Verification Of Status Research Articles

The first international competition on computational models of argumentation: Results and analysis

We report on the First International Competition on Computational Models of Argumentation (ICCMA'15) which took place in the first half of 2015 and focused on reasoning tasks in abstract argumentation frameworks. Performance of submitted solvers was evaluated on four computational problems wrt. four different semantics relating to the verification of the acceptance status of arguments, and computing jointly acceptable sets of arguments. In this paper, we describe the technical setup of the competition, and give an overview on the submitted solvers. Moreover, we report on the results and discuss our findings.

Cytology versus HPV testing for cervical cancer screening in the general population.

Cervical cancer screening has traditionally been based on cervical cytology. Given the aetiological relationship between human papillomavirus (HPV) infection and cervical carcinogenesis, HPV testing has been proposed as an alternative screening test. To determine the diagnostic accuracy of HPV testing for detecting histologically confirmed cervical intraepithelial neoplasias (CIN) of grade 2 or worse (CIN 2+), including adenocarcinoma in situ, in women participating in primary cervical cancer screening; and how it compares to the accuracy of cytological testing (liquid-based and conventional) at various thresholds. We performed a systematic literature search of articles in MEDLINE and Embase (1992 to November 2015) containing quantitative data and handsearched the reference lists of retrieved articles. We included comparative test accuracy studies if all women received both HPV testing and cervical cytology followed by verification of the disease status with the reference standard, if positive for at least one screening test. The studies had to include women participating in a cervical cancer screening programme who were not being followed up for previous cytological abnormalities. We completed a 2 x 2 table with the number of true positives (TP), false positives (FP), true negatives (TN), and false negatives for each screening test (HPV test and cytology) used in each study. We calculated the absolute and relative sensitivities and the specificities of the tests for the detection of CIN 2+ and CIN 3+ at various thresholds and computed sensitivity (TP/(TP + TN) and specificity (TN/ (TN + FP) for each test separately. Relative sensitivity and specificity of one test compared to another test were defined as sensitivity of test-1 over sensitivity of test-2 and specificity of test-1 over specificity of test-2, respectively. To assess bias in the studies, we used the Quality Assessment of Diagnostic test Accuracy Studies (QUADAS) tool. We used a bivariate random-effects model for computing pooled accuracy estimates. This model takes into account the within- and between-study variability and the intrinsic correlation between sensitivity and specificity. We included a total of 40 studies in the review, with more than 140,000 women aged between 20 and 70 years old. Many studies were at low risk of bias. There were a sufficient number of included studies with adequate methodology to perform the following test comparisons: hybrid capture 2 (HC2) (1 pg/mL threshold) versus conventional cytology (CC) (atypical squamous cells of undetermined significance (ASCUS)+ and low-grade squamous intraepithelial lesions (LSIL)+ thresholds) or liquid-based cytology (LBC) (ASCUS+ and LSIL+ thresholds), other high-risk HPV tests versus conventional cytology (ASCUS+ and LSIL+ thresholds) or LBC (ASCUS+ and LSIL+ thresholds). For CIN 2+, pooled sensitivity estimates for HC2, CC and LBC (ASCUS+) were 89.9%, 62.5% and 72.9%, respectively, and pooled specificity estimates were 89.9%, 96.6%, and 90.3%, respectively. The results did not differ by age of women (less than or greater than 30 years old), or in studies with verification bias. Accuracy of HC2 was, however, greater in European countries compared to other countries. The results for the sensitivity of the tests were heterogeneous ranging from 52% to 94% for LBC, and 61% to 100% for HC2. Overall, the quality of the evidence for the sensitivity of the tests was moderate, and high for the specificity.The relative sensitivity of HC2 versus CC for CIN 2+ was 1.52 (95% CI: 1.24 to 1.86) and the relative specificity 0.94 (95% CI: 0.92 to 0.96), and versus LBC for CIN 2+ was 1.18 (95% CI: 1.10 to 1.26) and the relative specificity 0.96 (95% CI: 0.95 to 0.97). The relative sensitivity of HC2 versus CC for CIN 3+ was 1.46 (95% CI: 1.12 to 1.91) and the relative specificity 0.95 (95% CI: 0.93 to 0.97). The relative sensitivity of HC2 versus LBC for CIN 3+ was 1.17 (95% CI: 1.07 to 1.28) and the relative specificity 0.96 (95% CI: 0.95 to 0.97). Whilst HPV tests are less likely to miss cases of CIN 2+ and CIN 3+, these tests do lead to more unnecessary referrals. However, a negative HPV test is more reassuring than a negative cytological test, as the cytological test has a greater chance of being falsely negative, which could lead to delays in receiving the appropriate treatment. Evidence from prospective longitudinal studies is needed to establish the relative clinical implications of these tests.

