WCN 2013 No: 2302 Topic: 36 — Other Topic Deficits in episodic memory relate to reduced hippocampal volumes in very-low-birth-weight (VLBW) young adults G. Lohaugen, K.J. Bjuland, M. Martinussen, J. Skranes. Child Rehabilitation, Sorlandet Hospital, Arendal, Norway; Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology (NTNU), Trondheim, Norway Background and aims: The hippocampus is regarded as a core structure for learning and memory functions. Academic problems are commonly reported in VLBW (bw ≤ 1500 g) children and adolescents, and the aims of this hospital-based, long-term follow-up study were to perform a comprehensive memory assessment in VLBW young adults and investigate the relationship between hippocampal volume and episodic memory compared to age-matched term born controls. Methods: Forty-two non-disabled VLBW and 61 age-matched controls were examined at age 19 with the WAIS-III, Wechsler Memory Scale-III and cerebral MRI. An automated MRI technique (FreeSurfer ver. 5.1) at 1.5 Tesla for morphometric analysis of hippocampal volumes was applied. Results: The VLBW group was at a disadvantage compared to controls on tests assessing visual immediate/delayed memory and working memory. The VLBW group had similar relative left (mean 0.244 (SE 0.003) mm, p = 0.242) and smaller right (mean: 0.243 (SE 0.004) mm, p = 0.027) hippocampal volumes vs. controls (left 0.249 (SE 0.003) mm; right 0.253 (SE 0.003) mm). Significant correlations were found between left (r = 0.344, p = 0.030) and right (r = 0.038, p = 0.016) relative hippocampal volumes and visual immediate memory. Working memory function was associated with right hippocampal volume (r = 0.392, p = 0.015). Conclusion: We found that being born preterm with VLBW has longterm negative consequences regarding memory functions, persisting into young adulthood. The relative hippocampal volumes were reduced in VLBW young adults compared to term born controls. Positive correlations were found between hippocampal volume and immediate visual and working memory function in the VLBW group. doi:10.1016/j.jns.2013.07.2305 Abstract — WCN 2013 No: 2310 Topic: 36 — Other Topic Oculomotor changes in multiple system atrophy: Clinical, MRI and laboratory features in eight patients WCN 2013 No: 2310 Topic: 36 — Other Topic Oculomotor changes in multiple system atrophy: Clinical, MRI and laboratory features in eight patients G. Lucii, F. Rosini, P. Federighi, E. Pretegiani, F. Giannini, A. Federico, A. Rufa. Eye Tracking & Visual Application Lab EVALab, UOC Neurologia e Malattie Neurometaboliche Dipartimento di Medicina Chirurgia e Neuroscienze, Universita degli Studi di Siena, Siena, Italy; UOC Neurofisiologia Clinica Dipartimento diMedicina Chirurgia e Neuroscienze, Universita degli Studi di Siena, Siena, Italy; c UOC Neurologia e Malattie Neurometaboliche Dipartimento di Medicina Chirurgia e Neuroscienze, Universita degli Studi di Siena, Siena, Italy Background: Multiple system atrophy (MSA) is a progressive adultonset α-synucleinopathy characterized by dysautonomia associated with cerebellar symptoms (MSA-C) or parkinsonism (MSA-P). Ocular motor changes, including saccadic dysmetria, saccadic intrusions and nystagmus, have been reported. Objective: To determine the ocular motor changes in MSA that may differentiate these patients from other neurodegenerative diseases with overlapping clinical features. Methods: Eight patients, six MSA-C and two MSA-P, were recorded. Mean age was 60 ± 3; mean disease duration was 4.87 ± 1.45 years. Horizontal (±10°; ±18°) and vertical (up/down 8°) visually-guided saccades and antisaccades were tested and compared with EVAlab's normative data. Three minutes of steady fixation were performed. Saccadic parameters, antisaccade errors with relative corrections and fixation changes were evaluated. Results: All patients showed significant reduction of amplitude (6.73° ± 2.11° vs 8.3° ± 0.09°)(P value = 0.026), and accuracy (2.01 ± 1.44 vs 1.17 ± 0.49)(P value = 0.004) of downward saccades. Amplitude at 18° of horizontal eccentricity (15.44° ± 2.56° vs 18.3° ± 0.9°) (P value b 0.0001) and accuracy at 10° (2.37 ± 0,86 vs 0.88 ± 0.52) (P value b 0.001) and 18° (4.86 ± 2.21 vs 1.22 ± 0.09)(P value b 0.001) of horizontal saccades were also decreased. Direction error in antisaccade task was about 45% with a 96% of spontaneous fast correction. Steady fixation was interrupted by saccadic intrusions (square wave jerks subtype, average number of 12/min and mean amplitude of 1.52° ± 0.31°). Conclusions: Our findings substantiate peculiar changes of saccade dynamics in MSA. Downward saccades are more impaired than horizontal. Voluntary saccades and fixation are also impaired and lesser than in other similar neurodegenerative diseases. Oculomotor profile helps to differentiate MSA from other neurodegenerative diseases with overlapping clinical features. doi:10.1016/j.jns.2013.07.2306 Abstract — WCN 2013 No: 2272 Topic: 36 — Other Topic Serial magnetic resonance imaging of acute necrotizing myelitis WCN 2013 No: 2272 Topic: 36 — Other Topic Serial magnetic resonance imaging of acute necrotizing myelitis E. Papageorgiou, K. Psychogios, D. Tzanetakos, I. Markakis, I. Xydakis, G. Gekas. Neurology, ‘St. Panteleimon’ General State Hospital, Nikaia,