s / Journal of Equine Veterinary Science 33 (2013) 838–859 855 Magnesium, chromium, and cinnamon have also been recommended for the control insulin resistance in horses, but there is a paucity of scientific evidence to support their use. It is conceivable that some horses respond to specific supplements whereas others do not, and this may be explained by the multiple manifestations of insulin dysregulation. However, veterinarians should be cautious about horse owners substituting supplements for good management practices until further scientific evidence is presented. The practice of harvesting blood to lower iron concentrations in horses is not condoned. This recommendation arose from findings in other species linking iron overload with insulin resistance. In a study recently performed by the University of Kentucky, resveratrol lowered insulin concentrations in horses with insulin dysregulation. Results have only been presented as an abstract to date; the full article must be evaluated before recommendations for resveratrol supplementation are made. 017 Fish oil is a modulator of neutrophil function in chronic laminitis Samantha M. Steelman , David M. Hood , Yang Y. Fan , Robert S. Chapkin , and Bhanu P. Chowdhary 1 Department of Veterinary Integrative Biosciences, Texas A&M University, Hoof Diagnostic and Rehabilitation Clinic, Bryan, TX, 3 Program in Integrative Nutrition & Complex Diseases, Texas A&M University Take-home message: Dietary supplementation with marine-based omega-3 fatty acids might be beneficial in chronic laminitis. Introduction: Recent experiments in our lab have shown that horses with chronic laminitis exhibit neutrophilic infiltration of the laminar tissue and that neutrophils from these animals produce elevated levels of inflammatory cytokines, suggesting a role for these cells in chronic laminitis. Fish oil has been shown to reduce chronic, neutrophil-driven inflammation in a number of other species. We therefore conducted a pilot experiment to determine the ability of fish oil supplementation to attenuate inflammation in horses with chronic laminitis. Materials and Methods: Four horses with chronic laminitis were fed 80 g of powdered fish oil daily for 45 days. Blood was collected on days 0, 7, 14, and 21, and force plate analyses were performed on days 0 and 45. Data were analyzed using ANOVA for repeated measures. Results: Fish oil supplementation significantly decreased neutrophil chemotaxis in response to zymosan and increased neutrophil production of resolvin D1, an antiinflammatory lipid. No changes in lameness or mean stance load pattern were noticed. Discussion and Conclusions: Contrary to some published reports, we found ample evidence to indicate that fish oil supplementation can reduce inflammation in horses. The lack of effect on measurements of lameness is likely due to the short duration of the study. Dietary supplementation with marine-based omega-3 fatty acids might be beneficial in chronic laminitis. 018 Equine Insulin Resistance (EIR): private veterinary practice prevention and management learned in over 1,000 cases in the last 3 years Frank K. Reilly Equine Medical & Surgical Associates, West Chester, PA Take-homemessage: With care, it is possible to return the horse to some grass turnout in a safe, practical, and tested manner. Equine Insulin Resistance (EIR) is now the leading cause of laminitis worldwide. Owners, farriers, and veterinarians are seeing an increase in the number of cases and want information on what works and what does not in avoiding EIR, and practical ways to manage the problem. Recent advances in diagnostic testing have helped to identify EIR through blood tests, but widely varying test techniques make it difficult for the owner to understand what the numbers mean. Telling owners to feed lousy hay and keep the horse on a dirt lot is not being accepted as an answer by most owners with EIR horses. The ability to return to some grass turnout in a safe, practical, and tested manner, so that the horse can bewith other horses and not be segregated, is important information.
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