Discriminating between Anxious and Non-Anxious Subjects Using the Toronto Hospital Alertness Test.

Alertness designates the internal feeling of wakefulness or arousal and is often described to be linked to the level of anxiety. An adequate level of anxiety favoring the alertness needed to deal with a faced specific situation efficiently; too much anxiety can result in failure to process information and respond appropriately. Thus, it would be of interest to verify if different alertness profiles can be observed depending on anxiety level. The Toronto Hospital Alertness Test (THAT) is a test designed to measure alertness. The present survey's aim is to verify if the THAT allows observing different alertness profile between self-described anxious and non-anxious subjects. Subjects >18 years were selected from online databases in three countries (Canada, USA, and UK). All respondents filled in a Hospital Anxiety Depression Scale questionnaire, and only those self-classified as anxious or non-anxious (HAD-A ≥11 or ≤7, respectively) took part to the survey and were asked to complete the THAT. Among 616 respondents retained in the survey, 414 were self-assessed as anxious and 202 as non-anxious. The mean THAT score for anxious and non-anxious subjects was 21.4 and 38.9, respectively. A receiver operating characteristic (ROC) curve of THAT scores indicated that a threshold score of 30 was required to achieve good sensitivity (86.7%) and specificity (88.6%), with good discriminatory power [an area under the curve (AUC) of 0.938]. As age was determined to be a potential confounder, subjects were age-matched giving a ROC with an AUC of 0.931, with good sensitivity (88.5%) and specificity (89.3%), and the threshold remaining at 30. The internal reliability of THAT in anxious subjects was good (Cronbach alpha = 0.84). No independent verification of anxious or non-anxious status or other eligibility criteria was done. The alertness profiles of self-defined anxious and non-anxious subjects observed on THAT are different. Based on a subject's alertness profile, it is possible to discriminate between self-defined anxious and non-anxious, using THAT, with good specificity and sensitivity at a threshold score of 30.

Factors influencing HPV vaccine delivery by healthcare professionals at public health posts in São Paulo, Brazil.

To assess the association between Brazilian healthcare providers' characteristics and their knowledge, perceptions, and practices regarding the HPV vaccine. An observational cross-sectional study was conducted at five public health posts in São Paulo between July 28 and August 8, 2014. Healthcare professionals directly involved in patient care were asked to complete a written survey. Factors associated with routine verification of HPV vaccination status were evaluated using Poisson regression. Among 200 participants included, 74 (38.5%) reported never and 70 (36.5%) reported always asking about HPV immunization status. Doctors were significantly less likely to report always asking than were community health agents (5/39 [12.8%] vs 32/60 [53.3%]; adjusted prevalence ratio [aPR] 0.25 [95% confidence interval (CI) 0.07-0.91]). Knowledge about the correct dosing schedule was associated with always rather than never verifying vaccination status (aPR 2.46 [95% CI 1.06-5.70]). Knowledge and attitude played secondary roles in influencing HPV vaccine verification. Community health agents were crucial for vaccine promotion; continued education and support of this group is essential for the sustained success of HPV immunization efforts in Brazil.

