This paper deals with the simulation of a permanent magnet synchronous machine (PMSM) to be developed for driving a scroll compressor of a vehicle air conditioning system. The simulations were needed for the verification of the pre-sizing and for the electromagnetic behavior analysis of the PMSM. These were performed by using the ANSYS Motor-CAD software. All the obtained results emphasized that the pre-sizing of the PMSM was performed correctly, and the designed electrical machine can fulfill all the prescribed requirements. To highlight the superiority of the chosen surface-mounted PMSM topology, a comparative study was performed for four PMSMs having the same stator but different rotor topologies having the same quantity of permanent magnets. The study revealed that the PMSM with permanent magnets on its rotor surface is the best-fitting variant for the foreseen application. By intensively using the ANSYS Motor-CAD software, the authors appreciated that this product is a very useful tool in the hands of the designers not only in evaluating the machine’s computed geometry (by checking its correctness and feasibility), but also in its in-depth electromagnetic analysis and in calculating its parameters of interest.