Abstract Introduction The discovery of antibiotics and the subsequent realization that these medications are the most effective treatments for a wide range of illnesses affecting the health of humans and animals constituted a revolution in medical history. Methods A review of the literature was done, looking for pertinent studies, using an explorative review method to discuss how the widespread use of antibiotics often led to bacterial resistance and antibiotic residue in food animals, which negatively impacted humans and animals. Results The study showed that treating bacterial resistance is a therapeutic challenge for physicians and veterinary professionals. Increased treatment failure rates, the severity of disease-causing infections, the frequency of blood infections, the length of time patients were sick, and the death rate in both humans and animals are all signs that the overuse of antibiotics is becoming a catastrophe. Discussion To prevent the negative effects of antibiotics in people, animals, and the environment, especially in developing nations, this article ends by recommending that strict guidelines, laws, and regulations regarding the use of antibiotics in clinical human and veterinary medicine be implemented. Concern must be expressed about the effects of inactivity on public health, both now and in the future. We may attempt to reverse the global resistance issue by increasing the use of antibiotics and reducing the frequency of resistance genes at all levels. Ultimately, the safety of animal products depends on the proper use of antibiotics in animal husbandry under the supervision of a veterinarian.
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