Investigation of chlorinated solvent pollution with resistivity and induced polarization

Globally, an enormous number of polluted areas are in need of remediation to prevent adverse effects on health and environment. In situ remediation and especially the monitoring thereof needs further development to avoid costly and hazardous shipments associated with excavation. The monitoring of in situ remediation actions needs easier and cheaper nondestructive methods for evaluation and verification of remediation degree and degradation status of the contaminants. We investigate the Direct Current resistivity and time-domain Induced Polarization tomography (DCIP) method and its use within the context of a DNAPL (Dense Non-Aqueous Phase Liquids) contaminated site in Varberg, Sweden, where an in situ remediation pilot test has been performed by stimulated reductive dechlorination by push injection. Our results show that the DCIP technique is an emerging and promising technique for mapping of underground structures and possibly biogeochemical spatial and temporal changes. The methodology could in combination with drilling, sampling and other complementary methods give an almost continuous image of the underground structures and delineation of the pollutant situation. It can be expected to have a future in monitoring approaches measuring time lapse induced polarization (IP), if more research is performed on the parameters and processes affecting the IP-signals verifying the interpretations. The IP technique can possibly be used for verification of the effectiveness of in situ remediation actions, as the current sampling methodology is inadequate.

Three-step method for menstrual and oral contraceptive cycle verification.

Fluctuating endogenous and exogenous ovarian hormones may influence exercise parameters; yet control and verification of ovarian hormone status is rarely reported and limits current exercise science and sports medicine research. The purpose of this study was to determine the effectiveness of an individualised three-step method in identifying the mid-luteal or high hormone phase in endogenous and exogenous hormone cycles in recreationally-active women and determine hormone and demographic characteristics associated with unsuccessful classification. Cross-sectional study design. Fifty-four recreationally-active women who were either long-term oral contraceptive users (n=28) or experiencing regular natural menstrual cycles (n=26) completed step-wise menstrual mapping, urinary ovulation prediction testing and venous blood sampling for serum/plasma hormone analysis on two days, 6-12days after positive ovulation prediction to verify ovarian hormone concentrations. Mid-luteal phase was successfully verified in 100% of oral contraceptive users, and 70% of naturally-menstruating women. Thirty percent of participants were classified as luteal phase deficient; when excluded, the success of the method was 89%. Lower age, body fat and longer menstrual cycles were significantly associated with luteal phase deficiency. A step-wise method including menstrual cycle mapping, urinary ovulation prediction and serum/plasma hormone measurement was effective at verifying ovarian hormone status. Additional consideration of age, body fat and cycle length enhanced identification of luteal phase deficiency in physically-active women. These findings enable the development of stricter exclusion criteria for female participants in research studies and minimise the influence of ovarian hormone variations within sports and exercise science and medicine research.

Smoking relapse-prevention intervention for cancer patients: Study design and baseline data from the surviving SmokeFree randomized controlled trial

Continued smoking after a cancer diagnosis contributes to several negative health outcomes. Although many cancer patients attempt to quit smoking, high smoking relapse rates have been observed. This highlights the need for a targeted, evidence-based smoking-relapse prevention intervention. The design, method, and baseline characteristics of a randomized controlled trial assessing the efficacy of a self-help smoking-relapse prevention intervention are presented. Cancer patients who had recently quit smoking were randomized to one of two conditions. The Usual Care (UC) group received the institution's standard of care. The smoking relapse-prevention intervention (SRP) group received standard of care, plus 8 relapse-prevention booklets mailed over a 3month period, and a targeted educational DVD developed specifically for cancer patients. Four hundred and fourteen participants were enrolled and completed a baseline survey. Primary outcomes will be self-reported smoking status at 6 and 12-months after baseline. Biochemical verification of smoking status was completed for a subsample. If found to be efficacious, this low-cost intervention could be easily disseminated with significant potential for reducing the risk of negative cancer outcomes associated with continued smoking.

Farm characteristics and perceptions regarding costs contribute to the adoption of biosecurity in Finnish pig and cattle farms

The goal of this study was to estimate how the perceived costs of biosecurity measures and the characteristics of the farm and the producer influence the adoption of four biosecurity measures: (1) the use of protective clothing when entering an animal shelter and (2) the use of protective shoes when entering an animal shelter, (3) the verification of the health status of animals coming to the farm, and (4) the use of a carcass container to temporarily store dead animals at the farm. Questionnaire data from 852 Finnish livestock farms were analysed by a logistic regression model. The higher the producers perceived the cost of the biosecurity measure the less likely they were to adopt that measure. However, this response was inelastic. The results suggest that the use of biosecurity could be promoted by providing producers with economic incentives to follow stricter biosecurity policy. University education and the producer’s activity to maintain his/her professional knowledge had a positive effect on the adoption of biosecurity measures. Also factors such as the producer’s gender, farm size and production type contributed significantly to the adoption of biosecurity measures. The ongoing structural change in the livestock sector likely increases the use of biosecurity measures as larger farms were more likely to adopt biosecurity measures.

