View Of Innovation Research Articles

Whole transcriptome analysis of unmutated sporadic ALS patients' peripheral blood reveals phenotype-specific gene expression signature.

Amyotrophic lateral sclerosis (ALS) is an adult neurodegenerative disorder. According to clinical criteria, ALS patients can be classified into eight subgroups: classic, bulbar, pyramidal, pure lower motor neuron, flail arm, pure upper motor neuron, flail leg, and respiratory. There are no well-established molecular biomarkers for early diagnosis, prognosis, and progression monitoring of this fatal disease. Classification based on clinical phenotypes could be associated with peculiar gene expression patterns shaped during lifespan, allowing the identification of specific sporadic ALS (sALS) subtypes with less heterogeneous clinical and biological features. Our objective was to define a phenotype-specific transcriptomic signature of distinct ALS phenotypes, and lay the foundation for biomarkers development. We characterized 48 sALS patients by clinical and paraclinical parameters, and subdivided them in "Classic" (n=12), "Bulbar" (n=10), "Flail Arm" (n=7), "Flail Leg" (n=10) and "Pyramidal" (n=9) phenotypes. RNAs extracted from patients' PBMCs and 19 controls were sequenced. Our analysis allowed the visualization of gene expression differential clusters between patients and controls. Interestingly, only one gene (Y3_RNA, a misc_RNA component of the Ro60 ribonucleoprotein involved in cellular response to interferon-alpha) was upregulated at different levels across all phenotypes, whereas other genes appeared phenotype-specific. The work proposed stress the innovative view of ALS as a multi-systemic disorder rather than a pure motor neuron-associated and 'neurocentric' pathology. The possibility to cluster ALS patients based on their molecular signature pave the way for future personalized clinical trials and early diagnosis.

Klaus Meier, Jose A. García-Avilés, Andy Kaltenbrunner, Colin Porlezza, Vinzenz Wyss, Renée Lugschitz & Korbinian Klinghardt. Innovations in journalism. Comparative research in five European countries. London and New York: transcript, 2024, pp. 327. ISBN 978-1-032-63041-0

Innovations in Journalism. Comparative Research in Five European Countries is an edited book authored and edited by Klaus Meier, Jose A. García-Avilés, Andy Kaltenbrunner, Colin Porlezza, Vinzenz Wyss, Renée Lugschitz, and Korbinian Klinghardt. Given the ongoing and recurring ‘storms in a teacup,’ fixations on the new by ignoring the old, hysterias, hasty actions, or (too) late decisions in the context of profound changes and transformations of journalism, it is encouraging to find a book that offers a composed and analytical view of significant innovations in journalism. Indeed, journalism needs to deal with changes and transformations in one way or another since “innovation becomes a crucial element for journalism to adjust and to (re-)invent itself in the light of ongoing changes” (p. 1). However, for news organizations, journalists, journalism scholars, and policymakers alike, it is not always easy to decide what to focus on, what aspects to consider, and how to evaluate the importance of alleged or actual innovations in journalism. The authors provide helpful anchor points for discussions on such questions, presented throughout their compelling, intelligible, and well-written book.

Overripening and increased temperature: Alternative strategies to enhance peptide production and bioactivity in salt-reduced boneless cured Iberian hams

Overripening and increased temperature: Alternative strategies to enhance peptide production and bioactivity in salt-reduced boneless cured Iberian hams

Can the time management trap be avoided by time management assistance among graduate students?

ABSTRACT Time management skills may impact all aspects of students’ performance and achievement. This study used mixed method research: a qualitative method together with a complementary quantitative method. The qualitative method study examined student’s preparation plans leading up to the graduate paper. The quantitative method research examined the relationship between time management skills, procrastination, and academic achievement among Master of Education (M.Ed.) students, working on their theses. This is a complex, long-term task calling for effective time management in order to avoid or minimise procrastination. Unexpectedly, time management assistance did not affect the number of on-time submissions (according to the recommended project outline). These skills were significantly positively associated with academic procrastination, indicating that individuals having good time management skills are also low procrastinators. Both variables are negatively associated with the number of on-time submissions and did not mediate the relationship between time management assistance and the number of on-time submissions contrary to the hypotheses. The number of on-time submissions was positively associated with the final mark in that, as expected, the greater the number of on-time submissions, the higher the final mark. This study provides an innovative view that improves understanding of time management assistance for students: time management assistance does not affect each student identically. It is not effective for those students with time management difficulties yet disrupts those students with good time management skills. Such students ignore the plan proposed to them by lecturers and prefer to work independently.

