Idiopathic intracranial hypertension (IIH) is characterized by elevated intracranial pressures and seen mostly in women of childbearing ages. In some cases, intracranial venous stenosis is observed during clinical workup and can manifest with symptoms such as headache, dizziness, and vision changes. Venous hypertension has a complex pathophysiological mechanism of collateralization with variable findings based on the degree of and location of stenosis, and remains to be fully understood. In this study, we seek to characterize the complex interaction of intracranial compartments and contributors to intracranial hypertension. A total of 30 patients with venous stenosis resulting in intracranial hypertension treated at Johns Hopkins Hospital were retrospectively reviewed in an IRB-approved study. Parameters recorded included patient demographics, location of stenosis, pre- and posttreatment manometric venous sinus and internal jugular pressure measurements, and symptoms before and after treatment. 27 patients demonstrated stenosis at the venous sinus level, 1 at the C1 level, and 2 at the internal jugular level. Mean pretreatment gradients across the stenosis were 20.8 mm Hg, 5 mm Hg, and 3 mm Hg, respectively. Posttreatment mean gradients were 2 mm Hg for venous sinus stenosis and 1.5 mm Hg for jugular stenosis (no treatment yet for the C1-level patient). Symptomatology was notable for near universal reduction in papilledema but variable reduction in headache. Facial fullness was seen exclusively with stenosis at or below the C1 level. Intracranial hypertension caused by venous stenosis is a complex pathophysiological phenomenon with symptoms that correlate with observed manometric findings. Different pressure gradient findings suggest delineation between series- and parallel-type resistance patterns depending on the level of stenosis, with symptoms and posttreatment manometry supporting this theory. Next steps include translation of observed findings into a multidimensional mathematical model of the circulatory system in development to simulate effects of treatment and predict expected findings in novel stenosis.