Survey among Hospitals on Strategies to Ensure Appropriate Use of Intravenous Acetaminophen.

*Assistant Professor, Institute for Healthcare Delivery Science, Department of Population Health Science & Policy, Icahn School of Medicine at Mount Sinai, New York; †Drug Information Clinical Pharmacy Coordinator, Department of Pharmacy, The Mount Sinai Hospital, New York; ‡Professor of Biostatistics and Director, Institute for Healthcare Delivery Science, Department of Population Health Science & Policy, Icahn School of Medicine at Mount Sinai, New York; §Chief Pharmacy Officer, Department of Pharmacy, The Mount Sinai Hospital, New York. *Corresponding author: Jashvant Poeran, MD, PhD, Institute for Healthcare Delivery Science, Department of Population Health Science & Policy, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue (Box 1077), New York, NY 10029; phone: 212-659-9650; fax: 212-423-2998; e-mail: jashvant.poeran@ mountsinai.org To the Editor: In November 2010, the US Food and Drug Administration (FDA) approved the intravenous formulation of acetaminophen (IV APAP). Its use appeared particularly promising in the postoperative setting as a means to reduce opioid consumption. However, the utility of IV APAP relative to the rectal and oral formulation has been the subject of discussion and ongoing study.1 After a price increase in May 2014, many institutions have been evaluating IV APAP to ensure its appropriate use and role in multimodal pain management. To get a better understanding of the different approaches utilized in institutions throughout the country, a 5-question electronic memberinitiated survey was distributed through the University HealthSystem Consortium (UHC) Pharmacy Council listserver on January 28, 2015 and closed on February 18, 2015. UHC comprises 117 academic medical centers as well as more than 328 of their affiliated hospitals. We received a reply from 65 recipients, with the majority of hospitals (n = 25; 38%) located in the nor theast United States and with a bed size of more than 500 beds (n = 37; 57%) (Table 1). In 54 (83%) hospitals, IV APAP was on formulary before May 2014; 16 (30%) of these indicated that it was removed from formulary, whereas 22 (41%) reported new restrictions to ensure proper utilization. Respondents were asked to describe the specific IV APAP restrictions at their institution that were put in place after May 2014. The majority described a restriction to nothing-by-mouth (NPO) or nothing-per-rectum (NPR) patients (n = 31; 70%) and restrictions related to the duration of an IV APAP order, most often 24 or 48 hours (n = 29; 66%). We believe the results of this survey would be beneficial to institutions looking for strategies to ensure the appropriate use of IV APAP. In addition to the nature of the restrictions imposed in other hospitals, the survey also yielded some interesting insights into the strategies used. Several hospitals mentioned the verification of NPO status through the existence of active orders for other oral drugs, in which case the IV APAP order was converted into oral. Other useful measures that were mentioned pertained to the sharing of pricing information with prescribing physicians or the adaptation of computerized physician order entry systems to restrict IV APAP orders to a predefined limit of order duration or number of doses. Given the ongoing discussion, more evidence on the utility of IV APAP in clinical practice in the United States is needed.

