Recently, many cervical total disc replacement (TDR) devices have been introduced in a variety of designs in an attempt to recreate motion behavior of the normal cervical spine thereby to limit the progression of adjacent degeneration. The purposes of this study were to evaluate and compare the range of motion (ROM) and location of instant center of rotation (COR), and load sharing characteristics of two major products with different design concepts in cervical TAR-Prodisc-C® and Prestige-LP®. A 3-D finite element (FE) model of intact cervical spine (C3-6) was made from CT scans of a normal person and validated. Based on this model, postoperative FE models simulating TDR implantation at the C4-5 disc space were made for Prodisc-C® (Synthes Spine, Paoli, PA) and Prestige-LP® (Medtronic Sofamor Danek, Memphis, TN), respectively. These two TDR devices feature different design concepts that affect kinematics: Rotations and some translations were allowed at the articulating surface of Prestige LP® as the ‘concave down’ articulating surface is less constrained whereas only rotations were allowed with Prodisc-C® that features ball & socket articulating surface in ‘concave up’ orientation. Hybrid protocol (intact: 1Nm) with a compressive follower load of 73.6N were applied at the superior endplate of the C3 vertebral body. The inferior endplate of C6 vertebral body was constrained in all directions. At the index level, Prestige-LP® showed 15% less motion than Prodisc-C® in extension and about the same in flexion. Differences in ROM were negligible at the adjacent level. Here, the COR of Prestige-LP® was located more postero-inferiorly than that of Prodisc-C® by about 1-mm during extension at the index level. Facet load was less with Prestige-LP® by about 10% at the index level but 14% more at the adjacent level. The results of this study indicated that the biomechanical behavior of the postoperative cervical spine can be indeed influenced by the design features such as concavity orientation and extent of constraint of the articulating surfaces. Particularly, ROM and COR location as well as the facet loads at the index level and adjacent levels were more sensitive during extension. It would be interesting to note that resulting differences in facet load at the index and adjacent levels between the two designs will manifest to different clinical results in terms of postoperative facet degeneration.