This paper analyses the radiotoxicity of spent nuclear fuel (SNF) of the VVER-1200 reactor after burning the 4.95 w/o UO2 fuel assembly up to 60 GWd/t. The calculated results are presented to display the radiotoxicity of the SNF nuclides in the pool period and the disposal period categorized by their half-lives. In the pool period, initially, very short-lived (VSL) nuclides contribute the most to the total radiotoxicity but their contribution drops to a negligible level (∼3%) after 1 year of cooling. The relative contribution of short-lived (SL) nuclides increases after 17 days of cooling, dominating the total radiotoxicity and this trend continues up to 1 year. After that, the medium-lived (ML) nuclides contribute the most to the total radiotoxicity and remain the highest contributor in the entire pool period (10 years). After pool period, 90% of the total radiotoxicity decreases. The relative contribution of ML nuclides drops to 4% after 500 years of cooling. Subsequently, the long-lived (LL) nuclides dominate the total radiotoxicity At the end of disposal period, the radiotoxicity becomes 99.9% less than the initial radiotoxicity. However, if Pu is removed from the SNF, the radiotoxicity will drop to the radiotoxicity level of natural uranium within 1000 years.