An interconnection network is usually modeled as a graph, in which vertices and edges correspond to processors and communication links, respectively. Connectivity is an important metric for fault tolerance of interconnection networks. A graph [Formula: see text] is said to be maximally local-connected if each pair of vertices [Formula: see text] and [Formula: see text] are connected by [Formula: see text] vertex-disjoint paths. In this paper, we show that Cayley graphs generated by [Formula: see text]([Formula: see text]) transpositions are [Formula: see text]-fault-tolerant maximally local-connected and are also [Formula: see text]-fault-tolerant one-to-many maximally local-connected if their corresponding transposition generating graphs have a triangle, [Formula: see text]-fault-tolerant one-to-many maximally local-connected if their corresponding transposition generating graphs have no triangles. Furthermore, under the restricted condition that each vertex has at least two fault-free adjacent vertices, Cayley graphs generated by [Formula: see text]([Formula: see text]) transpositions are [Formula: see text]-fault-tolerant maximally local-connected if their corresponding transposition generating graphs have no triangles.