Abstract This study quantifies tropical cyclone (TC) error statistics from the Hurricane Analysis and Forecast System (HAFS) across different environmental conditions (e.g., vertical wind shear) and inner core structural metrics. A particular focus is the evolution of poorly understood aspects of internal TC structure, including vortex tilt, and their impact on forecast errors. Although previous studies have demonstrated that vortex tilt, vertical wind shear, and precipitation processes impact TC intensity and track, this is the first known study to stratify these cooperative interactions to gain insights on their relationships with forecast errors. A three-year retrospective sample of forecasts in the North Atlantic basin from two HAFS configurations (-A and -B) demonstrates that TCs with larger tilt magnitudes have larger forecast track errors on average than smaller tilt TCs. Smaller tilt magnitudes have larger absolute intensity errors in short range forecasts, whereas larger tilt magnitudes tend to have larger negative intensity biases at medium range. TCs with a tilted vortex are shown to have both left of shear (maximizing DSL) and left of tilt oriented positional track biases. Furthermore, those cases with greater downshear biases tend to have more convection and larger positive intensity biases, highlighting the importance of the interplay between inner core characteristics and forecast errors.