MANAGING THE “S” IN ESG: HOW ASSET MANAGERS DISCLOSE AND CONSIDER HUMAN RIGHTS

Objective: The purpose of the research was to evaluate the commitment and due diligence measures directed at human rights in a sample of the largest international and European asset management companies, under OECD guidelines. Theoretical Framework: According to the OECD, companies can impact most internationally recognised human rights. However, there is a lack of studies that directly assess the human rights due diligence in investment companies. Method: A documentary and qualitative analysis of 45 investment companies was applied. Five key performance indicators were created to measure human rights commitment and due diligence practices such as disclosure of human rights policies, cascading of compliance/obligations to investees, due diligence before and during the investment and collaboration with industry and non-industry initiatives. All companies were classified and rated according to these criteria. Results and Discussion: This research reveals that there is a dichotomy between recommendations of human rights integration in investment and actual commitment and compliance, indicating that only a minority of companies were compliant and committed to considering human rights in their investment. Research Implications: The results provide an initial benchmark of the state of the commitment towards human rights in the investment sector, allowing for further investigations to be conducted to assess the development of this dimension of ESG and CSR, particularly in this sector Originality/Value: The analysis consisted of accessing and evaluating the public information of the larger investment firms from an individual investor perspective, which provides an innovative view of human rights awareness and compliance in the investment sector.

A matrix-centered view of mass spectrometry platform innovation for volatilome research.

Volatile organic compounds (VOCs) are carbon-containing molecules with high vapor pressure and low water solubility that are released from biotic and abiotic matrices. Because they are in the gaseous phase, these compounds tend to remain undetected when using conventional metabolomic profiling methods. Despite this omission, efforts to profile VOCs can provide useful information related to metabolic status and identify potential signaling pathways or toxicological impacts in natural or engineered environments. Over the past several decades mass spectrometry (MS) platform innovation has instigated new opportunities for VOC detection from previously intractable matrices. In parallel, volatilome research linking VOC profiles to other forms of multi-omic information (DNA, RNA, protein, and other metabolites) has gained prominence in resolving genotype/phenotype relationships at different levels of biological organization. This review explores both on-line and off-line methods used in VOC profiling with MS from different matrices. On-line methods involve direct sample injection into the MS platform without any prior compound separation, while off-line methods involve chromatographic separation prior to sample injection and analyte detection. Attention is given to the technical evolution of platforms needed for increasingly resolved VOC profiles, tracing technical progress over time with particular emphasis on emerging microbiome and diagnostic applications.

Theology as a factor of sociocultural development of society in the works of ‘Ata’ Allah Bayazitov

The article attempts to determine the role and historical significance of the innovative views of ‘Ata’ Allah Bayazitov (1846–1911) in the development of the cultural potential of the Tatar people. The author draws attention to the time and essence of innovations in traditional Russian Muslim society. A number of Tatar intellectuals laid down approaches and methods that met scientific requirements, tools suitable for discussing a new understanding and interaction of theological and philosophical knowledge. Innovators proposed new concepts of the theory of knowledge, aimed at revealing religious thought in its modern understanding: such as confidence in the human mind, the primacy of man, the immanence of God. Through understanding a number of conceptual issues of Islamic Theology, Tatar educational theologians developed methods for overcoming the ideological problems of the Muslim community. This, in turn, made it possible to lay the foundations for building a state-confessional dialogue. The author concludes that the paradigm of thinking built by the innovators was the need to implement divine instructions in social and production activities, and not just in the spiritual sphere. This is the key to the development of the cognitive function and the decisive criterion in the search for truth. Thus, we can observe the process of transformation of Theology from the medieval science of God into the modern science of faith.

Cover Essay: Fusing Technology with Art in Advertising.

