Objective To analyze the influence factors of lower extremities deep venous thrombosis after hip replacement, and provide guidance for perioperative prevention. Methods 52 cases of patients underwent total hip replacement were selected, who were given color doppler ultrasound examination for lower limb venous thrombosis after hip replacement.And analyzed risk factors of lower extremity deep vein thrombosis from patient's gender, age, blood lipid, D-dimer, complications and surgical index. Results During the 52 cases, 16 cases were found with postoperative lower limb deep vein thrombosis(30.8%);Single factor analysis showed that patients with age≥65 years, overweight or obese(BMI≥25kg/m2), high triglycerides(TG≥1.7mmol/L)and high D-dimer level(≥500μg/L), diabetes or high blood pressure,large blood transfusion combined with a greater incidence of postoperative deep vein thrombosis(P<0.05).Further multiple factors regression analysis showed that age≥65 years, overweight or obesity, high triglycerides, high D-dimer, diabetes, large blood transfusions were independent risk factors of lower extremity deep vein thrombosis(OR=15.693,1.278,9.832,3.053,1.855,1.014,all P<0.05). Conclusion Patients with total hip replacement should be given preoperative vein thrombosis risk assessment, patients with age≥65,overweight or obese, high triglycerides,D-dimer level, diabetes, large number of blood transfusions have higher risk of deep vein thrombosis, we should focus on perioperative monitoring, application of low molecular heparin, lower limb vein pump, etc.early postoperative lower limb rehabilitation exercise, to reduce the occurrence of deep vein thrombosis. Key words: Arthroplasty, hip; Lower extremity deep vein thrombosis; Factor analysis, statistics