Demand-controlled ventilation systems and carbon dioxide monitoring are critical to ensure indoor air quality (IAQ) comfort conditions. Their importance has become significantly more evident since the COVID-19 pandemic crisis. Control strategies for mechanical ventilation based on CO2 concentration are commonly used, although they are rarely applied in Italian and other Southern European country schools. Moreover, optimised ventilation systems can help maintain indoor air quality while reducing energy consumption for heating (i.e. exploiting heat recovery). The proposed paper aims to compare different remote-control strategies to manage three detached mechanical ventilation units (DMV) installed in a junior-high-school demo building in Torre Pellice (Northwest Italy), monitored with room detail since April 2021. Eight IAQ control logics are analysed considering both in situ tests, handling DMV accordingly to room sensors, and simulation tests using the Energy Management System of EnergyPlus in the neutral season. All different solutions are compared by considering air quality, temperature, and energy need indicators. Additionally, a yearly energy verification via hourly simplified analyses is performed by considering fan consumption and energy conservation. Threshold-based control logics result to be more effective than time-dependent ones, while all cases guarantee very high IAQ levels, although energy savings are limited. The choice of the correct control threshold(s) is site-dependent being influenced by user local habits.