Sustained smoking abstinence is associated with reductions in smoking-specific experiential avoidance among treatment-seeking smokers

Background and objectivesSmoking-specific experiential avoidance is related to the maintenance of cigarette smoking. However, it is unclear whether sustained smoking abstinence is associated with subsequent reductions in smoking-specific experiential avoidance. MethodsDaily smokers (n = 149) underwent a cessation attempt in the context of a 4-session smoking cessation treatment trial. Participants provided biochemical verification of smoking status at 1 week, 2 weeks, and 1 Month post-quit day. Smoking-specific experiential avoidance was assessed per the Avoidance and Inflexibility Scale (AIS) – the total score and two factor scores were examined at 1 Month post-quit day as a function of abstinence status. Two path models were conducted and included participant sex, treatment condition, and pre-cessation nicotine dependence, smoking-specific experiential avoidance, and presence of emotional disorders as covariates. ResultsAfter adjusting for covariates, sustained smoking abstinence was associated with a reduction in the AIS total score at Month 1 post-quit (β = −.45, p < .001). Sustained smoking abstinence was associated with reductions across both facets of experiential avoidance -- smoking-related thoughts and feelings (β = −.44, p < .001) and internal bodily sensations (β = −.41, p < .001). LimitationsBiochemical verification of smoking status was confirmed only at three time points post-quit day, and continued abstinence throughout the one-month post-quitting period is not fully known. ConclusionsSustained smoking abstinence may contribute to reductions in smoking-specific experiential avoidance. Findings add to the research documenting the relevance of experiential avoidance in various processes of smoking (including smoking abstinence).

An integrative description of Macrobiotus paulinae sp. nov. (Tardigrada: Eutardigrada: Macrobiotidae: hufelandi group) from Kenya.

In this paper we describe Macrobiotus paulinae, a new species of the hufelandi group from the Kenyan highlands. In addition to the traditional taxonomic description, aided with morphometrics as well as light and scanning microscopy imaging, we also provide nucleotide sequences of three nuclear (18S rRNA, 28S rRNA, ITS-2) and one mitochondrial (COI) DNA fragment of the new species. The sequences allowed not only a more accurate description but also provided an independent verification of the taxonomic status of Ma. paulinae sp. nov. Such integrative approach requires a considerable number of individuals and eggs, which we have partially subsidised by employing an in vitro culture of the new species. Our analyses revealed that Ma. paulinae sp. nov. is most similar to Macrobiotus madegassus Maucci, 1993 and Macrobiotus modestus Pilato & Lisi, 2009, however it differs from these species, as well as from all other known species of the hufelandi group, by the presence of seven paired dorso-lateral patches of cuticular granulation and the presence of chorionic filaments growing out of terminal discs of egg processes. Macrobiotus paulinae sp. nov. is an example of a species with a miniaturised buccal apparatus (i.e. with reduced peribuccal lamellae and oral cavity armature, and stylet supports inserted on the buccal tube more anteriorly than in typical Ma. hufelandi group species), and it therefore resembles two recently described two-macroplacoided Minibiotus species: Mi. acadianus Meyer & Domingue, 2011 and Mi. julianae Meyer, 2012. The re-examination of the type material for these two species confirmed that they are equipped with peribuccal lamellae and therefore we transfer them to the genus Macrobiotus, specifically to the hufelandi group.

Sensitive Detection of Deliquescent Bacterial Capsules through Nanomechanical Analysis.

Encapsulated bacteria usually exhibit strong resistance to a wide range of sterilization methods, and are often virulent. Early detection of encapsulation can be crucial in microbial pathology. This work demonstrates a fast and sensitive method for the detection of encapsulated bacterial cells. Nanoindentation force measurements were used to confirm the presence of deliquescent bacterial capsules surrounding bacterial cells. Force/distance approach curves contained characteristic linear-nonlinear-linear domains, indicating cocompression of the capsular layer and cell, indentation of the capsule, and compression of the cell alone. This is a sensitive method for the detection and verification of the encapsulation status of bacterial cells. Given that this method was successful in detecting the nanomechanical properties of two different layers of cell material, i.e. distinguishing between the capsule and the remainder of the cell, further development may potentially lead to the ability to analyze even thinner cellular layers, e.g. lipid bilayers.

Systematic Review of Tobacco Use after Lung or Head/Neck Cancer Diagnosis: Results and Recommendations for Future Research.

