This paper proposes a control method for the crank-slider mechanism as the active mass damper (AMD). Vibration isolation systems with spring support cause an increase in oscillating displacement at a natural frequency. Crank-slider mechanisms have been used for many kinds of industrial machines. A system of elastic supported machine frame with crank-slider mechanism can be expressed as time-varying system depends on crank angle.A state equation which contained variable parameters in coefficient matrices is derived from non-linear equations of motion. A controller is adapted the gain-scheduled control method for frame vibration reduction, and the linear velocity control method for crank motion control. State feedback gains are calculated by the linear quadratic regulator (LQR). The proposed method is confirmed by analysis and experiment. As results, the system is reduced disturbance vibration by using the slider as active mass. Furthermore, the system can consist of low costs since the existing mechanisms are used.