Effects Of Ventilation Research Articles

Pressure Control Ventilation Versus Volume Control Ventilation in Laparoscopic Surgery: A Narrative Review.

This review compares the safety and effectiveness of volume control ventilation (VCV) and pressure control ventilation (PCV) during laparoscopic surgery. Nine studies were chosen for in-depth examination following the application of stringent inclusion and exclusion criteria to the 184 publications that the literature search turned up. PCV is well-known for its capacity to preserve lower peak airway pressures during laparoscopic procedures, lowering the risk of volutrauma and barotrauma and enhancing oxygenation under these conditions of elevated intra-abdominal pressures. On the other hand, VCV guarantees a constant tidal volume and offers accurate ventilation management, both of which are essential for preserving stable carbon dioxide levels. VCV, however, may result in higher peak airway pressures, raising the risk of lung damage brought on by a ventilator. Research indicates that PCV provides better respiratory mechanics management during laparoscopic surgery, but VCV consistent tidal volume delivery is useful in some clinical situations. When choosing between PCV and VCV, the anesthesia team's experience, the demands of each patient, and the surgical circumstances should all be taken into consideration. Real-time monitoring tools and sophisticated ventilatory technology are essential for maximizing ventilation techniques. Further improving patient outcomes can be achieved by incorporating multimodal anesthesia approaches, such as the use of muscle relaxants and customized intraoperative fluid management. Muscle relaxants optimize conditions for mechanical ventilation by ensuring adequate muscle relaxation, reducing the risk of ventilator-associated lung injury, and enabling more precise control of ventilation parameters. Tailored intraoperative fluid management helps maintain optimal lung mechanics by avoiding fluid overload, which can lead to pulmonary edema and compromised gas exchange, necessitating adjustments in ventilation strategy. While both ventilation modalities can be utilized efficiently, the research suggests that PCV may be more advantageous in controlling oxygenation and airway pressures. In the dynamic and demanding world of laparoscopic surgery, ongoing research and clinical innovation are crucial to improving these tactics and guaranteeing the best possible treatment. In order to obtain the best possible patient outcomes during laparoscopic surgeries, this review emphasizes the significance of customized breathing techniques.

Airflow and aerosol transport in the hospital isolation zone based on dynamic scenarios

To contain the leakage of viral aerosols, buffer rooms are usually provided in front of isolation wards. However, dynamic events of door movement and healthcare worker (HCW) walking will result in highly concentrated aerosols intruding into the buffer room from the ward, challenging the control of virus transmission risk. In this work, airflow exchange and bioaerosol particle transport between the negative-pressure isolation ward and the buffer room under dynamic scenarios were studied by transient computational fluid mechanics (CFD) simulation, thereby the fate of particles was divided into invasion stage and decay stage. The effects of ventilation pattern and HCW location on the concentration level and attenuation trend of particles were quantitatively analyzed. The results showed that increasing the HCW walking distance could increase the peak particle concentration within the buffer room by 4.5 % during the invasion stage. The effect of the buffer room ventilation layout on air exchange and particle transport was more pronounced than the HCW stay position. In the decay stage, the two more effective ventilation layouts could decrease the complete clearance time of particles and the particle concentration in the breathing zone by 31 % and 42 %, respectively. To reduce the infection risk, bioaerosol levels need to be reduced both in the buffer room and in the HCW breathing zone.

Assessing ventilation through ambient carbon dioxide concentrations across multiple healthcare levels in Ghana.

