Tank vehicles are widely used for the road transportation of dangerous goods and especially flammable liquid fuels. Existing gross weight limitations, in such transportations, render the self-weight of the tank structure a crucial parameter of the design. For the design and the construction of metallic tank vehicles carrying dangerous goods, the European Standard EN13094:2015 is applied. This Standard poses a minimum thickness for the shell thickness for the tank construction according to the mechanical properties of the construction material. In the present paper, primarily, the proposed design was investigated and a weight minimization of such a tank vehicle with respect to its structural integrity was performed. As test case, a tank vehicle with a box-shaped cross-section and low gross weight was considered. For the evaluation of the structural integrity of the tank construction, the mechanical analysis software ANSYS ® 2019R1 was used. The boundary values and the suitable computation for structural integrity were applied, as they are defined in the corresponding Standards. The thickness of the construction material was decreased to a minimum, lower than that posed by the standards, indicating that the limit posed by them was by no means boundary in terms of structural integrity.