Tobacco use after cancer diagnosis is associated with adverse cancer outcomes, yet reliable prevalence estimates for this behavior are lacking. We conducted a systematic literature review of the prevalence of current tobacco use among individuals with a history of lung or head/neck cancer (CRD #42012002625). An extensive search of electronic databases (MEDLINE, EMBASE, Cochrane Library, CINAHL, PsycINFO, and Web of Science) identified 7,777 potentially relevant articles published between 1980 and 2014 and 131 of these yielded pertinent information. Aggregating results across heterogeneous study designs and diverse patient samples, the overall mean prevalence rate of current tobacco use (mostly cigarette smoking) was 33.0% (median, 31.0%). Among current tobacco users at cancer diagnosis, the mean prevalence rate of current tobacco use (mostly cigarette smoking) was 53.8% (median, 50.3%). In many cases, an operational definition of "current" tobacco use was absent, and biochemical verification of self-reported smoking status was infrequent. These and other observed methodologic limitations in the assessment and reporting of cancer patients' tobacco use underscore the necessity of uniform tobacco use assessment in future clinical research and cancer care.

Enhancing the Security of Vehicles and the Work of the DVLA Using GSM/SMS Technologies

Vehicle theft is seen as occurring almost on daily basis. From the survey carried out for this research, over 90 percent of respondents testified to its existence. This research took a closer look at collaborations of Driver and Vehicle Licensing Authority and the Security Services in combating this crime. It also sought the readiness of vehicle owners, DVLA and Ghana Police Service to embrace technology integration. A critical look at vehicle security in terms of its theft related problems, the integration of GSM/SMS technology into the Driver and Vehicle Licensing Authority Registration Database, making it easily accessible by the Security Services like the Ghana Police Service for quick and easy verification of driver or vehicle license status as well as the genuineness in relation to the ownership, in the fight against vehicle theft is very vital. Security personnel can send an SMS to the proposed system and instantly get reply containing significant particulars of the Vehicle and the owner.

Sentinel Lymph Node Detection Using Carbon Nanoparticles in Patients with Early Breast Cancer.

PurposeCarbon nanoparticles have a strong affinity for the lymphatic system. The purpose of this study was to evaluate the feasibility of sentinel lymph node biopsy using carbon nanoparticles in early breast cancer and to optimize the application procedure.MethodsFirstly, we performed a pilot study to demonstrate the optimized condition using carbon nanoparticles for sentinel lymph nodes (SLNs) detection by investigating 36 clinically node negative breast cancer patients. In subsequent prospective study, 83 patients with clinically node negative breast cancer were included to evaluate SLNs using carbon nanoparticles. Another 83 SLNs were detected by using blue dye. SLNs detection parameters were compared between the methods. All patients irrespective of the SLNs status underwent axillary lymph node dissection for verification of axillary node status after the SLN biopsy.ResultsIn pilot study, a 1 ml carbon nanoparticles suspension used 10–15min before surgery was associated with the best detection rate. In subsequent prospective study, with carbon nanoparticles, the identification rate, accuracy, false negative rate was 100%, 96.4%, 11.1%, respectively. The identification rate and accuracy were 88% and 95.5% with 15.8% of false negative rate using blue dye technique. The use of carbon nanoparticles suspension showed significantly superior results in identification rate (p = 0.001) and reduced false-negative results compared with blue dye technique.ConclusionOur study demonstrated feasibility and accuracy of using carbon nanoparticles for SLNs mapping in breast cancer patients. Carbon nanoparticles are useful in SLNs detection in institutions without access to radioisotope.

Decrypting Cryptic Click Beetle Species by Analysis of Sex Pheromones.

Despite sex pheromones being highly species specific, their use as phylogenetic characters and a tool for the verification of species status are still relatively few compared to use of morphological and molecular characters. Earlier studies revealed that within the click beetle species Idolus picipennis, two types can be separated based on pheromone composition. Gas chromatography/mass spectrometry analysis of pheromone from a third type of Idolus revealed the presence of geranyl hexanoate and geranyl octanoate in a ratio of ca. 1:9. Neryl esters and farnesyl esters, present in the glands of the other two species, are absent in this type. In field experiments, males of all three types were attracted specifically to synthetic mixtures of pheromone resembling their own females. This suggests that cross attraction among different types is unlikely and indicates that they are likely distinct species. Using the large numbers of male beetles caught in pheromone traps, morphological differences between the species were studied and an identification key derived. This study highlights the role of sex pheromones as a powerful tool in integrative taxonomy and systematics to study the phylogenetic position and evolution of taxa and to determine the taxonomic status of cryptic species.