Infection prevention and control (IPC) measures safeguard primary healthcare systems, especially as the infectious disease landscape evolves due to climate and environmental change, increased global mobility, and vaccine hesitancy and inequity, which can introduce unexpected pathogens. This study explores the importance of an "always-on," low-cost IPC approach, focusing on the role of natural ventilation in health facilities, particularly in low-resource settings. Ambient carbon dioxide (CO2) levels are increasingly used as a measure of ventilation effectiveness allowing for spot checks and targeted ventilation improvements. Data were collected through purposive sampling in Northern Ghana over a three-month period. Levels of CO2 ppm (parts per million) were measured by a handheld device in various healthcare settings, including Community-Based Health Planning and Services (CHPS) facilities, municipal and teaching hospitals, and community settings to assess ventilation effectiveness. Analyses compared CO2 readings in community and hospital settings as well as in those settings with and without natural ventilation. A total of 40 facilities were evaluated in this study; 90% were healthcare facilities and 75% had natural ventilation (with an open window, door or wall). Facilities that relied on natural ventilation were mostly community health centers (60% vs 0%) and more commonly had patients present (83% vs 40%) compared with facilities without natural ventilation. Facilities with natural ventilation had significantly lower CO2 concentrations (CO2 ppm: 663 vs 1378, p = 0.0043) and were more likely to meet international thresholds of CO2 < 800 ppm (87% vs 10%, p = <0.0001) and CO2 < 1000 ppm (97% vs 20%, p = <0.0001). The adjusted odds ratio of low CO2 in the natural facilities compared with non-natural were: odds ratios, OR (95% CI): 21.7 (1.89, 247) for CO2 < 800 ppm, and 16.8 (1.55, 183) for CO2 < 1000 ppm. Natural ventilation in these facilities was consistently significantly associated with higher likelihood of low CO2 concentrations. Improved ventilation represents one cost-effective layer of IPC. This study highlights the continuing role natural ventilation can play in health facility design in community health care clinics. Most health facilities met standard CO2 thresholds, particularly in community health facilities. Further research is needed to optimize the use of natural ventilation. The use of a handheld devices to track a simple metric, CO2 levels, could improve appreciation of ventilation among healthcare workers and public health professionals and allow for them to target improvements. This study highlights potential lessons in the built environment of community primary health facilities as a blueprint for low-cost, integrated multi-layer IPC measures to mitigate respiratory illness and anticipate future outbreaks.

Managing SARS-CoV-2 transmission risk in workplace COVID-19 outbreaks.

A Coronavirus disease 2019 (COVID-19) workplace outbreak is a risk to the health of workers and business continuity. To minimise this risk, companies have implemented risk management measures (RMMs) designed to mitigate SARS-CoV-2 transmission within the workforce. The objective of this work was to gather insights into the application of RMMs in non-healthcare workplaces and to improve understanding of the practical barriers to their implementation. Data were collected using a pre-designed framework from 12 volunteer workplaces through discussions with staff responsible for site safety and during site visits to observe the RMMs and work processes. To evaluate ventilation effectiveness, measurements for carbon dioxide (CO2) were taken during the site visit and logged over an extended period in selected occupied areas. RMMs that were implemented well included working at home for office and other non-production staff, provision, and use of face coverings, provision for hand hygiene, and as methods became commonly available, carrying out testing for infected people. However, maintaining adequate physical distancing in many production areas proved difficult because established factory layouts cannot be easily changed and there is often a need for workers to be close to each other to communicate. A major shortcoming identified was the understanding and application of measures to improve workplace ventilation. Rapidly installing and/or upgrading mechanical ventilation systems during a pandemic may not be practical and ideally should be considered in building design. Measuring CO2 in occupied workspaces proved to be a useful tool for identifying areas with potentially inadequate ventilation. Preventing workplace attendance by identifying infected individuals is challenging, making effective RMMs crucial to mitigating virus transmission. The effectiveness of individual RMMs can be uncertain; therefore, it is necessary to adopt multilayered RMMs. Successful implementation relies on measures that are specific to individual workplaces, identified by accurate risk assessment, regularly reviewed for effectiveness, and worker compliance. Establishing suitable risk mitigation policies and providing staff supervision are vital to ensure the sustained and effective implementation of RMMs. For RMMs that require technical understanding, such as workplace ventilation systems, specialist support may be necessary to ensure effective implementation.

