The erythrocytes form chain-like aggregates during sedimentation under gravitational field. The dynamic images of these are obtained by video-microscopic system by placing the erythrocyte suspension in plasma at hematocrit 5%, in a glass chamber of thickness 100 μm. The images at intervals of 2 min for 30 s duration are recorded. As the images are associated with high background noise, after digitization they are preprocessed for illumination correction, video de-interlacing, background subtraction, and deblurring, followed by post-processing involving edge enhancement, thresholding, median filtering and edge detection. By processing these images, to quantify the aggregation process, the morphometric parameters—projected aggregate area (PAA), projected aggregate perimeter (PAP) and form factor (FF), and sedimentation completion time (SCT) are obtained. To determine the variability of erythrocyte aggregation during human aging by this technique, blood samples from subjects of various age groups (from 20 to 60 years) are analyzed. The data obtained show the variability in the formation of aggregates in different age groups. The comparison in subjects of different age groups shows that the PAA, PAP and FF, and SCT are decreased significantly compared to that of subjects of age group 20–30 years. In subjects of 51–60 years, the formed aggregates are compact, which sediment faster compared to that of other age groups.