Drilling and blasting method is still an important method in the current tunnel excavation construction. Controlling the vibration effect of blasting during construction and its influence on the upper span tunnel is the key problem in tunnel construction. Based on Chongqing Science City tunnel excavation blasting project, combined with the tunnel blasting vibration monitoring and testing, this paper analyzes the propagation attenuation law of tunnel blasting vibration along the rock mass, and studies the load characteristics of the explosion stress wave propagating to the existing high-speed railway tunnel. Considering the influence of the buried depth of the blasting source, a mathematical prediction model of the attenuation law of the upper span existing high-speed railway tunnel caused by tunnel blasting is established. Based on the dynamic finite element numerical calculation method, the influence of blasting vibration on the structure of the existing high-speed railway tunnel under construction is analyzed, and the propagation and attenuation law of blasting vibration along the tunnel contour is studied. Based on the ultimate tensile stress criterion, the ultimate shear stress criterion and the Mohr criterion, and compared with the results obtained from the numerical simulation, the blasting safety criterion model of the existing high-speed railway tunnel over the tunnel is established.