A longitudinal study of volatile organic compounds from cooking under ventilation and purification intervention: Health risk assessment and odor nuisance control

Cooking oil fumes (COFs) expose occupants to hazardous air pollutants and nuisance odors, hence the real controlling effects of different intervention methods deserve to be explored. This longitudinal study conducted year-round field measurements in 10 apartments to explore the synergistic effects of dual ventilation and purification interventions on the exposure level, odor intensity, and health risk control of gaseous organic compounds during cooking. Gas chromatography-mass spectrometry (GC‒MS) and high performance liquid chromatography (HPLC) were used for quantification of volatile organic compounds (VOCs) and carbonyls. A total of 59 VOCs were detected during cooking, and the average ΣVOC concentrations in summer, the transition seasons, and winter were 483.16 μg/m3, 233.97 μg/m3, and 282.82 μg/m3, respectively, and the proportion of aldehydes was approximately 50 %. The small temperature differences between the indoors and outdoors led to a 24 % reduction in the effective air changes per hour (ACH) in the summer compared with that in other seasons. The average estimated carcinogenic risks of formaldehyde, acetaldehyde and benzene were 9.20 × 10−5, 1.11 × 10−5, and 6.05 × 10−6, respectively, for daily cooking conditions. It is difficult to guarantee a healthy cooking environment by mechanical ventilation alone. The inhalation carcinogenic risk of these 3 hazardous VOCs was reduced by approximately 130.9 % under air purification intervention but was still greater than 1E-6. The noncarcinogenic risk of acrolein under the different intervention modes ranged from 69.8 to 84.9. Moreover, acetaldehyde and hexanal were found to be the key odorants in kitchen. When the effective exhaust air rate was greater than 12 m3/min with air purifier in operation, the average inhalation health risk was 1.05–1.78 times that before cooking, and more than half of the users would not smell obvious odors during the cooking process. This study quantifies the effectiveness of the synergetic control strategy of independent purification modules combine with kitchen mechanical ventilation, with a view to implementing a healthy & comfortable living environment.

Effects of ventilation on open water characteristics of azimuth propellers under shallow water conditions

Inland waterway vessels can accommodate relatively large propellers due to the specially shaped sterns of these ships. Specifically, they can accommodate up to 20 percent larger diameter propellers, thereby enabling operation without ventilation. However, for an azimuth thruster with a freely positioned propeller, ventilation can occur due to the small distance between the water surface and the propeller. This can lead to dangerous operational situations, such as an inability to maneuver. Systematic investigations comprising model testing and numerical URANS simulations were performed to analyze open water characteristics of a typical azimuth thruster fitted with the newly invented shallow water duct. This so-called shallow water duct was developed to prevent air drawing of the thruster's propeller, i.e., to avoid the inception of propeller free surface ventilation inception (aeration). A typical thruster fitted with this duct was investigated at an immersion depth smaller than the minimum immersion depth recommended by the ITTC for open water tests. Compared to a thruster fitted with a conventional standard duct, the performance of the thruster fitted with this shallow water duct was improved significantly. At lower propeller advance coefficients, especially during bollard pull conditions, it generated more continuous thrust and torque with the propeller operating at the same operating point although, at higher propeller advance coefficients, this duct caused the thruster to act like a break. Especially when fitted with the shallow water duct, thrusters accommodated on inland waterway vessels represent a constructive solution to improve the maneuverability and operational safety of ships navigating in confined waters of limited depth. Fitting the shallow water duct is expected to improve the ability of the thruster to initially accelerate the ship.

The ventilatory effect of High Velocity Nasal Insufflation versus Non-invasive Positive Pressure Ventilation in the treatment of acute hypercapnic respiratory failure in patients with AECOPD

The ventilatory effect of High Velocity Nasal Insufflation versus Non-invasive Positive Pressure Ventilation in the treatment of acute hypercapnic respiratory failure in patients with AECOPD

The association of vaping and electronic cigarette use with postoperative hypoxemia and respiratory complications: a retrospective cohort analysis.

