This article studies the transformation and assembly process of the Volkswagen (VW) Crafter from conventional to hybrid vehicle of the department of vehicles engineering, University of Debrecen, and uses a computer-aided simulation (CAS) to design the vehicle based on the real measurement data (hardware-in-the-loop, HIL method) obtained from an online CAN bus data measurement platform using MATLAB/Simulink/Simscape and LabVIEW software. The conventional vehicle powered by a 6-speed manual transmission and a 4-stroke, 2.0 Turbocharged Direct Injection Common Rail (TDI CR) Diesel engine and the transformed hybrid electrified powertrain are designed to compare performance. A novel methodology is introduced using Netcan plus 110 devices for the CAN bus analysis of the vehicle’s hybrid version. The acquired raw CAN data is analyzed using LabVIEW and decoded with the help of the database (DBC) file into physical values. A classical proportional integral derivative (PID) controller is utilized in the hybrid powertrain system to manage the vehicle consumption and CO2 emissions. However, the intricate nonlinearities and other external environments could make its performance unsatisfactory. This study develops the energy management strategies (EMSs) on the basis of enhanced proportional integral derivative-based genetic algorithm (GA-PID), and compares with proportional integral-based particle swarm optimization (PSO-PI) and fractional order proportional integral derivative (FOPID) controllers, regulating the vehicle speed, allocating optimal torque and speed to the motor and engine and reducing the fuel and energy consumption and the CO2 emissions. The integral time absolute error (ITAE) is proposed as a fitness function for the optimization. The GA-PID demonstrates superior performance, achieving energy efficiency of 90%, extending the battery pack range from 128.75 km to 185.3281 km and reducing the emissions to 74.79 gCO2/km. It outperforms the PSO-PI and FOPID strategies by consuming less battery and motor energy and achieving higher system efficiency.