This paper presents a summary of the optimization design process for a multi-objective, two-level engineering problem, utilizing the generalized inverse cascade method under uncertainty. The primary objective is to enhance the vibration isolation performance of a mounting system, considering the influence of uncertain factors on its stiffness. The focus is on determining the value range of the design variables at the bottom layer, ensuring that the design goal is met with a specified confidence level. To illustrate the application of this methodology, the optimization design of a powertrain mount is used as a case study. A data-driven approach is adopted, establishing a quantitative mapping relationship between mount stiffness, force transmission rate, modal decoupling rate, and other design indicators. This is achieved through the development of a CRBM-DBN approximate model, which combines Conditional Restricted Boltzmann Machines (CRBMs) and a Deep Belief Network (DBN). Additionally, an intelligent optimization algorithm and interval search technology are employed to determine the optimal design interval for the mount stiffness. Simulation and experimental verification are conducted using selected parameter combinations. The results demonstrate notable improvements in the vibration isolation performance, modal decoupling rate, and vehicle NVH performance when compared to the original state. These findings provide valuable insights for the interval optimization design of similar multi-objective, as well as two-level engineering problems, serving as useful references for future research and applications.