Initially introduced as a safer alternative to smoking, electronic cigarettes (e-cigarettes) and vaping have since been associated with lung injury. Nevertheless, there is limited perioperative data on their potential contribution to the harmful effects of mechanical ventilation on the lungs. We hypothesized that, in adults undergoing noncardiothoracic surgeries, preoperative vaping/e-cigarette use is associated with hypoxemia during the first postoperative hour, and with an increased incidence of intraoperative and postoperative pulmonary complications. We conducted a retrospective cohort study in which we included patients reporting as vapers/e-cigarette users within one year before surgery as the exposure group, and nonvapers as the control group. The primary outcome was the time-weighted average (TWA) SpO2/FIO2 ratio in the postanesthesia care unit during the first postoperative hour. The secondary outcome was a composite of intraoperative and postoperative pulmonary complications until discharge. We used entropy balancing to adjust for confounding, and fit weighted linear regression and logistic regression models to estimate treatment effects. A total of 110,940 patients met the inclusion criteria, and 1,941 of these were vapers/e-cigarette users. The average treatment effect on the treated for TWA SpO2/FIO2 ratio (N = 109,217) was estimated to be a mean difference of 4 (95% confidence interval [CI], 1 to 8; P = 0.007). This is equivalent to a 4% change in SpO2 at a 30% FIO2 (or at a fixed FIO2). The difference was statistically significant. The average treatment effect on the treated for experiencing intraoperative and postoperative pulmonary complications (N = 110,940) was an odds ratio of 1.04 (95% CI, 0.71 to 1.54; P = 0.84). Vaping/e-cigarette use was neither associated with clinically significant hypoxemia during the first hour in the postanesthesia care unit nor with an increase in pulmonary complications. Nevertheless, our findings cannot definitively exclude the deleterious effects of vaping and e-cigarette use on the lungs, and anesthesiologists should consider potential perioperative complications.

Pollutant cross-transmission in courtyard buildings: Wind tunnel experiments and computational fluid dynamics (CFD) evaluation

Courtyards, a historical architectural feature surrounded by buildings, are common in urban housing and residential complexes. These spaces, often open-air and with rooms facing them, are crucial for daylight and natural ventilation. While courtyards are essential for introducing fresh airflow into adjacent indoor areas, the effectiveness of natural ventilation may be compromised due to potentially poor air circulation from limited openings. This raises a significant concern: could the design of courtyards inadvertently facilitate pollutant cross-transmission? Despite a wealth of research focused on airflow within courtyards, the indoor spaces in proximity to these courtyards have often been neglected in previous works, particularly concerning the exchange of pollutants between the indoor and courtyard environment. This research investigates the dynamics of indoor-outdoor pollutant cross-transmission in courtyard buildings, assessing factors like external wind flow patterns and internal pollutant sources. Wind tunnel experiments were conducted to measure internal pressure and CO2 concentration and to validate a computational model of the courtyard with 12 rooms. The validated Computational Fluid Dynamics (CFD) models were used to simulate the dispersion of pollutants from internal rooms under different wind conditions. The results showed that the k-epsilon Realizable model accurately simulated internal surface pressure distribution and pollutant dispersion in the courtyard building. It was observed that when pollutants were released from the downwind east-facing ground floor room, CO2 concentrations in adjacent side rooms on the same floor were significantly higher, increasing from the baseline of 400 ppm and reaching up to 3211 ppm in the north-facing room at a wind speed of 4.51 m/s and wind direction of 0°. Conversely, when pollutants originated from north- and south-facing side rooms, pollutants were minimally dispersed to adjacent rooms. Furthermore, at a wind direction of 45°, pollutants from wind-exposed rooms predominantly dispersed to downwind rooms, with peak concentrations exceeding 2400 ppm in downwind rooms. These findings demonstrate that pollutant dispersion is highly dependent on wind direction and the location of the pollutant source. The study concludes that while courtyards enhance indoor environmental quality through natural ventilation, their design must be carefully considered to prevent unintended pollutant cross-transmission, particularly under varying wind conditions and pollutant source locations.

