Prior research reveals that the encoding of affective stimuli is biased in a metaphorically consistent manner (e.g., good = up; bad = down). For example, negative words are evaluated faster if they are presented in a low versus high vertical position. The present studies extended this view by investigating whether such biases also correlate with individual differences in emotional experience. Specifically, in two studies, we examined whether vertical metaphor would be useful in understanding negative affect as manifested in neuroticism and depressive symptoms. We found support for this premise. That is, the higher the neuroticism (Studies 1 and 2) or depressive symptoms (Study 2) of participants, the faster they were to respond to or detect lower (versus higher) spatial attention targets. These results suggest that negative affect in general, and depressive symptoms in particular, appear to bias selective attention in a direction that favors lower regions of physical space.