Background: Azygous vein aneurysm is a rare occurrence and presenting as a mediastinal mass is even rarer. Its complications are dreadful as it may lead to rupture and demise if not properly diagnosed and attended. Aims: This report is prepared to present an infrequent ailment, clinical presentation, histopathologic findings and course of the disease. Results: This patient, a 58-year-old female, presented with dyspnoea and chest pain. She was brought to a hospital and showed tachypnoea. Upon admission, chest radiograph was performed displaying a lobulated soft tissue mass in the right suprahilar region which at first was considered as soft tissue mass versus an enlarged lymph node. The patient was transferred to the Philippine Heart Center for definitive management. Computed tomography (CT) of the chest showed a large saccular aneurysm (7.8×7.4×7.7 cm) emanating from the right lateral wall of the superior vena cava (SVC) with thrombus formation within its lumen, extending to the distal SVC. The patient was scheduled for aneurysm repair. Intraoperatively, the SVC was identified and discovered that the aneurysmally dilated vein was the azygous vein instead of the SVC. It was resected and the operation was successful. The specimen consisted of several, tan-gray, rubbery to friable tissues aggregately measuring 6.5×5.5×2.0 cm. Microsections showed vessel wall with fibrosis, myxoid areas within the medial layer and congested vascular channels in the adventitia. Haemorrhage and thrombus were seen. Trichrome stain revealed areas of fibrosis and marked increase in collagen fibres. Elastic stain revealed elastic fibre loss and fragmentation. The final histologic diagnosis was aneurysmal vessel wall with myxoid degeneration of media. Conclusion: Azygous vein aneurysm is rare, probably the first ever reported entity in the Philippines. Proper approach in early detection and keen clinical judgement are necessary to ensure good patient outcomes.
Read full abstract