The relationship between art and technology in the late nineteenth century was contested but increasingly characterized by a harmonious integration that reflected a progressive and optimistic view of technological innovation. This cover essay examines an advertising poster designed by the German-Italian commercial artist Adolfo Hohenstein for a public exhibition of infants in incubators, which opened in Paris in 1896. Hohenstein's poster for the Maternité Lion, with its distinctive and innovative use of an art nouveau style, captures the widespread enthusiasm for the new technologies and industries that characterized the art nouveau movement. The aesthetics of art nouveau expressed a broader cultural optimism about modernity and progress around the turn of the twentieth century. Hohenstein's poster exemplifies this by providing an aestheticized and exhibitory framework for introducing the incubator as a new technology, specifically to appeal to women.

Robert K. Merton and Innovation-Related Topics: Three Theoretical Ideas

As in other disciplines, such as organization science, sociology, and economics, there are good reasons for scholars in innovation and entrepreneurship research to revisit the classics within and outside their own research fields. Robert K. Merton (1910–2003) is not usually explicitly connected to innovation research, but to fields such as the sociology of science and knowledge. However, his scholarly productions include texts relevant to innovation and entrepreneurship. In 1935, he published on invention and innovation in American industry, and in 1938, he put forward the idea of innovation as deviant behavior or nonconformist adaptive behavior (Merton 1938a). In 1945, he began writing about the concept of serendipity, which he later discussed several times. This paper discusses how theoretical insights from Merton may inspire entrepreneurship, creativity, and innovation research. The discussion is framed around Merton’s innovation-related ideas and their relevance today, based on 20–25 Merton publications from 1934 to 2004 drawn from his larger scholarly production. The paper extracts three main examples of Merton’s theoretical ideas and insights. The first is his interest in simultaneous independent discoveries (Merton 1961a; 1961b), which has later been seen as a zeitgeist perspective on (scientific) creativity. The second is his view of innovation as deviant behavior and an adaptive response (Merton 1938), which is relevant to, among others, discussion of the dark side of innovation. The third is his interest in the idea of serendipity in scientific discovery (Merton 1945; 1948a), which is relevant today in relation to entrepreneurial opportunity and accidental innovation.

Walter Bagehot, creator of the modern Treasury Bill (1877)

Historians of economic thought have generally described Walter Bagehot as a scarcely original economist. This is tied to his refusal to adopt normative reasoning, which was deeply rooted in his evolutionary approach. This paper focuses on Bagehot’s opinions about the interactions between monetary and fiscal policy, which allows putting his thought in perspective beyond the narrow question of lending of last resort. We reconstruct his innovative views on the liquidity of short-term government securities, which cannot be found in his predecessors. Bagehot’s views were highly influential, as they led to the modernisation of government borrowing in the UK through the creation of the modern Treasury bill.

Analysis of Muhammad Shahrur's thoughts on the concept of justice in polygamy: A perspective of contemporary islamic law

Polygamy, the practice of marrying more than one partner simultaneously, has been a controversial topic in Islamic law and modern society. Although it is permitted in the Qur'an (QS. An-Nisa` 3) on the condition of justice, its practical implementation is often debated, especially in relation to the principles of justice established. In this context, Muhammad Syahrur provides an innovative view on polygamy. He uses a linguistic and contextual hermeneutic approach to interpret Qur'anic verses, arguing that justice in polygamy includes not only equal distribution of material goods but also emotional and psychological well-being. Shahrur argues that the application of polygamy must take into account the social context and changing times, emphasizing that monogamy may be more appropriate for achieving justice in modern societies. The critique of traditional interpretations and the emphasis on the unattainable principle of absolute justice are the main focus of his methodology. The analysis suggests that although polygamy is permitted, practical justice may be more easily achieved through monogamy in the contemporary context, in accordance with the principles of human rights and gender equality.

