: (1) Control: Use 100% inorganic fertiliser (150 kg N + 90 kg P2O5 + 150 kg K2O); (2) CT1: 25% inorganic fertiliser + 22.5 tons of composted chicken manure; (3) CT2: 25% inorganic fertiliser + 18 tons of vermicompost; (4) CT3: 25% inorganic fertiliser + 3750 kg of Que Lam 01 microbial organic fertiliser. The results showed that using earthworm organic fertiliser (CT2) had the highest actual yield. The fruiting rate in CT2 reached the highest at 68.55%, CT3 using Que Lam 01 microbial organic fertiliser had the lowest fruiting rate of 59.71%. CT2 achieved the highest number of fruits plant-1, 4.82 fruits plant-1. The actual yield was highest in CT2 (15.96 kg plot-1), and lowest in the control treatment (11.39 kg plot-1). The nitrate accumulated in cucumbers in all treatments was below the threshold. The vermicompost fertiliser treatment (CT2) also gave good quality indicators of cucumbers such as thick intestine and very crispy taste. From these results, CT2 treatment with 25% inorganic fertiliser and 18 tons of vermicompost is suitable for the growth, development, yield, and quality of the Khassib RZ F1 cucumber variety in Vinh Phuc province.