Verrucous Papules Research Articles

Genital benign chronic pemphigus (Hailey-Hailey disease) presenting as condylomas

Genital lesion sof benign chronic pemphigus (FBCP)(Hailey-Hailey disease) may present as verrucous papules. Genital warts and papular acantholytic dyskeratosis of the genitalia may be considered in the differential diagnosis. Our purpose was to describe the clinical characteristics and histologic features of verrucous anogenital FBCP. Six patients, five women and one man, with verrucous anogenital lesions of FBCP, initially diagnosed as warts, were examined and biopsy specimens were evaluated histologically. The lesions were located exclusively in the perineal and perianal regions with axillary involvement in one case. Family history was negative in three of the six cases. Histologic examination confirmed the diagnosis of FBCP but was significant for the absence of crusts and the presence of only minimal inflammation. Our cases and the literature are reviewed with the conclusion that all verrucoid genital lesions with the histologic characteristics of Hailey-Hailey disease may represent FBCP.

Linear Epidermal Nevus with Acantholytic Dyskeratosis in an Infant

A 7-month-old boy came to use with flat papules and small erosions on the extensor aspect of his left forearm and a linear arrangement of verrucous papules on the dorsum of his left hand. Histological examination revealed hyperkeratosis, parakeratosis, irregular acanthosis, and marked acantholysis from suprabasal through upper epidermis. This is the first reported case of linear epidermal nevus with acantholytic dyskeratosis in Japan.

Cowden's Disease with Associated Malignant Melanoma

Cowden's disease (multiple hamartoma syndrome), a rare genodermatosis, is inherited in an autosomal-dominant genetic pattern. It is characterized by mesodermal and epithelial hamartomas appearing as verrucous papules occurring predominantly over the central portion of the face, with perioral and acral papular lesions and papillomatosis of the lips, gingiva, and tongue extending through the entire length of the gastrointestinal tract. These skin lesions have been found to be associated with a number of benign and malignant tumors involving the breast, thyroid, skin, ovaries, adipose tissue, and gastrointestinal tract. The authors report the second case of Cowden's disease associated with malignant melanoma and emphasize the need for a high index of suspicion for related benign or malignant tumors in these cases.

Cowden's Disease: A Case Report and Review of the Literature

Cowden's disease is one of the rare genodermatoses. The most characteristic findings in this disease are cutaneous and oral lesions that are widespread papillomas and verrucous papules. On the palms the lesions are keratoses. Aside from these findings, this syndrome complex is sooner or later associated with various internal abnormalities involving the mammary, thyroid, gastrointestinal, reproductive and skeletal systems. In the 28 reported cases, 13 cancers have been found, most of the breasts. Because of the characteristic cutaneous and oral lesions, it is possible to recognize this disease early and then to follow afflicted patients closely for the possibility of development of cancers or other abnormalities of other organs.

Angiokeratoma corporis diffusum--a case report.

The case of angiokeratoma corporis diffusum here described is believed to be the fifth reported in this country. The patient, a Caucasoid man, was admitted to the hospital at the age of 23 years, with a neurological finding of left hemianesthesia. The dermatological symptoms had appeared at the age of 18 months in the form of many dark red, non-blanching, verrucous papules measuring from 0.5 to 4 mm. in diameter. They became larger, darker, and more numerous during his childhood. Their angiokeratomatous nature was recognized at biopsy. The underlying pathology is a thickening of arterial walls, the muscle cells of the tunica media being enlarged. Since the cardiovascular, renal, respiratory, and nervous systems all become involved, the symptoms are varied. The prognosis is poor, and the cause is unknown.