Vertebral Fracture Group Research Articles

老人性骨粗しょう症における椎体圧迫骨折群と大たい骨けい部骨折群との差異

Out of 35 osteoporotic women studied, 13 presented with vertebral compression fractures, 9 with a femoral neck fracture and 13 with both fractures. osteoporotic women with vertebral compression fracture were younger than those with femoral neck fracture or both fractures. The mean value of serum calcium was lower in the women with both fractures than in vertebral compression fracture group. Two densitometric parameters (GSmin. and Sigma GS/D) which indicated the bone density in the diaphysis of the 2nd metacarpus, showed lower value in the women with both fractures than in the vertebral compression fracture group.In conclusion, these results show that, vertebral compression fracture and femoral neck fracture in senile osteoporosis occur in different age groups with different cortical bone density.

Androgen and estrogen dynamics in women with vertebral crush fractures

Using constant infusions of [ 3h]androgen/[ 14c]estrogen we measured metabolic clearance and production rates and aromatization of androgens to estrogens in post-menopausal women with vertebral crush fractures and compared these results to similar measurements in a similar population of postmenopausal women who did not have vertebral crush fractures. The mean ±SEM values for the metabolic clearance rates of testosterone and estrone, 220±10 and 880±50 1/day per m 2, were significantly less in the crush fracture group than the respective mean values in the control group, 280±15 and 1110±70 1/day per m 2. The mean concentration of estradiol was higher in the crush fracture group, 18±2 pg/ml, compared to that in the control group, 13±1 pg/ml. However, for the crush fracture group the mean blood production rates of both androstenedione, 0.7±0.1 mg/day, and testosterone, 56±9 μg/day, were significantly less than the respective values in the control group, 1.2±0.2 mg/day and 115±15 μg/day. The production rates for estrone and estradiol were not different for the two groups. In addition the mean value for the fraction of adrostenedione converted to testosterone ([ϱ] BB A.T) was lower in the crush fracture, 0.030±0.002 compared to the control group, 0.041±0.004. Thus the amount of biologically available androgen is less in the vertebral crush fracture group than in the control group. However, since these measurements represent an isolated point temporally removed from major changes in bone morphology, their exact relationship to the crush fracture and osteoporotic process remains uncertain.

The assessment of postmenopausal osteoporosis by total body neutron activation analysis

Total body calcium (TBCa) was measured using a cyclotron for in vivo neutron activation analysis (IVNAA) in 20 healthy women, 15 women with vertebral compression fractures, and 8 women with wrist fractures. The precision of the technique, using phantoms, was 1.8% for a dose of 13 mSv. A formula for predicted TBCa (TBCaP) was derived from the 20 normal women based on span and years postmenopause. The coefficient of variation of TBCa after normalization in the normal women was 6.6%. The mean TBCa values for the vertebral and wrist fracture groups were 69% and 84% of TBCa p for women at the time of the menopause. The low TBCa in the wrist fracture group was attributable to postmenopausal bone loss. Of the low TBCa in the vertebral fracture group, about half the loss could be attributed to postmenopausal age and half to other factors.