A multilevel view of internal technological innovation

ABSTRACT This article views organizational innovation as a fundamentally multilevel phenomenon. Project teams conceive of new offerings and work to obtain their final approval. This process unfolds within a structural context shaped by executives in response to environmental dictates. Using Bower’s definition–impetus–context model as a guiding framework, I argue that structures and processes with both functional and dysfunctional consequences arise at various levels. Innovation teams develop well-defined cultures that, if not properly channeled, can produce negative effects on the innovation effort. Similarly, corporate leaders evolve a structural context to facilitate innovation, but risk introducing dislocations into existing patterns of interaction in doing so. Given these challenges, the mediating role of the corporate division takes on importance for organizations seeking to profit from innovative undertakings. Established firms that mobilize their corporate divisions to balance the competing needs of innovating teams and the broader company seem well poised to excel at internal technological innovation.

The genesis of the casual interpretation of legal norms

The author examines the evolutionary development of ideas about the casual interpretation of legal norms. The subject of the study is the legal understanding of casual interpretation in the process of formation of state and legal institutions. The object of the research is scientific publications, monographs, textbooks, treatises and other historical sources containing conceptual information on hermeneutics, legal interpretation and, in particular, on the casual interpretation of legal norms. The purpose of the research is to reveal the paradigms of the emergence and causes of the transformation of views on the casual interpretation of the legal text. The coverage of the present issue determines the initial appeal to the origins of the formation of the hermeneutical methodology itself. The author focuses on such aspects of the subject as the initial object of hermeneutics; its main historical variations; the close connection between the emergence of hermeneutical ideas with the gradual transformation of society and its forms of organization; the problem of establishing criteria for the implementation of true interpretation. The methodological basis of the work consists in the application of a historical, logical, comparative and systematic approach. The result of the research is expressed in the establishment of dominant events that are significant for the formation of the concept of the casual interpretation of legal norms at various stages of the historical development of society. The novelty of the research is predetermined by an innovative view of the formation of the hermeneutics in the context of the development of legal casuistry and legal understanding of individual life situations. The author notes that the emergence of hermeneutical methodology most vividly correlates with the desire of the subject of law to use various interpretations of emerging incidents, including legal ones. The improvement of methods of interpretation of dreams, predictions, signs, and subsequently words and text led to the emergence and doctrinal formulation of the concept of casual interpretation of normative prescriptions. In conclusion, the author summarizes that today there is a similar general theoretical understanding of the casual interpretation of the norms of law as an independent type of interpretation.

Technological innovation and profit

Technological innovation and profit

Business Model Innovation and Corporate Competitive Advantages in the Digital Economy Era

In the digital economy era, enterprises face unprecedented challenges and opportunities driven by the rapid advancement of digital technologies. To thrive in this dynamic environment, enterprises must continuously innovate their business models to create and capture value in new ways. This paper explores the relationship between business model innovation and corporate competitive advantage in the context of digital transformation. Drawing on the resource-based view, dynamic capabilities framework, and other theoretical perspectives, this paper examines the characteristics, mechanisms, and strategies of business model innovation in the digital age. Through a comprehensive literature review and analysis of representative cases, we identify three key trends shaping business model innovation: digitalization, platformization, and intelligentization. We argue that enterprises need to leverage these trends to design customer-centric value propositions, build digital capabilities, construct open and collaborative value networks, and foster an agile and innovative organizational culture. Our findings highlight the importance of value creation, value capture, and value network effects in driving competitive advantage through business model innovation. We propose a framework that integrates these mechanisms with the core components of business models, providing a holistic and systemic view of business model innovation in the digital economy. We also discuss the implications of our research for theory and practice, emphasizing the need for further studies on the dynamics and outcomes of business model innovation in different contexts and industries. This paper contributes to the growing literature on business model innovation and competitive strategy in the digital age. By bridging the gaps between different theoretical perspectives and providing actionable insights for practitioners, we aim to advance the understanding and application of business model innovation as a key driver of corporate competitive advantage. Our research suggests that enterprises that can effectively align their business models with the evolving digital landscape will be better positioned to create and sustain superior performance in the face of increasing complexity and uncertainty.

Zeolitic Imidazolate Frameworks as Solid-State Nanomachines.