Immunogenetic influences on acquisition of HIV-1 infection: consensus findings from two African cohorts point to an enhancer element in IL19 (1q32.2).

Numerous reports have suggested that immunogenetic factors may influence HIV-1 acquisition, yet replicated findings that translate between study cohorts remain elusive. Our work aimed to test several hypotheses about genetic variants within the IL10-IL24 gene cluster that encodes interleukin (IL)-10, IL-19, IL-20, and IL-24. In aggregated data from 515 Rwandans and 762 Zambians with up to 12 years of follow-up, 190 single nucleotide polymorphisms (SNPs) passed quality control procedures. When HIV-1-exposed seronegative subjects (n = 486) were compared with newly seroconverted individuals (n = 313) and seroprevalent subjects (n = 478) who were already infected at enrollment, rs12407485 (G>A) in IL19 showed a robust association signal in adjusted logistic regression models (odds ratio = 0.64, P = 1.7 × 10−4, and q = 0.033). Sensitivity analyses demonstrated that (i) results from both cohorts and subgroups within each cohort were highly consistent; (ii) verification of HIV-1 infection status after enrollment was critical; and (iii) supporting evidence was readily obtained from Cox proportional hazards models. Data from public databases indicate that rs12407485 is part of an enhancer element for three transcription factors. Overall, these findings suggest that molecular features at the IL19 locus may modestly alter the establishment of HIV-1 infection.

Psychomotor Performance Monitoring System in the Context of Fatigue and Accident Prevention

Perfecting modern design of technical objects highlights the long-known truth that the human is the most unreliable link in the human-technical object system. However, this is a superficial finding not taking into account the root cause of human error – non-ergonomic working conditions. The desire to improve this situation by increasingly including ergonomic requirements, such as in the design of equipment interfaces, brings significant results. Suitable reduction of fatigue of varying nature, in many cases leads to a reduction in the number of errors among equipment operators. The system model assumes the possibility of a verification of psychomotor status in the workplace directly on the job, not relying on the test results to resume work and only allowing the diagnosis of an undesirable condition. The model is based on, among others, Fitts’ Law. The testing software is a form of web application. Each user has an account on which the results are collected and form the basis for drawing conclusions about the state of fatigue. It is necessary therefore to assume that for dedicated positions there is no risk of distraction by the need for an additional device. Time spent on the task cannot be reduced by the tasks resulting from work. The paradigmatic example of the application of this method can be demonstrated in a study of urban transport vehicles before leaving the initial stop. A study of psychomotor skills can be used as an alternative to the fairly common in some countries testing of alcohol content in exhaled air. There are also breathalyzers integrated in such a way with control of the vehicle, that it is only after the verification of sobriety that one can start the vehicle. There are also no reasons that this check cannot warrant a short psychomotor test.

Risks of lending to small enterprises in the Republic of Serbia

Bearing in mind the major risks of lending to small enterprises and entrepreneurs in Serbia, this paper analyzes this problem and presents the concrete activities that commercial banks should undertake to mitigate these risks. After analyzing the business environment in Serbia and the current lending practice, we have concluded that in the process of approving loan applications, without exception, the following analyses and activities need to be undertaken: verification of the client's status, financial analysis of the entrepreneurial business, analysis of the entrepreneur's business operations, assessment of how regularly the entrepreneur settles his liabilities, analysis of risks entailed by the bank's offer (i.e. the set of products), evaluation of loan collaterals, currency risk of lending to the business, and risks of lending to a start-up entrepreneurial business. Similar studies were conducted in the United States, yet this particular analysis focuses on the needs and practices of the banking sector in Serbia, with the aim of suggesting to commercial banks to implement the above stated activities and analyses persistently and comprehensively, putting them ahead of accelerated lending procedures, acquisitions and sound, short-term business results.

Longitudinal gender differences in HIV and criminal justice outcomes

Longitudinal gender differences in HIV and criminal justice outcomes