This study investigates the vibration characteristics induced by single-phase flow at low velocities within helical coiled tube, encompassing laminar and turbulent flow transition regimes. Modal experiments were conducted to ascertain the natural frequencies in the radial and vertical directions within the helical coiled tube. The influence of fluid mass in tube on vibration was considered, revealing the fluid mass has a greater influence on the vibration frequency in the vertical direction. When the coil was filled with water, the radial natural frequency decreased by 0.1 Hz, while the vertical natural frequency decreased by 0.8 Hz.By simplifying the spiral coil into a spring system, the intrinsic causes of the influence of mass on the natural frequency are studied and verified with the experimental data. The results show that the radial natural frequency is only related to the local mass change of the pipe, while the vertical natural frequency is related to the static deformation of the system under the influence of gravity.By conducting single-phase flow induced vibration experiments inside the pipeline, the radial and vertical vibration response characteristics were obtained, and the modal experimental results were analyzed. Findings indicated larger vibration displacements when laminar flow prevailed within the tube, with radial RMS (Root Mean Square) at 10.1 μm and vertical RMS at 14.5 μm. After the transition to turbulent flow, significant reductions in vibration displacements were observed, reducing the radial RMS to 2.3 μm and vertical RMS to 5.5 μm.Based on statistical and frequency-domain analysis methods, the influence mechanism of secondary flow on the vibration of helical coils at low flow rates was revealed, and the importance of friction coupling was clarified. Moreover, this study considered the impact of fluid viscosity on vibration response and experimentally validated the critical role of friction coupling in exciting secondary flows.