Machines have continually developed with the needs of daily life and industrial applications. While the careful design of molecular-scale devices often displays enhanced properties along with mechanical movements, controlling mechanics within solid-state molecular structures remains a significant challenge. Here, we explore the distinct mechanical properties of zeolitic imidazolate frameworks (ZIFs)-frameworks that contain hidden mechanical components. Using a combination of experimental and theoretical approaches, we uncover the machine-like capabilities of ZIFs, wherein connected composite building units operate similarly to a mechanical linkage system. Importantly, this research suggests that certain ZIF subunits act as core mechanical components, paving an innovative view for the future design of solid-state molecular machines.

Zeolitic Imidazolate Frameworks as Solid‐State Nanomachines

AbstractMachines have continually developed with the needs of daily life and industrial applications. While the careful design of molecular‐scale devices often displays enhanced properties along with mechanical movements, controlling mechanics within solid‐state molecular structures remains a significant challenge. Here, we explore the distinct mechanical properties of zeolitic imidazolate frameworks (ZIFs)—frameworks that contain hidden mechanical components. Using a combination of experimental and theoretical approaches, we uncover the machine‐like capabilities of ZIFs, wherein connected composite building units operate similarly to a mechanical linkage system. Importantly, this research suggests that certain ZIF subunits act as core mechanical components, paving an innovative view for the future design of solid‐state molecular machines.

Digital Transformation in Jordan and Poland - Implications on the Legal Protection of Cultural Heritage and Sustainable Development

This paper aims to clarify the principles of Jordanian and Polish copyright laws applicable to the preservation of cultural heritage, and to recommend the adoption of certain policies to facilitate this task. It is meant to serve as a guide for stakeholders who deal with digital cultural heritage, directed particularly at museums, but also institutions such as libraries, archives, and art galleries. The research aims to discuss the role of copyright law in protecting cultural heritage in the face of the rapid development of ICT technologies. This includes identifying the risks and challenges associated with digital heritage, framing the relationship between authors of digital cultural content, rights holders, and institutions responsible for documenting and preserving it, and the need to establish a fair mechanism that guarantees their rights. The study aims to provide a presentation of the importance of compliance with copyright principles related to the digitization of cultural heritage and other relevant regulations in the Jordan region and the Polish legislation. The article was created as a result of international scientific cooperation in combination with an innovative view at the law-making and application processes in the era of dynamic development of science and technology. The analysis will include identification of legal acts, which aim to ensure the effective, future-oriented, and long-term protection of cultural heritage in Jordan and Poland.

Highly sensitive and label-free immunoassay of chloramphenicol based on poly-adenine-mediated spherical nucleic acid and hybridization chain reaction amplification

Highly sensitive and label-free immunoassay of chloramphenicol based on poly-adenine-mediated spherical nucleic acid and hybridization chain reaction amplification

Open innovation for sustainability in the agri-food sector: why, who and how?

PurposeThis paper examines open innovation (OI) based on sustainability principles within the agri-food sector. The study aims to understand the interplay between different actors and develop a typology of their roles in fostering sustainability. Three key research questions guided our inquiry: “WHY” sustainability is driving the OI initiatives as presented by companies, “WHO” participates in OI interactions and “HOW” these interactions are structured among diverse agri-food actors.Design/methodology/approachThrough a theoretical prism encompassing OI modes, types, practices, sustainability dimensions and multilevel perspectives, we analyzed 78 agri-food sustainable OI initiatives, as described by the companies, to identify and explain why, who and how they engage in OI to drive sustainability shifts.FindingsThe results reveal typical patterns of transaction and cooperation between actors and confirm the collaborative nature of sustainable OI in the agri-food sector when actors must transcend traditional economic boundaries and reshape both the internal performance culture and the broader industrial or community mindset. The paper also conceptualizes the roles of actors in co-creating value in the context of sustainable food transitions.Originality/valueThis study brings the theoretical lenses of OI to conceptualize the collaborative nature of sustainability transitions in the agri-food system. The focus on sustainability transitions is dominantly placed on innovators at the niche level, while incumbents tend to be depicted as protecting the status quo. Thus, the focus on the collaborative interplay among different actors engaged in OI for sustainability contributes to offering a more nuanced view of innovation in sustainability transitions. In turn, the development of a typology of actors, motivations and configurations of OI from sustainability transition perspectives contributes to strengthening the conceptualization of sustainable value co-creation in the OI realm.