Estimating the causal effect of filter ventilation levels in cigarettes on past 30-day smoking.

Cigarettes with higher levels of filter ventilation are misperceived as less harmful and may be more appealing to consumers. Setting limits on filter ventilation has been considered as a policy, but a better understanding of any potential unintended consequences is needed. Filter ventilation (0.2-61.1%) measured for 114 subbrands was merged with Wave 1 (2012-2013) of the Population Assessment of Tobacco Use and Health (PATH) data, restricted to adults 25+ years of age who smoked daily, and examined by quartiles. Inverse probability of exposure weights were used to estimate the causal effect of filter ventilation on past-30 day smoking at subsequent waves while accounting for potential confounders including demographics, menthol, heaviness of smoking and past quit attempts. Compared to those in the 1st (lowest) quartile of filter ventilation, those in the 2nd, 3rd and 4th quartiles had 1.02 (95% confidence interval: 0.57, 1.82), 0.86 (0.42, 1.73) and 1.52 (0.90, 2.56) times the odds of no past 30-day smoking at Wave 2 (approximately 1 year later, p=0.163), and 1.28 (0.80, 2.07), 1.11 (0.67, 1.83) and 1.65 (1.01, 1.24) times the odds of no past 30-day smoking at Wave 4 (3 years later, p = 0.238). This observational study found no strong evidence of a causal effect of filter ventilation on past 30-day smoking at approximately 1 and 3 years follow-up. However, our effect size estimates were not precise and thus an increase in the ability to quit smoking due to higher filter ventilation levels cannot be ruled out. Setting a maximum limit on filter ventilation (FV) in cigarettes could address the misperception that highly ventilated cigarettes are less harmful and the link between FV and lung adenocarcinoma. It is important to understand whether such a policy would have unintended consequences on longer-term smoking behavior. We found no strong evidence that FV affects past 30-day smoking 1-3 years later, but could not rule out the possibility that higher FV increases cessation rates. If future studies confirm these epidemiologic findings, this could mean that setting a limit on FV would not lead to reductions in the ability to quit smoking.

The promotion effect of human activity intensity on displacement ventilation efficiency by the enhancement indoor thermal stratification

In a displacement ventilation system, the human body heat source plays a significant role and should not be overlooked. The intensity of human activity is a crucial factor in determining the amount of heat generated by the human body. In this work, the impact of thermal plumes generated by different levels of human activity intensity on the temperature stratification and ventilation efficiency in displacement ventilation system have been explored with experimental and numerical methods. The airflow patterns in the displacement air supply system under various levels of human activity intensity were simulated. The results show that under the same air supply speed, as the human activity intensity increasing from 125 W to 402 W, the phenomenon of temperature stratification becomes more pronounced. With the promotion of thermal plumes, the air flow velocity on the human body surface increases, leading to an enhancement in ventilation efficiency. Therefore, to elimination of the indoor thermal load, the air supply speed can be reasonably reduced according to the human activity intensity in the room, further enhancing the energy-saving effect of displacement ventilation.

Investigation of the aerodynamic characteristics of the entire operation process of the car–counterweight system within the annular flow field of ultra-high-speed elevators

The ultra-high-speed elevator car–counterweight system will experience substantial aerodynamic effects when operating at high speeds in the annular flow field, particularly at the moment of intersection. These effects will have a considerable impact on the stability of the elevator's operation. This study utilized the unsteady Reynolds-averaged Navier–Stokes approach to investigate the aerodynamic characteristics of the car–counterweight system's entire operation process. The ultra-high-speed elevator three-dimensional transient model is created using dynamic layering mesh technology and then validated through experiments. We investigate the impact of three crucial factors—acceleration, car height, and contact ratio—on the aerodynamic characteristics of the car and the ventilation effect in the hoistway. Specifically, we analyze the instantaneous variations in the aerodynamic force of the car during the intersection process. The results indicate a rapid change in the car's drag and lift at the moment of intersection, with a greater magnitude of change observed in the pressure drag. The acceleration increases gradually, while the drag peak at the intersection time decreases by 1.8%, 3.0%, and 3.6%, respectively. Additionally, the hoistway exhaust volume ratio decreases by 0.9%, 1.5%, and 2.0%. Compared to the drag peak, the lift peak is more responsive to variations in car height. The contact ratio exhibits a sequential increase, but the lift peak demonstrates an uneven upward pattern with increments of 3.07%, 10.35%, and 16.88%. This study greatly enhances the investigation of the aerodynamic characteristics of ultra-high-speed elevators and offers a crucial point of reference for optimizing elevator design in engineering.

Historical Perspectives and Clinical Updates on Preterm Bottle Feeding With Noninvasive Ventilation.

The controversial topic of oral feeding while on noninvasive ventilation remains at the forefront of preterm intensive care management. The intersection of pulmonary, neurologic, and gastrointestinal maturation coalesces at a postmenstrual age that requires changes in practices compared with those used in older infants. Various animal models in the past decades aimed to gain physiological knowledge of noninvasive ventilation effects on the suck-swallow-breathe coordination sequence. However, the preterm infant poses nuanced anatomic challenges. Although concerns for oral feeding while on noninvasive ventilation include aspiration risks and potential inpatient obstacles, there is evidence to support the feasibility, initiation, and progression of oral feedings while an infant is supported on high-flow nasal cannula and continuous positive airway pressure. There is evidence to support that this may accelerate attainment of oral feeding milestones and, thus, eventual hospital discharge. More recent multidisciplinary institutional protocols may provide cautious guidance on evaluation and algorithms to assess infants who may benefit from initiation and advancement of oral feeding versus awaiting further maturation.

Long term effects of mechanical ventilation on lung function in critical care patients: Systematic review

Long term effects of mechanical ventilation on lung function in critical care patients: Systematic review

Effectiveness of Bilevel positive airway pressure ventilation for acute respiratory failure patients: A systematic review

Effectiveness of Bilevel positive airway pressure ventilation for acute respiratory failure patients: A systematic review

Evaluation of the outcomes of noninvasive ventilation in acute heart failure patients at Cardiovascular Center – E hospital

Background: Noninvasive ventilation is indicated in patients with acute respiratory failure, especially in acute heart failure. The study aimed to evaluate the effectiveness of noninvasive ventilation in patients with acute heart failure. Methods: The descriptive study on 23 patients with acute heart failure and respiratory failure who were applied non-invasive ventilation at Cardiovascular Center, E Hospital. Results: The mean age of the patients was relatively high (74 years old), the rate of male accounted for 56.5%. The main causes were ischemic heart disease accounting for 82.6% and acute myocardial infarction accounting for 43.5%. Non-invasive ventilation improved the respiratory failure condition: gradually reducing respiratory rate, increasing SPO2, PaO2, and P/F ratio. In addition, it improved the hemodynamic status: increasing mean blood pressure, reducing heart rate and increasing tissue perfusion by reducing lactate level. The successful rate of noninvasive ventilation is 65.2% and the mortality rate is 21.7%. Conclusion: Non-invasive ventilation is a simple respiratory support, easy to apply in many facilities to help improve respiratory condition and hemodynamic status.

Multi-objectives occupant-centric control of thermostats and natural ventilation systems in cold climate conditions using real-time occupant-related information

Recently, Occupant-Centric Controls (OCCs) have attracted great attention. Many studies have applied OCCs to mechanical ventilation systems, while natural ventilation systems have gathered much less attention. The natural ventilation effect, driven by opening windows or vents, can be effective in improving indoor air quality, however, result in a leakage of interior heating energy in winter in cold climates. Therefore, the controls of thermostats and natural ventilation systems shall be designed well so that satisfying levels of thermal comfort, air quality and energy conservation can be simultaneously guaranteed. This study proposes an OCC and applies it to thermostats and natural ventilation systems for indoor thermal comfort, air quality and heating energy management. The strategy comprises three controllers: occupancy-based on-off controller, controller of setpoint of indoor air temperature and window openness controller. First, real-time profiles of heat gains from occupants and window openness were collected by employing vision-based detection. Second, a parametric building simulation study was conducted, and then simulation data were generated to develop predictive shallow artificial neural networks for forecasting the indoor conditions and energy performance of the investigated room. Third, the performance of the proposed strategy was examined. Compared to the baselines, the control could offer a decrease in building heating loads by between 43.4% and 63.8 % and an improvement of predicted mean vote levels by 0.36–0.37. The proposed OCC could also maintain indoor CO2 concentrations below 1000 ppm for about 91 % of the studied time, while 84.2 % of the time with several peaks over 3000 ppm in the baseline cases.

Lessons from the COVID-19 pandemic for ventilation and indoor air quality.

The rapid global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at the beginning of 2020 presented the world with its greatest health challenge in decades. It soon became clear that governments were unprepared to respond appropriately to this crisis. National and international public health authorities were confused about the transmission routes of the virus and the control measures required to protect against it. In particular, the need to reduce the risk of infection through sufficient and effective ventilation of indoor spaces was given little attention. In this review, we discuss insights and key lessons learned from the COVID-19 pandemic regarding the role of ventilation as an effective means against airborne transmission of pathogens and, more broadly, for supporting good indoor air quality.

Effects of bronchoscopic alveolar lavage-assisted mechanical ventilation on postoperative pulmonary infection and inflammatory factors in patients undergoing lung cancer surgery

Effects of bronchoscopic alveolar lavage-assisted mechanical ventilation on postoperative pulmonary infection and inflammatory factors in patients undergoing lung cancer surgery

Analysis of the Effect of Non-Invasive Positive Pressure Ventilation in Emergency Treatment of Severe Bronchial Asthma with Respiratory Failure

Objective: This study aims to evaluate the clinical efficacy of non-invasive positive pressure ventilation (NIPPV) in patients with severe bronchial asthma combined with respiratory failure. Methods: 90 patients with severe bronchial asthma combined with respiratory failure between September 2022 and December 2023 were selected for the study and randomly divided into the experimental group (NIPPV-assisted treatment) and the control group. The differences between the two groups were compared in terms of total effective rate of treatment, days of clinical symptom disappearance, days of hospitalization, lung function indexes, incidence of adverse reactions, and quality of life. Results: Patients in the experimental group had a significantly higher total effective rate of treatment (97.78%) than the control group (75.56%). In terms of pulmonary function indexes, patients in the experimental group showed significant improvement after treatment, especially the increase in forced expiratory volume and forced vital capacity, while these improvements were not as obvious in the control group. In addition, the incidence of adverse reactions was significantly lower in the experimental group than in the control group, suggesting that the application of NIPPV is relatively safe. Quality of life assessment also showed that patients in the experimental group had significantly better quality of life than the control group after treatment. Conclusion: This study demonstrated the effectiveness of NIPPV as an adjunctive treatment for severe bronchial asthma combined with respiratory failure. NIPPV can improve lung function, reduce the incidence of adverse effects, increase the overall effectiveness of the treatment, and contribute to the improvement of patients’ quality of life. Therefore, NIPPV should be regarded as an effective and safe treatment in clinical management, especially in patients with severe bronchial asthma combined with respiratory failure, where its application has potential clinical significance.